Neuroimmunology Reports最新文献_第4页

Brazilian perspectives on neurosarcoidosis broad spectrum 巴西人对神经结节病广谱的看法

Neuroimmunology Reports Pub Date : 2025-01-01 DOI: 10.1016/j.nerep.2025.100249

Carolina B. Moura , Flávia Aguiar Machado , Johnatan Felipe Ferreira da Conceição , Isadora Gomes Mesquita , Rafael Santos Correia , Rodrigo Cutrim Gaudio , Melina da Silva Bernardes , Lucas F B Horta , Caroline Bittar-Braune

{"title":"Brazilian perspectives on neurosarcoidosis broad spectrum","authors":"Carolina B. Moura , Flávia Aguiar Machado , Johnatan Felipe Ferreira da Conceição , Isadora Gomes Mesquita , Rafael Santos Correia , Rodrigo Cutrim Gaudio , Melina da Silva Bernardes , Lucas F B Horta , Caroline Bittar-Braune","doi":"10.1016/j.nerep.2025.100249","DOIUrl":"10.1016/j.nerep.2025.100249","url":null,"abstract":"<div><h3>Background</h3><div>Neurosarcoidosis (NS) is a rare form of sarcoidosis, characterized by a wide range of neurological presentations due to granulomatous inflammation affecting different areas of the nervous system. The prevalence of NS in Brazil is not well-documented, suggesting a risk of underdiagnosis in this region.</div></div><div><h3>Case Series</h3><div>This study examines a series of five patients from Brazil with biopsy-confirmed systemic sarcoidosis and probable NS. Neurological manifestations varied widely, including longitudinally extensive myelitis, myopathy, cerebellar involvement, orbital apex syndrome, and multiple cranial neuropathies. NS was the initial presentation of sarcoidosis in most cases. Diagnoses were confirmed through a detailed assessment of clinical, radiological, laboratory, and pathological findings, following established NS diagnostic criteria. Each patient underwent MRI, cerebrospinal fluid analysis, and systemic evaluations, with systemic sarcoidosis confirmed by biopsy. Treatment primarily involved corticosteroids, with some patients requiring additional immunosuppressive therapy, resulting in favorable outcomes.</div></div><div><h3>Conclusions</h3><div>This case series highlights the diagnostic challenges of NS, particularly in Brazil, where awareness may be limited. Neurologists should consider NS in cases of unexplained neurological symptoms accompanied by systemic signs. Prompt diagnosis and treatment are essential to improve patient outcomes in this potentially debilitating condition.</div></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"7 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune demyelinating central nervous system disease in young male with persistently positive fluorescent treponemal antibody absorption test: A case report 自身免疫性脱髓鞘中枢神经系统疾病的年轻男性持续阳性荧光螺旋体抗体吸收试验：1例报告

Neuroimmunology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.nerep.2024.100233

Mario B Prado , Karen Joy Adiao

引用次数: 0

Guillain-Barré syndrome associated with COVID-19 infection: A case series 与COVID-19感染相关的格林-巴利综合征：病例系列

Neuroimmunology Reports Pub Date : 2024-11-13 DOI: 10.1016/j.nerep.2024.100231

João Hugo Abdalla Santos , Ligia Fernandes Abdalla , Luana Catarina Marinho Serruya , Wolfgang Lucas Silva de Paula , Felipe Gomes Naveca

引用次数: 0

Brain leptomeningeal enhancement and cranial nerve enhancement in a pediatric-onset multiple sclerosis patient during fingolimod rebound: A case report 一名儿科多发性硬化症患者在芬戈莫德反弹期间出现脑膜强化和颅神经强化：病例报告

Neuroimmunology Reports Pub Date : 2024-11-01 DOI: 10.1016/j.nerep.2024.100232

Nikoloz Karazanashvili , Monica M. Diaz , Jorge L. Almodovar , Bushra Javed , Stephanie Iyer , Irena Dujmovic Basuroski

{"title":"Brain leptomeningeal enhancement and cranial nerve enhancement in a pediatric-onset multiple sclerosis patient during fingolimod rebound: A case report","authors":"Nikoloz Karazanashvili , Monica M. Diaz , Jorge L. Almodovar , Bushra Javed , Stephanie Iyer , Irena Dujmovic Basuroski","doi":"10.1016/j.nerep.2024.100232","DOIUrl":"10.1016/j.nerep.2024.100232","url":null,"abstract":"<div><div>We report a case of leptomeningeal and trigeminal nerve enhancement in an African American male patient with pediatric onset (age 17) relapsing-remitting multiple sclerosis (MS) during fingolimod rebound. The patient was clinically and radiologically stable while on fingolimod for 3.5 years, but developed disease rebound following fingolimod self-discontinuation. During this episode, several new T2/fluid-attenuated inversion recovery (FLAIR) lesions, enlarging T2/FLAIR lesions and contrast-enhancing lesions in the brain (supratentorial, cerebellum, brainstem) and spinal cord, enhancement of both trigeminal nerves and mild leptomeningeal enhancement (LME) around the brainstem were seen on brain magnetic resonance imaging (MRI). LME or cranial nerve enhancement (CNE) were not present on prior MRI studies, or on MRI studies performed after the patient recovered from fingolimod rebound. LME and CNE in MS may occur during rebound MS activity following fingolimod discontinuation as a transient phenomenon.</div></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transiently elevated anti-CRMP-5 autoantibodies in two patients with myelitis without underlying malignancy 两名无恶性肿瘤基础的脊髓炎患者体内一过性升高的抗CRMP-5自身抗体

Neuroimmunology Reports Pub Date : 2024-10-30 DOI: 10.1016/j.nerep.2024.100229

Kennan Negrete , Zeinab Awada , Asaff Harel , Ilya Kister

{"title":"Transiently elevated anti-CRMP-5 autoantibodies in two patients with myelitis without underlying malignancy","authors":"Kennan Negrete , Zeinab Awada , Asaff Harel , Ilya Kister","doi":"10.1016/j.nerep.2024.100229","DOIUrl":"10.1016/j.nerep.2024.100229","url":null,"abstract":"<div><h3>Introduction</h3><div>Collapsin response-mediator protein 5 (CRMP-5) is a cytoplasmic regulator of neurite outgrowth. Antibodies against CRMP-5 are associated with various neurologic diseases, including myelitis. Underlying malignancy is present in 70 – 90 % of patients with CRMP-5 autoimmunity. We present two patients with myelitis and transiently elevated anti-CRMP-5 without evidence of malignancy and discuss the relevance of the antibody in these cases.</div></div><div><h3>Case Report</h3><div>1. A 44-year-old male presented with symptoms of subacute thoracic myelitis and was found to have a persistently enhancing cord lesion on MRI. Serum anti-CRMP-5 antibody levels were initially elevated but absent on subsequent testing. Three whole-body PET scans during a three-year follow-up failed to uncover a malignancy. Neurologic condition improved on steroids. 2. A 65-year-old female presented with symptoms of a cervical myelitis followed by left facial weakness. MRI demonstrated multiple brain and spinal cord lesions as well as evidence of cranial neuritis, which persisted despite pulse steroid courses. Elevated serum anti-CRMP-5 was noted nine months after symptom onset. Malignancy workup failed to identify neoplasm and anti-CRMP-5 level subsequently seroreverted. Clinical and radiographic improvement occurred over several years of follow-up.</div></div><div><h3>Conclusion</h3><div>CRMP-5 autoantibody is a marker for paraneoplastic autoimmune neurologic syndromes. However, these two cases illustrate the uncertainty regarding its significance, as anti-CRMP-5 was only transiently elevated and not associated with an underlying malignancy. The possibilities that anti-CRMP-5 autoantibodies were an incidental or false-positive finding are discussed.</div></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac events in the setting of ofatumumab treatment: An association or A Co-incidence? 使用伊妥单抗治疗时的心脏事件：关联还是巧合？

Neuroimmunology Reports Pub Date : 2024-10-14 DOI: 10.1016/j.nerep.2024.100228

Hamna Khan , Michelle Maynard , Ahmed Z. Obeidat

引用次数: 0

Very late-onset neuromyelitis optica presenting with simultaneous bilateral optic neuritis and myelitis: A case report 极晚期神经脊髓炎同时伴有双侧视神经炎和脊髓炎：病例报告

Neuroimmunology Reports Pub Date : 2024-09-14 DOI: 10.1016/j.nerep.2024.100227

S Gandelman , S Parauda , C Dohle

{"title":"Very late-onset neuromyelitis optica presenting with simultaneous bilateral optic neuritis and myelitis: A case report","authors":"S Gandelman , S Parauda , C Dohle","doi":"10.1016/j.nerep.2024.100227","DOIUrl":"10.1016/j.nerep.2024.100227","url":null,"abstract":"<div><h3>Background</h3><p>New-onset Neuromyelitis Optica Spectrum Disorder (NMOSD) has rarely been reported in adults over age 70. We describe a severe presentation in a 77-year-old female.</p></div><div><h3>Case</h3><p>The patient presented with left arm numbness, followed by left leg numbness and bilateral optic neuritis. Neuroimaging showed a C2-T1 lesion with C4-C7 holocord enhancement, and bilateral optic nerve enhancement extending to the optic chiasm. Serum testing detected anti-aquaporin-4 antibodies. She was left with dyschromatopsia, myelopathy, and ambulatory dysfunction. She had a history notable for rheumatoid arthritis, treated with rituximab, which had been discontinued six years prior to presentation.</p></div><div><h3>Discussion</h3><p>Very-late-onset NMOSD encompasses a unique cohort of patients with significant immunogenicity despite immunosenescence. Limited data suggest diagnostic delays, severe morbidity, and decreased utilization of disease-modifying therapies.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000287/pdfft?md5=911d5b73fdd8fbd05a4f3ee1c3b475a6&pid=1-s2.0-S2667257X24000287-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of autoimmune glial fibrillary acidic protein astrocytopathy with concurrent renal cell carcinoma 一例自身免疫性胶质纤维酸性蛋白星形细胞病变并发肾细胞癌的病例

Neuroimmunology Reports Pub Date : 2024-09-08 DOI: 10.1016/j.nerep.2024.100226

Krithika Arrabothu , Srinivas Govindan , Wilson Rodriguez , Christopher Tapia , Robert L. White III

{"title":"A case of autoimmune glial fibrillary acidic protein astrocytopathy with concurrent renal cell carcinoma","authors":"Krithika Arrabothu , Srinivas Govindan , Wilson Rodriguez , Christopher Tapia , Robert L. White III","doi":"10.1016/j.nerep.2024.100226","DOIUrl":"10.1016/j.nerep.2024.100226","url":null,"abstract":"<div><p>Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel central nervous system disorder characterized by subacute neuropsychiatric symptom development and rapid remission with corticosteroid therapy. In this paper, we describe a case of GFAP encephalitis found to have renal cell carcinoma. The patient was a 71-year-old man with a history of transient ischemic attacks, severe diabetic retinopathy and monoclonal gammopathy of undetermined significance, who presented with subacute cognitive decline. Anti-GFAP antibodies were detected in the cerebrospinal fluid. Computer Tomography (CT) of chest, abdomen and pelvis identified a renal mass that was resected. Subsequent pathology confirmed clear cell renal cell carcinoma. The patient was treated with corticosteroids with cognitive recovery near to baseline. In conclusion, we encourage the early consideration of autoimmune GFAP astrocytopathy for patients with clinical manifestation of subacute neuropsychiatric symptoms after other common conditions have been ruled out, as it usually has a great response to immunosuppressive therapy. In addition, this case highlights the importance of full body scan to identify possible underlying malignancy as a possible precipitating factor.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000275/pdfft?md5=2065be24e880ef5864893cd0798d0453&pid=1-s2.0-S2667257X24000275-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertrophic polyneuropathy in CMV related GBS in a paediatric patient 一名儿童患者因 CMV 引起的 GBS 而出现肥厚性多发性神经病变

Neuroimmunology Reports Pub Date : 2024-08-24 DOI: 10.1016/j.nerep.2024.100225

Bhanu B Gowda , Snehal Shah , Rahul Lakshmanan , Jonathan Silberstein

引用次数: 0

Resolution of optic neuritis and probable multiple sclerosis after long-term ingestion of very high doses of vitamin D3: A case report 长期摄入高剂量维生素 D3 后视神经炎和可能的多发性硬化症得到缓解：病例报告

Neuroimmunology Reports Pub Date : 2024-07-29 DOI: 10.1016/j.nerep.2024.100224

Nipith Charoenngam , Michael F. Holick

引用次数: 0