Neuroimmunology Reports最新文献_第5页

High viral load VZV encephalitis complicated by super refractory status epilepticus in a vaccinated child with in Acute Lymphocytic Leukemia: Case report and review of the literature 一名接种过疫苗的急性淋巴细胞白血病患儿并发高病毒载量 VZV 脑炎和超级难治性癫痫状态：病例报告和文献综述

Neuroimmunology Reports Pub Date : 2024-07-29 DOI: 10.1016/j.nerep.2024.100223

Antonella Frattari , Maria Vittoria De Angelis , Mariangela Battilana , Ennio Polilli , Alessandro Ferrieri , Daniela Onofrillo , Nicole Santoro , Antonella Sau , Anna D'Andreagiovanni , Pierluigi Tocco , Donatella Bosco , Giustino Parruti

{"title":"High viral load VZV encephalitis complicated by super refractory status epilepticus in a vaccinated child with in Acute Lymphocytic Leukemia: Case report and review of the literature","authors":"Antonella Frattari , Maria Vittoria De Angelis , Mariangela Battilana , Ennio Polilli , Alessandro Ferrieri , Daniela Onofrillo , Nicole Santoro , Antonella Sau , Anna D'Andreagiovanni , Pierluigi Tocco , Donatella Bosco , Giustino Parruti","doi":"10.1016/j.nerep.2024.100223","DOIUrl":"10.1016/j.nerep.2024.100223","url":null,"abstract":"<div><p>Varicella is a benign, self-limiting disease, but both primary VZV infection and VZV reactivation can be life-threatening in immunocompromised children, due to CNS and systemic dissemination of the virus. Reactivation of the vaccine-type VZV (vOka) has been reported sporadically, although SARS COV2 infection may have recently played a role in facilitating VZV reactivation. Here we report on the case of a young boy with Acute Lymphocytic Leukemia, in remission after induction chemotherapy, and recent SARS COV 2 infection. He developed VZV encephalitis due to massive reactivation of VZV virus, complicated by PRES, diagnosed with brain MRI, and Super Refractory Status Epilepticus, lasting until substantial suppression of VZV replication in the CNS. We also report and discuss the role of the remarkably augmented renal clearance persistently observed in our patient, complicating CNS involvement and making both antiviral and antiepileptic treatments more difficult to manage. Effective neuroprotection was completed by physical hypothermia and infusion of IVIG and steroids. The patient obtained complete functional recovery, with reversion of MRI signs of occipital involvement at presentation, at 6-month follow-up. Intense and daily interplay of intensivists, neurologists, hematologists and infectious disease experts likely made his uneventful recovery possible, combining all skills necessary to manage his unusual and complex clinical picture.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X2400024X/pdfft?md5=78f3514e7bb97f38fd7091c4f3ca5aaf&pid=1-s2.0-S2667257X2400024X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Multiple Sclerosis: Unveiling the Trajectory of a Toddler-Onset Case 小儿多发性硬化症：揭开幼儿发病病例的轨迹

Neuroimmunology Reports Pub Date : 2024-07-15 DOI: 10.1016/j.nerep.2024.100222

Rufaidah Rushdi , Nevin Shalaby

引用次数: 0

FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) presenting with psychosis and refractory seizures 抗 MOG 相关脑炎伴癫痫发作（FLAMES）中的 FLAIR 高密度病变，表现为精神病和难治性癫痫发作

Neuroimmunology Reports Pub Date : 2024-07-09 DOI: 10.1016/j.nerep.2024.100221

Samantha Anne Gutierrez , Alex Vu , Napo Kasirye-Mbugua , Jodie Burton

{"title":"FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) presenting with psychosis and refractory seizures","authors":"Samantha Anne Gutierrez , Alex Vu , Napo Kasirye-Mbugua , Jodie Burton","doi":"10.1016/j.nerep.2024.100221","DOIUrl":"10.1016/j.nerep.2024.100221","url":null,"abstract":"<div><p>Myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) is an idiopathic inflammatory demyelinating disease of the central nervous system commonly associated with optic neuritis, transverse myelitis, acute disseminated encephalomyelitis and cortical encephalitis. A somewhat rare and less recognized syndrome in MOGAD has been identified, and is characterized by cortical encephalitis and seizures with cortical FLAIR-hyperintense lesions on the MRI aptly termed FLAMES (<strong>F</strong>LAIR-hyperintense <strong>L</strong>esions in <strong>A</strong>nti-<strong>M</strong>OG-associated <strong>E</strong>ncephalitis with <strong>S</strong>eizures). We report a previously healthy middle-aged man who presented with focal seizures and status epilepticus refractory to initial interventions. He later developed headache, mood and behavioral changes and ultimately tested positive for anti-MOG antibody in the serum using a fixed cell-based assay. When his MRI was re-assessed in retrospect, it was determined to be in keeping with FLAMES.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000226/pdfft?md5=6860536818566cd5bfe9f7aa2d79514c&pid=1-s2.0-S2667257X24000226-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromyelitis Optica Spectrum Disorders (NMOSD) and structural renal diseases: A literature review 神经脊髓炎视网膜频谱疾病（NMOSD）与结构性肾病：文献综述

Neuroimmunology Reports Pub Date : 2024-06-30 DOI: 10.1016/j.nerep.2024.100220

Zohreh Abna , Seyed Amirhossein Fazeli , Ziba Khanmoradi , Mohammad Ali Sahraian

{"title":"Neuromyelitis Optica Spectrum Disorders (NMOSD) and structural renal diseases: A literature review","authors":"Zohreh Abna , Seyed Amirhossein Fazeli , Ziba Khanmoradi , Mohammad Ali Sahraian","doi":"10.1016/j.nerep.2024.100220","DOIUrl":"https://doi.org/10.1016/j.nerep.2024.100220","url":null,"abstract":"<div><p>Neuromyelitis Optica Spectrum Disorders (NMOSD) is an immune-mediated disease of the central nervous system that often leads to severe attacks of optic nerves and spinal cord. The discovery of Aquaporine 4 (AQP4) antibody as a potential biomarker of NMOSD has changed the global approach to this disease. There have been associations between NMOSD and systemic autoimmune diseases, both organ specific and non-organ specific. Here, we aimed to review the literature on co-incidence or possible association of kidney diseases with NMOSD.</p></div><div><h3>Methods</h3><p>we included All English relevant publications (reviews, original articles, case reports, case series and abstracts) from 1998 to 2023 using PubMed and google scholar database for this review.</p></div><div><h3>Results</h3><p>Nine case reports of co-existing NMOSD with renal disorders were evaluated. The patients were involved from 10–90 years old. The most common association was with nephrotic syndrome and in the context of systemic autoimmune disorders. However a case of NMOSD coincident with renal cell carcinoma without paraneoplastic etiology was reported.</p></div><div><h3>Conclusion</h3><p>Despite the expression of AQP4 in the collecting duct cells of kidney, whether AQP4-IgG, the pathogenic antibody in NMOSD, can damage to the kidney is still unknown.</p><p>Can structural kidney damages lead to AQP4 antigen being exposed to immune system and triggers the cascade of autoimmunity is a question that should be investigated in future studies.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000214/pdfft?md5=e281dd2eb65a975e216c4e913f51525a&pid=1-s2.0-S2667257X24000214-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141595000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancytopenia in neuromyelitis optica spectrum disorder induced by azathioprine-allopurinol interaction 硫唑嘌呤-阿洛嘌呤醇相互作用诱发的神经性脊髓炎视网膜频谱紊乱全血细胞减少症

Neuroimmunology Reports Pub Date : 2024-06-21 DOI: 10.1016/j.nerep.2024.100219

Cesar D. Bautista-Sanchez , Luis E. Martínez-Bravo , Diego A. Hidalgo-Díaz

引用次数: 0

Case report: Neuromyelitis optica spectrum disorder in a patient presented with orbital apex syndrome 病例报告：一名眼眶顶综合征患者的神经脊髓炎视网膜频谱紊乱症

Neuroimmunology Reports Pub Date : 2024-06-11 DOI: 10.1016/j.nerep.2024.100216

Feng Xiang, Xu Zhang, Rongfei Wang, Xiangqing Wang

{"title":"Case report: Neuromyelitis optica spectrum disorder in a patient presented with orbital apex syndrome","authors":"Feng Xiang, Xu Zhang, Rongfei Wang, Xiangqing Wang","doi":"10.1016/j.nerep.2024.100216","DOIUrl":"https://doi.org/10.1016/j.nerep.2024.100216","url":null,"abstract":"<div><h3>Background</h3><p>Orbital apex syndrome as the presentation of neuromyelitis optica spectrum disorder has not been reported in literature.</p></div><div><h3>Case presentation</h3><p>We reported a case in which the patient initially presented with ptosis, diplopia, ophthalmoplegia and visual impairment of the right eye. Clinical examination revealed no light perception in the right eye with the presence of relative afferent pupillary defect and involvement of cranial nerves II, III, V, and VI. Magnetic resonance imaging of the cranial and orbital regions revealed thickening in the intraorbital segment of the right optic nerve with T2-weighted hyperintensity, and Gadolinium-enhancement of the right optic nerve and its myelin sheath. Longitudinally extensive transverse myelitis subsequently developed, with detection of serum anti-aquaporin-4 antibody. Intravenous methylprednisolone was initiated, leading to significant clinical improvement.</p></div><div><h3>Conclusion</h3><p>This case report highlights the diverse manifestations of neuromyelitis optica spectrum disorder, including the orbital apex syndrome.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000172/pdfft?md5=7d2932e7bbd9739ff7dbc452293d28ce&pid=1-s2.0-S2667257X24000172-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe presentation of myelin oligodendrocyte glycoprotein antibody-associated disease: A case report 髓鞘少突胶质细胞糖蛋白抗体相关疾病的严重表现：病例报告

Neuroimmunology Reports Pub Date : 2024-06-10 DOI: 10.1016/j.nerep.2024.100217

Dominique Comeau , Olivia Cull , Yanis Saheb , Remi Leblanc , Ludivine Chamard-Witkowski

{"title":"Severe presentation of myelin oligodendrocyte glycoprotein antibody-associated disease: A case report","authors":"Dominique Comeau , Olivia Cull , Yanis Saheb , Remi Leblanc , Ludivine Chamard-Witkowski","doi":"10.1016/j.nerep.2024.100217","DOIUrl":"https://doi.org/10.1016/j.nerep.2024.100217","url":null,"abstract":"<div><h3>Background</h3><p>Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disease of the central nervous system. Relapse may be moderate to severe with an Expanded Disability Status Scale (EDSS) above 4.0 in half of patients, albeit most experience good to excellent motor recovery.</p></div><div><h3>Results</h3><p>Herein, we present an atypically severe case of MOGAD with an unusual clinical course. Patient initially presented with diplopia, lower limb motor deficit and hypoesthesia which rapidly deteriorated into quadriplegia. Corticosteroid regimen did not initially translate to significant clinical improvement (EDSS=9.0). At the 1 year follow up, patient had regained some mobility although with marked sequela (EDSS=6.5).</p></div><div><h3>Conclusion</h3><p>Although MOGAD is generally thought to be benign, it could also present with severe episodes.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000184/pdfft?md5=06ef7b6b09aee0cdcbb316f6cf60bb56&pid=1-s2.0-S2667257X24000184-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Susac syndrome with complete triad and concurrent kidney failure treated with plasmapheresis and rituximab: A case report 浆细胞分离术和利妥昔单抗治疗伴有完全性三联征和并发肾衰竭的苏萨克综合征：病例报告

Neuroimmunology Reports Pub Date : 2024-01-01 DOI: 10.1016/j.nerep.2024.100210

Mohammad Amin Sadri , Sarina Loghmani , Zahra Nikoo , Farinaz Tabibian , Vahid Shaygannejad

{"title":"Susac syndrome with complete triad and concurrent kidney failure treated with plasmapheresis and rituximab: A case report","authors":"Mohammad Amin Sadri , Sarina Loghmani , Zahra Nikoo , Farinaz Tabibian , Vahid Shaygannejad","doi":"10.1016/j.nerep.2024.100210","DOIUrl":"10.1016/j.nerep.2024.100210","url":null,"abstract":"<div><h3>Introduction</h3><p>Susac syndrome (SuS) is a rare autoimmune disease characterized by the clinical triad of brain dysfunction, branch retinal artery occlusion, and hearing loss. Many cases have been reported with irreversible sequelae due to misdiagnosis and late treatment of the disease.</p></div><div><h3>Case</h3><p>In this article, we describe the clinical course and diagnosis of SuS in a young woman with a history of type 1 diabetes mellitus and kidney transplantation who presented with the complete triad. The complex medical history required a tailored treatment approach, including plasmapheresis and rituximab, which significantly improved her condition.</p></div><div><h3>Conclusion</h3><p>This report highlights the diagnostic complexity of SuS and the value of personalized treatment strategies, contributing to the understanding of this rare disorder, and briefly reviews the current knowledge of the disease and discusses the probable pathophysiological relationship between SuS and kidney failure.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000111/pdfft?md5=13d1bb55b1b04759af609450efe4a57e&pid=1-s2.0-S2667257X24000111-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive multifocal leukoencephalopathy successfully treated with intravenous immunoglobulin 静脉注射免疫球蛋白成功治疗进行性多灶性白质脑病

Neuroimmunology Reports Pub Date : 2024-01-01 DOI: 10.1016/j.nerep.2024.100214

Swansu Batra, Ruchika Tandon, Saurabh Nigam

引用次数: 0

Two cases of nasopharyngeal negative COVID-19 infections in patients with demyelinating diseases on anti-CD20 treatments 两例接受抗 CD20 治疗的脱髓鞘疾病患者鼻咽部 COVID-19 阴性感染病例

Neuroimmunology Reports Pub Date : 2024-01-01 DOI: 10.1016/j.nerep.2023.100197

Alexandra Balshi, Jacob A Sloane

引用次数: 0