{"title":"细菌热原性研究II*","authors":"Stanley Marcus, Carl Anselmo, Joanna Luke","doi":"10.1002/jps.3030490915","DOIUrl":null,"url":null,"abstract":"<div><p>The basis and procedure for a culture method employing membrane filters to test freshly prepared parenteral solutions for pyrogenic capacity is presented. Under the limiting conditions described, solutions which yielded counts of less than 10,000 per L. were found to be nonpyrogenic by rabbit test. On the basis of laboratory and field trial, it is concluded that the bacteriological assay for the purpose described is as specific and sensitive as the rabbit assay for pyrogenicity.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 616-619"},"PeriodicalIF":0.0000,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490915","citationCount":"4","resultStr":"{\"title\":\"Studies on Bacterial Pyrogenicity II*\",\"authors\":\"Stanley Marcus, Carl Anselmo, Joanna Luke\",\"doi\":\"10.1002/jps.3030490915\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The basis and procedure for a culture method employing membrane filters to test freshly prepared parenteral solutions for pyrogenic capacity is presented. Under the limiting conditions described, solutions which yielded counts of less than 10,000 per L. were found to be nonpyrogenic by rabbit test. On the basis of laboratory and field trial, it is concluded that the bacteriological assay for the purpose described is as specific and sensitive as the rabbit assay for pyrogenicity.</p></div>\",\"PeriodicalId\":100839,\"journal\":{\"name\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"volume\":\"49 9\",\"pages\":\"Pages 616-619\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1960-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/jps.3030490915\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0095955315363149\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315363149","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The basis and procedure for a culture method employing membrane filters to test freshly prepared parenteral solutions for pyrogenic capacity is presented. Under the limiting conditions described, solutions which yielded counts of less than 10,000 per L. were found to be nonpyrogenic by rabbit test. On the basis of laboratory and field trial, it is concluded that the bacteriological assay for the purpose described is as specific and sensitive as the rabbit assay for pyrogenicity.
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