Neuroimmunology Reports最新文献

Autoimmune demyelinating central nervous system disease in young male with persistently positive fluorescent treponemal antibody absorption test: A case report

Neuroimmunology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.nerep.2024.100233

Mario B Prado , Karen Joy Adiao

引用次数: 0

Guillain-Barré syndrome associated with COVID-19 infection: A case series 与COVID-19感染相关的格林-巴利综合征：病例系列

Neuroimmunology Reports Pub Date : 2024-11-13 DOI: 10.1016/j.nerep.2024.100231

João Hugo Abdalla Santos , Ligia Fernandes Abdalla , Luana Catarina Marinho Serruya , Wolfgang Lucas Silva de Paula , Felipe Gomes Naveca

引用次数: 0

Brain leptomeningeal enhancement and cranial nerve enhancement in a pediatric-onset multiple sclerosis patient during fingolimod rebound: A case report 一名儿科多发性硬化症患者在芬戈莫德反弹期间出现脑膜强化和颅神经强化：病例报告

Neuroimmunology Reports Pub Date : 2024-11-01 DOI: 10.1016/j.nerep.2024.100232

Nikoloz Karazanashvili , Monica M. Diaz , Jorge L. Almodovar , Bushra Javed , Stephanie Iyer , Irena Dujmovic Basuroski

{"title":"Brain leptomeningeal enhancement and cranial nerve enhancement in a pediatric-onset multiple sclerosis patient during fingolimod rebound: A case report","authors":"Nikoloz Karazanashvili , Monica M. Diaz , Jorge L. Almodovar , Bushra Javed , Stephanie Iyer , Irena Dujmovic Basuroski","doi":"10.1016/j.nerep.2024.100232","DOIUrl":"10.1016/j.nerep.2024.100232","url":null,"abstract":"<div><div>We report a case of leptomeningeal and trigeminal nerve enhancement in an African American male patient with pediatric onset (age 17) relapsing-remitting multiple sclerosis (MS) during fingolimod rebound. The patient was clinically and radiologically stable while on fingolimod for 3.5 years, but developed disease rebound following fingolimod self-discontinuation. During this episode, several new T2/fluid-attenuated inversion recovery (FLAIR) lesions, enlarging T2/FLAIR lesions and contrast-enhancing lesions in the brain (supratentorial, cerebellum, brainstem) and spinal cord, enhancement of both trigeminal nerves and mild leptomeningeal enhancement (LME) around the brainstem were seen on brain magnetic resonance imaging (MRI). LME or cranial nerve enhancement (CNE) were not present on prior MRI studies, or on MRI studies performed after the patient recovered from fingolimod rebound. LME and CNE in MS may occur during rebound MS activity following fingolimod discontinuation as a transient phenomenon.</div></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transiently elevated anti-CRMP-5 autoantibodies in two patients with myelitis without underlying malignancy 两名无恶性肿瘤基础的脊髓炎患者体内一过性升高的抗CRMP-5自身抗体

Neuroimmunology Reports Pub Date : 2024-10-30 DOI: 10.1016/j.nerep.2024.100229

Kennan Negrete , Zeinab Awada , Asaff Harel , Ilya Kister

{"title":"Transiently elevated anti-CRMP-5 autoantibodies in two patients with myelitis without underlying malignancy","authors":"Kennan Negrete , Zeinab Awada , Asaff Harel , Ilya Kister","doi":"10.1016/j.nerep.2024.100229","DOIUrl":"10.1016/j.nerep.2024.100229","url":null,"abstract":"<div><h3>Introduction</h3><div>Collapsin response-mediator protein 5 (CRMP-5) is a cytoplasmic regulator of neurite outgrowth. Antibodies against CRMP-5 are associated with various neurologic diseases, including myelitis. Underlying malignancy is present in 70 – 90 % of patients with CRMP-5 autoimmunity. We present two patients with myelitis and transiently elevated anti-CRMP-5 without evidence of malignancy and discuss the relevance of the antibody in these cases.</div></div><div><h3>Case Report</h3><div>1. A 44-year-old male presented with symptoms of subacute thoracic myelitis and was found to have a persistently enhancing cord lesion on MRI. Serum anti-CRMP-5 antibody levels were initially elevated but absent on subsequent testing. Three whole-body PET scans during a three-year follow-up failed to uncover a malignancy. Neurologic condition improved on steroids. 2. A 65-year-old female presented with symptoms of a cervical myelitis followed by left facial weakness. MRI demonstrated multiple brain and spinal cord lesions as well as evidence of cranial neuritis, which persisted despite pulse steroid courses. Elevated serum anti-CRMP-5 was noted nine months after symptom onset. Malignancy workup failed to identify neoplasm and anti-CRMP-5 level subsequently seroreverted. Clinical and radiographic improvement occurred over several years of follow-up.</div></div><div><h3>Conclusion</h3><div>CRMP-5 autoantibody is a marker for paraneoplastic autoimmune neurologic syndromes. However, these two cases illustrate the uncertainty regarding its significance, as anti-CRMP-5 was only transiently elevated and not associated with an underlying malignancy. The possibilities that anti-CRMP-5 autoantibodies were an incidental or false-positive finding are discussed.</div></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac events in the setting of ofatumumab treatment: An association or A Co-incidence? 使用伊妥单抗治疗时的心脏事件：关联还是巧合？

Neuroimmunology Reports Pub Date : 2024-10-14 DOI: 10.1016/j.nerep.2024.100228

Hamna Khan , Michelle Maynard , Ahmed Z. Obeidat

引用次数: 0

Very late-onset neuromyelitis optica presenting with simultaneous bilateral optic neuritis and myelitis: A case report 极晚期神经脊髓炎同时伴有双侧视神经炎和脊髓炎：病例报告

Neuroimmunology Reports Pub Date : 2024-09-14 DOI: 10.1016/j.nerep.2024.100227

S Gandelman , S Parauda , C Dohle

{"title":"Very late-onset neuromyelitis optica presenting with simultaneous bilateral optic neuritis and myelitis: A case report","authors":"S Gandelman , S Parauda , C Dohle","doi":"10.1016/j.nerep.2024.100227","DOIUrl":"10.1016/j.nerep.2024.100227","url":null,"abstract":"<div><h3>Background</h3><p>New-onset Neuromyelitis Optica Spectrum Disorder (NMOSD) has rarely been reported in adults over age 70. We describe a severe presentation in a 77-year-old female.</p></div><div><h3>Case</h3><p>The patient presented with left arm numbness, followed by left leg numbness and bilateral optic neuritis. Neuroimaging showed a C2-T1 lesion with C4-C7 holocord enhancement, and bilateral optic nerve enhancement extending to the optic chiasm. Serum testing detected anti-aquaporin-4 antibodies. She was left with dyschromatopsia, myelopathy, and ambulatory dysfunction. She had a history notable for rheumatoid arthritis, treated with rituximab, which had been discontinued six years prior to presentation.</p></div><div><h3>Discussion</h3><p>Very-late-onset NMOSD encompasses a unique cohort of patients with significant immunogenicity despite immunosenescence. Limited data suggest diagnostic delays, severe morbidity, and decreased utilization of disease-modifying therapies.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000287/pdfft?md5=911d5b73fdd8fbd05a4f3ee1c3b475a6&pid=1-s2.0-S2667257X24000287-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of autoimmune glial fibrillary acidic protein astrocytopathy with concurrent renal cell carcinoma 一例自身免疫性胶质纤维酸性蛋白星形细胞病变并发肾细胞癌的病例

Neuroimmunology Reports Pub Date : 2024-09-08 DOI: 10.1016/j.nerep.2024.100226

Krithika Arrabothu , Srinivas Govindan , Wilson Rodriguez , Christopher Tapia , Robert L. White III

{"title":"A case of autoimmune glial fibrillary acidic protein astrocytopathy with concurrent renal cell carcinoma","authors":"Krithika Arrabothu , Srinivas Govindan , Wilson Rodriguez , Christopher Tapia , Robert L. White III","doi":"10.1016/j.nerep.2024.100226","DOIUrl":"10.1016/j.nerep.2024.100226","url":null,"abstract":"<div><p>Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel central nervous system disorder characterized by subacute neuropsychiatric symptom development and rapid remission with corticosteroid therapy. In this paper, we describe a case of GFAP encephalitis found to have renal cell carcinoma. The patient was a 71-year-old man with a history of transient ischemic attacks, severe diabetic retinopathy and monoclonal gammopathy of undetermined significance, who presented with subacute cognitive decline. Anti-GFAP antibodies were detected in the cerebrospinal fluid. Computer Tomography (CT) of chest, abdomen and pelvis identified a renal mass that was resected. Subsequent pathology confirmed clear cell renal cell carcinoma. The patient was treated with corticosteroids with cognitive recovery near to baseline. In conclusion, we encourage the early consideration of autoimmune GFAP astrocytopathy for patients with clinical manifestation of subacute neuropsychiatric symptoms after other common conditions have been ruled out, as it usually has a great response to immunosuppressive therapy. In addition, this case highlights the importance of full body scan to identify possible underlying malignancy as a possible precipitating factor.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000275/pdfft?md5=2065be24e880ef5864893cd0798d0453&pid=1-s2.0-S2667257X24000275-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertrophic polyneuropathy in CMV related GBS in a paediatric patient 一名儿童患者因 CMV 引起的 GBS 而出现肥厚性多发性神经病变

Neuroimmunology Reports Pub Date : 2024-08-24 DOI: 10.1016/j.nerep.2024.100225

Bhanu B Gowda , Snehal Shah , Rahul Lakshmanan , Jonathan Silberstein

引用次数: 0

Resolution of optic neuritis and probable multiple sclerosis after long-term ingestion of very high doses of vitamin D3: A case report 长期摄入高剂量维生素 D3 后视神经炎和可能的多发性硬化症得到缓解：病例报告

Neuroimmunology Reports Pub Date : 2024-07-29 DOI: 10.1016/j.nerep.2024.100224

Nipith Charoenngam , Michael F. Holick

引用次数: 0

High viral load VZV encephalitis complicated by super refractory status epilepticus in a vaccinated child with in Acute Lymphocytic Leukemia: Case report and review of the literature 一名接种过疫苗的急性淋巴细胞白血病患儿并发高病毒载量 VZV 脑炎和超级难治性癫痫状态：病例报告和文献综述

Neuroimmunology Reports Pub Date : 2024-07-29 DOI: 10.1016/j.nerep.2024.100223

Antonella Frattari , Maria Vittoria De Angelis , Mariangela Battilana , Ennio Polilli , Alessandro Ferrieri , Daniela Onofrillo , Nicole Santoro , Antonella Sau , Anna D'Andreagiovanni , Pierluigi Tocco , Donatella Bosco , Giustino Parruti

{"title":"High viral load VZV encephalitis complicated by super refractory status epilepticus in a vaccinated child with in Acute Lymphocytic Leukemia: Case report and review of the literature","authors":"Antonella Frattari , Maria Vittoria De Angelis , Mariangela Battilana , Ennio Polilli , Alessandro Ferrieri , Daniela Onofrillo , Nicole Santoro , Antonella Sau , Anna D'Andreagiovanni , Pierluigi Tocco , Donatella Bosco , Giustino Parruti","doi":"10.1016/j.nerep.2024.100223","DOIUrl":"10.1016/j.nerep.2024.100223","url":null,"abstract":"<div><p>Varicella is a benign, self-limiting disease, but both primary VZV infection and VZV reactivation can be life-threatening in immunocompromised children, due to CNS and systemic dissemination of the virus. Reactivation of the vaccine-type VZV (vOka) has been reported sporadically, although SARS COV2 infection may have recently played a role in facilitating VZV reactivation. Here we report on the case of a young boy with Acute Lymphocytic Leukemia, in remission after induction chemotherapy, and recent SARS COV 2 infection. He developed VZV encephalitis due to massive reactivation of VZV virus, complicated by PRES, diagnosed with brain MRI, and Super Refractory Status Epilepticus, lasting until substantial suppression of VZV replication in the CNS. We also report and discuss the role of the remarkably augmented renal clearance persistently observed in our patient, complicating CNS involvement and making both antiviral and antiepileptic treatments more difficult to manage. Effective neuroprotection was completed by physical hypothermia and infusion of IVIG and steroids. The patient obtained complete functional recovery, with reversion of MRI signs of occipital involvement at presentation, at 6-month follow-up. Intense and daily interplay of intensivists, neurologists, hematologists and infectious disease experts likely made his uneventful recovery possible, combining all skills necessary to manage his unusual and complex clinical picture.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X2400024X/pdfft?md5=78f3514e7bb97f38fd7091c4f3ca5aaf&pid=1-s2.0-S2667257X2400024X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0