中华核医学与分子影像杂志最新文献

{"title":"Environment-responsive fluorescence probes in image-guided surgery","authors":"Jing Zhu, Chengchao Chu","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.11.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.11.014","url":null,"abstract":"Unlike conventional imaging technologies, fluorescent imaging benefits from its safety, high-spatial resolution and real-time capability, which make it a highly adoptable imaging method for tumor detection and image-guided surgery in clinics. There are two types of fluorescent probes, including always-on type and environment-responsive type, wherein environment-responsive probes are preferred due to higher target-to-background ratios, which can improve sensitivity and specificity. The environment-responsive probes include enzyme-reactive probes, pH-sensitive probes and hypoxia responsive probes. This review summarizes recent progress in environment-responsive probes, and discusses their potentials in tumor detection and image-guided surgery. \u0000 \u0000 \u0000Key words: \u0000Molecular probes; Fluorescence; Tumor microenvironment; Enzymes; Hydrogen-ion concentration; Cell hypoxia; Trends","PeriodicalId":10099,"journal":{"name":"中华核医学与分子影像杂志","volume":"39 1","pages":"694-697"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46799956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of brown adipose tissue imaging technology","authors":"X. Shao, Xiaoliang Shao, Zhenxing Jiang, Yuetao Wang","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.11.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.11.012","url":null,"abstract":"Diabetes, obesity, and metabolic diseases are globally prevalent, and induction and increase of endogenous energy consumption, especially activation of brown adipose tissue (BAT), is a new therapeutic target. Non-invasive imaging techniques, including radionuclide imaging, MRI, ultrasound imaging, and optical imaging, have attracted wide attention in BAT monitoring and have good application prospects. This article reviews the progress and application of these imaging techniques in BAT monitoring. \u0000 \u0000 \u0000Key words: \u0000Adipose tissue, brown; Radionuclide imaging; Magnetic resonance imaging; Ultrasonography; Trends","PeriodicalId":10099,"journal":{"name":"中华核医学与分子影像杂志","volume":"39 1","pages":"685-687"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49054995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of 11C-methionine PET/CT imaging for detecting the recurrence of supratentorial glioma","authors":"Qiao Zhen, Zhao Xiaobin, C. Qian, Wang Kai, Fan Di, Ai Lin","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.11.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.11.002","url":null,"abstract":"Objective \u0000To assess the diagnostic values of 11C-methionine (MET) PET/CT semiquantitative parameters for detecting recurrence in patients who were diagnosed with suspicious recurrence by MRI after resection of supratentorial gliomas. \u0000 \u0000 \u0000Methods \u0000A total of 164 patients (107 males, 57 females, age 6-74 years; high-grade 94, low-grade 63, unclear 7) with supratentorial gliomas who underwent 11C-MET PET/CT between June 2015 and June 2017 in Beijing Tiantan Hospital were enrolled respectively. All patients were with suspicious recurrence after surgery showed by MRI and followed up for 6 months at least. The final diagnosis was determined with histopathological analysis or clinical follow-up. The maximum and mean standardized uptake value (SUVmax and SUVmean), tumor-to-background ratios (TBR) of SUVmax and SUVmean (TBRmax and TBRmean) were recorded and compared between patients with recurrence or without recurrence using independent-sample t test. Receiver operating characteristic (ROC) curves were drawn to determine the threshold, and the diagnostic sensitivity and specificity of each parameter were calculated. \u0000 \u0000 \u0000Results \u0000According to the clinical diagnosis, there were 139 patients with recurrence and 25 without recurrence. SUVmax, SUVmean, TBRmax and TBRmean were significantly higher for patients with recurrence than those without recurrence (4.19±1.95 vs 2.59±1.18, 2.34±1.08 vs 1.46±0.72, 2.95±1.17 vs 1.83±0.79, 2.64±1.11 vs 1.59±0.71; t values: 5.126-6.183, all P 0.05), for which the optimal cut-off values were 3.05, 1.65, 1.96 and 1.79, respectively, and the corresponding sensitivities/specificities for the diagnosis of recurrence were 67.6%(94/139)/100%(25/25), 67.6%(94/139)/100%(25/25), 79.9%(111/139)/100%(25/25), 74.8%(104/139)/100%(25/25), respectively. Patients with (n=81) or without (n=13) recurrence had different semiquantitative parameters in high-grade glioma group (t values: 5.137-5.871, all P 0.05). Among 37 patients with recurrence confirmed by pathology, there were no significant differences in the semiquantitative parameters between the high-grade and low-grade glioma groups and AUCs were not different either (t values: 1.387-1.937, z values: 0.106-1.752, all P>0.05). \u0000 \u0000 \u0000Conclusions \u0000Semiquantitative parameters of 11C-MET PET/CT are equally accurate in the differentiation of recurrence from radiation injury in patients with gliomas, while TBRmean was superior than SUVmean in patients with the high-grade gliomas. Among the patients with recurrence confirmed by pathology, the value of the semiquantitative parameter is limited for the identification of high- and low- grade gliomas. \u0000 \u0000 \u0000Key words: \u0000Glioma; Supratentorial neoplasms; Neoplasm recurrence, local; Positron-emission tomography; Tomography, X-ray computed; Methionine","PeriodicalId":10099,"journal":{"name":"Chinese Journal of Nuclear Medicine and Molecular Imaging","volume":"39 1","pages":"647-652"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45538507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-FDG PET/CT imaging manifestations of peritoneal carcinomatosis from colorectal cancer and its clinical significance","authors":"Sun Chunfeng, Tang Zhonghua, G. Yan, Zhu Jianwei, M. Xiaoying, Ge Chengchun, Bao Shanlei","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.11.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.11.003","url":null,"abstract":"Objective \u0000To analyze 18F-fluorodeoxyglucose(FDG) PET/CT imaging manifestations in patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) and investigate its clinical significance. \u0000 \u0000 \u0000Methods \u0000From May 2016 to August 2018, 46 patients (25 males, 21 females; age range: 36-82(62.0±10.4) years) with PC from CRC who underwent 18F-FDG PET/CT imaging in Affiliated Hospital of Nantong University and had complete clinical data were retrospectively analyzed. The peritoneal carcinomatosis index (PCI) grading system was used to evaluate the PC lesions. Independent-sample t test and Kruskal-Wallis H test were used for data analysis. \u0000 \u0000 \u0000Results \u0000There were various CT manifestations of PC, while FDG metabolism on PET was observed in all 46 patients. Patients were divided into different groups according to the location of the primary CRC lesion. The diameter of PC lesion in the left colon group was (2.46±1.26) cm, which was significantly different from that of the rectum group ((3.19±1.72) cm; t=-2.77, P 0.05). Ten patients had abdominal and pelvic effusion. \u0000 \u0000 \u0000Conclusion \u000018F-FDG PET/CT can well display the PC in patients with CRC, and the combination of PCI and 18F-FDG PET/CT plays an important role in the diagnosis and treatment of PC. \u0000 \u0000 \u0000Key words: \u0000Colorectal neoplasms; Neoplasm metastasis; Peritoneum; Positron-emission tomography; Tomography, X-ray computed; Deoxyglucose","PeriodicalId":10099,"journal":{"name":"Chinese Journal of Nuclear Medicine and Molecular Imaging","volume":"39 1","pages":"653-656"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48308626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of nanomaterials in enhancing internal radiotherapy of radionuclide for cancer","authors":"Su Weiwei, Tao Wang, Changjing Zuo","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.10.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.10.014","url":null,"abstract":"The therapeutic efficiency of radionuclides for cancer is closely related to the accumulation level, residence time and distribution in tumor, and is also influenced by the radiation resistance and hypoxia microenvironment of tumor. Nanomaterials, with a series of characteristics including special dimension effect and functionally modifiable surface, can not only work as the isotopic carrier to transport nuclide into tumor, but also combine with chemical, thermal or photodynamic therapies to generate synergistic therapeutic effect or destroy the hypoxic microenvironment of tumor to reduce radiation resistance, thus achieving the radiosensitization effect. This article reviews the application of nanomaterials in enhancing the therapeutic efficiency of radionuclide for cancer. \u0000 \u0000Key words: \u0000Neoplasms; Radiotherapy; Radioisotopes; Radiation-sensitizing agents; Nanostructures; Trends","PeriodicalId":10099,"journal":{"name":"Chinese Journal of Nuclear Medicine and Molecular Imaging","volume":"39 1","pages":"632-635"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42770523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of 18F-PSMA-1007 by one-step method and PET/CT imaging in prostate cancer","authors":"Xing Zhou, Taipeng Shen, Yutang Yao, Hao Lu, Shirong Chen, Dingqiong Xiao, Meng Zhao, Guohui Xu, Jinhui You, Zhuzhong Cheng","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.10.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.10.007","url":null,"abstract":"Objective \u0000To synthesize and analyze 18F-prostate specific membrane antigen (PSMA)-1007, followed by its imaging in prostate cancer. \u0000 \u0000 \u0000Methods \u0000Based on one-step method, 18F-PSMA-1007 was produced by the CFN-MPS-200 automatic synthesis module and its quality analysis was conducted. 18F-PSMA-1007 PET/CT imaging was performed in a prostate cancer patient (66 years old). \u0000 \u0000 \u0000Results \u0000The synthesis time of 18F-PSMA-1007 was about 50 min, and the radiochemical yield was (25.0±5.0) % (attenuation correction, n=3). The radiochemical purity was above 99.0% and was above 98.0% after 6 h. The product was colorless transparent solution with pH value of 7.0-7.5, and the specific activity was (410.0±11.0) MBq/ml and the radioactive nuclear purity was above 99.0%. PET/CT imaging in the patient showed that 18F-PSMA-1007 was highly concentrated in prostate cancer with maximum standardized uptake value (SUVmax) of 40.9. \u0000 \u0000 \u0000Conclusion \u0000Based on CFN-MPS-200 multifunction synthesis module, 18F-PSMA-1007 can be stably synthesized with high radiochemical yield and can be concentrated in prostate cancer. \u0000 \u0000 \u0000Key words: \u0000Prostate neoplasms; Prostate-specific membrane antigen; Fluorine radioisotopes; Chemical synthesis; Positron-emission tomography; Tomography, X-ray computed","PeriodicalId":10099,"journal":{"name":"Chinese Journal of Nuclear Medicine and Molecular Imaging","volume":"39 1","pages":"606-609"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42011604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of GP73 in liver cirrhosis and its assistant value in grading of liver cirrhosis","authors":"Xuefei Wei, M-L Shi, Zairong Chen, Xuefeng Feng","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.10.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.10.005","url":null,"abstract":"Objective \u0000To investigate the expression of Golgi protein 73 (GP73) in liver cirrhosis and its assistant value in grading of liver cirrhosis. \u0000 \u0000 \u0000Methods \u0000A total of 160 patients with liver cirrhosis (96 males, 64 females, age: (58.6±10.3) years) and 60 healthy controls (35 males, 25 females, age: (53.5±12.2) years) were included to detect the GP73 level. Serum levels of alpha-fetoprotein (AFP), albumin (ALB), total bilirubin (TBIL) and prothrombin time (PT) were also measured. The correlations between the above indicators and the GP73 level were analyzed with Pearson correlation. The GP73 levels among patients with different Child-Pugh grading and different CT morphological grading were compared using one-way analysis of variance and the least significant difference t test. The receiver operating characteristic (ROC) curve analysis was used to analyze the diagnostic sensitivity and specificity of GP73/AFP for liver cirrhosis. \u0000 \u0000 \u0000Results \u0000The area under the ROC curve for GP73 was 0.886 with the cut-off value of 144.5 μg/L. The sensitivity of GP73 in the diagnosis of liver cirrhosis was 70.4%, and the specificity was 87.8%. After combining with AFP, the sensitivity and specificity were elevated to 71.6% and 90.2% respectively. GP73 levels among patients with different Child-Pugh grading and those with different CT morphological grading were significantly different (F: 3.15, 2.82, both P<0.05), and GP73 levels among groups also showed significant differences (all P<0.05). The GP73 level was correlated with AFP, ALB, TBIL, and PT (r values: 0.362, -0.428, 0.672, 0.575, all P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Serum GP73 level increases with progression of liver cirrhosis, and it has an assistant value in the diagnosis of liver cirrhosis. \u0000 \u0000 \u0000Key words: \u0000Liver cirrhosis; Golgin; Alpha-fetoprotein; Tomography, X-ray computed","PeriodicalId":10099,"journal":{"name":"Chinese Journal of Nuclear Medicine and Molecular Imaging","volume":"39 1","pages":"597-600"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41947430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of residual radioactivity in postoperative inpatients with differentiated thyroid carcinoma after 131I treatment using robot","authors":"Q. Ji, R. Di, Weina Chen, Jing Pan, Yang Liu, Hui Shang, Gege Kong, Yaoshan Ye, Bing Cheng, Xiangzhou Li, Xin Wen, Xingmin Han","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.10.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.10.006","url":null,"abstract":"Objective \u0000To evaluate the residual radioactivity after 131I treatment in postoperative inpatients with differentiated thyroid carcinoma (DTC) using service robot in nuclear medicine ward, and assess the time for patients to be released from isolation. \u0000 \u0000 \u0000Methods \u0000From September 2017 to June 2018, 297 patients (94 males, 203 females, age: 19-80 years) with DTC who underwent 131I treatment after surgery were included. According to the purpose of treatment and the prescription dosage of 131I, patients were divided into 8 groups: 4 groups accepted 131I remnant ablation therapy (RAT) with different dosages, which were 3 700 MBq (RAT1, n=34), 4 440 MBq (RAT2, n=122), 5 550 MBq (RAT3, n=81) and 7 400 MBq (RAT4, n=27), respectively; 4 groups had 131I treatment for recurrent/metastatic lesions (RMLT), and the dosages were 3 700 MBq (n=1), 4 440 MBq (n=2), 5 550 MBq (n=14) and 7 400 MBq (n=16). At 4, 24, 48 and 72 h after 131I administration, the dose equivalent rates at 2 cm away from the patient′s neck and at 1 m away from the body were measured by the robot designed for nuclear medicine ward. Kruskal-Wallis rank sum test and Mann-Whitney U test were used to analyze the data. \u0000 \u0000 \u0000Results \u0000Neck dose equivalent rates for patients with RAT at different time points (4, 24, 48 and 72 h) after 131I administration were significantly different among 4 groups (H values: 20.889-46.410, all P 0.05). The radioactivity retention in patients decreased rapidly within 24 h, then slowed down gradually and became extremely low at 72 h. At 72 h after 131I administration, 96.6%(255/264) patients with RAT and 100%(33/33) patients with RMLT were lower than 23.3 μSv/h, which meant the patients could be discharged from hospitalization. \u0000 \u0000 \u0000Conclusions \u0000Nuclear medicine ward service robots may dynamically measure residual radioactivity in DTC patients who take 131I treatment, providing individualized isolation solutions. \u0000 \u0000 \u0000Key words: \u0000Thyroid neoplasms; Radiotherapy; Iodine radioisotopes; Drug residues; Radiation dosage; Robotics","PeriodicalId":10099,"journal":{"name":"Chinese Journal of Nuclear Medicine and Molecular Imaging","volume":"39 1","pages":"601-605"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44240212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-ML-10 PET/CT imaging in early evaluation of doxorubicin-induced cardiotoxicity","authors":"Q. Shi, Yuyun Sun, Sheng Cao, Jian Zhang, J. Zhan, Yongping Zhang, Shaoli Song, YingJian Zhang, Mingwei Wang","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.10.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.10.002","url":null,"abstract":"Objective \u0000To investigate the feasibility of early monitoring doxorubicin (DOX)-induced cardiotoxicity by apoptosis molecular imaging of 2-(5-[18F]fluoro-pentyl)-2-methyl-malonic acid (18F-ML-10) PET/CT. \u0000 \u0000 \u0000Methods \u0000Forty-seven BALB/c mice were randomly divided into the chemotherapy group (n=30) and the control group (n=17) according to the random number table. The mice in chemotherapy group were intraperitoneally injected with DOX (4 mg/kg) once a week for 3 weeks and mice in the control group were injected with the same amount of normal saline. All mice were subjected to 18F-fluorodeoxyglucose (FDG) and 18F-ML-10 PET/CT imaging at day 0, 2, 9, 16, and left ventricular ejection fraction (LVEF) was continuously monitored using cine cardiac MR (cine-CMR) imaging. The region of interest (ROI) was delineated on PET/CT images, and the maximum percentage activity of injection dose per gram of tissue (%ID/g) was calculated. The mice were sacrificed after imaging, and the heart tissue was taken for HE staining and TdT-mediated dUTP nick end labeling (TUNEL) assay. One-way analysis of variance, independent-samples t test and Pearson correlation analysis were used to analyze the data. \u0000 \u0000 \u0000Results \u0000In the chemotherapy group, the myocardial 18F-FDG uptake on day 0, 2, 9, 16 were (63.3±14.5), (93.7±24.0), (153.6±20.6) and (135.8±32.5) %ID/g respectively, and 18F-ML-10 uptake were (0.09±0.02), (0.18±0.03), (0.22±0.04) and (0.55±0.12) %ID/g respectively. Compared with baseline (day 0), 18F-FDG and 18F-ML-10 uptake were significantly increased in the chemotherapy group at each time point after DOX administration(F=6.823, 20.848, both P 0.05). TUNEL and HE staining indicated that the cardiomyocytes in the chemotherapy group showed obvious apoptosis and vacuolization, and the apoptotic index (AI) was positively correlated with the 18F-ML-10 uptake (r=0.950, P<0.01). The cine-CMR imaging results showed that the LVEF in the chemotherapy group continued to decrease after DOX administration (F=4.507, P<0.05), and significant difference was identified at day 16 (t=2.980, P<0.05). There was a significant negative correlation between 18F-ML-10 uptake and LVEF (r=-0.709, P=0.01). \u0000 \u0000 \u0000Conclusions \u0000Both 18F-FDG and 18F-ML-10 PET/CT imaging can early assess DOX-induced cardiotoxicity in vivo. Given the high targeting specificity of 18F-ML-10, it may have a greater clinical transformation advantage over 18F-FDG in early assessment of cardiotoxicity. \u0000 \u0000 \u0000Key words: \u0000Cardiotoxicity; Doxorubicin; Positron-emission tomography; Tomography, X-ray computed; Mice","PeriodicalId":10099,"journal":{"name":"Chinese Journal of Nuclear Medicine and Molecular Imaging","volume":"39 1","pages":"581-586"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47516238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on optimizing rapid acquisition time of CZT-SPECT myocardial perfusion imaging using different injection doses","authors":"B. Xue, Jianming Li","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.10.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.10.008","url":null,"abstract":"Objective \u0000To explore the optimal and rapid imaging acquisition time and clinical applicability when using high- and low-dose one day rest/stress myocardial perfusion imaging (MPI) with cadmium-zinc-telluride heart dedicated SPECT (CZT-SPECT). \u0000 \u0000 \u0000Methods \u0000The MPI data with high-dose rest/stress protocol in 51 patients (22 males, 29 females, age: (55.4±8.5) years) between November 2017 and December 2017 and those with low-dose protocol in 50 patients (27 males, 23 females, age: (59.1±12.8) years) between July 2018 and October 2018 were retrospectively analyzed. The MPI was performed with CZT-SPECT. Each patient received 296-370 MBq rest dose of 99Tcm-methoxyisobutylisonitrile (MIBI) for high-dose protocol, 111-222 MBq rest dose of 99Tcm-MIBI for low-dose protocol. Stress dose was 3 times of the corresponding rest dose. Rest and stress scans were acquired 6 min and 4 min for high-dose protocol, while 8 min and 6 min for low-dose protocol in total. All rest or stress imaging data were reconstructed from list-mode raw data to obtain scan durations of 1 min, 2 min, etc, up to the maximum of acquisition time. Image quality at different acquisition times were evaluated, and myocardial perfusion and function parameters were compared. Paired t test, Wilcoxon signed rank test, Pearson correlation and Bland-Altman analyses were used for data analysis. \u0000 \u0000 \u0000Results \u0000The image quality was rated as excellent/good in all patients (100%, 51/51) when acquisition time ≥3 min and ≥2 min respectively for rest and stress imaging with high-dose protocol, the similar results was obtained (100%, 50/50) when acquisition time ≥4 min and ≥3 min respectively for rest and stress imaging with low-dose protocol. The quantitative perfusion parameters(summed rest scores, summed stress scores, total perfusion deficit) and left ventricle ejection fraction (LVEF) at shorter acquisition times (3 min/2 min, 4 min/3 min) were not significantly different from the results at the longer acquisition times (6 min/4 min, 8 min/6 min; t values: from -1.196 to 1.597, z values: from -1.963 to 1.945, all P>0.05). Those parameters at shorter and longer acquisition times showed strong correlations (all r>0.700, all P<0.001), and Bland-Altman analysis revealed good agreement between them. \u0000 \u0000 \u0000Conclusion \u0000The optimal acquisition time is 3 min/2 min for high-dose one-day rest/stress CZT-SPECT MPI, and 4 min/3 min for low-dose protocol, which can significantly shorten the MPI acquisition time, then reliable perfusion parameters and LVEF can be obtained under the premise of ensuring image quality, making it the better clinical applicability. \u0000 \u0000 \u0000Key words: \u0000Coronary disease; Myocardial perfusion imaging; Cadmium; Zinc; Tellurium; Tomography, emission-computed, single-photon; Time management; Technetium Tc 99m sestamibi","PeriodicalId":10099,"journal":{"name":"Chinese Journal of Nuclear Medicine and Molecular Imaging","volume":"39 1","pages":"610-615"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47557817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}