Pharmacological Research - Reports

Bilirubin, a potent and persistent inhibitor of genetic damage induced by gamma rays in D. melanogaster

Pub Date : 2024-03-01 DOI: 10.1016/j.prerep.2024.100022 Elizabeth Jiménez , Emilio Pimentel , Martha P. Cruces , Viviana Valadez-Graham , Zazil Velázquez

Discovery of novel peptide deformylase inhibitors: Ensemble complex-based pharmacophore modeling, docking and binding affinity studies

Pub Date : 2024-03-01 DOI: 10.1016/j.prerep.2024.100011 Vijaya Bhaskar Baki , Siva Rajesh Sivarathri , Munichandra Babu Tirumalasetty , M.V. Jyothi Kumar , Rammohan Aluru

The synthetic peptide, PnPP-15, derived from the PnTx2-6 toxin of the spider Phoneutria nigriventer, induces peripheral antinociception involving neprilysin, opioid, and cannabinoid systems

Pub Date : 2024-03-01 DOI: 10.1016/j.prerep.2024.100012 Renata Cristina Mendes Ferreira , Edleusa Marques Lima-Batista , Ana Cristina Nogueira Freitas , Xavier Maia Mariano , Marcelo Ferreira Marcondes Machado , Dongchen Na , Adriana Karaoglanovic Carmona , Steve Peigneur , William Gustavo Lima , Brener Cunha Carvalho , Carlos Alberto Tagliati , Jan Tytgat , Igor Dimitri Gama Duarte , Maria Elena de Lima