An Evaluation of Certain Hypotensive Agents IV.*

Abstract

Certain diquaternarized piperidine derivatives and several bis-tertiary amines were evaluated in the anesthetized rat and dog. The most active hypotensive agents were: 3-mor-pholinopropyl N-methylpipecolinate di-methiodide (JB-643), 2-morpholinoethyl N-methylpipecolinate dimethobromide (JB-654), and beta (3-diethylamino-1-propynyl)-N-methylpiperidine dimethobromide (JB-579). The compounds JB-643 and JB-654, administered orally to unanesthetized dogs, produced marked hypotensive responses persisting for more than eleven hours.