Neuroimmunology Reports最新文献_第4页

Interferon-beta-1a induced retinopathy in a 14-year-old female patient with multiple sclerosis 一名 14 岁女性多发性硬化症患者因干扰素-β-1a 引起的视网膜病变

Neuroimmunology Reports Pub Date : 2024-01-01 DOI: 10.1016/j.nerep.2024.100202

C. Tsimakidi, M. Gontika, D. Gkougka, K Rizonaki, S. Fanouraki, C. Kotsalis

引用次数: 0

Multiple sclerosis and optic neuritis triggered by COVID-19 mRNA 由 COVID-19 mRNA 引发的多发性硬化症和视神经炎

Neuroimmunology Reports Pub Date : 2024-01-01 DOI: 10.1016/j.nerep.2023.100198

Giovanna Thais Torques Moretti , Giorgio Fabiani , Georgette Mouchaileh Evangelista Ferreira , Jessica Pizatto de Araujo , Eduardo Hummelgen

{"title":"Multiple sclerosis and optic neuritis triggered by COVID-19 mRNA","authors":"Giovanna Thais Torques Moretti , Giorgio Fabiani , Georgette Mouchaileh Evangelista Ferreira , Jessica Pizatto de Araujo , Eduardo Hummelgen","doi":"10.1016/j.nerep.2023.100198","DOIUrl":"https://doi.org/10.1016/j.nerep.2023.100198","url":null,"abstract":"<div><h3>Background</h3><p>In December 2019, the World Health Organization declared COVID-19 a pandemic; an unprecedented health crisis has rocked the world. Enormous efforts by governments, the pharmaceutical industry, and health professionals, including a new mRNA vaccine technology against SARS-CoV-2, have been massively employed to control the COVID-19 pandemic. The vaccine's primary mechanism is based on S glycoprotein, the leading viral surface antigen, which induces protective neutralizing antibodies.</p></div><div><h3>Case presentation</h3><p>This project aims to present two cases of demyelinating syndromes in previously asymptomatic patients. The triggering factor in both cases was vaccination against COVID-19 with mRNA vaccines.</p></div><div><h3>Case Report</h3><p>The first case is a young female, 25 years old, previously asymptomatic, one week after the ChAdOx1 Vaccine developed right hemiparesis. Brain MRI and MRI of the spinal cord demonstrated multiple hyperintense lesions, acute and chronic. The second case is an 8-year-old Caucasian male; 12 days after the double dose of the Pfizer-BioNTech vaccine, the patient complained of bilateral visual blurring. The patient was pulsed with methylprednisolone one g/day/5 days with complete recovery.</p></div><div><h3>Conclusion</h3><p>Rarely can vaccines trigger multiple sclerosis or optic neuritis. This report demonstrated two demyelinating syndromes triggered by the m-RNA COVID-19 vaccine.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X23000360/pdfft?md5=1e126c4ed0de1246d9be568a068d877f&pid=1-s2.0-S2667257X23000360-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139111690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transitory recurrent diplopia and dysarthria with MRI mimicking central pontine myelinolysis: a peculiar NMOSD onset 短暂性复发性复视和构音障碍，核磁共振成像模拟中枢神经髓鞘溶解：一种特殊的 NMOSD 发病情况

Neuroimmunology Reports Pub Date : 2024-01-01 DOI: 10.1016/j.nerep.2024.100207

C. Chiavazza , E. Genovese , M. Narracci , S. Gasverde , C. Baima , D.M. Papurello

引用次数: 0

Allopurinol treatment in pediatric multiple sclerosis 别嘌醇治疗小儿多发性硬化症

Neuroimmunology Reports Pub Date : 2024-01-01 DOI: 10.1016/j.nerep.2024.100209

Yousef A Assaleh , Farah Thabet , Kalthoum Graies-Tlili , Brahim Tabarki

引用次数: 0

Chronic inflammatory demyelinating polyneuropathy or subacute Guillain-Barré syndrome? Not always an easy differential diagnosis 慢性炎症性脱髓鞘多发性神经病还是亚急性格林-巴利综合征？鉴别诊断并非易事

Neuroimmunology Reports Pub Date : 2024-01-01 DOI: 10.1016/j.nerep.2023.100196

Elisabetta Cecconi , Sara Torricelli , Gabriele Rosario Rodolico , Martina Sperti , Maddalena Spalletti , Roberto Fratangelo , Valentina Bessi , Leonello Guidi , Sabrina Matà

{"title":"Chronic inflammatory demyelinating polyneuropathy or subacute Guillain-Barré syndrome? Not always an easy differential diagnosis","authors":"Elisabetta Cecconi , Sara Torricelli , Gabriele Rosario Rodolico , Martina Sperti , Maddalena Spalletti , Roberto Fratangelo , Valentina Bessi , Leonello Guidi , Sabrina Matà","doi":"10.1016/j.nerep.2023.100196","DOIUrl":"https://doi.org/10.1016/j.nerep.2023.100196","url":null,"abstract":"<div><p>Guillain-Barré syndrome (GBS) is an immuno-mediated disorder of the peripheral nervous system with an acute onset of 2–4 weeks, and a monophasic course. In the subacute variant the symtpoms nadir is reached in 4–8 weeks. However, in sporadic cases the onset and the evolution of the disease may be different than expected, leading to significant diagnostic difficulties.</p><p>Case report: A 78-yrs old man presented at our Hospital with a 4-month history of progressive, diffuse motor and sensory deficit. He had previously undergone two electrophysiological examinations with uncertain findings. At hospitalization the nerve conduction study (NCS) and the cerebrospinal fluid examination were consistent with inflammatory demyelinating polyradiculoneuropathy. While a 5-day high-dose of intravenous methylprednisolone proved to be ineffective, a single intravenous immunoglobulin cycle risulted in a significant clinical improvement without relapse after an 18-month follow-up. Based on clinical and neurophysiological findings, a diagnosis of atypical subacute GBS was finally made.</p><p>Conclusion: Although generally accepted that GBS has an acute onset within a few weeks, with a maximum of 8 weeks in the subacute variant, this case report shows that it may initially present with a very slow clinical progression and inconsistent NCS findings. However, its recognition and differentiation from the chronic inflammatory nerve disorders, which have a chronic, long-term evolution, is mandatory to provide the correct therapy protocol.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X23000347/pdfft?md5=bc393de806866f1835e31510e0e11ef3&pid=1-s2.0-S2667257X23000347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139109168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to “Atypical Myelin Oligodendrocyte Glycoprotein Antibody Disease Presenting with Isolated Elevated Intracranial Pressure” [Neuroimmunology Reports Volume 1, December 2021, 100028] 非典型髓鞘少突胶质细胞糖蛋白抗体病伴有孤立性颅内压升高》勘误 [《神经免疫学报告》第 1 卷，2021 年 12 月，100028]

Neuroimmunology Reports Pub Date : 2024-01-01 DOI: 10.1016/j.nerep.2024.100203

Alexandria Valdrighi , Jeffrey Russ , Emmanuelle Waubant , Nailyn Rasool , Carla Francisco

引用次数: 0

Rapidly progressive cerebral dysfunction in a 5-year-old child: A reminder of subacute sclerosing panencephalitis (SSPE) and the importance of measles vaccination coverage 一名 5 岁儿童出现快速进展性脑功能障碍：提醒人们注意亚急性硬化性泛脑炎（SSPE）和麻疹疫苗接种的重要性

Neuroimmunology Reports Pub Date : 2023-12-12 DOI: 10.1016/j.nerep.2023.100195

Mustafa Bakir , Nadir Khan , Jonathan Gehlbach

{"title":"Rapidly progressive cerebral dysfunction in a 5-year-old child: A reminder of subacute sclerosing panencephalitis (SSPE) and the importance of measles vaccination coverage","authors":"Mustafa Bakir , Nadir Khan , Jonathan Gehlbach","doi":"10.1016/j.nerep.2023.100195","DOIUrl":"https://doi.org/10.1016/j.nerep.2023.100195","url":null,"abstract":"<div><p>We present a case of a preschool boy admitted to the pediatric intensive care unit with generalized weakness and encephalopathy that progressed to coma and spastic paralysis over the next few weeks. Extensive evaluation of a wide range of possible diagnoses, including infectious, post-infectious, autoimmune, and paraneoplastic disorders, proved unrevealing. Owing to concerns regarding autoimmune encephalitis, the patient received plasmapheresis, intravenous immunoglobulin, high-dose glucocorticoids, anakinra, rituximab, and empirical botulinum antitoxin. Despite these treatments, the patient's neurological condition continued to deteriorate, requiring endotracheal intubation. The patient developed repeated tremors and dystonic events, which progressed to hypertonia with gaze deviation. His-EEG in the third week of admission showed Radermecker complexes most consistent with SSPE. Because of his history of travel to Afghanistan at 8 months of age, before he was vaccinated for measles, and after a measles-like illness upon return, we checked the measles IgG titer in the CSF from the initial lumbar puncture and found it to be elevated. Global coverage with the first dose of the measles vaccine has dropped to 81 % by 2021, the lowest rate since 2008. This decline raises the concern of a possible increase in the incidence of measles and its fatal complications such as SSPE.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X23000335/pdfft?md5=ef8643cee9acbe6325a3886533c4de17&pid=1-s2.0-S2667257X23000335-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138769624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regaining walking and restoring corticospinal tract excitability after neuromyelitis optica spectrum disorder: A case report 视神经脊髓炎后恢复行走和皮质脊髓束兴奋性1例

Neuroimmunology Reports Pub Date : 2023-11-20 DOI: 10.1016/j.nerep.2023.100193

Hui-Ting Shih , Hui-Ting Goh , Seema Sikka , Rita Hamilton , Chad Swank

引用次数: 0

Decades-delayed onset of subcutaneous granulomata and calcifications from interferon-beta-1a in a patient with multiple sclerosis 多发性硬化症患者皮下肉芽肿和钙化的干扰素- β -1a延迟发作数十年

Neuroimmunology Reports Pub Date : 2023-11-17 DOI: 10.1016/j.nerep.2023.100190

Mara Bahri , Kristi Epstein , Yinan Zhang

引用次数: 0

A case of refractory tumefactive multiple sclerosis in an African American woman 非裔美国妇女难治性肿瘤性多发性硬化症1例

Neuroimmunology Reports Pub Date : 2023-11-15 DOI: 10.1016/j.nerep.2023.100192

Conor Kelly , Jennings Gyedu , Rock Heyman , Cigdem Isitan Alkawadri

{"title":"A case of refractory tumefactive multiple sclerosis in an African American woman","authors":"Conor Kelly , Jennings Gyedu , Rock Heyman , Cigdem Isitan Alkawadri","doi":"10.1016/j.nerep.2023.100192","DOIUrl":"https://doi.org/10.1016/j.nerep.2023.100192","url":null,"abstract":"<div><h3>Background</h3><p>Tumefactive multiple sclerosis (TMS) is a rare subtype of multiple sclerosis (MS) that poses a diagnostic and therapeutic challenge, with relatively little available published data. Though studies have demonstrated similar disease course in TMS with non-tumefactive disease, refractory cases requiring early escalation of therapy are noted and risk factors are unclear. Furthermore, no studies have presented data specifically on adult African American patients with TMS.</p></div><div><h3>Case report</h3><p>We present a case of TMS refractory to steroids and plasma exchange in an African-American woman. Disease progression was halted after treatment with cyclophosphamide. The patient was later transitioned to rituximab maintenance therapy.</p></div><div><h3>Conclusions</h3><p>This case contributes to the limited data on disease course and treatment response of this rare disease process in a population that is under-represented in the literature. We note the importance of further studies to identify risk factors for refractory disease requiring early initiation of high-efficacy disease modifying treatment (DMT).</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"4 ","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X2300030X/pdfft?md5=b1b38b50fa7f97267d8101a19bd57fd0&pid=1-s2.0-S2667257X2300030X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136696887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0