Intelligent Pharmacy最新文献

{"title":"A green alternative: Evaluation of Solanum torvum (Sw.) leaf extract for control of Aedes aegypti (L.) and its molecular docking potential","authors":"R. Murugesan,&nbsp;K. Vasuki,&nbsp;B. Kaleeswaran","doi":"10.1016/j.ipha.2023.11.012","DOIUrl":"10.1016/j.ipha.2023.11.012","url":null,"abstract":"<div><p>Due to the unavailability of effective vaccines and treatments, mosquito-borne diseases continue to pose a threat to global public health. Insecticide-treated mosquito nets and room sprays have both been successfully treated with plant-based biopesticides to protect people from mosquito bites. The extensive use of chemical pesticides is known to cause serious harm to human and animal health. From this point of view, the demand for plant extracts has recently increased worldwide. The aim of the current study was to determine the effectiveness of a <em>Solanum torvum</em> (Sw.) leaf extract as a larvicidal, adulticidal and <em>in silico</em> study against the mosquito <em>Aedes aegypti</em>. The plant extract from <em>S. torvum</em> was obtained using a simple method. Preliminary qualitative analysis shows the presence of steroids, saponins, phenol, flavonoids, tannins, and anthraquinones in the aqueous leaf extract of <em>S. torvum</em>. A total, 15 compounds were identified using GC–MS. The larvicidal activity, observed during 24-h and 48-h exposure cycles of 4^th instar larvae, exhibits a maximum (100 ​%) mortality rate at 200 ​μg/ml. The adulticidal activity, observed during the 24-h exposure cycle of adult mosquitoes, exhibits a maximum (92 ​%) mortality rate at 2 ​mg/mL. The molecular docking observation of Protease Sterol Carrier Protein-2 (IPZ4) was noted campesterol had the most favourable docking score with a value of −10. This finding suggests that campesterol may have a high affinity for the target molecule under study. Based on the results, the current study suggests that the use of <em>S. torvum</em> leaf extract could serve as an environmentally friendly alternative to chemical insecticides in controlling mosquito populations and controlling mosquito bone diseases.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23001260/pdfft?md5=1129f2c43cd836de384217ab5d76f41d&pid=1-s2.0-S2949866X23001260-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139299272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards designing of some potential new autoimmune disorder inhibitors using crystal structures and Hirshfeld surface analyses in combination with molecular docking and molecular dynamics simulations","authors":"Emmanuel Israel Edache ,&nbsp;Adamu Uzairu ,&nbsp;Paul Andrew Mamza ,&nbsp;Gideon Adamu Shallangwa ,&nbsp;Muhammad Tukur Ibrahim","doi":"10.1016/j.ipha.2023.11.008","DOIUrl":"10.1016/j.ipha.2023.11.008","url":null,"abstract":"<div><p>The emergence of multi-drug-resistant autoimmune diseases poses a significant risk to human health and has garnered global attention. In this study, metformin and sulfasalazine have been used as starting materials or control. This research has successfully designed a hundred compounds, to assess their efficacy against two autoimmune disease pathogens: type 1 diabetes and rheumatoid arthritis. The DFT method was engaged to calculate the vibrational frequencies and Frontier Molecular orbitals (FMOs) of the selected compounds. The reactivity and selectivity of the selected compounds are analyzed using parameters like MEP and global reactivity descriptors, which are calculated and interpreted. The Density of state (DOS) of the molecule has been plotted and interpreted. Furthermore, docking results showed favorable interactions of the designed compound D385 with catalytically important amino acid residues. The interactions of the best active D385 when compared with the template and the standard drugs show similar binding sites. DFT studies further confirm the presence of HOMO orbital centered on the isoxazole ring further highlighting its importance for receptor-ligand hydrogen and hydrophobic interactions. The molecular dynamics simulations and MM/GBSA analysis reveal that the inhibitory nature of the designed compound D385 is a proven inhibitor of diabetes type 1 and rheumatoid arthritis inhibitor activities. Our study suggested that the designed compounds showed comparable results to that of metformin and sulfasalazine and may be used for further experimental studies. It can also be used as a pipeline to search for and design new potential autoimmune disease inhibitors. The most promising candidates from computational trials can be examined in a wet laboratory experiment before moving on to clinical trials.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23001223/pdfft?md5=b31200ee4b0f1ad99e7cfdc235da0ce0&pid=1-s2.0-S2949866X23001223-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of carvedilol and pitavastatin for antihyperlipidemic activity in tyloxapol-induced hyperlipidemia in Wistar rats","authors":"Md. Akbar ,&nbsp;Hasan Ali ,&nbsp;Md. Azizur Rahman","doi":"10.1016/j.ipha.2023.11.009","DOIUrl":"10.1016/j.ipha.2023.11.009","url":null,"abstract":"<div><p>Aim of the study was designed to investigate the antihyperlipidemic activity of carvedilol and pitavastatin in tyloxapol-induced hyperlipidemia in Wistar rats. The rats were randomly divided into 6 groups. The vehicle control group-I received 2 ​mL of normal saline for eight days. The pathological control group-II received tyloxapol (400 ​mg/kg) on 8th day. The treated group-III received 10 ​mg/kg carvedilol and group-IV received 20 ​mg/kg carvedilol for eight days and tyloxapol (400 ​mg/kg) on the 8th day. The group-V received pitavastatin (0.3 ​mg/kg) for eight days and tyloxapol (400 ​mg/kg) on the 8th day. The group-VI received carvedilol (20 ​mg/kg) only for eight days. After eight days of treatment, triglycerides, total cholesterol, high-density lipoprotein, very low-density lipoprotein, thiobarbituric acid reactive substances, and glutathione were estimated in the serum and myocardial tissues along with DNA fragmentation of the liver tissue using gel-electrophoresis. Oral administration of carvedilol to tyloxapol-induced hyperlipidemic rats normalized the changes in the above parameters in a dose dependent manner. Hence, carvedilol with pitavastatin has antihyperlipidemic activity in tyloxapol-induced hyperlipidemia in Wistar rats.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23001235/pdfft?md5=8b316c7007423929357be787f7e0c207&pid=1-s2.0-S2949866X23001235-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling of novel bornoel analogs as Influenza A Virus inhibitors through genetic function approximation, comparative molecular fields, molecular docking, and ADMET/Pharmacokinetic studies","authors":"Mustapha Abdullahi ,&nbsp;Adamu Uzairu ,&nbsp;Gideon Adamu Shallangwa ,&nbsp;Paul Andrew Mamza ,&nbsp;Muhammad Tukur Ibrahim","doi":"10.1016/j.ipha.2023.11.004","DOIUrl":"10.1016/j.ipha.2023.11.004","url":null,"abstract":"<div><p>Influenza A Virus (IAV) is a human respiratory pathogen prone to mutations and genome re-assortment leading to global pandemics. In this study, we applied the molecular modelling strategies such as, two-dimensional (2D), three-dimensional (3D)-quantitative structure–activity relationship (QSAR), and molecular docking simulation on a novel series of borneol compounds as influenza inhibitors. The best developed 2D-QSAR models, MLR (Q² ​= ​0.8735, R² _(train) ​= ​0.9096) and ANN [3-2-1] (Q² ​= ​0.8987, R²_(train) ​= ​0.9171) revealed good and acceptable statistical validation metrics for the inhibitory activity predictions. The 3D-QSAR models were generated using the comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA), which showed CoMFA_S ​+ ​E (Q² ​= ​0.559, R²_(train) ​= ​0.939) and CoMSIA_S ​+ ​E (Q² ​= ​0.577, R²_(train) ​= ​0.941) as the best-observed models in accordance with the model acceptability standards. In addition, the contour maps generated from the CoMFA and CoMSIA models illustrates the steric and electrostatic molecular field relationships with the inhibitory effects of the studied molecules. Moreover, the binding modes of the active ligands were studied through molecular docking simulation with the Human Hemagglutinin (HA) receptor of influenza A virus (A/Puerto Rico/8/34(H1N1)). The studied compounds revealed the formation of H-bonds, CH-bonds, and hydrophobic interactions with the active amino acid residues such as Asn 543, Asn 614, Asn 617, Leu 618, Ser 540, Lys 539, and Lys 621 in the HA binding cavity. The prediction of drug-likeness and ADMET properties of the compounds revealed their good bioavailability and pharmacokinetic profiling. This study may provide a valuable <em>in-silico</em> guideline for discovering novel potent influenza inhibitors.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23001181/pdfft?md5=a24a770f820d6cc9021c6b00a3d015cc&pid=1-s2.0-S2949866X23001181-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139298746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for clinical treatment failure and death in patients with ceftazidime-avibactam-resistant Gram-negative bacteria: A single-centre retrospective analysis","authors":"Tingting Liu ,&nbsp;Gang Li ,&nbsp;Huijie Yue ,&nbsp;Xuejiao Liu","doi":"10.1016/j.ipha.2023.11.003","DOIUrl":"10.1016/j.ipha.2023.11.003","url":null,"abstract":"<div><h3>Objective</h3><p>In recent years, the number of Gram-negative bacteria (GNB) resistant to ceftazidime-avibactam (CZA) isolated from clinic has been increasing. We aimed to evaluate the clinical efficacy in patients with CZA-resistant GNB infections, and analyze the risk factors for clinical treatment failure and death.</p></div><div><h3>Methods</h3><p>Clinical data of patients with CZA-resistant GNB infections were collected retrospectively, and the influencing factors were analyzed by binary logistic regression.</p></div><div><h3>Results</h3><p>A total of 75 patients with CZA-resistant GNB infections were enrolled in the study, and the clinical effective rate was 56% (42/75). Multivariate analysis showed that continuous renal replacement therapy (CRRT) during anti-infection treatment was an independent risk factor for clinical treatment failure (OR 0.177, 95% CI 0.05–0.63, <em>p</em> ​= ​0.008). The 28-day mortality rate in 75 patients was 18.7% (14/75). Multivariate analysis showed that the regimen of colistin E 750,000 U q12h (OR 0.020, 95% CI 0.00–0.56, ​<em>p</em> ​= ​0.021), co-administration of tigecycline (OR 8.851, 95% CI 2.38–1316.87, ​<em>p</em> ​= ​0.012) and CRRT during anti-infection treatment (OR 79.610, 95% CI 4.87–1300.26, <em>p</em> ​= ​0.002) were independent affecting factors for 28-day mortality in patients with CZA-resistant GNB infections.</p></div><div><h3>Conclusions</h3><p>Patients with CZA-resistant GNB infections had a higher possibility of clinical treatment failure and death. The results of the study based on small sample size from a single center showed that clinical treatment failure and death were more likely to happen in patients on CRRT, and the regimen of colistin E 750,000 U q12h or co-administration of tigecycline may reduce or increase mortality, respectively. Further validation in rigorously designed multicenter clinical studies with larger sample sizes is needed.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X2300117X/pdfft?md5=d4fb4e85d261e055c6185e218f28dcf4&pid=1-s2.0-S2949866X2300117X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135664956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplifying the concept of level of evidence in lay language for all aspects of learners: In brief review","authors":"Abdullah Al Noman ,&nbsp;Onusree Sarkar ,&nbsp;Tanzia Mohsin Mita ,&nbsp;Khadiza Siddika ,&nbsp;Fahmida Afrose","doi":"10.1016/j.ipha.2023.11.002","DOIUrl":"10.1016/j.ipha.2023.11.002","url":null,"abstract":"<div><p>The level of evidence is a fundamental structure for assessing the excellence of evidence while making healthcare choices. It assesses medical research according to its structure, credibility, and relevance. The different degrees of proof are frequently represented as a triangle shape, with the most powerful proof on the highest point. The pyramid is divided into two primary parts: refined data (systematic reviews, meta-analyses) that combines information from multiple studies, and raw data (randomized trials, cohort studies, case series) that consists of original research. Systematic evaluations condense results from various investigations on a subject using thorough, replicable approaches. Meta-analyses mathematically integrate information from similar research studies. Case studies provide information about a specific patient. Case-control studies examine the occurrences in separate groups of people who have a particular illness and those who do not. Randomly assigned intervention and control groups are compared in randomized controlled experiments to observe the differences in their outcomes. Cohort studies track groups over a period to investigate connections between factors and results. The upper levels of the pyramid are typically seen as more trustworthy proof because of thorough combination or research structure. However, every level provides valuable information. Recognizing the positive aspects of various research methods enables individuals to assess the credibility of information when making choices related to healthcare.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23001168/pdfft?md5=189b562cabffc4f128b5711680581493&pid=1-s2.0-S2949866X23001168-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135614459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Docking study of novel designed indazole derivatives against topoisomerase-II DNA gyrase enzyme for antibacterial screening","authors":"Nabeela Mareyam ,&nbsp;Md Nematullah ,&nbsp;Md Faheem Haider ,&nbsp;Md Akbar ,&nbsp;Md Azizur Rahman","doi":"10.1016/j.ipha.2023.11.001","DOIUrl":"10.1016/j.ipha.2023.11.001","url":null,"abstract":"<div><p>Aim of the study was designed for the design of novel indazole derivatives and evaluation of their docking against topoisomerase-II DNA gyrase enzyme for the antibacterial screening. Different novel substituted indazol-3-yl benzenesulfonamide derivatives were designed for the synthesis from <em>o</em>-chlorobenzonitrile and phenyl hydrazine reaction and further, with benzene sulphonyl chloride reaction. These were evaluated for their docking targeting topoisomerase-II DNA gyrase enzyme for the antibacterial screening. A range of binding affinity (˗12.2 to ˗9.6 ​kcal/mol) was observed. Compound, 4-chloro-<em>N</em>-(1-phenyl-1<em>H</em>-indazol-3-yl)benzenesulfonamide had the highest binding affinity (˗12.2 ​kcal/mol) which is better than the standard norfloxacin (˗10.7 ​kcal/mol). Compounds (<strong>12a, 12c, 12e</strong> and <strong>12g</strong>) with chloro-substitution at para position of sulfonamide had higher affinity as compared to the compounds (<strong>12b, 12d, 12f</strong> and <strong>12h</strong>) with methyl substitution. A convenient method for the synthesis of indazole derivatives has been developed. 4-chloro-<em>N</em>-(1-phenyl-1<em>H</em>-indazol-3-yl)benzenesulfonamide had shown the best binding affinity. Further, more diverse bioactive moieties may be incorporated into indazole scaffold in the near future by future researchers and a great amount of effort may be dedicated to the exploration of medicinal approaches for their preparation and evaluation of their biological activities.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23001156/pdfft?md5=c199f3aa7d5819f8355e1ba5bb2f52f9&pid=1-s2.0-S2949866X23001156-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective potential of phenolic rich fractions of Solanum nigrum leaves on oxidative and inflammatory reactions in a cecal ligation and puncture (CLP) induced sepsis model in experimental animal","authors":"Priyanka Bajpai, Om Prakash, Shazia Usmani","doi":"10.1016/j.ipha.2023.10.009","DOIUrl":"https://doi.org/10.1016/j.ipha.2023.10.009","url":null,"abstract":"The present work aimed to investigate the neuroprotective effect of Solanum nigrum leaves against CLP-induced septic encephalopathy in rats. The study was designed to evaluate the effect of Solanum nigrum leaves on behavioral and biochemical changes that occur during septic encephalopathy. Adult male Wistar rats were distributed into five experimental groups and subjected to caecal ligation and puncture, while the control animals were subjected to a sham operation. Solanum nigrum leaf aqueous extract (doses of 200 mg/kg and 400 mg/kg), ethanolic extract (doses of 200 mg/kg and 400 mg/kg), and vehicle, given orally, were administered for one week after the surgery procedure. Behavioral parameters like anxiety, depressive behavior, and nonaversive memory were evaluated. Anti-inflammatory activity was measured by the membrane stabilization method. At the end of the study, animals were sacrificed and their brains removed. Brain homogenates were prepared to assess antioxidant activity (SOD, CAT, MDA, and GSH). Brain tissue sections were stained by hematoxylin and eosin to examine the histopathologic changes such as neuron degeneration, and perinuclear spaces in the brain. Aqueous and ethanolic extracts at doses of 200 mg/kg and 400 mg/kg, showed significant improvement in behavioral parameters, prevention of oxidative stress, neuron degeneration, and perinuclear edema respectively. Aqueous extract and ethanolic fraction at a concentration of 200μg/mL significantly protected the lysis of the erythrocyte membrane induced by the hypotonic solution. Collectively, these results demonstrate that Solanum nigrum leaf aqueous extract and ethanolic extract could be used for the prevention of sepsis-associated encephalopathy.","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135455360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of Ferulic acid and Oleic acid containing liposomal gel for skin nourishment","authors":"Aditya Singh, Shubhrat Maheshwari","doi":"10.1016/j.ipha.2023.10.014","DOIUrl":"https://doi.org/10.1016/j.ipha.2023.10.014","url":null,"abstract":"This study aimed to develop a topical drug delivery system using a liposomal gel loaded with Ferulic acid and Oleic acid, with a dual focus on the treatment of aging skin and skin nourishment. To formulate liposomes containing Ferulic acid and Oleic acid via the thin-film hydration technique. To incorporate the optimized liposomes into a Carbopol® 934 gel matrix. To comprehensively characterize the physicochemical properties of the liposomes and liposomal gel. To evaluate the potential of the developed liposomal gel as an efficacious topical solution for addressing skin aging and promoting skin nourishment. Liposomes were meticulously prepared using the thin-film hydration technique and were subsequently integrated into a Carbopol® 934 gel matrix. A range of crucial assessments were conducted, encompassing entrapment efficiency, drug loading, particle size, polydispersity index (PDI), and zeta potential. The physicochemical attributes of both the liposomes and liposomal gel were systematically examined. The study also sought to evaluate the potential of the liposomal gel for its dual role in combating skin aging and enhancing skin nourishment. The optimized liposomes exhibited remarkable characteristics, including an entrapment efficiency of 95.1%, drug loading of 67.5%, a particle size of 1028 nm, a polydispersity index (PDI) of 0.488, and a zeta potential of -49 mV. These parameters underscored the successful formulation of Ferulic acid and Oleic acid-loaded liposomes, which were seamlessly incorporated into the Carbopol® 934 gel matrix. In conclusion, the Ferulic acid and Oleic acid-loaded liposomal gel developed in this study holds significant promise as a topical drug delivery system for both the treatment of aging skin and skin nourishment. The high entrapment efficiency, substantial drug loading, and desirable particle size and zeta potential collectively demonstrate the efficacy of this liposomal gel as a versatile delivery platform. It has the potential to effectively address clinical manifestations of aging skin, including wrinkles, loss of elasticity, and textural irregularities, while simultaneously providing essential nourishment to the skin. Further in vivo investigations are warranted to ascertain the therapeutic effectiveness and safety of this liposomal gel in the context of skin aging treatment and nourishment.","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135455868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel anoikis-related gene signature predicts in lung adenocarcinoma","authors":"Mengying Xiao ,&nbsp;Yong Li ,&nbsp;Yusheng Zhou ,&nbsp;Xingyun Liu ,&nbsp;Guotao Tang","doi":"10.1016/j.ipha.2023.10.013","DOIUrl":"10.1016/j.ipha.2023.10.013","url":null,"abstract":"<div><h3>Objective</h3><p>To generate a prognostic model prognosis based on anoikis-related genes (ANRGs) expression for Lung adenocarcinoma (LUAD), an exploration of the prognostic value of ANRGs in LUAD was conducted.</p></div><div><h3>Methods</h3><p>Based on the expression matrix of genes from the TCGA database, we built the co-expressed modules by weighted gene co-expression network analysis (WGCNA). Then we identified the differentially expressed ANRGs (DE-ANGs) between LUAD and normal samples by the WGCNA results, DEGs, and the 345 ANRGs. The biofunction of the DE-ANRGs was interpreted using the GO and KEGG databases. Univariate and multivariate regression models were used to verify whether the risk model could serve as an independent prognostic factor. A nomogram was utilized to predict overall survival (OS) in LUAD.</p></div><div><h3>Results</h3><p>The expression of 56 DE-ANRGs was significantly different in tumor tissues. We established a 4-ANRG prognostic signature. In the TCGA cohort and the external GSE31210 validation cohort, the OS of the high-risk group was lower than that of the low-risk group significantly. Moreover, the prediction performance of the risk model was excellently verified by the ROC curve. In addition, both univariate COX and multivariate Cox analyses indicated that risk score could act as an independent prognostic factor for LUAD patients. The calibration curve and C-index demonstrated that the nomogram was satisfactory in predicting 1, 3- and 5-year survival in LUAD patients.</p></div><div><h3>Conclusions</h3><p>Our study developed a novel prognostic signature of 4 ANRGs with Excellent prognostic performance for LUAD patients.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23001041/pdfft?md5=08896887bc49246baf2a9a59fe184e8c&pid=1-s2.0-S2949866X23001041-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}