发布求助
文献互助 智能选刊 最新文献

Journal of the American Pharmaceutical Association (Scientific ed.)最新文献

筛选
英文 中文
Note on the Characteristics of an Apomorphine Response in Pigeons* 鸽子对阿波啡反应的特征注释*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-08-01 DOI: 10.1002/jps.3030490819
A.M. Burkman
{"title":"Note on the Characteristics of an Apomorphine Response in Pigeons*","authors":"A.M. Burkman","doi":"10.1002/jps.3030490819","DOIUrl":"10.1002/jps.3030490819","url":null,"abstract":"<div><p>Quantitative relationships between the dose and incidence, latent period, duration of action, cumulative and minute responses of the apomorphine-induced pecking syndrome are described.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 8","pages":"Pages 558-559"},"PeriodicalIF":0.0,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23439935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Synthesis and Metabolic Studies of Cl4-Labeled Hemicholinium Number Three* cl4标记3号钬的合成与代谢研究*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-08-01 DOI: 10.1002/jps.3030490817
Floyd R. Domer , F.W. Schueler
{"title":"Synthesis and Metabolic Studies of Cl4-Labeled Hemicholinium Number Three*","authors":"Floyd R. Domer ,&nbsp;F.W. Schueler","doi":"10.1002/jps.3030490817","DOIUrl":"10.1002/jps.3030490817","url":null,"abstract":"<div><p>Synthesis of C<sup>I4</sup>-labeled hemicholinium No. 3 (HC-3) with a specific activity of 2.788 mc./m<em>M</em> is described. Twenty-four hour studies of rats in metabolism cages indicated 57.5 per cent of an injected dose is excreted in the urine, 15.6 per cent is excreted in the feces, and none is excreted in the expired carbon dioxide. Tissue distribution studies did not show any site of localization in rats.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 8","pages":"Pages 553-556"},"PeriodicalIF":0.0,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490817","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82121613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
The lynn index. A bibliography of phytochemistry. Monograph IV. Organized and edited by John W. Schermerhorn and Maynard W. Quimby. Massachusetts College of Pharmacy, Longwood Ave., Boston 15, Mass., 1960. 70 pp. 15 × 23 cm 林恩索引。植物化学书目。专著 IV。John W. Schermerhorn 和 Maynard W. Quimby 整理编辑。马萨诸塞州药学院，长木大道，波士顿 15 号，马萨诸塞州，1960 年。70 pp.15 × 23 厘米
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-08-01 DOI: 10.1002/jps.3030490823
{"title":"The lynn index. A bibliography of phytochemistry. Monograph IV. Organized and edited by John W. Schermerhorn and Maynard W. Quimby. Massachusetts College of Pharmacy, Longwood Ave., Boston 15, Mass., 1960. 70 pp. 15 × 23 cm","authors":"","doi":"10.1002/jps.3030490823","DOIUrl":"10.1002/jps.3030490823","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 8","pages":"Page 563"},"PeriodicalIF":0.0,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490823","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134880695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Facilitative Action of Reserpine on Metrazol Convulsions When Modified by Iproniazid* 利血平对咪唑类异丙咪唑类惊厥的促进作用*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-08-01 DOI: 10.1002/jps.3030490808
L.R. Weiss , J.W. Nelson, A. Tye
{"title":"The Facilitative Action of Reserpine on Metrazol Convulsions When Modified by Iproniazid*","authors":"L.R. Weiss ,&nbsp;J.W. Nelson,&nbsp;A. Tye","doi":"10.1002/jps.3030490808","DOIUrl":"10.1002/jps.3030490808","url":null,"abstract":"<div><p>The effects of reserpine, iproniazid, and their combination on the convulsive threshold, facilitative action, ana seizure pattern of metrazol-treated mice was investigated. The effect of reserpine on metrazol convulsions is a marked decrease in convulsive dose which is accompanied by a reduced seizure latency time in the convulsive pattern with an increasing facilitative action. Iproniazid was found to increase the convulsive dose and lengthen the latency interval. Prior treatment with iproniazid before reserpine reversed the depressive state produced by the latter agent to that of stimulation. This was accompanied by an increased anticonvulsant effect, longer latency interval, and absence of a facilitative action. Treatment with iproniazid after reserpine failed to elicit these effects. These results are compatible with the hypothesis that iproniazid and reserpine produce their effect through a biochemical change, the former by monoamine oxidase inhibition and the latter by release of norepinephrine and other amines from their storage sites in the central nervous system.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 8","pages":"Pages 514-517"},"PeriodicalIF":0.0,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490808","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23446605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Synthesis and organisation in the Bacterial Cell. By E. F. Gale. John Wiley & Sons, Inc., 440 Fourth Ave., New York 16, N. Y., 1959. vii + 110 pp. 12.5 × 18.5 cm 细菌细胞中的合成和组织。E. F. Gale 著。John Wiley & Sons, Inc., 440 Fourth Ave., New York 16, N. Y., 1959. vii + 110 pp.12.5 × 18.5 厘米
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-08-01 DOI: 10.1002/jps.3030490822
{"title":"Synthesis and organisation in the Bacterial Cell. By E. F. Gale. John Wiley & Sons, Inc., 440 Fourth Ave., New York 16, N. Y., 1959. vii + 110 pp. 12.5 × 18.5 cm","authors":"","doi":"10.1002/jps.3030490822","DOIUrl":"10.1002/jps.3030490822","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 8","pages":"Page 563"},"PeriodicalIF":0.0,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490822","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134809708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultraviolet Photometric Assay of Thiopental and Pentobarbital in Blood and Plasma* 血液和血浆中硫喷妥钠和戊巴比妥的紫外光度测定*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-08-01 DOI: 10.1002/jps.3030490806
Stephen I. Oroszlan, Gertrude D. Maengwyn-Davies
{"title":"Ultraviolet Photometric Assay of Thiopental and Pentobarbital in Blood and Plasma*","authors":"Stephen I. Oroszlan,&nbsp;Gertrude D. Maengwyn-Davies","doi":"10.1002/jps.3030490806","DOIUrl":"10.1002/jps.3030490806","url":null,"abstract":"<div><p>A procedure for the determination of sodium pentobarbital and sodium thiopental under rigidly standardized conditions of extraction, using Allen's absorption factor, is described. This method makes possible the reliable quantitative determination of 1 mcg./ml. or smaller concentration differences. In an appendix Allen's absorption factor for sodium pentobarbital is derived.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 8","pages":"Pages 507-509"},"PeriodicalIF":0.0,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490806","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23443564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Relationship of Chemical Structure to Central Nervous System Effects of Tranquilizing and Anticonvulsant Drugs* 镇静和抗惊厥药物的化学结构与中枢神经系统作用的关系*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-07-01 DOI: 10.1002/jps.3030490703
T.C. Barnes
{"title":"Relationship of Chemical Structure to Central Nervous System Effects of Tranquilizing and Anticonvulsant Drugs*","authors":"T.C. Barnes","doi":"10.1002/jps.3030490703","DOIUrl":"10.1002/jps.3030490703","url":null,"abstract":"<div><p>Isolated mice provide a method of testing tranquilizing and anticonvulsant drugs on abnorml animals. Trifluoroperazine was effective in abolishing head twitch in lower doses than chlorpromazine, showing potency of the added piperazine ring. Phenobarbital inhibited convulsive movements induced by tactile stimulation but did not abolish head twitch.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 7","pages":"Pages 415-417"},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490703","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23439543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The Photo-oxidation of Dihydroxyphenylalanine in the Presence of 8-Methoxypsoralen* 8-甲氧基补骨脂素存在下二羟基苯丙氨酸的光氧化反应*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-07-01 DOI: 10.1002/jps.3030490712
Joseph Judis
{"title":"The Photo-oxidation of Dihydroxyphenylalanine in the Presence of 8-Methoxypsoralen*","authors":"Joseph Judis","doi":"10.1002/jps.3030490712","DOIUrl":"10.1002/jps.3030490712","url":null,"abstract":"<div><p>8-Methoxypsoralen (8-MOP) is well known for its ability to stimulate melanin formation in vitiligo or normal skin if administration is coupled with exposure to sunlight or ultraviolet light. As an approach to studying the mechanism of action of 8-MOP, the latter was incubated with DOPA and exposed to various types of light. Sunlight, white light, or long wave ultraviolet light (3660 Å.) stimulated the oxidation of DOPA in the presence of 8-MOP but not in the absence of the latter. 8-MOP protected DOPA against short wavelength ultraviolet(2540 Å.) although DOPA was oxidized by the latter in the absence of 8-MOP. The photo-oxidation of DOPA in the presence of long wavelength ultraviolet light and 8-MOP was more rapid at pH values above 7 and was completely inhibited by ascorbic acid, cysteine, cysteamine, <em>β</em>-aminoethylisothiuronium bromide HBr, and partially inhibited by sodium thioglycollate. The possible implication of these <em>in vitro</em> observations to the mode of action of 8-MOP <em>in vivo</em> is discussed.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 7","pages":"Pages 447-450"},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490712","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23442294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
The Relationship of Metal Binding to the Biological Activities of Phenethylbiguanide* 金属结合与苯乙基双胍生物活性的关系
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-07-01 DOI: 10.1002/jps.3030490710
Eugene D. Weinberg, Robert Chernin, John H. Billman
{"title":"The Relationship of Metal Binding to the Biological Activities of Phenethylbiguanide*","authors":"Eugene D. Weinberg,&nbsp;Robert Chernin,&nbsp;John H. Billman","doi":"10.1002/jps.3030490710","DOIUrl":"10.1002/jps.3030490710","url":null,"abstract":"<div><p>Phenethylbiguanide has been found to form metal complexes with divalent copper and nickel; on the basis of infrared absorption spectra and on theoretical considerations, a revised structure for the metal complexes of biguanides is proposed. Antimicrobial activities of phenethylbiguanide are not affected by divalent copper and nickel but are significantly depressed by iron. The relationship of these findings to the biological mechanisms of action of the compound is discussed.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 7","pages":"Pages 441-444"},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490710","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23446600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Solubility of Benzoic Acid in Mixed Solvents* 苯甲酸在混合溶剂中的溶解性*
Journal of the American Pharmaceutical Association (Scientific ed.) Pub Date : 1960-07-01 DOI: 10.1002/jps.3030490711
Marvin J. Chertkoff , Alfred N. Martin
{"title":"The Solubility of Benzoic Acid in Mixed Solvents*","authors":"Marvin J. Chertkoff ,&nbsp;Alfred N. Martin","doi":"10.1002/jps.3030490711","DOIUrl":"10.1002/jps.3030490711","url":null,"abstract":"<div><p>The solubility of benzoic acid was determined in mixtures of several solvents of varying polarity. The experimental results were compared with the theoretical solubility as calculated from the Hildebrand equation for regular solutions. The theoretical and experimental results agree well in the region where the solubility parameter of the solute approaches that of the solvent mixture.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 7","pages":"Pages 444-447"},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490711","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72312941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信