{"title":"镇静和抗惊厥药物的化学结构与中枢神经系统作用的关系*","authors":"T.C. Barnes","doi":"10.1002/jps.3030490703","DOIUrl":null,"url":null,"abstract":"<div><p>Isolated mice provide a method of testing tranquilizing and anticonvulsant drugs on abnorml animals. Trifluoroperazine was effective in abolishing head twitch in lower doses than chlorpromazine, showing potency of the added piperazine ring. Phenobarbital inhibited convulsive movements induced by tactile stimulation but did not abolish head twitch.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 7","pages":"Pages 415-417"},"PeriodicalIF":0.0000,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490703","citationCount":"6","resultStr":"{\"title\":\"Relationship of Chemical Structure to Central Nervous System Effects of Tranquilizing and Anticonvulsant Drugs*\",\"authors\":\"T.C. Barnes\",\"doi\":\"10.1002/jps.3030490703\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Isolated mice provide a method of testing tranquilizing and anticonvulsant drugs on abnorml animals. Trifluoroperazine was effective in abolishing head twitch in lower doses than chlorpromazine, showing potency of the added piperazine ring. Phenobarbital inhibited convulsive movements induced by tactile stimulation but did not abolish head twitch.</p></div>\",\"PeriodicalId\":100839,\"journal\":{\"name\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"volume\":\"49 7\",\"pages\":\"Pages 415-417\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1960-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/jps.3030490703\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0095955315362442\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315362442","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Relationship of Chemical Structure to Central Nervous System Effects of Tranquilizing and Anticonvulsant Drugs*
Isolated mice provide a method of testing tranquilizing and anticonvulsant drugs on abnorml animals. Trifluoroperazine was effective in abolishing head twitch in lower doses than chlorpromazine, showing potency of the added piperazine ring. Phenobarbital inhibited convulsive movements induced by tactile stimulation but did not abolish head twitch.
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