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Journal of the American Pharmaceutical Association (Scientific ed.)最新文献

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Investigation and Development of Protective Ointments III* 保护软膏的研究与开发*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-09-01 DOI: 10.1002/jps.3030490902
K.F. Finger , A.P. Lemberger, D.E. Wurster, T. Higuchi
{"title":"Investigation and Development of Protective Ointments III*","authors":"K.F. Finger ,&nbsp;A.P. Lemberger,&nbsp;D.E. Wurster,&nbsp;T. Higuchi","doi":"10.1002/jps.3030490902","DOIUrl":"10.1002/jps.3030490902","url":null,"abstract":"<div><p>The adsorption of sarin from <em>n</em>-heptane solutions by silica gels, alumina, bentonite, and certain carbonaceous adsorbents was studied. The results obtained have been interpreted according to the Langmuir adsorption isotherm. Of the various adsorbents tested, those of a silicaceous nature were found to be superior, exhibiting very strong adsorptive tendencies toward the fluorophosphate ester. A linear relationship was found to exist between the limiting adsorptive capacity and the specific surface area of the adsorbents. The average area occupied by a sarin molecule, furthermore, was found to be approximately 80 Å<sup>2</sup>, irrespective of the adsorbent, a value in reasonable agreement with that suggested by a molecular model. Both of these relationships indicate that sarin is adsorbed primarily as a unimolecular layer.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 565-568"},"PeriodicalIF":0.0,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82157153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Comparative Study of Theophylline Preparations: Digestive Absorption* 茶碱制剂的比较研究:消化吸收*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-09-01 DOI: 10.1002/jps.3030490916
Samuel H. Waxler, Herbert B. Moy
{"title":"A Comparative Study of Theophylline Preparations: Digestive Absorption*","authors":"Samuel H. Waxler,&nbsp;Herbert B. Moy","doi":"10.1002/jps.3030490916","DOIUrl":"10.1002/jps.3030490916","url":null,"abstract":"<div><p>Six theophylline preparations have been tested for their absorption from the gastrointestinal tracts of animals as reflected by blood theophylline levels. These values were obtained first from the stomach, and then from the remainder of the gastrointestinal tract. The results showed satisfactory absorption with all medications, and the wide variation inherent in oral preparations. No real superiority was evident in the six preparations when the available theophylline was the same in each drug.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 619-621"},"PeriodicalIF":0.0,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490916","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86838619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
An Evaluation of Certain Hypotensive Agents IV.* 某些降压药的评价
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-09-01 DOI: 10.1002/jps.3030490907
J.P. Buckley, M.L. Jacquart, J.A. Bianculli, R.K. Bickerton , W.J. Hudak , F.M. Schalit , J.J. Defeo
{"title":"An Evaluation of Certain Hypotensive Agents IV.*","authors":"J.P. Buckley,&nbsp;M.L. Jacquart,&nbsp;J.A. Bianculli,&nbsp;R.K. Bickerton ,&nbsp;W.J. Hudak ,&nbsp;F.M. Schalit ,&nbsp;J.J. Defeo","doi":"10.1002/jps.3030490907","DOIUrl":"10.1002/jps.3030490907","url":null,"abstract":"<div><p>Certain diquaternarized piperidine derivatives and several bis-tertiary amines were evaluated in the anesthetized rat and dog. The most active hypotensive agents were: 3-mor-pholinopropyl N-methylpipecolinate di-methiodide (JB-643), 2-morpholinoethyl N-methylpipecolinate dimethobromide (JB-654), and beta (3-diethylamino-1-propynyl)-N-methylpiperidine dimethobromide (JB-579). The compounds JB-643 and JB-654, administered orally to unanesthetized dogs, produced marked hypotensive responses persisting for more than eleven hours.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 586-589"},"PeriodicalIF":0.0,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490907","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81859514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Studies on Bacterial Pyrogenicity II* 细菌热原性研究II*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-09-01 DOI: 10.1002/jps.3030490915
Stanley Marcus, Carl Anselmo, Joanna Luke
{"title":"Studies on Bacterial Pyrogenicity II*","authors":"Stanley Marcus,&nbsp;Carl Anselmo,&nbsp;Joanna Luke","doi":"10.1002/jps.3030490915","DOIUrl":"10.1002/jps.3030490915","url":null,"abstract":"<div><p>The basis and procedure for a culture method employing membrane filters to test freshly prepared parenteral solutions for pyrogenic capacity is presented. Under the limiting conditions described, solutions which yielded counts of less than 10,000 per L. were found to be nonpyrogenic by rabbit test. On the basis of laboratory and field trial, it is concluded that the bacteriological assay for the purpose described is as specific and sensitive as the rabbit assay for pyrogenicity.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 616-619"},"PeriodicalIF":0.0,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490915","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88635588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Aids to Biochemistry. 5th ed. By S. P. Datta and J. H. Ottaway. Baillière, Tindall and Cox, London, 1960. Exclusive U. S. Agents, the Williams & Wilkins Co., 428 East Preston St., Baltimore 2, Md. viii + 266 pp. 10 × 16 cm. price $3.75 S. P. Datta 和 J. H. Ottaway 著。S. P. Datta 和 J. H. Ottaway 著。伦敦 Baillière、Tindall 和 Cox 出版社，1960 年。美国独家代理，Williams & Wilkins Co., 428 East Preston St.10 × 16 厘米。
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-09-01 DOI: 10.1002/jps.3030490928
{"title":"Aids to Biochemistry. 5th ed. By S. P. Datta and J. H. Ottaway. Baillière, Tindall and Cox, London, 1960. Exclusive U. S. Agents, the Williams & Wilkins Co., 428 East Preston St., Baltimore 2, Md. viii + 266 pp. 10 × 16 cm. price $3.75","authors":"","doi":"10.1002/jps.3030490928","DOIUrl":"10.1002/jps.3030490928","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Page 626"},"PeriodicalIF":0.0,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490928","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134811802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cahiers de Synthèse Organique. Vol. 6. Méthodes et Tableaux D'application. Edited by Leon Velluz. Masson et Cie., 120, Boulevard Saint-Germain, Paris VIe, France, 1960. 417 pp. 16 × 22 cm. Price 120 NF 有机合成笔记本。6卷。方法和应用表。它是由Leon Velluz编辑的。马森公司，120，圣日耳曼大道，巴黎生活，法国，1960年。417页16 × 22厘米。价格120 NF
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-09-01 DOI: 10.1002/jps.3030490934
{"title":"Cahiers de Synthèse Organique. Vol. 6. Méthodes et Tableaux D'application. Edited by Leon Velluz. Masson et Cie., 120, Boulevard Saint-Germain, Paris VIe, France, 1960. 417 pp. 16 × 22 cm. Price 120 NF","authors":"","doi":"10.1002/jps.3030490934","DOIUrl":"10.1002/jps.3030490934","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Page 626"},"PeriodicalIF":0.0,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134801238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Encyclopaedia of Microscopic Stains. By Edward Gurr. The Williams & Wilkins Co., 428 East Preston St., Baltimore 2, Md., 1960. xi + 498 pp. 15 × 24.5 cm. Price $18.50 显微染色百科全书。Edward Gurr 著。The Williams & Wilkins Co., 428 East Preston St.15 × 24.5 厘米。售价 18.50 美元
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-09-01 DOI: 10.1002/jps.3030490936
{"title":"Encyclopaedia of Microscopic Stains. By Edward Gurr. The Williams & Wilkins Co., 428 East Preston St., Baltimore 2, Md., 1960. xi + 498 pp. 15 × 24.5 cm. Price $18.50","authors":"","doi":"10.1002/jps.3030490936","DOIUrl":"10.1002/jps.3030490936","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Page 626"},"PeriodicalIF":0.0,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490936","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134801239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
General Chemistry–laboratory Manual. By Garth L. Lee and Harris O. Van Orden. W. B. Saunders Co., West Washington Square, Philadelphia 5, Pa., 1960. v + 217 pp. 22 × 28 cm. Paperbound. Price $3.75 普通化学实验手册》。作者：Garth L. Lee 和 Harris O. Van Orden。W. B. Saunders Co., West Washington Square, Philadelphia 5, Pa., 1960. v + 217 pp.22 × 28 厘米。纸质装订。价格 3.75 美元
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-09-01 DOI: 10.1002/jps.3030490933
{"title":"General Chemistry–laboratory Manual. By Garth L. Lee and Harris O. Van Orden. W. B. Saunders Co., West Washington Square, Philadelphia 5, Pa., 1960. v + 217 pp. 22 × 28 cm. Paperbound. Price $3.75","authors":"","doi":"10.1002/jps.3030490933","DOIUrl":"10.1002/jps.3030490933","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Page 626"},"PeriodicalIF":0.0,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490933","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134881897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Kinetic Study of Glucose Degradation in Acid Solution* 葡萄糖在酸性溶液中的降解动力学研究*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-09-01 DOI: 10.1002/jps.3030490909
Kenneth R. Heimlich , Alfred N. Martin
{"title":"A Kinetic Study of Glucose Degradation in Acid Solution*","authors":"Kenneth R. Heimlich ,&nbsp;Alfred N. Martin","doi":"10.1002/jps.3030490909","DOIUrl":"10.1002/jps.3030490909","url":null,"abstract":"<div><p>The degradation of glucose in acid solution was carried out at various temperatures. The first-order rate constants for the decomposition reaction, obtained from the initial rate of formation of 5-hydroxymethylfurfural (5HMF), were consistently higher than those calculated from glucose depletion measurements over long periods of time at temperatures above 100°. At 100° the rate of formation of 5-HMF increased with time for the early portion of the break-down. The rate constant did not coincide with the Arrhenius plot for higher temperatures. This indicates the possibility of a change of mechanism at lower temperatures. The rate data was fitted to kinetic expressions for first-order consecutive reactions. Agreement between calculated and experimental values indicates that the reaction proceeds by the step-wise mechanism. Data obtained from degradation in varying acid concentrations show that the rate constant does not vary linearly with normality. Decomposition in dioxane-water mixtures indicates that the logarithm of the rate constant varies linearly with the reciprocal of the dielectric constant.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 592-597"},"PeriodicalIF":0.0,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490909","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73347400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 46
A System for Measuring Contractions of the Rat Ventricle Strip* 一种测量大鼠心室条收缩的系统*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-09-01 DOI: 10.1002/jps.3030490914
Duane G. Wenzel, Ivens A. Siegel, Robert E. Nichols
{"title":"A System for Measuring Contractions of the Rat Ventricle Strip*","authors":"Duane G. Wenzel,&nbsp;Ivens A. Siegel,&nbsp;Robert E. Nichols","doi":"10.1002/jps.3030490914","DOIUrl":"10.1002/jps.3030490914","url":null,"abstract":"<div><p>A system is described for the quantitative measurement of the contractions of the electrically driven rat ventricle strip. The apparatus includes the components of the transducer-amplifier-recording system as well as a simplified muscle-holder and electrode assembly. As normally employed, the system accurately measures semi-isometric (&gt;0.025 mm. displacement) muscle contractions at a stimulus frequency of four per second. It may also be employed at other frequencies and for moderate isotonic contractions as well as for gas displacement.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 614-616"},"PeriodicalIF":0.0,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490914","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80904708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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