Guillain-Barré syndrome associated with COVID-19 infection: A case series

Abstract

This study reports three cases of Guillain-Barré Syndrome (GBS) associated with SARS-CoV-2 infection at a tertiary hospital in Manaus, Brazil. The patients presented with atypical epidemiological profiles and manifestations, deviating from the classic presentation of the syndrome. In the first case, a 20-year-old patient exhibited lower limb paresthesias and respiratory symptoms. The second case involved a 29-year-old patient with a range of symptoms, including asthenia, diarrhea, and vertigo. The third case, a 51-year-old patient with a history of COVID-19, initially manifested dysautonomia and later developed weakness in the lower limbs. The administration of human immunoglobulin led to significant improvements in all cases within a period of one month to six weeks. Despite these outcomes, the underlying mechanisms varied between cases, highlighting the complexity of this association and emphasizing the need for further research to better understand the factors involved in the link between GBS and COVID-19.