Infectious Medicine最新文献

{"title":"Detection and genetic identification of Borrelia lusitaniae in questing Ixodes inopiatus tick from Tunisia","authors":"Rachid Selmi ,&nbsp;Khaoula Abdi ,&nbsp;Hanène Belkahia ,&nbsp;Meriem Ben Abdallah ,&nbsp;Aymen Mamlouk ,&nbsp;Myriam Kratou ,&nbsp;Mourad Ben Said ,&nbsp;Lilia Messadi","doi":"10.1016/j.imj.2024.100093","DOIUrl":"https://doi.org/10.1016/j.imj.2024.100093","url":null,"abstract":"<div><h3>Background</h3><p>Until now, there has been limited information on the prevalence and the phylogeny of <em>Borrelia burgdorferi</em> sensu lato in <em>Ixodes</em> ticks in Tunisia, particularly in <em>Ixodes inopinatus</em>.</p></div><div><h3>Methods</h3><p>The present study aimed to determine the prevalence and the phylogeny of <em>B. burgdorferi</em> s.l., in coexisted <em>I. ricinus</em> and <em>I. inopinatus</em> ticks collected from Northern Tunisia. One hundred questig ticks were collected during winter 2020 by tick-dragging method in Beja gouvernorate located in the north of Tunisia. Real-time PCR panel targeting <em>B. burgdorferi</em> s.l. 23S rRNA gene were performed. Positive DNA samples were subjected to conventional PCRs targeting 457 bp fragment of the <em>Borrelia</em> sp. flagellin (<em>fla</em>) gene using primers FlaF/FlaR. The identified <em>Borrelia</em> sp. isolate underwent partial sequence analysis to determine genospecies and evaluate their phylogenetic position.</p></div><div><h3>Results</h3><p>The study revealed a prevalence rate of 28% (28/100) for <em>B. burgdorferi</em> sensu lato in the <em>Ixodes</em> ticks. The prevalence rates across tick species and genders did not show significant variations (<em>p</em> &gt; 0.05). Interestingly, the study underlines the coexistence of <em>I. inopinatus</em> and <em>I. ricinus</em> sharing the same geographic areas in Northern Tunisia. Furthermore, DNA of <em>B. lusitaniae</em> was detected in <em>I. inopinatus</em> ticks for the first time in Tunisia. Revealed <em>B. lusitaniae</em> bacterium is similar to previously identified strains in Mediterranean region, but distinct from those isolated exclusively from countries of Eastern and Central Europe, such as Serbia, Romania, and Poland. This study highlights the prevalence of <em>B. burgdorferi</em> s.l. in <em>I. ricinus</em>/<em>I. inopinatus</em> ticks, and reveals <em>B. lusitaniae</em> in <em>I. inopinatus</em> ticks for the first time in Tunisia.</p></div><div><h3>Conclusion</h3><p>These findings suggest the involvement of <em>I. inopinatus</em> as a potential vector of this pathogenic genospeciess in Tunisia. This may help understanding the ecology of <em>Ixodes</em> ticks, the natural infection and the transmission dynamics of <em>Borrelia</em> species in this country.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100093"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000078/pdfft?md5=06d39c71ab063374656042c0958c561c&pid=1-s2.0-S2772431X24000078-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140052411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Infectious Medicine is becoming a globally high-level scientific journal","authors":"Xue-Jie Yu","doi":"10.1016/j.imj.2024.100091","DOIUrl":"10.1016/j.imj.2024.100091","url":null,"abstract":"","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100091"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000054/pdfft?md5=b527359b8a0393f23cdbe396e4b10bfb&pid=1-s2.0-S2772431X24000054-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139965834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of new generation biosorbents for the sustainable treatment of antibiotic residues and antibiotic resistance genes from polluted waste effluent","authors":"Barkha Madhogaria ,&nbsp;Sangeeta Banerjee ,&nbsp;Atreyee Kundu ,&nbsp;Prasanta Dhak","doi":"10.1016/j.imj.2024.100092","DOIUrl":"https://doi.org/10.1016/j.imj.2024.100092","url":null,"abstract":"<div><p>Antimicrobials are frequently used in both humans and animals for the treatment of bacterially-generated illnesses. Antibiotic usage has increased for more than 40% from last 15 years globally per day in both human populations and farm animals leading to the large-scale discharge of antibiotic residues into wastewater. Most antibiotics end up in sewer systems, either directly from industry or healthcare systems, or indirectly from humans and animals after being partially metabolized or broken down following consumption. To prevent additional antibiotic compound pollution, which eventually impacts on the spread of antibiotic resistance, it is crucial to remove antibiotic residues from wastewater. Antibiotic accumulation and antibiotic resistance genes cannot be effectively and efficiently eliminated by conventional sewage treatment plants. Because of their high energy requirements and operating costs, many of the available technologies are not feasible. However, the biosorption method, which uses low-cost biomass as the biosorbent, is an alternative technique to potentially address these problems. An extensive literature survey focusing on developments in the field was conducted using English language electronic databases, such as PubMed, Google Scholar, Pubag, Google books, and ResearchGate, to understand the relative value of the available antibiotic removal methods. The predominant techniques for eliminating antibiotic residues from wastewater were categorized and defined by example. The approaches were contrasted, and the benefits and drawbacks were highlighted. Additionally, we included a few antibiotics whose removal from aquatic environments has been the subject of extensive research. Lastly, a few representative publications were identified that provide specific information on the removal rates attained by each technique. This review provides evidence that biosorption of antibiotic residues from biological waste using natural biosorbent materials is an affordable and effective technique for eliminating antibiotic residues from wastewater.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100092"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000066/pdfft?md5=7c83d4e728810427edc392ecb9d71dd1&pid=1-s2.0-S2772431X24000066-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox reinfection: A rapid systematic review of case reports","authors":"Tingting Li ,&nbsp;Zhijin Li ,&nbsp;Yu Xia ,&nbsp;Jiang Long ,&nbsp;Li Qi","doi":"10.1016/j.imj.2024.100096","DOIUrl":"https://doi.org/10.1016/j.imj.2024.100096","url":null,"abstract":"<div><h3>Background</h3><p>Mpox re-emerged worldwide with the multi-country outbreaks that occurred in May 2022, threatening the public health of human beings.</p></div><div><h3>Methods</h3><p>This rapid systematic review summarized mpox reinfection cases documented. Electronic databases (PubMed, MedRxiv, and Social Science Research Network) were searched without time limitation, using the keywords “mpox,” “monkeypox,” &amp; “reinfection,” “reoccur,” “reoccurrence,” “episode,” and “relapse”. All laboratory-confirmed cases of mpox reinfection published in the literature were included in this study.</p></div><div><h3>Results</h3><p>A total of seven publications (nine cases) from Africa, Europe, and South America were included. All mpox reinfection cases were male, with a median age of 36; 88.89% of cases had unprotected sexual behaviors with other males before each illness episode. The average onset interval between the two episodes was about 4 months. Perianal lesions and lymphadenopathy were major symptoms in both episodes, and no differences in clinical severity were reported between the two episodes. The mean duration of the two episodes was approximately 22 days and 13 days, respectively; which the mean duration of the second episode was shorter than the first infection (<em>t</em> = 2.17, <em>p</em> = 0.0487). Sexually transmitted infections were commonly concurrent among most cases, accounting for 55.6% and 77.8% in the two episodes, respectively. Full vaccination against mpox was rare among reinfection cases.</p></div><div><h3>Conclusion</h3><p>A second infection is possible even in a short period. Reinforcing monitoring, reducing high-risk behaviors, and heightening health education regarding mpox for high-risk populations are crucial to limit mpox spread, including persons with a history of mpox infection.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000108/pdfft?md5=0b7a710c6427c707a641b2af0bc92293&pid=1-s2.0-S2772431X24000108-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid adaptive substitution of L226Q in HA protein increases the pathogenicity of H9N2 viruses in mice","authors":"Min Tan ,&nbsp;Ye Zhang ,&nbsp;Hong Bo ,&nbsp;Xiyan Li ,&nbsp;Shumei Zou ,&nbsp;Lei Yang ,&nbsp;Jia Liu ,&nbsp;Qi Chen ,&nbsp;Xiaohao Xu ,&nbsp;Wenfei Zhu ,&nbsp;Dayan Wang","doi":"10.1016/j.imj.2024.100090","DOIUrl":"10.1016/j.imj.2024.100090","url":null,"abstract":"<div><h3>Background</h3><p>Since the first human infection with H9N2 virus was reported in 1998, the number of cases of H9N2 infection has exceeded one hundred by 2021. However, there is no systematic description of the biological characteristics of H9N2 viruses isolated from humans.</p></div><div><h3>Methods</h3><p>Therefore, this study analyzed the pathogenicity in mice of all available H9N2 viruses isolated from human cases in China from 2013 to 2021.</p></div><div><h3>Results</h3><p>Although most of the H9N2 viruses analyzed showed low or no pathogenicity in mice, the leucine to glutamine substitution at residue 226 (L226Q) in the hemagglutinin (HA) protein rapidly emerged during the adaptation of H9N2 viruses, and was responsible for severe infections and even fatalities. HA amino acid 226Q conferred a remarkable competitive advantage on H9N2 viruses in mice relative to viruses containing 226L, increasing their virulence, infectivity, and replication.</p></div><div><h3>Conclusion</h3><p>Thus, our study demonstrates that the adaptive substitution HA L226Q rapidly acquired by H9N2 viruses during the course of infection in mice contributed to their high pathogenicity.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100090"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000042/pdfft?md5=840636298c0b0df5df65b91187530cc7&pid=1-s2.0-S2772431X24000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139879654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viremia and clinical manifestations in acute febrile patients of Chikungunya infection during the 2016 CHIKV outbreak in Delhi, India","authors":"Rohit Sagar ,&nbsp;Siva Raghavendhar ,&nbsp;Vineet Jain ,&nbsp;Naushad Khan ,&nbsp;Anmol Chandele ,&nbsp;Ashok Kumar Patel ,&nbsp;Murali Kaja ,&nbsp;Pratima Ray ,&nbsp;Neera Kapoor","doi":"10.1016/j.imj.2024.100088","DOIUrl":"10.1016/j.imj.2024.100088","url":null,"abstract":"<div><h3>Background</h3><p>Chikungunya virus (CHIKV) is an infectious agent that caused several outbreaks among different countries and affected approximately 1.3 million Indian populations. It is transmitted by <em>Aedes</em> mosquito–either <em>A. albopictus</em> or <em>A. aegypti</em>. Generally, the clinical manifestations of CHIKV infection involve high-grade fever, joint pain, skin rashes, headache, and myalgia. The present study aims to investigate the relationship between the CHIKV virus load and clinical symptoms of the CHIKV infection so that better patient management can be done in the background of the CHIKV outbreak as there is no licensed anti-viral drug and approved vaccines available against CHIKV.</p></div><div><h3>Methods</h3><p>CHIKV RTPCR positive samples (<em>n</em> = 18) (Acute febrile patients having D.O.F ≤ 7 days) were taken for the quantification of CHIKV viremia by Real-Time PCR. Clinical features of the febrile patients were recorded during the collection of blood samples.</p></div><div><h3>Results</h3><p>The log mean virus load of 18 RT-PCR-positive samples was 1.3 × 10⁶ copies/mL (1.21 × 10³–2.33 × 10⁸ copies/mL). Among the observed clinical features, the log mean virus load (CHIKV) of the patients without skin rash is higher than in the patients with skin rash (6.61 vs 5.5, <em>P</em> = 0.0435).</p></div><div><h3>Conclusion</h3><p>The conclusion of the study was that the patients with skin rashes had lower viral load and those without skin rashes had higher viral load.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100088"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000029/pdfft?md5=6d5351739d6973b9ffae4969fcacd1b4&pid=1-s2.0-S2772431X24000029-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139888839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HBsAg kinetics after 7 years of therapy with tenofovir disoproxil fumarate in a cohort of naïve patients affected by chronic hepatitis B with different genotypes","authors":"Lucio Boglione ,&nbsp;Tommaso Lupia ,&nbsp;Giacomo Stroffolini ,&nbsp;Valentina Dodaro ,&nbsp;Giovanni Di Perri","doi":"10.1016/j.imj.2024.100087","DOIUrl":"10.1016/j.imj.2024.100087","url":null,"abstract":"<div><p>The role of different genotypes in nucleos(t)ide analogs (NAs) treatment is still debated. Previous studies conducted on special populations evidenced that the E genotype had the lower virological and serological response. This descriptive study aims to recognize the hepatitis B “s” antigen (HBsAg) decline during tenofovir disoproxil fumarate (TDF) treatment in a cohort of patient affected by chronic hepatitis B (CHB). We retrospectively included all patients with CHB treated with TDF between April 2007 and March 2012 with a duration of treatment of 7 years. Kinetics of HBsAg was determined as serological response in this cohort. We include 110 subjects; virological response was observed in all subjects with genotypes A, B, and D; in 17 patients with C genotype (94.4%) and 24 with E genotype (96%). HBeAg loss was observed in 2 patients with genotype A (50%), 3 with B (100%), 0 with C (0%), 1 with D (20%), and 1 with E genotype (25%). In multivariate analysis we observed as predictive factors of HBsAg decline the baseline level of HBsAg (OR = 1.467; 95%CI: 1.221–5.113; <em>p</em> = 0.017) and viral genotypes (OR = 11.218; 95%CI: 5.441–41.138; <em>p</em> &lt; 0.001). This study confirmed higher HBsAg decline after 7 years of treatment in A and B genotypes, and lower in C, E, and D genotypes. However, no evidence is enough to choose a single NAs, but in special populations, as well as in genotype E, the use of TDF should be preferred to entecavir.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000017/pdfft?md5=9c0e74705261b2b3e144603d1fcee903&pid=1-s2.0-S2772431X24000017-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139685809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary nasopharyngeal carcinoma with cerebrospinal fluid EBV positivity: A case report and mini literature review","authors":"Jinli Feng ,&nbsp;Shuang Wang ,&nbsp;Hongli Zhang,&nbsp;Jun Zhao,&nbsp;Xuling Wang","doi":"10.1016/j.imj.2024.100089","DOIUrl":"10.1016/j.imj.2024.100089","url":null,"abstract":"<div><h3>Background</h3><p>To summarize the diagnosis and treatment of a patient with nasopharyngeal carcinoma and cerebrospinal fluid (CSF) Epstein-Barr virus (EBV) positivity (determined by next-generation sequencing), review the relevant literature, and explore the significance of EBV presence in the CSF of patients with nasopharyngeal carcinoma.</p></div><div><h3>Methods</h3><p>A patient presenting with headache as the initial symptom was diagnosed with nasopharyngeal carcinoma and admitted to the Eighth Medical Center of Chinese PLA General Hospital on March 3, 2021. Available databases were screened for reports on nasopharyngeal carcinoma with EBV-positive CSF and analyzed. The patients’ general information, initial symptoms, treatment, and prognosis were subsequently evaluated.</p></div><div><h3>Results</h3><p>EBV-positive CSF is commonly observed in patients with recurrent nasopharyngeal carcinoma. However, no reports of EBV-positive CSF in patients with primary nasopharyngeal carcinoma have been published to date.</p></div><div><h3>Conclusion</h3><p>The presence of EBV in the CSF of patients with recurrent nasopharyngeal carcinoma is indicative of a poor prognosis. Thus, newly diagnosed nasopharyngeal carcinoma patients should undergo a lumbar puncture as soon as possible to have their CSF tested for EBV. Such a measure would promptly predict the prognosis and facilitate the development of a personalized treatment strategy.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100089"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000030/pdfft?md5=048b6ed6134b8c754b25c42836abb239&pid=1-s2.0-S2772431X24000030-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139827730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing and reintegrating traceability of infectious diseases via metagenomic next-generation sequencing: Study of a severe case of Rickettsia japonica infection","authors":"Zhenhua Lu ,&nbsp;Jing Han ,&nbsp;Yuanyuan Wang ,&nbsp;Zhen He ,&nbsp;Shuxuan Song ,&nbsp;Kun Liu ,&nbsp;Zhongjun Shao","doi":"10.1016/j.imj.2024.100094","DOIUrl":"https://doi.org/10.1016/j.imj.2024.100094","url":null,"abstract":"<div><h3>Background</h3><p>In this study, we present a case of Japanese spotted fever (JSF) caused by <em>Rickettsia japonica</em> and use this case to investigate the process of diagnosing and reintegrating traceability of infectious diseases via metagenomic next-generation sequencing (mNGS).</p></div><div><h3>Methods</h3><p>From data relating to epidemiological history, clinical and laboratory examinations, and mNGS sequencing, a diagnosis of severe JSF was concluded.</p></div><div><h3>Results</h3><p>A detailed field epidemiological investigation discovered parasitic <em>Haemaphysalis longicornis</em> from a host animal (dog) in the domicile of the patient, within which <em>R. japonica</em> was detected, along with a diverse array of other potentially pathogenic microorganisms that could cause other infectious diseases.</p></div><div><h3>Conclusion</h3><p>The mNGS provided an efficient method to diagnose JSF infection. This methodology could also be applied to field epidemiological investigations to establish the traceability of infectious diseases.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X2400008X/pdfft?md5=e620a7ac3519227211f93076ee936eb7&pid=1-s2.0-S2772431X2400008X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140000367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative applications of artificial intelligence during the COVID-19 pandemic","authors":"Chenrui Lv ,&nbsp;Wenqiang Guo ,&nbsp;Xinyi Yin ,&nbsp;Liu Liu ,&nbsp;Xinlei Huang ,&nbsp;Shimin Li ,&nbsp;Li Zhang","doi":"10.1016/j.imj.2024.100095","DOIUrl":"https://doi.org/10.1016/j.imj.2024.100095","url":null,"abstract":"<div><p>The COVID-19 pandemic has created unprecedented challenges worldwide. Artificial intelligence (AI) technologies hold tremendous potential for tackling key aspects of pandemic management and response. In the present review, we discuss the tremendous possibilities of AI technology in addressing the global challenges posed by the COVID-19 pandemic. First, we outline the multiple impacts of the current pandemic on public health, the economy, and society. Next, we focus on the innovative applications of advanced AI technologies in key areas such as COVID-19 prediction, detection, control, and drug discovery for treatment. Specifically, AI-based predictive analytics models can use clinical, epidemiological, and omics data to forecast disease spread and patient outcomes. Additionally, deep neural networks enable rapid diagnosis through medical imaging. Intelligent systems can support risk assessment, decision-making, and social sensing, thereby improving epidemic control and public health policies. Furthermore, high-throughput virtual screening enables AI to accelerate the identification of therapeutic drug candidates and opportunities for drug repurposing. Finally, we discuss future research directions for AI technology in combating COVID-19, emphasizing the importance of interdisciplinary collaboration. Though promising, barriers related to model generalization, data quality, infrastructure readiness, and ethical risks must be addressed to fully translate these innovations into real-world impacts. Multidisciplinary collaboration engaging diverse expertise and stakeholders is imperative for developing robust, responsible, and human-centered AI solutions against COVID-19 and future public health emergencies.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000091/pdfft?md5=e5f18de374c9cba5d1d5fb5a13429695&pid=1-s2.0-S2772431X24000091-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}