{"title":"Étude de l'activité du cromoglycate disodique sur le décours de la réaction nasale d'origine allergique provoquée par l'administration locale de l'antigène sensibilisant","authors":"J. Mélon, R. Boniver","doi":"10.1016/S0035-2845(73)80039-3","DOIUrl":"10.1016/S0035-2845(73)80039-3","url":null,"abstract":"<div><p>Chez dix patients atteints de rhume des foins, nous avons comparé l'activité du cromoglycate disodique et d'un placebo sur la réaction nasale d'origine anaphylactique, provoquée par l'administration locale de l'antigène sensibilisant, en dehors de la période de pollinisation. Nous n'avons pas trouvé de différence significative entre les effets du cromoglycate et ceux du placebo.</p></div><div><p>In ten patients suffering from hay fever, a comparison was made between the action of disodic cromoglycate and a placebo on the nasal reaction of anaphylactic origin caused by local administration of the sensitizing antigen at a time other than that of pollinisation. No significant difference was found between the effects of the cromoglycate and the placebo.</p></div>","PeriodicalId":101127,"journal":{"name":"Revue Fran?aise d'Allergologie (1970)","volume":"13 3","pages":"Pages 241-246"},"PeriodicalIF":0.0,"publicationDate":"1973-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0035-2845(73)80039-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86717953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Le role de l'AMP cyclique dans l'hypersensibilité immédiate","authors":"M. Renoux , G. de Montis","doi":"10.1016/S0035-2845(73)80045-9","DOIUrl":"10.1016/S0035-2845(73)80045-9","url":null,"abstract":"<div><p>Après un appel de la théorie du « second messagerde Sutherland, sont revus les travaux expérimentaux qui ont étudié le taux de 3′5′ AMP cyclique, tant en rapport avec la production d'anticorps ou la transformation blastique qu'avec la dégranulation des mastocytes ou des basophiles. Dans ce dernier cas, les drogues qui élèvent les taux cellulaires d'AMP cyclique déterminent une diminution de la libération d'histamine ou de SRS-A en présence d'antigène. Ces résultats viennent à l'appui de la théorie bêta-adrénergique de l'atopie proposée par Szentivanyi. Ils permettent une meilleure compréhension de l'action de médicaments tels qu'isoprotérénol, théophylline ou corticoïdes.</p></div><div><p>After recalling Sutherland's « second messengertheory, the authors review the experimental research which has been carried out on cyclic 3′5′ AMP, both in relation to the production of antibodies or blastic transformation and degranulation of mastocytes or basophils. In the latter case, drugs which raise the cellular levels of cyclic AMP cause a decrease in the liberation of histamine or of SRS-A in the presence of the antigen. These results support the beta-adrenergic theory of atopy put forward by Szentivanyi. They make for a better understanding of the action of drugs such as isoproterenol theophylline or the corticoids.</p></div>","PeriodicalId":101127,"journal":{"name":"Revue Fran?aise d'Allergologie (1970)","volume":"13 3","pages":"Pages 293-301"},"PeriodicalIF":0.0,"publicationDate":"1973-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0035-2845(73)80045-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76130120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applications des découvertes de Besredka en clinique allergologique","authors":"R. Wolfromm","doi":"10.1016/S0035-2845(73)80038-1","DOIUrl":"10.1016/S0035-2845(73)80038-1","url":null,"abstract":"<div><p>Les découvertes de Besredka ont pour application la mieux connue du médecin praticien, sa méthode d'accoutumance en sérothérapie. Elles sont à l'origine de nombreuses autres acquisitions devenues fondamentales en allergologie.</p><p>Cet auteur établit notamment la notion de rigoureuse spécificité de l'allergène, la hiérarchie d'agressivité, fonction de sa nature physique et chimique, l'importance de la voie d'apport de l'allergène de gravité croissante (orale, sous-cutanée, musculaire, veineuse). La communauté de réaction des espèces animales à un facteur commun est démontrée : le choc anaphylactique, mais aussi le moyen de s'en protéger par établissement d'une anti-anaphylaxie, le rendant réfractaire par injection unique à dose subléthale ou mieux par doses subintrantes qui établissent une immunité où la cellule bronchique, cutanée est la citadelle de défense anti-anaphylactique</p></div><div><p>The discoveries of Besredka are best known to the practising doctor by their application acquisitions which have become fundamental tenets of allergology.</p><p>This author establishes notably the strict specificity of the allergen, the hierarchy of aggressivity depending on its physical and chemical nature, the importance in increasing order of gravity of the manner in which the allergen is communicated (oral, sub-cutaneous, muscular, venous). The common reaction of animal species to a common factor is demonstrated: anaphylactic shock, but also the means of protecting against it by building up anti-anaphylaxis making it refractory by a single injection of a sublethal dose or, better, by subintrant doses which set up an immunity in which the bronchial, cutaneous cell is the anti-anaphylactic bulwark.</p></div>","PeriodicalId":101127,"journal":{"name":"Revue Fran?aise d'Allergologie (1970)","volume":"13 3","pages":"Pages 231-239"},"PeriodicalIF":0.0,"publicationDate":"1973-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0035-2845(73)80038-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82026122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Confrontation anatomo-clinique des tests épicutanés","authors":"E. Grosshans, J. Foussereau","doi":"10.1016/S0035-2845(73)80042-3","DOIUrl":"10.1016/S0035-2845(73)80042-3","url":null,"abstract":"<div><p>L'étude comparative, clinique et anatomo-pathologique, de 278 tests épicutanés permet de délimiter les critères du diagnostic d'une réaction allergique de contact et des effects irritants primaires des divers réactogènes testés. Dans 24 cas, une discordance entre l'aspect clinique du test et son interprétation histopathologique a été constatée : il s'agit de tests aux ammoniums quaternaires, aux détersifs ménagers, au nickel, à la colophane, à la térébenthine. Dans ces cas, le caractère apparemment allergique des réactions observées n'a pas pu être confirmé par la biopsie du test. Cette discordance, particulièrement nette pour les ammoniums quaternaires, est illustrée par trois figures.</p></div><div><p>A comparative clinical and anatomopathological study of 278 epicutaneous tests enabled diagnostic criteria to be formulated for distinguishing between an allergic contact reaction and the primary irritant effects of the various reactogenic agents tested. In 24 cases, there was found to be a discrepancy between the clinical aspect of the test and its histo-pathological interpretation : these tests involved the use of quaternary ammonias, household detergents, nickel, rosin, turpentine. In these cases, the apparently allergic nature of the reactions observed could not be confirmed by test biopsy. This discrepancy, which was particularly marked with quaternary ammonias, is illustrated by three figures.</p></div>","PeriodicalId":101127,"journal":{"name":"Revue Fran?aise d'Allergologie (1970)","volume":"13 3","pages":"Pages 267-275"},"PeriodicalIF":0.0,"publicationDate":"1973-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0035-2845(73)80042-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82301962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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