纳米材料在增强肿瘤放射性核素内放疗中的应用

中华核医学与分子影像杂志 Pub Date : 2019-10-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2019.10.014

Su Weiwei, Tao Wang, Changjing Zuo

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引用次数: 0

摘要

放射性核素对肿瘤的治疗效果与肿瘤内的积累水平、停留时间和分布密切相关，也受肿瘤耐辐射和缺氧微环境的影响。纳米材料具有特殊的尺寸效应和表面功能可修饰等一系列特性，不仅可以作为同位素载体将核素输送到肿瘤中，还可以与化学、热或光动力疗法结合，产生协同治疗效果或破坏肿瘤的缺氧微环境，降低辐射抵抗，从而达到放射增敏效果。本文综述了纳米材料在提高放射性核素治疗癌症疗效方面的应用。关键词:肿瘤;放射治疗;放射性同位素;Radiation-sensitizing代理商;纳米结构;趋势

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Application of nanomaterials in enhancing internal radiotherapy of radionuclide for cancer

The therapeutic efficiency of radionuclides for cancer is closely related to the accumulation level, residence time and distribution in tumor, and is also influenced by the radiation resistance and hypoxia microenvironment of tumor. Nanomaterials, with a series of characteristics including special dimension effect and functionally modifiable surface, can not only work as the isotopic carrier to transport nuclide into tumor, but also combine with chemical, thermal or photodynamic therapies to generate synergistic therapeutic effect or destroy the hypoxic microenvironment of tumor to reduce radiation resistance, thus achieving the radiosensitization effect. This article reviews the application of nanomaterials in enhancing the therapeutic efficiency of radionuclide for cancer. Key words: Neoplasms; Radiotherapy; Radioisotopes; Radiation-sensitizing agents; Nanostructures; Trends

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.