iLIVER最新文献

{"title":"Innovations in 3D bioprinting and biomaterials for liver tissue engineering: Paving the way for tissue-engineered liver","authors":"Qi Wang, Yutian Feng, Anqi Wang, Yuelei Hu, Yannan Cao, Jingjing Zheng, Yinpeng Le, Juan Liu","doi":"10.1016/j.iliver.2024.100080","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100080","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"25 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139890135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting up an integrated service for PSC-IBD patients: A quality improvement project","authors":"S. Kotha, Ioannis Koumoutsos, Ben Warner, Eleni Theocharidou, Joel Mawdsley, Philip Berry","doi":"10.1016/j.iliver.2024.100076","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100076","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"60 9-10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139891507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for esophagogastric variceal-related poor outcomes in primary biliary cholangitis: A prospective cohort study","authors":"Lin Han, Huan Xie, Xue-Mei Ma, Xiao-Long Lu, Jun Zhao, Qing-Sheng Liang, Zheng-Sheng Zou, Jing-Feng Bi, Bo Jin, Ying Sun","doi":"10.1016/j.iliver.2024.100081","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100081","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"24 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139873882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging role of molecular diagnosis and personalized therapy for hepatocellular carcinoma","authors":"Ming-Da Wang, Yongkang Diao, Lan-Qing Yao, Zhonghong Fan, Ke-Chun Wang, Han Wu, Li-Hui Gu, Jia-Hao Xu, Chao Li, Guoyue Lv, Tian Yang","doi":"10.1016/j.iliver.2024.100083","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100083","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"32 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139813451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine diagnosis and treatment based on systematics","authors":"Zhanhong Wang ,&nbsp;Danli Wang ,&nbsp;Wen Liu ,&nbsp;Zhongxia Wang","doi":"10.1016/j.iliver.2023.08.004","DOIUrl":"10.1016/j.iliver.2023.08.004","url":null,"abstract":"<div><h3>Background</h3><p>Traditional Chinese Medicine (TCM) is a well-established medical system with a long history. However, the overall concept and systematic thinking in TCM are not comprehensively understood and applied in its inheritance and development.</p></div><div><h3>Objective</h3><p>This study aims to provide a basic theory for TCM diagnosis using systematics as the guiding principle. Using modern scientific and technological achievements, we aim to explore a new TCM diagnosis method.</p></div><div><h3>Methods</h3><p>We analyzed previous studies on TCM diagnosis and treatment, and reviewed clinical research on TCM diagnosis and treatment from the viewpoint of systematics. We propose a new process model based on systematics for TCM diagnosis and treatment. This is a generalized model that summarizes the process of “establishing an image to express meaning”.</p></div><div><h3>Results</h3><p>The proposed model was implemented in the clinical practice of TCM. We monitored the detailed treatment process of patients in the Department of Liver Diseases at Beijing Hospital. One patient underwent a treatment program that lasted 1 year and 45 days, consisting of 12 iterative cycles, each guided by the proposed diagnostic model and tailored to the patient's evolving condition. This case study validates the effectiveness of the proposed model in the diagnosis and treatment of liver disease in TCM. The therapeutic efficacy has been validated through the examination of both TCM indicators and Western medical auxiliary parameters. Among these, the TCM indicators consist of 2 components: tongue diagnosis and pulse diagnosis. Meanwhile, the Western medical auxiliary indicators encompass a range of assessments, including whole blood cell analysis, professional liver function examination, a series of liver function assessments, a high-sensitivity hepatitis B pentathlete test, as well as color Doppler ultrasound evaluations of the liver, bile duct, pancreas, spleen, and assessments of liver elasticity, among other related examination parameters. In conclusion, it is evident that the syndrome of liver depression and spleen deficiency has significantly diminished, and the viral load has decreased to levels below the detectable threshold, thereby confirming the restoration of normal liver function. These findings indicate that the disease is now under control.</p></div><div><h3>Conclusions</h3><p>In this study, we applied the guiding principle of systematics to the study of TCM diagnosis and treatment, and combined it with modern medical technology. We proposed a TCM diagnosis and treatment process model, and a TCM model to establish an image, which can effectively support the diagnosis and treatment of TCM diseases. We illustrated the effectiveness of these models by applying them to TCM liver disease.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 4","pages":"Pages 181-187"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277294782300035X/pdfft?md5=cee617f900a16d95c3527195f1503ac8&pid=1-s2.0-S277294782300035X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91298095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in diagnostic ultrasound techniques for assessing liver steatosis in nonalcoholic fatty liver disease","authors":"Zhaoxin Wang ,&nbsp;Yarong Ma ,&nbsp;Xiaolei Wu ,&nbsp;Yingxin Lu ,&nbsp;Qiuyun She","doi":"10.1016/j.iliver.2023.10.002","DOIUrl":"10.1016/j.iliver.2023.10.002","url":null,"abstract":"<div><p>The incidence of nonalcoholic fatty liver disease (NAFLD), a common chronic liver disease, is increasing yearly. With increasing degrees of liver steatosis, NAFLD can progress to varying degrees of hepatic fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC), with a concomitant increase in the risk of metabolic syndrome and cardiovascular disease. Therefore, early diagnosis and accurate assessment of NAFLD are particularly significant. Although liver biopsy is regarded as the standard for evaluating the degree of hepatic steatosis in NAFLD, it is not frequently utilized due to its invasiveness. Ultrasound technology as a noninvasive diagnostic method has the advantages of operating simplicity and economy. It can effectively diagnose and assess the disease of NAFLD. This article mainly summarizes the current status and progress of research on the assessment of NAFLD and liver steatosis by two main types of ultrasound techniques, semi-quantitative and quantitative ultrasound, as well as other emerging techniques, and briefly describes the strengths and limitations of B-mode ultrasound, controlled attenuation parameters (CAP), and attenuation imaging (ATI) in this field.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 4","pages":"Pages 214-218"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947823000476/pdfft?md5=cb93636a35d167eae49a42f36f6370ca&pid=1-s2.0-S2772947823000476-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135410606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective cohort study to examine the association between the persistence of abdominal pain after cholecystectomy and ejection fraction on HIDA scan in patients with biliary dyskinesia","authors":"Baldeep Kaur Mann ,&nbsp;Janpreet Singh Bhandohal ,&nbsp;Ishaan Kalha ,&nbsp;Brian Jean","doi":"10.1016/j.iliver.2023.10.003","DOIUrl":"10.1016/j.iliver.2023.10.003","url":null,"abstract":"<div><h3>Background and aims</h3><p>The persistence of pain in patients who underwent cholecystectomy primarily for biliary dyskinesia has been associated with gall bladder ejection fraction (GBEF) found on hepatobiliary iminodiacetic acid (HIDA) scan. Cholecystectomy is a definitive treatment for cholelithiasis but is questionable in biliary dyskinesia. During the postoperative follow-up, gastroenterologists and surgeons often found that some patients with biliary dyskinesia continue to experience biliary pain even after surgery. This study aims to investigate whether the value of GBEF found on the HIDA scan predicts the persistence of pain after cholecystectomy in patients with biliary dyskinesia (EF &lt;35% on HIDA scan).</p></div><div><h3>Methods</h3><p>It is a retrospective cohort study conducted at Kern Medical by recruiting patients from November 2019 to October 2022 in consecutive manner. It is a single sample study consisting of post-cholecystectomy biliary dyskinesia patients with dichotomous outcomes, i.e., persistent typical recurrent epigastric or right upper quadrant pain with/without meals versus no pain. The primary outcome was the presence of pain 30 days after the cholecystectomy. Univariate analysis was performed with some of the bivariate indicators and continuous predictors, which contained fewer missing elements and had more variation.</p></div><div><h3>Results</h3><p>Univariate logistic regression suggested that HIDA GBEF as a continuous variable does not suggest a relationship with pain after surgery (<em>p</em> = 0.3951). A ROC analysis suggested a cutoff of HIDA GBEF = 16 (AUC = 0.60, Specificity = 0.5455, Sensitivity = 0.7333).</p></div><div><h3>Conclusion</h3><p>Our study does not support the relationship between GBEF found on HIDA scan to improved outcomes after the surgery. But larger controlled trials comparing outcomes of the patients with biliary dyskinesia who did and didn't undergo cholecystectomy are needed to look for other factors.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 4","pages":"Pages 208-213"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947823000488/pdfft?md5=933a22542fb9be778c1c930efc43e5eb&pid=1-s2.0-S2772947823000488-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136128016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrahepatic cholestasis of pregnancy is associated with increased risk of hepatobiliary disease and adverse fetal outcomes: A systematic review and meta-analysis","authors":"Peter Olujimi Odutola ,&nbsp;Peter Oluwatobi Olorunyomi ,&nbsp;Olanrewaju Olamide Olatawura ,&nbsp;Ifeoluwapo Olorunyomi ,&nbsp;Olukayode Madojutimi ,&nbsp;Ayomide O. Fatunsin ,&nbsp;Uju Okeke","doi":"10.1016/j.iliver.2023.11.001","DOIUrl":"10.1016/j.iliver.2023.11.001","url":null,"abstract":"<div><h3>Background and aims</h3><p>The aim of this study was to review the literature and perform a meta-analysis to clarify the association between intrahepatic cholestasis of pregnancy and risks of long-term maternal hepatobiliary disease as well as adverse fetal outcomes including preterm birth, meconium-stained amniotic fluid, and stillbirth.</p></div><div><h3>Methods</h3><p>This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search was performed using Cochrane, Embase, and PubMed databases to identify observational or cohort studies comparing pregnant women with intrahepatic cholestasis of pregnancy (ICP) to pregnant women without ICP. Data from the included studies were analyzed using the Review Manager 5.4.1 software.</p></div><div><h3>Results</h3><p>The meta-analysis showed a significant association between ICP and the risk of hepatobiliary diseases (pooled risk ratio [RR]: 2.81, 95% confidence interval [CI]: 2.66–2.97, <em>p</em> &lt; 0.00001), hepatitis C (HC): a significant association between ICP and risk of HC (pooled RR: 4.02, 95% CI: 3.12–5.19, <em>p</em> &lt; 0.00001), meconium-stained amniotic fluid (MSAF): ICP was significantly associated with an increased risk of MSAF (pooled RR: 1.91, 95% CI: 1.65–2.21, <em>p</em> &lt; 0.00001), and preterm birth: the meta-analysis demonstrated a significant association between ICP and preterm birth (pooled RR: 2.11, 95% CI: 2.01–2.21, <em>p</em> &lt; 0.00001).</p></div><div><h3>Conclusion</h3><p>ICP demonstrated statistically significant associations with increased risks of hepatobiliary disease, HC, MSAF, and preterm birth.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 4","pages":"Pages 219-226"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277294782300049X/pdfft?md5=d36b2c294671ab21de9c42465cca01cc&pid=1-s2.0-S277294782300049X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135714993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of positive cofactor 4 as a diagnostic and prognostic biomarker associated with immune infiltration in hepatocellular carcinoma","authors":"Liangliang Bai ,&nbsp;Guan Liu ,&nbsp;Gang Dou ,&nbsp;Xiaojun He ,&nbsp;Chenyu Gong ,&nbsp;Hongbin Zhang ,&nbsp;Kai Tan ,&nbsp;Xilin Du","doi":"10.1016/j.iliver.2023.08.007","DOIUrl":"10.1016/j.iliver.2023.08.007","url":null,"abstract":"<div><h3>Background and aims</h3><p>Human positive cofactor 4 (PC4) is associated with the development and therapeutic resistance of several malignancies. However, the role of PC4 in hepatocellular carcinoma (HCC) remains obscure.</p></div><div><h3>Methods</h3><p>The expression status of PC4 was explored in Gene Expression Omnibus and The Cancer Genome Atlas datasets. Subsequently, the prognostic and diagnostic significance of PC4 in HCC patients was analyzed. Functional enrichment analyses were conducted to explore biological functions and potential mechanisms. The CIBERSORT algorithm was used for immune infiltration analysis. The risk signature was constructed by LASSO-Cox regression and was validated with the International Cancer Genome Consortium dataset. Quantitative real-time polymerase chain reaction was used to verify the expression levels of all genes. Tumor Immune Dysfunction and Exclusion analysis evaluated immunotherapy response. Finally, using online databases, PC4-related competing endogenous RNA networks were constructed.</p></div><div><h3>Results</h3><p>PC4 levels were significantly upregulated in HCC and positively correlated with the pathological grade and clinical stage. The PC4-high expression group showed worse prognosis. In addition, PC4 could distinguish between tumor and normal tissues with an area under the curve of 0.965. The PC4 level was associated with immune checkpoints and immune cell infiltration. In the training and validation sets, the eight-gene risk signature strongly correlated with HCC patient prognosis. Tumor Immune Dysfunction and Exclusion analysis showed that patients in both the PC4-low and low-risk groups were more likely to benefit from immunotherapy. Finally, an lncRNA/microRNA-101-3p/PC4 network was constructed.</p></div><div><h3>Conclusion</h3><p>We confirmed PC4 as a diagnostic and prognostic biomarker in HCC patients. We also developed and validated an eight-gene risk signature, which will help in clinical decision-making. The competing endogenous RNA network could help explore the regulatory mechanisms of PC4 in HCC.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 4","pages":"Pages 188-201"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947823000385/pdfft?md5=930d9cb49c9e240b356b591e6696644d&pid=1-s2.0-S2772947823000385-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic cholecystectomy based on Laennec approach via the cystic plate with lymphadenectomy in Calot's triangle for gallbladder neoplasms: Initial experience and technical details","authors":"Bin Ouyang ,&nbsp;Laizhu Zhang ,&nbsp;Yajuan Cao ,&nbsp;Zhongjie Xing ,&nbsp;Jin Peng ,&nbsp;Yang Yue ,&nbsp;Decai Yu","doi":"10.1016/j.iliver.2023.10.001","DOIUrl":"10.1016/j.iliver.2023.10.001","url":null,"abstract":"<div><h3>Background</h3><p>It is still challenging to define the exact stage of early gallbladder carcinoma with preoperative imaging. Generally, subserous gallbladder is dissected for the potential early gallbladder carcinoma, which may cause incomplete tumor resection or tumor spread especially for the patients with T2 stage. Here, we reported our experience and safety of Laennec approach via the cystic plate to dissect the whole gallbladder with lymphadenectomy in Calot's triangle for accurate diagnosis and stage in gallbladder neoplasms.</p></div><div><h3>Methods</h3><p>The anatomical gap between Laennec capsule and the cystic plate serves as the landmark to dissect the whole gallbladder through Laennec approach. Laparoscopic cholecystectomy based on Laennec approach via the cystic plate, together with lymphadenectomy in Calot's triangle, was performed in 17 patients with gallbladder neoplasms.</p></div><div><h3>Results</h3><p>All patients had less intraoperative bleeding, no gallbladder breakage, no bile leakage, and accurate intraoperative rapid pathological staging under the corresponding strategies. The duration of surgery was comparable to that of traditional laparoscopic cholecystectomy.</p></div><div><h3>Conclusion</h3><p>Laparoscopic cholecystectomy based on Laennec approach via the cystic plate, together with lymphadenectomy in Calot's triangular is safe for gallbladder neoplasms. In the future, the prospective clinical trial is going on to confirm the feasibility and effectiveness of this approach.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 4","pages":"Pages 202-207"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947823000464/pdfft?md5=0e69e827749a60ba27f7bfdbc17e8206&pid=1-s2.0-S2772947823000464-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135810975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}