{"title":"两例接受抗 CD20 治疗的脱髓鞘疾病患者鼻咽部 COVID-19 阴性感染病例","authors":"Alexandra Balshi, Jacob A Sloane","doi":"10.1016/j.nerep.2023.100197","DOIUrl":null,"url":null,"abstract":"<div><p>We report two cases of nasopharyngeal negative COVID-19 infections in patients with demyelinating diseases on anti-CD20 treatments. Despite negative nasopharyngeal polymerase chain reaction (PCR) tests, both patients exhibited radiological features consistent with SARS-CoV-2 infection, with one confirmed in bronchoalveolar lavage fluid. Immunocompromised patients may have limited immune responses, possibly contributing to persistent COVID-19 infections despite vaccination history. These findings underscore the need for increased vigilance and consideration of lower respiratory tract infections in immunocompromised patients on anti-CD20 therapies.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100197"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X23000359/pdfft?md5=fcae974d72a548531ac7e57592fa75a4&pid=1-s2.0-S2667257X23000359-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Two cases of nasopharyngeal negative COVID-19 infections in patients with demyelinating diseases on anti-CD20 treatments\",\"authors\":\"Alexandra Balshi, Jacob A Sloane\",\"doi\":\"10.1016/j.nerep.2023.100197\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We report two cases of nasopharyngeal negative COVID-19 infections in patients with demyelinating diseases on anti-CD20 treatments. Despite negative nasopharyngeal polymerase chain reaction (PCR) tests, both patients exhibited radiological features consistent with SARS-CoV-2 infection, with one confirmed in bronchoalveolar lavage fluid. Immunocompromised patients may have limited immune responses, possibly contributing to persistent COVID-19 infections despite vaccination history. These findings underscore the need for increased vigilance and consideration of lower respiratory tract infections in immunocompromised patients on anti-CD20 therapies.</p></div>\",\"PeriodicalId\":100950,\"journal\":{\"name\":\"Neuroimmunology Reports\",\"volume\":\"5 \",\"pages\":\"Article 100197\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667257X23000359/pdfft?md5=fcae974d72a548531ac7e57592fa75a4&pid=1-s2.0-S2667257X23000359-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroimmunology Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667257X23000359\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimmunology Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667257X23000359","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Two cases of nasopharyngeal negative COVID-19 infections in patients with demyelinating diseases on anti-CD20 treatments
We report two cases of nasopharyngeal negative COVID-19 infections in patients with demyelinating diseases on anti-CD20 treatments. Despite negative nasopharyngeal polymerase chain reaction (PCR) tests, both patients exhibited radiological features consistent with SARS-CoV-2 infection, with one confirmed in bronchoalveolar lavage fluid. Immunocompromised patients may have limited immune responses, possibly contributing to persistent COVID-19 infections despite vaccination history. These findings underscore the need for increased vigilance and consideration of lower respiratory tract infections in immunocompromised patients on anti-CD20 therapies.
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