Pharmacological Research - Reports最新文献

{"title":"Bongkrekic acid inhibits 2-deoxygulcose-induced apoptosis, leading to enhanced cytotoxicity and necrotic cell death","authors":"Arihiro Kano ,&nbsp;Miho Fujiki ,&nbsp;Keiya Fukami ,&nbsp;Mitsuru Shindo ,&nbsp;Jeong-Hun Kang","doi":"10.1016/j.prerep.2024.100017","DOIUrl":"10.1016/j.prerep.2024.100017","url":null,"abstract":"<div><p>Targeting glucose metabolism using the glycolysis inhibitor, 2-deoxyglucose (2-DG), is a promising therapeutic strategy for cancers characterized by elevated glucose requirements. Although clinical studies have revealed that effective doses cause side effects, research on combination therapies is ongoing. 2-DG inhibits not only glycolysis but also glycosylation of newly synthesized proteins and disturbs protein folding, resulting in endoplasmic reticulum (ER) stress-mediated apoptosis. Meanwhile, bongkrekic acid (BKA) is a toxic compound, which has been reported to inhibit ADP/ATP exchange in the mitochondria and suppress apoptosis by interfering with cytochrome <em>c</em> release from the mitochondria. Herein, 100 µM BKA inhibited 2-DG-induced apoptosis but showed enhanced cytotoxicity in the 4T1 murine breast cancer cell line, resulting in necrotic cell death. Surprisingly, BKA did not suppress 2-DG-induced cytochrome <em>c</em> release from the mitochondria, but effectively inhibited caspase activation. Furthermore, BKA did not suppress the upregulation of ER stress marker C/EBP homologous protein but suppressed autophagy flux. Our findings suggest an alternative treatment for cancer using BKA in combination with 2-DG.</p></div>","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"2 ","pages":"Article 100017"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295020042400017X/pdfft?md5=6233f23e686d434fe534ea56eacfdc67&pid=1-s2.0-S295020042400017X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of chronic plaque psoriasis: An overview on current update","authors":"Priyanka Jurel,&nbsp;Shiv Bahadur,&nbsp;Meenakshi Bajpai","doi":"10.1016/j.prerep.2024.100004","DOIUrl":"10.1016/j.prerep.2024.100004","url":null,"abstract":"<div><h3>Introduction</h3><p>Chronic plaque psoriasis is an inflammatory skin disorder that affects 2–3% of the population. The severity of the disease is influenced by the number and location of skin lesions, concomitant conditions such psoriatic arthritis, and the impact on daily life. Several comorbidities, such as depression, cardiometabolic disorders, and psoriatic arthritis, are linked to plaque psoriasis. Hence, aim of current review is to highlight the comprehensive information on the pathophysiology, mechanism of action of recent approved drugs and future prospective. Further, clinical research and lengthy prospective cohort studies have been discussed.</p></div><div><h3>Materials and methods</h3><p>The data were collected from the various reported literatures PubChem, scopus and other search engines which are suggesting for the management of plaque psoriasis. These literature review were selected based on the current updated treatment of chronic plaque psoriasis.</p></div><div><h3>Result</h3><p>Various biologics have been promoted by the National Psoriasis Foundation guidelines as a first-line treatment option for moderate to severe plaque psoriasis due to their effectiveness in treating the condition and their acceptable safety profiles. The aryl hydrocarbon receptor (AhR) modulator tapinarof, the phosphodiesterase-4 (PDE4) inhibitor roflumilast and the tyrosine kinase 2 (TYK2) inhibitor deucravacitinib are the new drugs approved by US Food and Drug Administration (FDA) for promising treatment mild-severe plaque psoriasis.</p></div><div><h3>Discussions</h3><p>The conventional systemic therapy for treatment of plaque psoriasis was found to be unsatisfactory due to several significant adverse effects and contraindications. It is vital to continue developing efficacious, safe, and tolerant systemic medication approach capable of being employed as first-line systemic treatments for those with moderate-to-severe psoriasis. The recent approved drugs by USFDA for the management of psoriasis offer the potential for enhanced efficacy and better disease control.</p></div>","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"2 ","pages":"Article 100004"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950200424000041/pdfft?md5=d24caf82979e1f1dd5cde9a96f162fa6&pid=1-s2.0-S2950200424000041-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140268471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the Rumsfeld matrix to anticancer natural product target discovery","authors":"Christian Bailly","doi":"10.1016/j.prerep.2024.100023","DOIUrl":"10.1016/j.prerep.2024.100023","url":null,"abstract":"<div><div>For a long time, natural products (NP) contribute to the treatment of human pathologies, notably to cancer treatment with microbial and plant-derived products. The mechanism of action of new NP can be investigated using computational methods, boosted by artificial intelligence-assisted procedures, to guide target discovery. But there remain many bioactive NP with unknown targets and/or an incompletely understood or opaque mechanism of action. The most innovative compounds are those with a previously unknown chemical scaffold associated to an unknown mechanism of action, despite evidence of bioactivities in pharmacological assays. This challenging “unknown unknown” category of compounds requires major efforts to elucidate their mechanism of action, with the possibility to identify unprecedented first-in-class approaches to treat advanced cancers. There are also chemically well-known NP for which novel properties and medicinal applications are revealed without an associated target. Such compounds belong to the “known unknown” group, as it is the case for the anticancer drug etoposide and its potent anti-inflammatory action exploited to treat lymphohistiocytosis. The situation is different with new scaffolds for which a potential mechanism or molecular target can be predicted on the basis of functional analogies with other molecules. The “known unknown” and “unknown known” products can be classified using a Rumsfeld ignorance matrix by categorizing them into four subgroups. A Johari window-type classification of NP and associated targets is proposed. The matrix can help compound management and identification of research gaps to generate insights for further study. The review retraces a scientific excursion into the unknown of NP pharmacology.</div></div>","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"2 ","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenebrio molitor as a new alternative model for the investigation of chemotherapy-induced intestinal toxicity","authors":"Lara Luisa Valerio de Mello Braga ,&nbsp;Gisele Simão ,&nbsp;Carolina Silva Schiebel ,&nbsp;Yasmin Felipichuki Oliveira ,&nbsp;Liza Brandão da Rosa ,&nbsp;Marcelo Biondaro Gois ,&nbsp;Elizabeth Soares Fernandes ,&nbsp;Daniele Maria-Ferreira","doi":"10.1016/j.prerep.2024.100013","DOIUrl":"10.1016/j.prerep.2024.100013","url":null,"abstract":"<div><p>Alternative animal models have become increasingly necessary due to legal regulations aimed at reducing the use of laboratory animals. Invertebrates are gaining in importance and have been intensively researched in recent years due to their pathophysiological similarities with rodents. Among these organisms, <em>Tenebrio molitor</em>, also known as the yellow mealworm beetle, stands out. In this study, we investigated whether <em>T. molitor</em> could be an alternative for studying the toxicity of chemotherapeutic agents. For this purpose, <em>T. molitor</em> larvae were inoculated with irinotecan (IRI) or 5-fluorouracil (5-FU). Both chemotherapeutic agents increased the morbidity and mortality of <em>T. molitor</em> and led to an increase in total circulating cells. Glucose levels were decreased after treatment with 5-FU and alanine aminotransferase levels were decreased after IRI administration. Administration of IRI or 5-FU resulted in changes in the appearance, consistency and amount of T. molitor frass. Finally, both IRI and 5-FU promoted severe histologic damage in the midgut and increased melanin deposition in peripheral tissues. Finally, we succeeded in developing an alternative experimental model for evaluating the toxicity of IRI and 5-FU. This model exhibits significant features of toxicity and intestinal damage, making it suitable for translational research purposes. <em>T. molitor</em> proves to be a versatile model organism with numerous advantages for experimental studies and offers a viable alternative for acquiring and expanding knowledge in the field of toxicology and pharmacology.</p></div>","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"2 ","pages":"Article 100013"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950200424000132/pdfft?md5=c542c740d2a16d2352324ad8fa204d09&pid=1-s2.0-S2950200424000132-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141711022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diacerein reduces sensorimotor deficits after spinal cord injury by clip-compression in female rats by protection of cellular damage in long time","authors":"Fernando da Silva Fiorin ,&nbsp;Douglas Buchmann Godinho ,&nbsp;Rafael Parcianello Cipolat ,&nbsp;Luiz Fernando Freire Royes ,&nbsp;Caroline Cunha do Espírito Santo","doi":"10.1016/j.prerep.2024.100015","DOIUrl":"10.1016/j.prerep.2024.100015","url":null,"abstract":"<div><p>Spinal cord injury (SCI) is a cause of long-term disability, and one of the main problems is sensorimotor response impairment. Thus, become important treatments that reduce the progressive secondary damage that causes the loss of spared neurons. Due to the oxidative stress and inflammation interaction after damage, we tested if diacerein, a classic pharmacologic anti-inflammatory, could reduce the cell damage in the long term and recover sensorimotor responses after SCI in rats. Clip-compression SCI model in female Wistar rats caused severe locomotory loss performance showed through assessment by the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale and induced thermal hyperalgesia observed by Plantar Test Apparatus. When diacerein was administered twice a day for thirty-five days, the data presented a significant recovery of locomotion and an attenuation of thermal hyperalgesia. The increased adrenal glands’ weight and reduced soleus muscle mass were attenuated by diacerein. The immunoblotting showed that diacerein prevented progressive damage at the site of injury demonstrated by the recovery of nuclear factor erythroid-2 related factor 2 (Nrf2) levels, reduction of protein nitration by 3-nitrotyrosine (3-NT) expression and inflammation decreased showed by a less expression in glial fibrillary acidic protein (GFAP) immune content induced by injury. Therefore, the present data suggest that blockage of secondary damage by diacerein can inhibit the oxidative/inflammatory process by increasing Nrf2 and improving sensorimotor recovery in rats.</p></div>","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"2 ","pages":"Article 100015"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950200424000156/pdfft?md5=422266203990cb7120bc4cd73df23797&pid=1-s2.0-S2950200424000156-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142084415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fosfomycin mitigated apoptosis while increased mucin secretion in swine intestinal explants challenged by Lawsonia intracellularis","authors":"D.S.Pérez Gaudio ,&nbsp;C. Fodor ,&nbsp;J.M. Decundo ,&nbsp;G. Martínez ,&nbsp;J. Mozo ,&nbsp;V. Eguía ,&nbsp;S.N. Dieguez ,&nbsp;A.L. Soraci ,&nbsp;E.R. Cobo","doi":"10.1016/j.prerep.2024.100009","DOIUrl":"10.1016/j.prerep.2024.100009","url":null,"abstract":"<div><p>Lesions induced by the obligate intracellular bacterium <em>Lawsonia intracellularis</em>, the etiological agent of porcine proliferative enteropathy, are characterized by crypt hyperplasia in the intestinal epithelium with minimal inflammatory infiltration. An increased population of immature enterocytes at the expense of reduced goblet cells suggests that dysregulated apoptosis may be crucial in the pathogenesis of <em>L. intracellularis</em>.</p><p>Fosfomycin, a widely employed antibiotic in swine production, has also exhibited non-microbicidal effects, encompassing immunomodulation, augmentation of phagocytosis, and the promotion of cell survival. In this study, we assessed the immunomodulatory impact of fosfomycin on intestinal epithelial homeostasis using porcine intestinal explants challenged with <em>L. intracellularis</em>.</p><p>Our findings reveal that <em>L. intracellularis</em> elicited significant nuclear alterations, increased apoptotic indices, and prompted extensive mucin secretion in the intestinal explants. When fosfomycin was added to <em>L. intracellularis</em>-challenged intestinal explants, it mitigated the degree of apoptosis but also induced an inflammatory response. Consequently, treatment with fosfomycin in the context of <em>L. intracellularis</em> challenge appears to initiate an early mucosal response, maintaining cell viability, preserving the mucin barrier, and fostering inflammatory recruitment.</p></div>","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"2 ","pages":"Article 100009"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950200424000090/pdfft?md5=67944480687976e5019a36b6537e20f8&pid=1-s2.0-S2950200424000090-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141049871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology, single gene survival analysis and molecular docking to study the mechanism of Sotetsuflavone in the treatment of pancreatic cancer","authors":"Zi-Yong Chu ,&nbsp;Xue-Jiao Zi","doi":"10.1016/j.prerep.2024.100010","DOIUrl":"https://doi.org/10.1016/j.prerep.2024.100010","url":null,"abstract":"<div><p>Pancreatic cancer is a highly lethal cancer with limited treatment options. The number of pancreatic cancer patients is increasing rapidly worldwide. Many natural products have been shown to have anticancer activity in a range of studies. Sotetsuflavone is derived from <em>Cycas revoluta</em> Thunb. and exhibits anticancer activity. The present study incorporates network pharmacology, single gene survival analysis, gene expression analysis and molecular docking to reveal the mechanism of Sotetsuflavone in the treatment of pancreatic cancer. We have acquired 31 hub targets for the treatment of pancreatic cancer by Sotetsuflavone, namely ABCB1, AURKA, CDK1, and so on. Kaplan-Meier survival analyses demonstrated that ABCB1, AURKA, CDK1, HDAC6, MET, and MMP3 are promising hub targets that can be used as biomarkers for pancreatic cancer diagnosis and prognosis. These hub targets are highly expressed in pancreatic cancer tissues compared to normal tissues. The molecular docking results showed a strong binding capacity of Sotetsuflavone to these hub targets. In summary, it is proposed that Sotetsuflavone is a new anticancer drug, which can regulate pancreatic cancer-related signalling pathways by inhibiting the activities of ABCB1, AURKA, CDK1, HDAC6, MET, and MMP3, which are hub targets with up-regulated expression in pancreatic cancer tissues, in order to treat pancreatic cancer. However, it also requires a series of in vivo and in vitro studies to ensure its safety and efficacy.</p></div>","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"2 ","pages":"Article 100010"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950200424000107/pdfft?md5=ec0f71c0bf1559690366d7ef6e9c5241&pid=1-s2.0-S2950200424000107-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141084724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refinement by gentle handling of mice affects oral-dosing pharmacokinetic end points and response to stress under drug administration and sampling","authors":"Julia Swan ,&nbsp;Elina Kallio ,&nbsp;Johanna Magga ,&nbsp;Janne Mannila ,&nbsp;Elin Weber ,&nbsp;Elin Törnqvist","doi":"10.1016/j.prerep.2024.100020","DOIUrl":"10.1016/j.prerep.2024.100020","url":null,"abstract":"<div><div>Lifting mice by their tails is a common handling method used for laboratory mice, yet it causes substantial stress. Alternative handling methods have a positive impact on animal welfare, but, there are limited studies on the effects of handling and habituation on scientific endpoints; hindering implementation and refinement in academia and industry. The purpose of this study was to investigate the effects of handling method (tail lifting vs. tube lifting) and habituation to handling (habituation) on drug uptake, exposure, and welfare parameters in a basic pharmacokinetic study. CD1 mice were either tail lifted without habituation, tube lifted without habituation, or tube lifted and habituated using a 10-day habituation protocol. A compound (mexiletine) was then administered by oral gavage and a 24 h pharmacokinetics study was performed in an industrial setting. The habituated group had a higher maximum serum concentration (C_max), lower time to C_max (T_max) and a 30 % higher drug exposure than the tail and tube-lifted groups. These effects correlated well with reduced stress levels, as indicated by lower facial grimace scores in the tube-lifted groups than in the tail-lifted group. Handler interaction, after repeated blood sampling, was highest in the habituated group, and only the habituated group voluntarily climbed on the handler after blood sampling. Our results indicate that stress caused by tail lifting, oral gavage, and blood sampling results in reduced drug uptake and exposure. This stress can be reduced by gentle handling and habituation, which may result in more relevant pharmacokinetic data, increased scientific quality, and improved animal welfare.</div></div>","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"2 ","pages":"Article 100020"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295020042400020X/pdfft?md5=049134362260496908e5ecb62d2013a4&pid=1-s2.0-S295020042400020X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antihyperlipidemic and antioxidant effects of biogenic copper oxide nanoparticles in diabetic rats","authors":"Manisha Nitin Chalse ,&nbsp;Urmila Manoj Aswar ,&nbsp;Aniroodha Vasant Pethkar","doi":"10.1016/j.prerep.2024.100008","DOIUrl":"10.1016/j.prerep.2024.100008","url":null,"abstract":"<div><p>Diabetes mellitus is often associated with metabolic disorders like hyperglycemia, hyperlipidemia, oxidative stress and obesity. Health problems related to these disorders are on a rise globally. Although nanotechnology based approaches have been explored for diabetes treatment, specific information on alleviation of the associated health problem is scanty. Here we report the beneficial effects of copper oxide nanoparticles (CuOnpls) for the control of hyperlipidemia and oxidative stress caused due to diabetes. Wistar rats were fasted overnight and type 2 diabetes was induced by intraperitoneal (i.p.) injection of freshly prepared nicotinamide followed by streptozotocin. Induction of diabetes was confirmed by estimation of blood glucose levels of the animals. Estimation of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein-cholesterol (HDL-c) from the serum was carried out for ascertaining hyperlipidemia. Biogenic CuOnpls (spherical, 88.25 nm diameter) capped with bud extract of <em>Syzygium aromaticum</em> and α-tocopherol were administered in the animals per-oral route. Superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels were determined to evaluate antioxidant activity of CuOnpls. The nanoparticles were characterized for surface chemical groups by FTIR and HRLC-MS. The nanoparticles revealed novel surface groups responsible for site-specific delivery and beneficial effects. Diabetic rats showed enhanced serum BG, TC, TG and LDL levels and reduction in levels of HDL-c, SOD, CAT and GSH. Administration of CuOnpls caused significant reversal of the effects of diabetes on lipid profile and oxidative stress enzymes. The results pointed to the beneficial effects of CuOnpls for management of post-diabetes complications.</p></div>","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"2 ","pages":"Article 100008"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950200424000089/pdfft?md5=807c3783fbb2dfdffaf9d693aa35d217&pid=1-s2.0-S2950200424000089-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141048841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential mechanisms underlying Taohong Siwu Decoction ameliorates vascular calcification in chronic kidney disease based on network pharmacology and molecular docking","authors":"Yurou Chen, Dongping Chen, Zhaodong Liu, Lin Xu, Yuan Zhou, Shengchun Liao, Yufeng Xing, Yijing Zhou, Chaoyang Ye","doi":"10.1016/j.prerep.2024.100003","DOIUrl":"https://doi.org/10.1016/j.prerep.2024.100003","url":null,"abstract":"","PeriodicalId":101015,"journal":{"name":"Pharmacological Research - Reports","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140277608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}