Expression of GP73 in liver cirrhosis and its assistant value in grading of liver cirrhosis

中华核医学与分子影像杂志 Pub Date : 2019-10-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2019.10.005

Xuefei Wei, M-L Shi, Zairong Chen, Xuefeng Feng

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引用次数: 1

Abstract

Objective To investigate the expression of Golgi protein 73 (GP73) in liver cirrhosis and its assistant value in grading of liver cirrhosis. Methods A total of 160 patients with liver cirrhosis (96 males, 64 females, age: (58.6±10.3) years) and 60 healthy controls (35 males, 25 females, age: (53.5±12.2) years) were included to detect the GP73 level. Serum levels of alpha-fetoprotein (AFP), albumin (ALB), total bilirubin (TBIL) and prothrombin time (PT) were also measured. The correlations between the above indicators and the GP73 level were analyzed with Pearson correlation. The GP73 levels among patients with different Child-Pugh grading and different CT morphological grading were compared using one-way analysis of variance and the least significant difference t test. The receiver operating characteristic (ROC) curve analysis was used to analyze the diagnostic sensitivity and specificity of GP73/AFP for liver cirrhosis. Results The area under the ROC curve for GP73 was 0.886 with the cut-off value of 144.5 μg/L. The sensitivity of GP73 in the diagnosis of liver cirrhosis was 70.4%, and the specificity was 87.8%. After combining with AFP, the sensitivity and specificity were elevated to 71.6% and 90.2% respectively. GP73 levels among patients with different Child-Pugh grading and those with different CT morphological grading were significantly different (F: 3.15, 2.82, both P<0.05), and GP73 levels among groups also showed significant differences (all P<0.05). The GP73 level was correlated with AFP, ALB, TBIL, and PT (r values: 0.362, -0.428, 0.672, 0.575, all P<0.01). Conclusion Serum GP73 level increases with progression of liver cirrhosis, and it has an assistant value in the diagnosis of liver cirrhosis. Key words: Liver cirrhosis; Golgin; Alpha-fetoprotein; Tomography, X-ray computed

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GP73在肝硬化中的表达及其对肝硬化分级的辅助价值

目的探讨高尔基蛋白73（GP73）在肝硬化中的表达及其在肝硬化分级中的辅助价值。方法对160例肝硬化患者（男96例，女64例，年龄（58.6±10.3）岁）和60例健康对照者（男35例，女25例，年龄：（53.5±12.2）岁）进行GP73水平检测。还测定了血清甲胎蛋白（AFP）、白蛋白（ALB）、总胆红素（TBIL）和凝血酶原时间（PT）的水平。采用Pearson相关分析上述指标与GP73水平的相关性。采用单向方差分析和最小显著性差异t检验比较不同Child-Pugh分级和不同CT形态分级患者的GP73水平。采用受试者工作特性（ROC）曲线分析GP73/AFP对肝硬化的诊断敏感性和特异性。结果GP73的ROC曲线下面积为0.886，截止值为144.5μg/L。GP73诊断肝硬化的敏感性为70.4%，特异性为87.8%，与AFP联合应用后，敏感性和特异性分别提高到71.6%和90.2%。不同Child-Pugh分级的患者和不同CT形态分级的患者GP73水平有显著差异（F:3.15，2.82，均P<0.05），组间GP73水平也有显著性差异（均P<0.05），结论血清GP73水平随肝硬化的进展而升高，对肝硬化的诊断具有辅助价值。关键词：肝硬化；戈尔金；甲胎蛋白；层析成像，X射线计算机

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.