Intelligent Pharmacy最新文献

{"title":"A review on electromedicine its various properties and emerging application in various fields","authors":"Vaibhavi Vijay Kshatriya ,&nbsp;Manoj Ramesh Kumbhare ,&nbsp;Shraddha Vikas Jadhav ,&nbsp;Prajakta Jaywant Thorat ,&nbsp;Rushikesh Gajanan Bhambarge","doi":"10.1016/j.ipha.2024.05.001","DOIUrl":"10.1016/j.ipha.2024.05.001","url":null,"abstract":"<div><div>Electromedicine can be defined as the study of different types of electrical therapies used for the treatment of various medical ailments. Electromedicine has been practiced for hundreds of years, according to the historical data available. In the early years after the death of Christ, a growing interest in the use of electricity and magnetism was observed. Electrotherapy is the use of electrical energy as a medical treatment. In medicine, the term electrotherapy can apply to a variety of treatments, including the use of electrical devices such as deep brain stimulators for neurological disease. The term has also been applied specifically to the use of electric current to speed wound healing. Electric diathermy uses high-frequency alternating electric or magnetic fields, sometimes with no electrode or device contact to the skin, to induce gentle deep tissue heating by induction or dipole rotation. Additionally, the term “electrotherapy” or “electromagnetic therapy” has also been applied to a range of alternative medical devices and treatments. The aim of this review is to highlight emerging role of electromedicines in health care industries as well as how these are effective as compared to medicines. Moreover, electromedicine offers amazing diagnostic potential.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 6","pages":"Pages 777-783"},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141054625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoliposome: As a smart nanocarrier in transdermal drug delivery system","authors":"Subhabrota Majumdar ,&nbsp;Beduin Mahanti ,&nbsp;Ayan Kumar Kar ,&nbsp;Hiranmoy Parya ,&nbsp;Arya Ghosh ,&nbsp;Banhishikha Kar","doi":"10.1016/j.ipha.2024.04.004","DOIUrl":"10.1016/j.ipha.2024.04.004","url":null,"abstract":"<div><div>In the current advancement of drug delivery systems, nanoliposome vesicles act as a modernized technology for the encapsulation of bioactive agents. The prerequisite to expand biocompatible, structured, patient compliance, and guarded treatments in the biomedical sector is gaining distinctive recognition for employing the field of nanotechnology as capable medium to design new drug delivery systems. The liberty of this review is to initiate the concept of nanoliposomes and also elaborate on a few facets and mechanisms of nanoliposomes at the transdermal site. The enormous list of bioactive materials can be incorporated into nanoliposomes, ranging from the pharmaceuticals and cosmetics industry. The prototypical liposomes have inadequate possibility as a carrier for drug delivery via the skin because they do not penetrate the deeper layer of the skin. Only designed liposomes have the capacity to achieve enhanced delivery. It has unusual properties like biodegradability, biocompatibility, and nano size. The exclusive characteristics of nanoliposomes are their ability to solubilize and sectionalize both hydrophilic and hydrophobic bioactive agents. It intensifies the performance of bioactive agent by enhancing their solubility and bioavailability. High-quality phospholipids, the cornerstone of nanoliposomal lipid bilayer are the key components. This review article intends to provide an overview of liposomes and nanoliposomes their properties, preparation methods, and evaluation parameters. Also, it explains various applications of nanoliposomes in nanotherapy including diagnostics, specifically cancer, cosmetics, and nutraceuticals.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 6","pages":"Pages 768-776"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoliposome enabled topical gel-based drug delivery system of ivermectin: Fabrication, characterization, in vivo and in vitro investigation","authors":"Banhishikha Kar ,&nbsp;Beduin Mahanti ,&nbsp;Ayan Kumar Kar ,&nbsp;Rana Mazumder ,&nbsp;Arpan Roy ,&nbsp;Subhabrota Majumdar","doi":"10.1016/j.ipha.2024.04.002","DOIUrl":"10.1016/j.ipha.2024.04.002","url":null,"abstract":"<div><div>Nanoliposomes loaded with ivermectin possess the ability to deliver the drug to an intended area, ensuring optimal stability and eventual release at that precise location. The nanoliposome's size range results in an expanded surface area, which enables the delivery of the maximum amount of medication to the designed location. This investigation shows that the thin film lipid hydration technique can be employed to formulate nanoliposomes. For the formulation, the amount of cholesterol and phosphatidylcholine was chosen applying response surface methodology (RSM). With a range of zeta potentials from −13.4 ​± ​0.14 ​mV to −34.5 ​± ​0.11 ​mV, average dimension of the particles in the different formulation tested in this study is between 93.2 ​nm and 156.4 ​nm. The factorial design optimization demonstrates that the entrapment efficiency (Y3) has a <em>p</em>-value of 0.0160, the percentage of medicament release rate 8 ​h (Y1) has a <em>p</em>-value of 0.0414, and the percentage of medicament release rate 12 ​h (Y2) has a <em>p</em>-value of 0.0119. Therefore, all the models and responses were significant. After the thorough assessment from the present investigation, it was found that F7 batch has the highest R² value and n exponent, the release kinetics of the ivermectin-loaded nanoliposome accompanied zero-order release model as well as korsmeyer–peppas model. Additionally, the current study demonstrated the histopathological assessments in the course of wound healing in animal model. Investigated results showcased that the ivermectin loaded nanoliposomes has substantial possibility as a nano conveyor for the targeted drug delivery system.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 6","pages":"Pages 745-755"},"PeriodicalIF":0.0,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schematized study for tackling COVID-19 with Machine Learning (ML), Artificial Intelligence (AI), and Internet of Things (IoT)","authors":"Vrisha Sheth ,&nbsp;Anya Priyal ,&nbsp;Kavya Mehta ,&nbsp;Nirali Desai ,&nbsp;Manan Shah","doi":"10.1016/j.ipha.2024.04.003","DOIUrl":"10.1016/j.ipha.2024.04.003","url":null,"abstract":"<div><div>The novel Coronavirus (COVID-19) is caused by the newly identified strain of the coronavirus family severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), whose target organ is the lungs. It has become a global pandemic, and COVID-19 poses so far unprecedented challenges to healthcare systems around the globe, particularly to those with weakened immune systems. Effective methods for managing, diagnosing, and lessening the effects of COVID-19 are critical because, by 2024, the virus has already caused over 7 million deaths. In this study, we anatomize the impacts of the latest COVID-19 virus on patients with the help of computational intelligence, like Machine learning, artificial intelligence, and IoT-enabled technologies for managing, analyzing, diagnosing, and predicting COVID-19. With tools for early identification, risk assessment, and therapy optimization, machine learning and artificial intelligence have shown tremendous promise in the healthcare industry. These tools can examine big datasets to find patterns and trends that might not be noticeable to human observers. Additionally, IoT will enable healthcare firms to monitor patient scenarios properly and reduce the readmission of COVID-19 patients. Wearable sensors and remote monitoring systems are two examples of IoT-enabled gadgets that are vital for tracking the COVID-19 virus's spread and keeping an eye on its sufferers. These gadgets can gather data in real-time on environmental variables, symptoms, and vital signs, giving medical professionals important insights into the state of their patients' health and the course of their diseases. This study will play a vital role in competing for safety considerations of reducing SARS-CoV-2, COVID-19, and exposure with the assistance of smart technology and provide much-needed information regarding the impact of COVID-19 on patients that will benefit globally.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 6","pages":"Pages 756-767"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metaphorical investigation of aqueous distillate of Cichorium intybus, Foeniculum vulgare and Solanum nigrum along with atorvastatin and orlistat in experimental rodent models of dyslipidaemia and obesity","authors":"Rufaida Wasim,&nbsp;Tarique Mahmood,&nbsp;Arshiya Shamim,&nbsp;Farogh Ahsan,&nbsp;Aditya Singh","doi":"10.1016/j.ipha.2023.08.011","DOIUrl":"10.1016/j.ipha.2023.08.011","url":null,"abstract":"<div><h3>Background</h3><p>Arq is a traditional Unani liquid formulation. In this study we explored Arq-Makoh, Arq-Badiyan and Arq-Kasni for their pharmacological potential to alleviate the symptoms of hyperlipidaemia and obesity and develop an amalgamation with modern drugs that have clinically well reported antihyperlipidaemic and antiobesity potential.</p></div><div><h3>Materials and methods</h3><p>Rats were fed High Fat Diet for 4 weeks. 10 ​ml/kg of each of the three arqs were given alone and along with atorvastatin and orlistat daily for 28 days P.O. During the course of treatment body weight and food intake were carefully observed and after the end of the study, liver weight, heart weight, plasma lipid profile, blood glucose level, insulin and leptin level, serum lipase, lactate dehydrogenase, and antioxidant activity were studied in all treatment groups.</p></div><div><h3>Result</h3><p>Both Arqs and Atorvastatin and Orlistat significantly reduced body weight, lipid profile in HFD fed rats. Arqs when given along with Atorvastatin and Orlistat produced more significant decrease in the serum lipid profile, serum lipase, atherogenic index, lactate Dehydrogenase and TBARS compared with HFD Control group and elevated the levels of HDL-C and SOD. Apart from antihyperlipidaemic and antiobesity effects the treatment groups showed a significant reduction in elevated fasting blood glucose levels (as a result of HFD model used in the study). The above parameters were further confirmed by histopathological studies.</p></div><div><h3>Conclusion</h3><p>The present study indicates that Arq-Makoh, Arq-Badiyan and Arq-Kasni has lipid lowering potential and could potentiate the antihyperlipidaemic and antiobesity potential of Atorvastatin and Orlistat.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 1","pages":"Pages 1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23000709/pdfft?md5=3d04078bbf3cab1f4e08abace1f45b82&pid=1-s2.0-S2949866X23000709-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135388914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the influenza virus inhibitory potential: Ligand-based docking, pharmacophore, MM-GBSA, and molecular dynamic simulation of phytochemicals and cyanobacteria metabolites","authors":"John Maria Jancy Rani ,&nbsp;Karunanithi Kalaimathi ,&nbsp;Srinivasan Prabhu ,&nbsp;Muniappan Ayyanar ,&nbsp;Shine Kadaikunnan ,&nbsp;Subramaniyan Vijayakumar ,&nbsp;Sathammai Priya ,&nbsp;Jayasree Sheshadri ,&nbsp;Singamoorthy Amalraj ,&nbsp;Muthu Thiruvengadam ,&nbsp;Stanislaus Antony Ceasar","doi":"10.1016/j.ipha.2023.10.011","DOIUrl":"10.1016/j.ipha.2023.10.011","url":null,"abstract":"<div><p>Viral outbreaks facilitated by global travel and modernity pose significant threats to global health. Influenza viruses, particularly α-influenza and β-influenza strains, have been plaguing human populations since time immemorial. Despite their long-standing impact, effective drugs are yet to be developed, and co-infection with these viruses can lead to severe health complications. In light of these challenges, this study aimed to investigate the potential antiviral molecules sourced from cyanobacteria and herbs. We conducted virtual screening using ligand-based docking to identify potential phytochemicals and cyanobacterial metabolites as candidates for further evaluation. Subsequently, pharmacophore modeling was employed to validate the binding modes of the selected compounds, followed by MM-GBSA calculations to assess their binding affinities and stabilities within the viral target. Among the molecules investigated, the cyanobacterial compound Symplocamide A (−8.042) demonstrated notable outcomes in docking than the herb molecules in the docked ligand. This finding suggests its potential as a therapeutic agent against influenza A virus proteins. Additionally, cyanobacterial molecules such as Lyngbyastatins 3 (−8.001), Lyngbyastatin G1 (−7.501), and Kempenopeptide (−6.128) exhibit stronger binding affinities and more potent docking scores, making them promising candidates for targeting viral proteins in potential therapeutic applications. The present study reveals the possibility of harnessing cyanobacterial molecules as novel antiviral agents against influenza viruses. Ultimately, we believe that this research will serve as a stepping stone in the quest for innovative drugs to combat respiratory diseases caused by viral infections.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 1","pages":"Pages 83-93"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23001028/pdfft?md5=deae6c97c3e2da7f8acfd9ad4a9e4897&pid=1-s2.0-S2949866X23001028-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135410454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation, development and evaluation of Woodfordia fruticosa and β-sitosterol mediated silver nanoparticles gel for synergistic effect","authors":"Aditya Singh ,&nbsp;Shubhrat Maheshwari","doi":"10.1016/j.ipha.2023.10.012","DOIUrl":"10.1016/j.ipha.2023.10.012","url":null,"abstract":"<div><h3>Background</h3><p>Silver nanoparticles (AgNP) are frequently utilized metallic nanoparticles in healthcare systems. In this investigation, AgNP was produced employing β-sitosterol and <em>Woodfordia fruticosa</em> gel for the purpose of ameliorating wound healing.</p></div><div><h3>Methods</h3><p>The characterization of AgNP was conducted via SEM and spectrophotometry analysis. Simultaneously, a solution with a concentration of 1 ​mM of silver nitrate was prepared by dissolving 16.99 ​mg of silver nitrate in 100 ​ml of distilled water. Subsequently, the API and the silver nitrate solution were utilized in the synthesis of silver nanoparticles. The physicochemical properties, stability, and morphology of the synthesized silver nanoparticles were evaluated through various techniques, such as zeta potential analysis and electron microscopy. These techniques were employed for the purpose of assessing the aforementioned properties. Following the gel preparation, an assessment of the gel was performed.</p></div><div><h3>Result</h3><p>The investigation successfully produced silver nanoparticles (AgNP) using β-sitosterol and <em>Woodfordia fruticosa</em> gel. To characterize the synthesized AgNP, various techniques were employed, including SEM and spectrophotometry analysis. A 1 ​mM solution of silver nitrate was prepared and used in the synthesis process, and the physicochemical properties, stability, and morphology of the AgNP were assessed through zeta potential analysis and electron microscopy.</p></div><div><h3>Conclusion</h3><p>The results of this study indicate the successful synthesis of silver nanoparticles using β-sitosterol and <em>Woodfordia fruticosa</em> gel. The characterization techniques, including SEM and spectrophotometry, confirmed the formation of AgNP. The analysis of physicochemical properties and stability, particularly through zeta potential analysis, provided valuable insights into the stability of the synthesized nanoparticles. These findings have significant implications in the context of wound healing. Silver nanoparticles have been widely studied for their potential wound healing properties due to their antimicrobial and anti-inflammatory characteristics. The utilization of natural compounds like β-sitosterol and botanical sources like <em>Woodfordia fruticosa</em> gel for the synthesis of AgNP is particularly promising as it may reduce potential toxicity and enhance the biocompatibility of these nanoparticles.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 1","pages":"Pages 94-101"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X2300103X/pdfft?md5=e5b3a1922c1ab6c7626665f1f0890a8f&pid=1-s2.0-S2949866X2300103X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135509936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combat against antibiotic resistance is a challenge in Bangladesh","authors":"M. Roney, A. M. Huq, Mohd Fadhlizil Fasihi Mohd Aluwi","doi":"10.1016/j.ipha.2024.02.002","DOIUrl":"https://doi.org/10.1016/j.ipha.2024.02.002","url":null,"abstract":"","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"192 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current advances in nano drug delivery system for dengue treatment and prevention","authors":"Prajakta Jaywant Thorat, M. Kumbhare, Vaibhavi Vijay Kshatriya, Shraddha Vilas Jadhav, Rushikesh Gajanan Bhambarge","doi":"10.1016/j.ipha.2024.01.007","DOIUrl":"https://doi.org/10.1016/j.ipha.2024.01.007","url":null,"abstract":"","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"10 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139877964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan fortified repaglinide gastro-retentive mucoadhesive microsphere with improved anti-diabetic attribute","authors":"Anil Pawar, Pranjal Lohakane, R. Pandhare, Popat Mohite, Shubham Munde, Sudarshan Singh, Vijay Chidrawar","doi":"10.1016/j.ipha.2024.01.012","DOIUrl":"https://doi.org/10.1016/j.ipha.2024.01.012","url":null,"abstract":"","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"36 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139885372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}