Intelligent Pharmacy最新文献_第9页

Cardioprotective potential of Rosuvastatin against isoproterenol induced cardiac dysfunction and hypertrophy in the experimental model of rodents 在啮齿动物实验模型中，瑞舒伐他汀对异丙肾上腺素诱发的心功能障碍和心肌肥厚具有保护作用

Intelligent Pharmacy Pub Date : 2024-10-01 Epub Date: 2023-09-14 DOI: 10.1016/j.ipha.2023.09.002

{"title":"Cardioprotective potential of Rosuvastatin against isoproterenol induced cardiac dysfunction and hypertrophy in the experimental model of rodents","authors":"","doi":"10.1016/j.ipha.2023.09.002","DOIUrl":"10.1016/j.ipha.2023.09.002","url":null,"abstract":"<div><h3>Aims</h3><div>Cardiovascular disease is the primary cause of mortality and morbidity, and its terminal phase is chronic heart failure. The present study aimed to examine the protective impact of rosuvastatin on isoproterenol-induced chronic heart failure and investigate plausible related mechanisms. Rosuvastatin, a drug with multiple pleiotropic properties, has been examined for its cardioprotective effects in heart failure induced by isoproterenol.</div></div><div><h3>Methods</h3><div>Male Sprague Dawley rats were given isoproterenol 5 mg/kg once a day for 7 days to establish heart failure by subcutaneous injection. Simultaneously, rosuvastatin (10 mg/kg) was orally administrated from day 1 to day 14. Protective effects were evaluated by heart grading and gross morphology, hemodynamic parameter, cardiac troponin I, heart mitochondrial enzyme and lysosomal hydrolases and pro inflammatory cytokines levels were analyzed.</div></div><div><h3>Results</h3><div>Rosuvastatin (10 mg/kg) significantly attenuated isoproterenol-induced hypertrophy, remodeling and dysfunction of the ventricle, reduced the heart mitochondrial enzyme and lysosomal hydrolases and normalized the increased hemodynamic and pro inflammatory cytokines levels.</div></div><div><h3>Conclusions</h3><div>The study highlights the preventive effects of, rosuvastatin, against heart failure. The results of the research indicate that rosuvastatin has cardioprotective effects on the experimental model, which were supported by several characteristics. However, further research is required to identify the precise molecular mechanisms and signalling pathways of rosuvastatin's impact on heart failure.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 651-661"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Removal notice to “Ziziphus mauritiana: An in-depth review of its medicinal attributes and pharmacological activities” [Intell. Pharm. 2 (2024) 274–283] 删除 "Ziziphus mauritiana：关于其药用特性和药理活性的深入研究" [Intell.

Intelligent Pharmacy Pub Date : 2024-10-01 Epub Date: 2024-10-30 DOI: 10.1016/j.ipha.2024.07.005

Deepak Jha , Pallavi Hangargekar , Md Akbar , Ashish Singh Parihar , Saurabh Kashyap , Amol Joshi , Md Azizur Rahman

引用次数: 0

Sea buckthorn: A potential dietary supplement with multifaceted therapeutic activities 沙棘：具有多方面治疗作用的潜在膳食补充剂

Intelligent Pharmacy Pub Date : 2024-10-01 Epub Date: 2023-12-22 DOI: 10.1016/j.ipha.2023.12.003

{"title":"Sea buckthorn: A potential dietary supplement with multifaceted therapeutic activities","authors":"","doi":"10.1016/j.ipha.2023.12.003","DOIUrl":"10.1016/j.ipha.2023.12.003","url":null,"abstract":"<div><div>Sea buckthorn (<em>Hippophae rhamnoides</em> L.) is a plant with various nutritional and medicinal properties. It contains vitamins, carotenoids, polyphenols, fatty acids, and phytosterols, which have antioxidant, anticancer, anti-hyperlipidemic, anti-obesity, anti-inflammatory, antimicrobial, antiviral, dermatological, neuroprotective, and hepatoprotective effects. Sea buckthorn can be used as a functional food or a dietary supplement for the prevention and treatment of chronic diseases. This review summarizes the phytochemistry, health benefits, and food applications of sea buckthorn, and highlights the potential and challenges for its further development and utilization. Sea buckthorn not only has greatmedicinal and therapeutic potential, but also is a promising economic plant. The potential of seabuckthorn in the human food industry has attracted the research interest of researchers and pro- ducers. The present review mainly summarizes the phytochemistry, nutrients, health benefits, andfood applications of sea buckthorn. Overall, sea buckthorn is a dietary source of bioactive ingredi- ents with the potential to be developed into functional foods or dietary supplements for the pre- vention and treatment of certain chronic diseases, which deserves further research.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 681-687"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI's role in revolutionizing personalized medicine by reshaping pharmacogenomics and drug therapy 通过重塑药物基因组学和药物疗法，人工智能在个性化医疗变革中的作用

Intelligent Pharmacy Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1016/j.ipha.2024.08.005

Hamed Taherdoost , Alireza Ghofrani

引用次数: 0

A systematic review on the effectiveness of Zingiber officinale in reducing dental caries 关于辣根在减少龋齿方面功效的系统综述

Intelligent Pharmacy Pub Date : 2024-10-01 Epub Date: 2024-08-05 DOI: 10.1016/j.ipha.2024.08.001

Raghu Dhanapal , Subramani Parasuraman , Mohammed Zahedul Islam Nizami , Galvin Sim Siang Lin , Jogikalmat Krithikadatta

{"title":"A systematic review on the effectiveness of Zingiber officinale in reducing dental caries","authors":"Raghu Dhanapal , Subramani Parasuraman , Mohammed Zahedul Islam Nizami , Galvin Sim Siang Lin , Jogikalmat Krithikadatta","doi":"10.1016/j.ipha.2024.08.001","DOIUrl":"10.1016/j.ipha.2024.08.001","url":null,"abstract":"<div><div>According to the Global Burden of Disease Study and the World Health Organization, dental caries is one of the most prevalent oral diseases globally. It is well known that dental caries are associated with cariogenic bacteria and their biofilm. Many preventive strategies and therapeutic compounds have been proposed for decades. Among them, various plant-based phytochemical compounds have been investigated against cariogenic bacteria. In this review, we plan to show the effectiveness of <em>Zingiber officinale</em> to reduce dental caries. <em>Z. officinale</em> in ginger is a bioactive spice compound that shows antimicrobial activity. Therefore, it is reasonable to consider the antimicrobials and biofilm inhibition properties of bioactive <em>Z. officinale</em> to rationalize its potential in reducing dental caries. While the literature highlights the general antimicrobial properties of <em>Z. officinale</em>, this review focuses on <em>Z. officinale</em>’s capability against cariogenic microbes and their biofilms. Reported results of minimum inhibition concentration (MIC), minimum bactericidal concentration (MBC), and biofilm inhibition (glucans and adhesion) were systematically reviewed. Common search engines like PubMed, Science Direct, and the Web of Science database are used to retrieve data using the keywords “<em>Zingiber officinale” and</em> “dental caries”. Out of 122 resulting reports, 11 of them were included in this review. It can be concluded that <em>Z. officinale</em> effect against cariogenic bacteria varies depending on microbial and analytical factors. However, translational advanced studies have not yet been conducted to verify its clinical application.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 638-642"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive evaluation of PD-1 inhibitors marketed in China based on a Quick Guideline for drug evaluation and selection in Chinese Medical Institutions (second edition) 基于《中国医疗机构药物评价与遴选快速指南》（第二版）对在中国上市的PD-1抑制剂进行综合评价

Intelligent Pharmacy Pub Date : 2024-10-01 Epub Date: 2024-08-05 DOI: 10.1016/j.ipha.2024.07.006

Long Min , Zhao Yulan , Li Wenrui , Shi Weilin , Chen Wanyi

{"title":"Comprehensive evaluation of PD-1 inhibitors marketed in China based on a Quick Guideline for drug evaluation and selection in Chinese Medical Institutions (second edition)","authors":"Long Min , Zhao Yulan , Li Wenrui , Shi Weilin , Chen Wanyi","doi":"10.1016/j.ipha.2024.07.006","DOIUrl":"10.1016/j.ipha.2024.07.006","url":null,"abstract":"<div><h3>Objective</h3><div>To conduct a comprehensive evaluation of PD-1 inhibitors for the treatment of advanced non-small cell lung cancer on the market in China, using <em>A Quick Guideline for Drug Evaluation and Selection in Chinese Medical Institutions (Second Edition)</em>, and to provide a reference for the selection of and decision-making on clinical drugs in hospitals.</div></div><div><h3>Method</h3><div>The Sanzhi drug evaluation and selection system was used to evaluate the PD-1 inhibitors for the treatment of advanced non-small cell lung cancer on the market in China, according to five characteristics: pharmaceutical characteristics, efficiency, safety, economy, and others.</div></div><div><h3>Results</h3><div>Based on the above evaluation criteria, the scores of all PD-1 inhibitors were above 61 points. The main difference among the five characteristics were efficiency and economy. The difference between the other characteristics was relatively small. Sintilimab injection had the highest score due to the advantages among characteristics except the other attributes. Nivolumab injection (100 mg/10 mL (10 mg/mL)) had the lowest total score due to its low effectiveness and economy scores.</div></div><div><h3>Conclusion</h3><div>PD-1 inhibitors are effective therapeutic drugs for immunotherapy in patients with advanced non-small cell lung cancer. Different PD-1 inhibitors have different advantages in clinical treatment. The comprehensive evaluation of PD-1 inhibitors for the treatment of advanced non-small cell lung cancer on the market in China through <em>A Quick Guide for Drug Evaluation and Selection of Chinese Medical Institutions (Second Edition)</em> can provide a basis for drug selection and scientific, reasonable, and safe drug use in medical institutions.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 630-637"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence in anti-dengue drug development 人工智能在抗登革热药物开发中的应用

Intelligent Pharmacy Pub Date : 2024-10-01 Epub Date: 2024-02-01 DOI: 10.1016/j.ipha.2024.01.006

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A comprehensive review on the chemical composition and pharmacological activities of ACACIA ARABICA 阿拉伯金合欢化学成分和药理活性综述

Intelligent Pharmacy Pub Date : 2024-10-01 Epub Date: 2024-01-28 DOI: 10.1016/j.ipha.2024.01.008

引用次数: 0

Mimusops elengi: A comprehensive review Mimusops elengi 的药理、植物化学和治疗功效

Intelligent Pharmacy Pub Date : 2024-10-01 Epub Date: 2023-11-24 DOI: 10.1016/j.ipha.2023.11.007

{"title":"Mimusops elengi: A comprehensive review","authors":"","doi":"10.1016/j.ipha.2023.11.007","DOIUrl":"10.1016/j.ipha.2023.11.007","url":null,"abstract":"<div><div><em>Mimusops elengi</em>, a widely distributed tree species in tropical regions, has been used for centuries in traditional medicine due to its numerous therapeutic properties. In this study, we conducted a comprehensive analysis of the phytocompounds present in various parts of <em>Mimusops elengi</em>, including leaves, bark, and flowers using advanced analytical techniques. The objective was to identify and quantify the bioactive compounds responsible for the plant's medicinal attributes. Our findings revealed a diverse range of phytochemicals in <em>Mimusops elengi</em>. The analysis detected various classes of compounds, including alkaloids, flavonoids, tannins, phenolic compounds, terpenoids and glycosides. Notably, the leaves contained a significant concentration of alkaloids, particularly elengioside, which has demonstrated potential anti-inflammatory and analgesic properties. Additionally, the flowers were rich in flavonoids and tannins, such as quercetin and catechin, known for their antioxidant and anti-cancer activities. Furthermore, the bark of <em>Mimusops elengi</em> exhibited the presence of terpenoids, including lupeol and betulinic acid, which have been associated with anti-inflammatory and antiviral properties. These compounds may contribute to the plant's traditional use for treating various ailments, including skin disorders and respiratory issues. This review provides valuable insights into the phytochemical composition <em>of Mimusops elengi,</em> shedding light on its potential therapeutic applications. <em>Mimusops elengi</em> holds promise as a valuable source of natural compounds with health-promoting benefits.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 672-680"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational transformation in drug discovery: A comprehensive study on molecular docking and quantitative structure activity relationship (QSAR) 药物发现中的计算转换：分子对接和定量结构活性关系 (QSAR) 综合研究

Intelligent Pharmacy Pub Date : 2024-10-01 Epub Date: 2024-03-09 DOI: 10.1016/j.ipha.2024.03.001

{"title":"Computational transformation in drug discovery: A comprehensive study on molecular docking and quantitative structure activity relationship (QSAR)","authors":"","doi":"10.1016/j.ipha.2024.03.001","DOIUrl":"10.1016/j.ipha.2024.03.001","url":null,"abstract":"<div><div>The procedure for learning and creating a new medicine is widely seen as a drawn-out and costly endeavor. Different rational strategies are considered, depending on their requirements, as potential ways; nevertheless, techniques to designing drugs based on structure and ligands are well acknowledged as very practical and potent tactics in drug discovery. Computational approaches help decrease the need for Medicinal research with animals, helping to develop fresh, safe therapeutic concepts via rational design and positioning of existing products and supporting pharmaceutical scientists and medicinal chemists during the medication development process. Computer-aided drug discovery (CADD) methods are useful for reducing the time and cost of drug discovery and development and understanding the molecular mechanisms of drug action and toxicity. Molecular docking is a technique that predicts a ligand's binding mode and affinity to a target protein. At the same time, QSAR is a technique that establishes mathematical relationships between the structural features and biological activities of a series of compounds. This study reviews the current state and applications of CADD methods, focusing on molecular docking and quantitative structure–activity relationship (QSAR) techniques. This study reviews the principles, advantages, limitations, and challenges of these methods, as well as some recent advances and examples of their applications in drug discovery for various diseases. The study also discusses the future prospects and directions of CADD methods in the era of big data and artificial intelligence.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 589-595"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0