Infectious Medicine最新文献

{"title":"Rapid adaptive substitution of L226Q in HA protein increases the pathogenicity of H9N2 viruses in mice","authors":"Min Tan, Ye Zhang, H. Bo, Xi-yan Li, Shu-mei Zou, Lei Yang, Jia Liu, Qi Chen, Xiaohao Xu, Wenfei Zhu, Dayan Wang","doi":"10.1016/j.imj.2024.100090","DOIUrl":"https://doi.org/10.1016/j.imj.2024.100090","url":null,"abstract":"","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"38 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139819573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary nasopharyngeal carcinoma with cerebrospinal fluid EBV positivity: a case report and mini literature review","authors":"Jinli Feng, Shuang Wang, Hongli Zhang, Jun Zhao, Xuling Wang","doi":"10.1016/j.imj.2024.100089","DOIUrl":"https://doi.org/10.1016/j.imj.2024.100089","url":null,"abstract":"","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139887741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viremia and clinical manifestations in acute febrile patients of Chikungunya infection during the 2016 CHIKV outbreak in Delhi, India","authors":"R. Sagar, Siva Raghavendhar, Vineet Jain, Naushad Khan, A. Chandele, Ashok Kumar Patel, M. Kaja, Pratima Ray, Neera Kapoor","doi":"10.1016/j.imj.2024.100088","DOIUrl":"https://doi.org/10.1016/j.imj.2024.100088","url":null,"abstract":"","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"246 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139828928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A major pain in the hip - Destruction of the left acetabulum and femoral head secondary to Tuberculosis: A case report and review of the literature","authors":"Dominic A. Haigh ,&nbsp;Dillan Mistry ,&nbsp;Hamzah Z. Farooq ,&nbsp;Katherine M.B. Ajdukiewicz","doi":"10.1016/j.imj.2023.12.001","DOIUrl":"10.1016/j.imj.2023.12.001","url":null,"abstract":"<div><p>A 68-year-old-gentleman presented with left hip pain, night sweats, fatigue, and weight loss. He had previously experienced pain with white discharge until he underwent an arthroscopic washout and reduction. The left lower limb was shortened and wasted with limited hip movements. He had recently travelled to Zambia, his country of origin. Imaging demonstrated a large mass with chronic erosions of the acetabulum and femoral head. Synovial biopsy grew <em>Mycobacterium tuberculosis</em>, which was treated with rifampicin, isoniazid, pyrazinamide, and ethambutol for 2 months then 4 months of rifampicin and isoniazid. Whole genome sequencing indicated full sensitivity. Complex reconstructive surgery is scheduled, with a custom femoral head and acetabulum. This case illustrates the importance of considering tuberculosis in patients with erosive joint pathology and a multidisciplinary approach as delayed diagnosis results in high morbidity. Prompt diagnosis using newer modalities such as whole genome sequencing on synovial fluid can enable timely treatment.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X23000709/pdfft?md5=6444f2f536ae594732452f47b7d685b1&pid=1-s2.0-S2772431X23000709-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139025600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular evolution, virology and spatial distribution of HCV genotypes in Pakistan: A meta-analysis","authors":"Arslan Habib ,&nbsp;Nadiya Habib ,&nbsp;Khalid Mahmood Anjum ,&nbsp;Riffat Iqbal ,&nbsp;Zeeshan Ashraf ,&nbsp;Muhammad Usman Taj ,&nbsp;Muhammad Asim ,&nbsp;Kanwal Javid ,&nbsp;Faezeh Idoon ,&nbsp;Saeid Dashti ,&nbsp;Cassio Rocha Medeiros ,&nbsp;Ana Pavla Almeida Diniz Gurgel ,&nbsp;Henrique Douglas Melo Coutinho","doi":"10.1016/j.imj.2023.11.007","DOIUrl":"https://doi.org/10.1016/j.imj.2023.11.007","url":null,"abstract":"<div><h3>Background</h3><p>Hepatitis C, caused by the Hepatitis C Virus (HCV), is the second most common form of viral hepatitis. The geographical distribution of HCV genotypes can be quite complex, making it challenging to ascertain the most prevalent genotype in a specific area.</p></div><div><h3>Methods</h3><p>To address this, a review was conducted to determine the prevalence of HCV genotypes across various provinces and as a whole in Pakistan. The scientific literature regarding the prevalence, distribution, genotyping, and epidemiology of HCV was gathered from published articles spanning the years 1996–2020.</p></div><div><h3>Results</h3><p>Genotype 1 accounted for 5.1% of the patients, with its predominant subtype being 1a at 4.38%. The frequencies of its other subtypes, 1b and 1c, were observed to be 1.0% and 0.31% respectively. Genotype 2 had a frequency of 2.66%, with the most widely distributed subtype being 2a at 2.11% of the patients. Its other subtypes, 2b and 2c, had frequencies of 0.17% and 0.36% respectively. The most prevalent genotype among all isolates was 3 (65.35%), with the most frequent subtype being 3a (55.15%), followed by 3b (7.18%). The prevalence of genotypes 4, 5, and 6 were scarce in Pakistan, with frequencies of 0.97%, 0.08%, and 0.32% respectively. The prevalence of untypeable and mixed genotypes was 21.34% and 3.53% respectively. Estimating genotypes proves to be a productive method in assisting with the duration and selection of antiviral treatment. Different HCV genotypes can exhibit variations in their response to specific antiviral treatments. Different genotypes may have distinct natural histories, including variations in disease progression and severity. Some genotypes may lead to more rapid liver damage, while others progress more slowly.</p></div><div><h3>Conclusions</h3><p>This information can guide screening and testing strategies, helping to identify individuals at higher risk of developing severe complications. Studying the distribution of HCV genotypes in a population can provide valuable insights into the transmission dynamics of the virus.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"2 4","pages":"Pages 324-333"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X2300062X/pdfft?md5=57a8370dce8f385f0f8f4acbc58eb8e7&pid=1-s2.0-S2772431X2300062X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138739238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Nocardia beijingensis infection in a patient with postoperative abscess and misuse of antibiotics in China","authors":"Lihua Qi ,&nbsp;Weihong Fan ,&nbsp;Jing Li ,&nbsp;Hongfei Cui ,&nbsp;Jianxia Xu ,&nbsp;Dongmei Gu ,&nbsp;Jiaojiao Meng ,&nbsp;Jie Liu","doi":"10.1016/j.imj.2023.11.002","DOIUrl":"10.1016/j.imj.2023.11.002","url":null,"abstract":"<div><p>Here we describe the first case of abscess infection caused by <em>Nocardia beijingensis</em> in China. The patient was immunocompetent but suffered from postoperative abscess for 6 years. This study highlights the necessity of long-term infected foci to be thoroughly examined to identify the pathogen, as well as the importance of accurate <em>Nocardia</em> identification and antimicrobial susceptibility tests for understanding the pathogen's epidemiology, clinical significance, and treatment strategy.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"2 4","pages":"Pages 343-348"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X23000576/pdfft?md5=ee13cccdedfd564cc3be09b140f6ecbd&pid=1-s2.0-S2772431X23000576-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135614319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SUPER Score Contributes to Warning and Management in Early-Stage COVID-19","authors":"Yuan Bian ,&nbsp;Qi Han ,&nbsp;Yue Zheng ,&nbsp;Yu Yao ,&nbsp;Xinhui Fan ,&nbsp;Ruijuan Lv ,&nbsp;Jiaojiao Pang ,&nbsp;Feng Xu ,&nbsp;Yuguo Chen","doi":"10.1016/j.imj.2023.09.003","DOIUrl":"10.1016/j.imj.2023.09.003","url":null,"abstract":"<div><h3>Background</h3><p>Some COVID-19 patients deteriorate to severe cases with relatively higher case-fatality rates, which increases the medical burden. This necessitates identification of patients at risk of severe disease. Early assessment plays a crucial role in identifying patients at risk of severe disease. This study is to assess the effectiveness of SUPER score as a predictor of severe COVID-19 cases.</p></div><div><h3>Methods</h3><p>We consecutively enrolled COVID-19 patients admitted to a comprehensive medical center in Wuhan, China, and recorded clinical characteristics and laboratory indexes. The SUPER score was calculated using parameters including oxygen saturation, urine volume, pulse, emotional state, and respiratory rate. In addition, the area under the receiver operating characteristic curve (AUC), specificity, and sensitivity of the SUPER score for the diagnosis of severe COVID-19 were calculated and compared with the National Early Warning Score 2 (NEWS2).</p></div><div><h3>Results</h3><p>The SUPER score at admission, with a threshold of 4, exhibited good predictive performance for early identification of severe COVID-19 cases, yielding an AUC of 0.985 (95% confidence interval [CI] 0.897–1.000), sensitivity of 1.00 (95% CI 0.715–1.000), and specificity of 0.92 (95% CI 0.775–0.982), similar to NEWS2 (AUC 0.984; 95% CI 0.895–1.000, sensitivity 0.91; 95% CI 0.587–0.998, specificity 0.97; 95% CI 0.858–0.999). Compared with patients with a SUPER score&lt;4, patients in the high-risk group exhibited lower lymphocyte counts, interleukin-2, interleukin-4 and higher fibrinogen, C-reactive protein, aspartate aminotransferase, and lactate dehydrogenase levels.</p></div><div><h3>Conclusions</h3><p>In conclusion, the SUPER score demonstrated equivalent accuracy to the NEWS2 score in predicting severe COVID-19. Its application in prognostic assessment therefore offers an effective early warning system for critical management and facilitating efficient allocation of health resources.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"2 4","pages":"Pages 308-314"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X23000540/pdfft?md5=f8f981ef0eb3e49bfab32ba43008cd11&pid=1-s2.0-S2772431X23000540-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135922285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The presence of foci of Rickettsia conorii infection in China","authors":"Nannan Xu ,&nbsp;Hui Liu ,&nbsp;Chunmei Qu ,&nbsp;Sai Wen ,&nbsp;Wenlu Zou ,&nbsp;Caiyun Chang ,&nbsp;Gang Wang","doi":"10.1016/j.imj.2023.09.002","DOIUrl":"10.1016/j.imj.2023.09.002","url":null,"abstract":"<div><p>China is not considered as an endemic area of <em>Rickettsia conorii</em>, so there is no routine clinical way to diagnose this infection. This study aims to determine whether 2 febrile patients who had a tick bite in East China were indeed infected with <em>R. conorii.</em> The citrate synthase gene (<em>gltA</em>) was amplified with universal rickettsial primers by real-time fluorescent PCR from the patients’ blood samples. Nested PCR was used to amplify the outer membrane protein A gene (<em>ompA</em>) for positive specimens. PCR products were further identified and analyzed through nucleic acid sequencing. Positive amplification of the <em>gltA</em> and <em>ompA</em> genes was found in both patients. The nucleotide sequences (303 bp) of the <em>ompA</em> gene of the 2 patients had high homology (99%) with the <em>R. conorii</em> Indian tick typhus strain in GenBank. A more than 4-fold increase in IgG against <em>R. conorii</em> provided supportive evidence of SFG Rickettsia infection. And the rapid recovery after doxycycline treatment also supported a rickettsial cause for the disease. Physicians in East China should be aware of human infections with <em>R. conorii.</em> PCR-based diagnostic methods offer a rapid and precise way to diagnose rickettsiosis, improving patient identification and management.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"2 4","pages":"Pages 334-337"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X2300045X/pdfft?md5=9f6384bf1674c07115256aad5bee51f4&pid=1-s2.0-S2772431X2300045X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135348592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of SARS-CoV-2 variants and vaccines: Viral properties, mutations, vaccine efficacy, and safety","authors":"Md. Aminul Islam","doi":"10.1016/j.imj.2023.08.005","DOIUrl":"10.1016/j.imj.2023.08.005","url":null,"abstract":"<div><p>The severe acute respiratory syndrome coronavirus disease 2 instigated by coronavirus disease of 2019 (COVID-19) has delivered an unfathomable obstruction that has touched all sectors worldwide. Despite new vaccine technologies and mass administration of booster doses, the virus persists, and unknown the ending of the pandemic for new variants and sub-variants. Moreover, whether leaning on home medications or using plant extracts is sufficient often to combat the virus has generated tremendous interest in the scientific fraternity. Different databases including PubMed, Scopus, Web of Science, and Google Scholar used to find published articles linked with related topics. Currently, COVID-19 third and fourth shots of vaccines are progressively administered worldwide, where some countries trail others by a significant margin. Many proteins related to viral activity have changed, possibly boosting the virus infectivity and making antibodies ineffective. This study will reminisce the viral genome, associated pathways for viral protein functions, variants, and their mutations. The current, comprehensive review will also provide information on vaccine technologies developed by several biotech companies and the efficacy of their doses, costs including boosters on a mass level. As no vaccine is working to protect fully against all the variants, the new proactive vaccine research needs to be conducted based on all variants, their sub-lineage, and mutations.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"2 4","pages":"Pages 247-261"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X23000448/pdfft?md5=37b73576b07e4da7572a883b7b19b2d4&pid=1-s2.0-S2772431X23000448-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135890163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox virus (MPXV): A Brief account of global spread, epidemiology, virology, clinical features, pathogenesis, and therapeutic interventions","authors":"Md Aminul Islam ,&nbsp;Jubayer Mumin ,&nbsp;Md Masudul Haque ,&nbsp;Md. Azizul Haque ,&nbsp;Ahrar Khan ,&nbsp;Prosun Bhattacharya ,&nbsp;Md Atiqul Haque","doi":"10.1016/j.imj.2023.11.001","DOIUrl":"10.1016/j.imj.2023.11.001","url":null,"abstract":"<div><p>The largest monkeypox virus (MPXV) outbreak of the 21st century occurred in 2022, which caused epidemics in many countries. According to WHO, physical contact with infected persons, contaminated surfaces, or affected animals might be a source of this virus transmission. A febrile sickness including few symptoms found in MPX disease. Skin rash, lesions, fever, headache, fatigue, and muscle aches symptoms were observed commonly for this disease. Animal and in vitro, studies have shown that the antiviral medications cidofovir and brincidofovir are effective against MPXV. The first-generation vaccinia virus vaccine was developed in 1960, and it helped to protect against MPXV with its side effects. A second-generation vaccination with limitations was launched in 2000. However, the CDC advised vaccinations for risk groups in endemic countries, including positive patients and hospital employees. The JYNNEOS vaccine, administered in 2 doses, also provides protection from MPX. This article presents concisely the most recent findings regarding epidemiology, genomic transmission, signs and symptoms, pathogenesis, diagnosis, and therapeutic interventions for MPXV, which may be helpful to researchers and practitioners. WHO declared that MPX was no longer a global health emergency due to its declining case rate, and a number of countries have reported new incidences. Further research-based investigations must be carried out based on the 2022 outbreak.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"2 4","pages":"Pages 262-272"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X23000564/pdfft?md5=dc2676d1c5c5c0f25465494fea43ec10&pid=1-s2.0-S2772431X23000564-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135455092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}