Neuroimmunology Reports最新文献_第6页

Pediatric Multiple Sclerosis: Unveiling the Trajectory of a Toddler-Onset Case 小儿多发性硬化症：揭开幼儿发病病例的轨迹

Neuroimmunology Reports Pub Date : 2024-12-01 Epub Date: 2024-07-15 DOI: 10.1016/j.nerep.2024.100222

Rufaidah Rushdi , Nevin Shalaby

引用次数: 0

Pancytopenia in neuromyelitis optica spectrum disorder induced by azathioprine-allopurinol interaction 硫唑嘌呤-阿洛嘌呤醇相互作用诱发的神经性脊髓炎视网膜频谱紊乱全血细胞减少症

Neuroimmunology Reports Pub Date : 2024-12-01 Epub Date: 2024-06-21 DOI: 10.1016/j.nerep.2024.100219

Cesar D. Bautista-Sanchez , Luis E. Martínez-Bravo , Diego A. Hidalgo-Díaz

引用次数: 0

Case report: Neuromyelitis optica spectrum disorder in a patient presented with orbital apex syndrome 病例报告：一名眼眶顶综合征患者的神经脊髓炎视网膜频谱紊乱症

Neuroimmunology Reports Pub Date : 2024-12-01 Epub Date: 2024-06-11 DOI: 10.1016/j.nerep.2024.100216

Feng Xiang, Xu Zhang, Rongfei Wang, Xiangqing Wang

{"title":"Case report: Neuromyelitis optica spectrum disorder in a patient presented with orbital apex syndrome","authors":"Feng Xiang, Xu Zhang, Rongfei Wang, Xiangqing Wang","doi":"10.1016/j.nerep.2024.100216","DOIUrl":"https://doi.org/10.1016/j.nerep.2024.100216","url":null,"abstract":"<div><h3>Background</h3><p>Orbital apex syndrome as the presentation of neuromyelitis optica spectrum disorder has not been reported in literature.</p></div><div><h3>Case presentation</h3><p>We reported a case in which the patient initially presented with ptosis, diplopia, ophthalmoplegia and visual impairment of the right eye. Clinical examination revealed no light perception in the right eye with the presence of relative afferent pupillary defect and involvement of cranial nerves II, III, V, and VI. Magnetic resonance imaging of the cranial and orbital regions revealed thickening in the intraorbital segment of the right optic nerve with T2-weighted hyperintensity, and Gadolinium-enhancement of the right optic nerve and its myelin sheath. Longitudinally extensive transverse myelitis subsequently developed, with detection of serum anti-aquaporin-4 antibody. Intravenous methylprednisolone was initiated, leading to significant clinical improvement.</p></div><div><h3>Conclusion</h3><p>This case report highlights the diverse manifestations of neuromyelitis optica spectrum disorder, including the orbital apex syndrome.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000172/pdfft?md5=7d2932e7bbd9739ff7dbc452293d28ce&pid=1-s2.0-S2667257X24000172-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune demyelinating central nervous system disease in young male with persistently positive fluorescent treponemal antibody absorption test: A case report 自身免疫性脱髓鞘中枢神经系统疾病的年轻男性持续阳性荧光螺旋体抗体吸收试验：1例报告

Neuroimmunology Reports Pub Date : 2024-12-01 Epub Date: 2024-11-26 DOI: 10.1016/j.nerep.2024.100233

Mario B Prado , Karen Joy Adiao

引用次数: 0

A case of autoimmune glial fibrillary acidic protein astrocytopathy with concurrent renal cell carcinoma 一例自身免疫性胶质纤维酸性蛋白星形细胞病变并发肾细胞癌的病例

Neuroimmunology Reports Pub Date : 2024-12-01 Epub Date: 2024-09-08 DOI: 10.1016/j.nerep.2024.100226

Krithika Arrabothu , Srinivas Govindan , Wilson Rodriguez , Christopher Tapia , Robert L. White III

{"title":"A case of autoimmune glial fibrillary acidic protein astrocytopathy with concurrent renal cell carcinoma","authors":"Krithika Arrabothu , Srinivas Govindan , Wilson Rodriguez , Christopher Tapia , Robert L. White III","doi":"10.1016/j.nerep.2024.100226","DOIUrl":"10.1016/j.nerep.2024.100226","url":null,"abstract":"<div><p>Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel central nervous system disorder characterized by subacute neuropsychiatric symptom development and rapid remission with corticosteroid therapy. In this paper, we describe a case of GFAP encephalitis found to have renal cell carcinoma. The patient was a 71-year-old man with a history of transient ischemic attacks, severe diabetic retinopathy and monoclonal gammopathy of undetermined significance, who presented with subacute cognitive decline. Anti-GFAP antibodies were detected in the cerebrospinal fluid. Computer Tomography (CT) of chest, abdomen and pelvis identified a renal mass that was resected. Subsequent pathology confirmed clear cell renal cell carcinoma. The patient was treated with corticosteroids with cognitive recovery near to baseline. In conclusion, we encourage the early consideration of autoimmune GFAP astrocytopathy for patients with clinical manifestation of subacute neuropsychiatric symptoms after other common conditions have been ruled out, as it usually has a great response to immunosuppressive therapy. In addition, this case highlights the importance of full body scan to identify possible underlying malignancy as a possible precipitating factor.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000275/pdfft?md5=2065be24e880ef5864893cd0798d0453&pid=1-s2.0-S2667257X24000275-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Very late-onset neuromyelitis optica presenting with simultaneous bilateral optic neuritis and myelitis: A case report 极晚期神经脊髓炎同时伴有双侧视神经炎和脊髓炎：病例报告

Neuroimmunology Reports Pub Date : 2024-12-01 Epub Date: 2024-09-14 DOI: 10.1016/j.nerep.2024.100227

S Gandelman , S Parauda , C Dohle

{"title":"Very late-onset neuromyelitis optica presenting with simultaneous bilateral optic neuritis and myelitis: A case report","authors":"S Gandelman , S Parauda , C Dohle","doi":"10.1016/j.nerep.2024.100227","DOIUrl":"10.1016/j.nerep.2024.100227","url":null,"abstract":"<div><h3>Background</h3><p>New-onset Neuromyelitis Optica Spectrum Disorder (NMOSD) has rarely been reported in adults over age 70. We describe a severe presentation in a 77-year-old female.</p></div><div><h3>Case</h3><p>The patient presented with left arm numbness, followed by left leg numbness and bilateral optic neuritis. Neuroimaging showed a C2-T1 lesion with C4-C7 holocord enhancement, and bilateral optic nerve enhancement extending to the optic chiasm. Serum testing detected anti-aquaporin-4 antibodies. She was left with dyschromatopsia, myelopathy, and ambulatory dysfunction. She had a history notable for rheumatoid arthritis, treated with rituximab, which had been discontinued six years prior to presentation.</p></div><div><h3>Discussion</h3><p>Very-late-onset NMOSD encompasses a unique cohort of patients with significant immunogenicity despite immunosenescence. Limited data suggest diagnostic delays, severe morbidity, and decreased utilization of disease-modifying therapies.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"6 ","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000287/pdfft?md5=911d5b73fdd8fbd05a4f3ee1c3b475a6&pid=1-s2.0-S2667257X24000287-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive multifocal leukoencephalopathy successfully treated with intravenous immunoglobulin 静脉注射免疫球蛋白成功治疗进行性多灶性白质脑病

Neuroimmunology Reports Pub Date : 2024-01-01 Epub Date: 2024-05-08 DOI: 10.1016/j.nerep.2024.100214

Swansu Batra, Ruchika Tandon, Saurabh Nigam

引用次数: 0

Susac syndrome with complete triad and concurrent kidney failure treated with plasmapheresis and rituximab: A case report 浆细胞分离术和利妥昔单抗治疗伴有完全性三联征和并发肾衰竭的苏萨克综合征：病例报告

Neuroimmunology Reports Pub Date : 2024-01-01 Epub Date: 2024-04-20 DOI: 10.1016/j.nerep.2024.100210

Mohammad Amin Sadri , Sarina Loghmani , Zahra Nikoo , Farinaz Tabibian , Vahid Shaygannejad

{"title":"Susac syndrome with complete triad and concurrent kidney failure treated with plasmapheresis and rituximab: A case report","authors":"Mohammad Amin Sadri , Sarina Loghmani , Zahra Nikoo , Farinaz Tabibian , Vahid Shaygannejad","doi":"10.1016/j.nerep.2024.100210","DOIUrl":"10.1016/j.nerep.2024.100210","url":null,"abstract":"<div><h3>Introduction</h3><p>Susac syndrome (SuS) is a rare autoimmune disease characterized by the clinical triad of brain dysfunction, branch retinal artery occlusion, and hearing loss. Many cases have been reported with irreversible sequelae due to misdiagnosis and late treatment of the disease.</p></div><div><h3>Case</h3><p>In this article, we describe the clinical course and diagnosis of SuS in a young woman with a history of type 1 diabetes mellitus and kidney transplantation who presented with the complete triad. The complex medical history required a tailored treatment approach, including plasmapheresis and rituximab, which significantly improved her condition.</p></div><div><h3>Conclusion</h3><p>This report highlights the diagnostic complexity of SuS and the value of personalized treatment strategies, contributing to the understanding of this rare disorder, and briefly reviews the current knowledge of the disease and discusses the probable pathophysiological relationship between SuS and kidney failure.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000111/pdfft?md5=13d1bb55b1b04759af609450efe4a57e&pid=1-s2.0-S2667257X24000111-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromyelitis optica spectrum disorder in a pediatric patient with ARCN1-related syndrome: A coincidental co-morbidity or disease association? 一名患有 ARCN1 相关综合征的儿科患者出现神经脊髓炎视网膜频谱紊乱：巧合共病还是疾病关联？

Neuroimmunology Reports Pub Date : 2024-01-01 Epub Date: 2024-03-12 DOI: 10.1016/j.nerep.2024.100205

Fazila Aseem, Irena Dujmovic Basuroski

{"title":"Neuromyelitis optica spectrum disorder in a pediatric patient with ARCN1-related syndrome: A coincidental co-morbidity or disease association?","authors":"Fazila Aseem, Irena Dujmovic Basuroski","doi":"10.1016/j.nerep.2024.100205","DOIUrl":"https://doi.org/10.1016/j.nerep.2024.100205","url":null,"abstract":"<div><h3>Background</h3><p>Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare central nervous system autoimmune disease commonly associated with aquaporin-4 antibody (AQP4 Ab). ARCN1-related syndrome is a rare genetic syndrome caused by mutations in archain 1 (ARCN1) gene that encodes the coatomer subunit delta protein in the coat protein complex-I involved in intracellular protein transport. Impaired intracellular trafficking might predispose to autoimmunity. We report a boy with AQP4 Ab positive NMOSD and ARCN1<em>-</em>related syndrome.</p></div><div><h3>Case report</h3><p>A 7-year-old boy with ARCN1<em>-</em>related syndrome (c.508C>T; p.Arg170*; pathogenic variant) presented with severe right sided optic neuritis, fever, intractable hiccups and vomiting. The patient was diagnosed with NMOSD based on clinical presentation (optic neuritis, area postrema syndrome) and positive AQP4 Ab (serum titer, > 1:100,000). After a 5- day intravenous course of high dose methylprednisolone (30 mg/kg/day), his vision did not improve but other symptoms resolved. Maintenance treatment with intravenous immunoglobulin (IVIG, 0.4 g/kg/monthly) was started, but the patient continued to have recurrent left optic neuritis attacks despite escalating maintenance treatment regimen to oral prednisone in addition to IVIG. At the age of 8, the patient was started on a combination therapy with Rituximab and IVIG and has been NMOSD relapse free since then.</p></div><div><h3>Conclusion</h3><p>To date, this is the only reported case of NMOSD in a patient with ARCN1 mutation. Our case might further support an increased risk of autoimmunity in carriers of ARCN1 mutation.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100205"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000068/pdfft?md5=b9e19f4965e2b670e5e7bd9842b693a4&pid=1-s2.0-S2667257X24000068-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140139063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On-pump coronary artery bypass graft in a patient with multiple sclerosis: A case report 多发性硬化症患者的冠状动脉旁路移植术：病例报告

Neuroimmunology Reports Pub Date : 2024-01-01 Epub Date: 2024-01-07 DOI: 10.1016/j.nerep.2024.100200

Osman Fehmi Beyazal , Ferhat Yıldız , Koray Apaydın , Zülfiye Yıldız , Gültekin Saday

{"title":"On-pump coronary artery bypass graft in a patient with multiple sclerosis: A case report","authors":"Osman Fehmi Beyazal , Ferhat Yıldız , Koray Apaydın , Zülfiye Yıldız , Gültekin Saday","doi":"10.1016/j.nerep.2024.100200","DOIUrl":"https://doi.org/10.1016/j.nerep.2024.100200","url":null,"abstract":"<div><h3>Background</h3><p>Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by inflammation, demyelination, gliosis, and neuronal loss. The risk of relapse may increase in the perioperative period in surgical interventions, especially in cardiac surgeries performed using cardiopulmonary bypass (CPB) and the use of CPB with MS patients is controversial.</p></div><div><h3>Case presentation</h3><p>In this case report, the management of a patient with MS to reduce the risk of relapse in the perioperative period is described and a case of coronary artery bypass graft (CABG) performed with CPB without any problems is presented.</p></div><div><h3>Conclusions</h3><p>CABG with CPB can be performed successfully in MS patients. Adjusting the operation time and neurological medications, closely monitoring body temperature and electrolytes in the intraoperative and postoperative period, and ensuring hemodynamic stability can reduce the risk of relapse and infection.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100200"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000019/pdfft?md5=2da13190a9278f51d62d62d485db16d4&pid=1-s2.0-S2667257X24000019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139434533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0