环境响应荧光探针在图像引导手术中的应用

中华核医学与分子影像杂志 Pub Date : 2019-11-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2019.11.014

Jing Zhu, Chengchao Chu

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引用次数: 0

摘要

与传统成像技术不同，荧光成像具有安全性、高空间分辨率和实时性等优点，是临床肿瘤检测和图像引导手术的首选成像方法。荧光探针有两种类型，包括永开型和环境响应型，其中环境响应型探针由于具有更高的目标与背景比，可以提高灵敏度和特异性，因此是首选。环境响应探针包括酶反应探针、ph敏感探针和缺氧响应探针。本文综述了近年来环境敏感探针的研究进展，并讨论了它们在肿瘤检测和图像引导手术中的潜力。关键词:分子探针;荧光;肿瘤微环境;酶;氢离子浓度;细胞缺氧;趋势

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Environment-responsive fluorescence probes in image-guided surgery

Unlike conventional imaging technologies, fluorescent imaging benefits from its safety, high-spatial resolution and real-time capability, which make it a highly adoptable imaging method for tumor detection and image-guided surgery in clinics. There are two types of fluorescent probes, including always-on type and environment-responsive type, wherein environment-responsive probes are preferred due to higher target-to-background ratios, which can improve sensitivity and specificity. The environment-responsive probes include enzyme-reactive probes, pH-sensitive probes and hypoxia responsive probes. This review summarizes recent progress in environment-responsive probes, and discusses their potentials in tumor detection and image-guided surgery. Key words: Molecular probes; Fluorescence; Tumor microenvironment; Enzymes; Hydrogen-ion concentration; Cell hypoxia; Trends

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.