Infectious Medicine最新文献

{"title":"Establishment and application of a rapid visualization method for detecting Vibrio parahaemolyticus nucleic acid","authors":"Yachao Hou ,&nbsp;Xinping Liu ,&nbsp;Ya'nan Wang ,&nbsp;Liang Guo ,&nbsp;Lvying Wu ,&nbsp;Wenrong Xia ,&nbsp;Yongqi Zhao ,&nbsp;Weiwei Xing ,&nbsp;Jin Chen ,&nbsp;Changguo Chen","doi":"10.1016/j.imj.2024.100111","DOIUrl":"10.1016/j.imj.2024.100111","url":null,"abstract":"<div><h3>Background</h3><p>Swift and accurate detection of <em>Vibrio parahaemolyticus</em>, which is a prominent causative pathogen associated with seafood contamination, is required to effectively combat foodborne disease and wound infections. The <em>toxR</em> gene is relatively conserved within <em>V. parahaemolyticus</em> and is primarily involved in the expression and regulation of virulence genes with a notable degree of specificity. The aim of this study was to develop a rapid, simple, and constant temperature detection method for <em>V. parahaemolyticus</em> in clinical and nonspecialized laboratory settings.</p></div><div><h3>Methods</h3><p>In this study, specific primers and CRISPR RNA were used to target the <em>toxR</em> gene to construct a reaction system that combines recombinase polymerase amplification (RPA) with CRISPR‒Cas13a. The whole-genome DNA of the sample was extracted by self-prepared sodium dodecyl sulphate (SDS) nucleic acid rapid extraction reagent, and visual interpretation of the detection results was performed by lateral flow dipsticks (LFDs).</p></div><div><h3>Results</h3><p>The specificity of the RPA-CRISPR/Cas13a-LFD method was validated using <em>V. parahaemolyticus</em> strain ATCC-17802 and six other non-parahaemolytic <em>Vibrio</em> species. The results demonstrated a specificity of 100%. Additionally, the genomic DNA of <em>V. parahaemolyticus</em> was serially diluted and analysed, with a minimum detectable limit of 1 copy/µL for this method, which was greater than that of the TaqMan-qPCR method (10² copies/µL). The established methods were successfully applied to detect wild-type <em>V. parahaemolyticus</em>, yielding results consistent with those of TaqMan-qPCR and MALDI-TOF MS mass spectrometry identification. Finally, the established RPA-CRISPR/Cas13a-LFD method was applied to whole blood specimens from mice infected with <em>V. parahaemolyticus</em>, and the detection rate of <em>V. parahaemolyticus</em> by this method was consistent with that of the conventional PCR method.</p></div><div><h3>Conclusions</h3><p>In this study, we describe an RPA-CRISPR/Cas13a detection method that specifically targets the <em>toxR</em> gene and offers advantages such as simplicity, rapidity, high specificity, and visual interpretation. This method serves as a valuable tool for the prompt detection of <em>V. parahaemolyticus</em> in nonspecialized laboratory settings.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X2400025X/pdfft?md5=0efd833aa0c30f7f59c3a181b970263f&pid=1-s2.0-S2772431X2400025X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucormycosis during COVID-19 era: A retrospective assessment","authors":"Tuhin Mukherjee ,&nbsp;Tanisha Das ,&nbsp;Sourav Basak ,&nbsp;Satyajit Mohanty ,&nbsp;Krishnendu Adhikary ,&nbsp;Prity Chatterjee ,&nbsp;Rajkumar Maiti ,&nbsp;Prithviraj Karak","doi":"10.1016/j.imj.2024.100112","DOIUrl":"10.1016/j.imj.2024.100112","url":null,"abstract":"<div><p>In a retrospective view, this review examines the impact of mucormycosis on health workers and researchers during the COVID era. The diagnostic and treatment challenges arising from unestablished underlying pathology and limited case studies add strain to healthcare systems. Mucormycosis, caused by environmental molds, poses a significant threat to COVID-19 patients, particularly those with comorbidities and compromised immune systems. Due to a variety of infectious Mucorales causes and regionally related risk factors, the disease's incidence is rising globally. Data on mucormycosis remains scarce in many countries, highlighting the urgent need for more extensive research on its epidemiology and prevalence. This review explores the associations between COVID-19 disease and mucormycosis pathology, shedding light on potential future diagnostic techniques based on the fungal agent's biochemical components. Medications used in ICUs and for life support in ventilated patients have been reported, revealing the challenge of managing this dual onslaught. To develop more effective treatment strategies, it is crucial to identify novel pharmacological targets through “pragmatic” multicenter trials and registries. In the absence of positive mycology culture data, early clinical detection, prompt treatment, and tissue biopsy are essential to confirm the specific morphologic features of the fungal agent. This review delves into the history, pathogens, and pathogenesis of mucormycosis, its opportunistic nature in COVID or immunocompromised individuals, and the latest advancements in therapeutics. Additionally, it offers a forward-looking perspective on potential pharmacological targets for future drug development.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000261/pdfft?md5=4cd5d441ec5f1a486c83a6d2d23f67f2&pid=1-s2.0-S2772431X24000261-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycobacterium tuberculosis joint infections: A case series","authors":"Gui Luo,&nbsp;Jinshui Yang,&nbsp;Qianqian Zhao,&nbsp;Jian Zhu,&nbsp;Jianglin Zhang,&nbsp;Zheng Zhao","doi":"10.1016/j.imj.2024.100107","DOIUrl":"10.1016/j.imj.2024.100107","url":null,"abstract":"<div><p>Tuberculosis is a chronic infectious disease, caused by <em>Mycobacterium tuberculosis</em>, that seriously endangers human health. Skeletal tuberculosis is the most common type of extrapulmonary tuberculosis and tuberculous arthritis is the second most common type of skeletal tuberculosis. We report a case series of patients with tuberculous arthritis, two of whom had no joint disease in the past and presented as monoarthritis. The final patient had a history of rheumatoid arthritis, with polyarthritis that was aggravated during treatment with glucocorticoids and immunosuppressive drugs. This series of cases can contribute to early diagnosis and treatment with appropriate infection control measures.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000212/pdfft?md5=eb90e1029a7c070059c6186679c72eb3&pid=1-s2.0-S2772431X24000212-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the recombination events, mechanisms and consequences of Coxsackievirus A6","authors":"Zequn Wang ,&nbsp;Hongling Wen","doi":"10.1016/j.imj.2024.100115","DOIUrl":"10.1016/j.imj.2024.100115","url":null,"abstract":"<div><p>Hand, foot, and mouth disease (HFMD) is one of the most common class C infectious diseases, posing a serious threat to public health worldwide. Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) have been regarded as the major pathogenic agents of HFMD; however, since an outbreak caused by coxsackievirus A6 (CV-A6) in France in 2008, CV-A6 has gradually become the predominant pathogen in many regions. CV-A6 infects not only children but also adults, and causes atypical clinical symptoms such as a more generalized rash, eczema herpeticum, high fever, and onychomadesis, which are different from the symptoms associated with EV-A71 and CV-A16. Importantly, the rate of genetic recombination of CV-A6 is high, which can lead to changes in virulence and the rapid evolution of other characteristics, thus posing a serious threat to public health. To date, no specific vaccines or therapeutics have been approved for CV-A6 prevention or treatment, hence it is essential to fully understand the relationship between recombination and evolution of this virus. Here, we systematically review the genetic recombination events of CV-A6 that have occurred worldwide and explore how these events have promoted virus evolution, thus providing important information regarding future HFMD surveillance and prevention.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000297/pdfft?md5=c55b20e7169853252373ef4b99b3d656&pid=1-s2.0-S2772431X24000297-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and etiology of hand, foot, and mouth disease in Zhengzhou, China, from 2009 to 2021","authors":"Bowen Dai ,&nbsp;Yu Chen ,&nbsp;Shujie Han ,&nbsp;Shouhang Chen ,&nbsp;Fang Wang ,&nbsp;Huifen Feng ,&nbsp;Xiaolong Zhang ,&nbsp;Wenlong Li ,&nbsp;Shuaiyin Chen ,&nbsp;Haiyan Yang ,&nbsp;Guangcai Duan ,&nbsp;Guowei Li ,&nbsp;Yuefei Jin","doi":"10.1016/j.imj.2024.100114","DOIUrl":"10.1016/j.imj.2024.100114","url":null,"abstract":"<div><h3>Background</h3><p>Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease caused by a variety of enteroviruses (EVs). To explore the epidemiological characteristics and etiology of HFMD in Zhengzhou, China, we conducted a systematic analysis of HFMD surveillance data from Zhengzhou Center for Disease Control and Prevention from January 2009 to December 2021 (<span>https://wjw.zhengzhou.gov.cn/</span><svg><path></path></svg>).</p></div><div><h3>Methods</h3><p>Surveillance data were collected from Zhengzhou Center for Disease Control and Prevention from January 2009 to December 2021 (<span>https://wjw.zhengzhou.gov.cn/</span><svg><path></path></svg>). Cases were analyzed according to the time of onset, type of diagnosis, characteristics, viral serotype, and epidemiological trends.</p></div><div><h3>Results</h3><p>We found that the primary causative agent responsible for the HFMD outbreaks in Zhengzhou was Enterovirus A71 (EVA-71) (48.56%) before 2014. After 2015, other EVs gradually became the dominant strains (57.68%). The data revealed that the HFMD epidemics in Zhengzhou displayed marked seasonality, with major peaks occurring from April to June, followed by secondary peaks from October to November, except in 2020. Both the severity and case-fatality ratio of HFMD decreased following the COVID-19 pandemic (severity ‰: 13.46 vs. 0.17; case-fatality ‰: 0.21 vs. 0, respectively). Most severe cases were observed in patients aged 1 year and below, accounting for 45.81%.</p></div><div><h3>Conclusions</h3><p>Overall, the incidence rate of HFMD decreased in Zhengzhou following the introduction of the EVA-71 vaccine in 2016. However, it is crucial to acknowledge that HFMD prevalence continues to exhibit a distinct seasonal pattern and periodicity, and the occurrence of other EV infections poses a new challenge for children's health.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000285/pdfft?md5=6d7a9212964c42f8995b1c28c7bdfc6a&pid=1-s2.0-S2772431X24000285-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic next-generation sequencing identified a brain abscess caused by mixed oral anaerobe infection: A case report","authors":"Zepeng Ma ,&nbsp;Hui Liu ,&nbsp;Ming Liu ,&nbsp;Yuhao Wang ,&nbsp;Chao Li ,&nbsp;Yifei Xu","doi":"10.1016/j.imj.2024.100109","DOIUrl":"10.1016/j.imj.2024.100109","url":null,"abstract":"<div><p><em>Fusobacterium vincentii</em> brain abscesses are relatively rare. Here, we report our treatment of an anaerobic brain abscess caused by a mixed infection of <em>Parvimonas micra, Streptococcus constellatus, Fusobacterium vincentii</em>, and <em>Bacteroides heparinolyticus</em> diagnosed by metagenomic next-generation sequencing (mNGS). This is the first reported case of <em>Fusobacterium vincentii</em> in a brain abscess. This case highlights the possibility that oral anaerobic microbes can cause a brain abscess and demonstrates that mNGS has the potential to be deployed to provide rapid infection diagnosis and rationalize antimicrobial therapy for brain abscesses.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000236/pdfft?md5=253f37c9df90ed0530a320cc94a698f6&pid=1-s2.0-S2772431X24000236-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly pathogenic avian influenza A (H5N1) virus outbreak in Peru in 2022–2023","authors":"Nieves Sevilla ,&nbsp;Wendy Lizarraga ,&nbsp;Victor Jimenez-Vasquez ,&nbsp;Veronica Hurtado ,&nbsp;Iris S. Molina ,&nbsp;Lilian Huarca ,&nbsp;Priscila Lope-Pari ,&nbsp;Ivan Vargas ,&nbsp;Gloria Arotinco ,&nbsp;Carlos Padilla-Rojas","doi":"10.1016/j.imj.2024.100108","DOIUrl":"10.1016/j.imj.2024.100108","url":null,"abstract":"<div><h3>Background</h3><p>An epizootic of highly pathogenic avian influenza A (H5N1) has spread worldwide since 2022. Even though this virus has been extensively studied for many decades, little is known about its evolution in South America.</p></div><div><h3>Methods</h3><p>Here, we describe the sequencing and characterization of 13 H5N1 genomes collected from wild birds, poultry, and wild mammals in Peru during the genomic surveillance of this outbreak.</p></div><div><h3>Results</h3><p>The samples belonged to the highly pathogenic avian influenza (H5N1) 2.3.4.4b clade. Chilean and Peruvian samples clustered in the same group and therefore share a common ancestor. An analysis of the hemagglutinin and neuraminidase genes detected new mutations, some dependent upon the host type.</p></div><div><h3>Conclusions</h3><p>The genomic surveillance of highly pathogenic avian influenza is necessary to promote the One Health policy and to overcome the new problems entailed by climate change, which may alter the habitats of resident and migratory birds.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000224/pdfft?md5=fa804259af594e61781a9193ac2b525d&pid=1-s2.0-S2772431X24000224-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on One Health for establishing an enhanced and integrated surveillance system for key infectious diseases","authors":"Yanpeng Cheng ,&nbsp;Zhen Zhang ,&nbsp;Yuelong Shu ,&nbsp;Lili Ren ,&nbsp;Min Kang ,&nbsp;Dongfeng Kong ,&nbsp;Xiaolu Shi ,&nbsp;Qiuying Lv ,&nbsp;Zhigao Chen ,&nbsp;Yinghui Li ,&nbsp;Renli Zhang ,&nbsp;Puxuan Lu ,&nbsp;Yan Lu ,&nbsp;Tingting Liu ,&nbsp;Nixuan Chen ,&nbsp;Huawei Xiong ,&nbsp;Chen Du ,&nbsp;Jun Yuan ,&nbsp;Liang Wang ,&nbsp;Rongqi Liu ,&nbsp;Tiejian Feng","doi":"10.1016/j.imj.2024.100106","DOIUrl":"10.1016/j.imj.2024.100106","url":null,"abstract":"<div><p>China has been continuously improving its monitoring methods and strategies to address key infectious diseases (KIDs). After the severe acute respiratory syndrome epidemic in 2003, China established a comprehensive reporting system for infectious diseases (IDs) and public health emergencies. The relatively lagging warning thresholds, limited warning information, and outdated warning technology are insufficient to meet the needs of comprehensive monitoring for modern KIDs. Strengthening early monitoring and warning capabilities to enhance the public health system has become a top priority, with increasing demand for early warning thresholds, information, and techniques, thanks to constant innovation and development in molecular biology, bioinformatics, artificial intelligence, and other identification and analysis technologies. A panel of 31 experts has recommended a fourth-generation comprehensive surveillance system targeting KIDs (41 notifiable diseases and emerging IDs). The aim of this surveillance system is to systematically monitor the epidemiology and causal pathogens of KIDs in hosts such as humans, animals, and vectors, along with associated environmental pathogens. By integrating factors influencing epidemic spread and risk assessment, the surveillance system can serve to detect, predict, and provide early warnings for the occurrence, development, variation, and spread of known or novel KIDs. Moreover, we recommend comprehensive ID monitoring based on the fourth-generation surveillance system, along with a data-integrated monitoring and early warning platform and a consortium pathogen detection technology system. This series of considerations is based on systematic and comprehensive monitoring across multiple sectors, dimensions, factors, and pathogens that is supported by data integration and connectivity. This expert consensus will provides an opportunity for collaboration in various fields and relies on interdisciplinary application to enhance comprehensive monitoring, prediction, and early warning capabilities for the next generation of ID surveillance. This expert consensus will serve as a reference for ID prevention and control as well as other related activities.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000200/pdfft?md5=ca12c7ec5fb0dd197437dde782d43ce5&pid=1-s2.0-S2772431X24000200-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140782936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the emergence and evolution of monkeypox virus: Historical perspectives, epidemiology, genetic diversity, transmission, and preventative measures","authors":"Smriti Krishna ,&nbsp;Chhaya Kurrey ,&nbsp;Manisha Yadav ,&nbsp;Shakuntala Mahilkar ,&nbsp;Subash Chandra Sonkar ,&nbsp;Naveen Kumar Vishvakarma ,&nbsp;Anand Sonkar ,&nbsp;Lal Chandra ,&nbsp;Bidhan Chandra Koner","doi":"10.1016/j.imj.2024.100105","DOIUrl":"10.1016/j.imj.2024.100105","url":null,"abstract":"<div><p>In 2022, just before the COVID-19 pandemic ended, many countries noticed a viral monkeypox outbreak. Monkeypox virus, a zoonotic pathogen, causes a febrile illness in humans and resembles smallpox. Prevention strategies encompass vaccination, strict infection control measures, and avoiding contact with infected persons. As monkeypox and related poxviruses continue to pose challenges, ongoing surveillance, early diagnosis, prompt isolation, and effective control measures are crucial for limiting transmission and mitigating the impact of outbreaks on public health. This review provides valuable insights into the evolution of the monkeypox virus and its various modes of transmission, including postmortem transmission, and offers an overall perspective on the guidelines issued by the Government of India to prevent and effectively control the spread of this disease.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000194/pdfft?md5=5f6a35848bf4308c4aba538ba1c47380&pid=1-s2.0-S2772431X24000194-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal patterns and clinical characteristics of healthcare-associated infections in surgery patients: A retrospective study in a major Chinese tertiary hospital","authors":"Tianyi Zhang ,&nbsp;Li Yan ,&nbsp;Shan Wang ,&nbsp;Ming Chen ,&nbsp;Yunda Jiao ,&nbsp;Zhuoqi Sheng ,&nbsp;Jianchao Liu ,&nbsp;Lihua Liu","doi":"10.1016/j.imj.2024.100103","DOIUrl":"10.1016/j.imj.2024.100103","url":null,"abstract":"<div><h3>Background</h3><p>Given the preventable nature of most healthcare-associated infections (HAIs), it is crucial to understand their characteristics and temporal patterns to reduce their occurrence.</p></div><div><h3>Methods</h3><p>A retrospective analysis of medical record cover pages from a Chinese hospital information system was conducted for surgery inpatients from 2010 to 2019. Association rules mining (ARM) was employed to explore the association between disease, procedure, and HAIs. Joinpoint models were used to estimate the annual HAI trend. The time series of each type of HAI was decomposed to analyze the temporal patterns of HAIs.</p></div><div><h3>Results</h3><p>The study included data from 623,290 surgery inpatients over 10 years, and a significant decline in the HAI rate was observed. Compared with patients without HAIs, those with HAIs had a longer length of stay (29 days vs. 9 days), higher medical costs (96226.57 CNY vs. 22351.98 CNY), and an increased risk of death (6.42% vs. 0.18%). The most common diseases for each type of HAI differed, although bone marrow and spleen operations were the most frequent procedures for most HAI types. ARM detected that some uncommon diagnoses could strongly associate with HAIs. The time series pattern varied for each type of HAI, with the peak occurring in January for respiratory system infections, and in August and July for surgical site and bloodstream infections, respectively.</p></div><div><h3>Conclusions</h3><p>Our findings demonstrate that HAIs impose a significant burden on surgery patients. The differing time series patterns for each type of HAI highlight the importance of tailored surveillance strategies for specific types of HAI.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000170/pdfft?md5=0f63f57f8419c21f6bc25a081e9aee3e&pid=1-s2.0-S2772431X24000170-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}