Pharmacological Research - Reports

S-adenosyl-L-methionine modulates hippocampal DNA methylation, exerting fast and long-lasting anti-stress effects independent of alterations in TrkB-mTOR expression

Pub Date : 2025-02-01 DOI: 10.1016/j.prerep.2025.100032 Amanda J. Sales, Izaque S. Maciel, Francisco S. Guimarães

Design, and evaluation of in-silico anti-cancer activity of novel gefitinib analogues against 21 target proteins

Pub Date : 2025-01-14 DOI: 10.1016/j.prerep.2025.100030 Supriti Khan Ushna , Ananta Kumar Das

Curcumin mitigates dichlorvos-initiated multi-organ dysfunction in rats by attenuating systemic oxidative stress and brain inflammatory mRNA transcripts

Pub Date : 2025-01-14 DOI: 10.1016/j.prerep.2025.100029 Adio Jamiu Akamo , Boluwatife Adenike Olagunju , Ofem Effiom Eteng , Iyabode Adekemi Kehinde , Adetutu Omolola Ojelabi , Mushafau Adewale Akinsanya , Adedayo Adebisi Adebisi , Tobi Stephen Adekunbi , Abiola Fatimoh Adenowo , Flourence Anifowose , Olufemi Mulkah Ajagun-Ogunleye , Jacob Kehinde Akintunde