iLIVER最新文献

{"title":"The potential role of extracellular vesicles as hepatic diagnostic and therapeutic tools: Can the dream come true?","authors":"Nourhan Badwei","doi":"10.1016/j.iliver.2024.100078","DOIUrl":"10.1016/j.iliver.2024.100078","url":null,"abstract":"<div><p>Chronic liver disease of various aetiologies with underlying cirrhosis is a serious cause of liver-related morbidity and mortality globally. The emerging role of non-invasive diagnostic/therapeutic tools in different stages of liver disease represents a challenge and an area of great interest for many researchers, which could differ in the clinical outcome of liver disease patients. Over a decade, several studies have evaluated the emerging role of circulating extracellular vesicles (EVs) as biomarkers and therapeutic targets in different liver diseases; They are small membrane-encapsulated particles that can act as potent vehicles via their cargos between different hepatic cell types and also between organs, because of their ability to transfer proteins, lipids, and nucleic acids to affect the recipient cells' related physiological functions. Hence, the issues related to the potential use of EVs as biomarkers in liver disease diagnosis, prognosis, and even to assess the response to treatment, have been handled in our review concluding that EVs have shown promising results as potential diagnostic tools and for further evaluation as therapeutic targets.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"3 1","pages":"Article 100078"},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947824000033/pdfft?md5=e2a429e7cf7c88e97b724fa454068312&pid=1-s2.0-S2772947824000033-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139831606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting up an integrated service for PSC-IBD patients: A quality improvement project","authors":"Sreelakshmi Kotha,&nbsp;Ioannis Koumoutsos,&nbsp;Ben Warner,&nbsp;Eleni Theocharidou,&nbsp;Joel Mawdsley,&nbsp;Philip Berry","doi":"10.1016/j.iliver.2024.100076","DOIUrl":"10.1016/j.iliver.2024.100076","url":null,"abstract":"<div><h3>Background and aims</h3><p>Primary sclerosing cholangitis (PSC) often co-exists with inflammatory bowel disease (IBD) and together they are associated with increased risk of complications, including cancer (hepatobiliary, colorectal, gallbladder) and death. Guidelines for follow up and surveillance vary, but our local guidelines advise annual surveillance with magnetic resonance cholangiopancreatography (MRCP), colonoscopy and ultrasound (US) (6 monthly if cirrhotic). We aimed to assess the quality of care in our PSC-IBD patients, including adherence to local surveillance guidelines, and resultant detection of complications, before and after the introduction of an integrated PSC and IBD out-patient service.</p></div><div><h3>Methods</h3><p>Data on management of PSC-IBD patients was collected retrospectively before, and prospectively following, the introduction of an integrated service. Descriptive comparisons of diagnoses, adherence to planned surveillance and outcomes were made between cohorts pre- and post-service redesign.</p></div><div><h3>Results</h3><p>Prior to the service re-design there was significant variability in care and poor adherence to guidelines. Introduction of an integrated PSC-IBD service led to 89 referrals with possible PSC-IBD at 36 months after service re-design. Detailed review led to appropriate identification of 68 PSC-IBD patients. There was significant improvement in surveillance with annual colonoscopy in 90%, MRI/MRCP in 81%, US in 35%, compared to 55%, 55% and 7% respectively in the baseline cohort. This translated to diagnosis and appropriate treatment of colonic dysplasia in 4 patients, colorectal cancer (CRC) in 4 patients and cholangiocarcinoma (CCA) in 2 patients.</p></div><div><h3>Conclusion</h3><p>Establishment of an integrated out-patient service for PSC-IBD patients results in better compliance with guidelines, effective detection of complications, and appropriate management.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"3 2","pages":"Article 100076"},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277294782400001X/pdfft?md5=35c1c6c9dd0795abd3cb099d97232389&pid=1-s2.0-S277294782400001X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139831646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomic features on contrast-enhanced images of the remnant liver predict the prognosis of hepatocellular carcinoma after partial hepatectomy","authors":"Meilong Wu, Liping Liu, Xiaojuan Wang, Ying Xiao, Shizhong Yang, Jiahong Dong","doi":"10.1016/j.iliver.2024.100079","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100079","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"23 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139880292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-based pathological analysis of liver cancer: Current advancements and interpretative strategies","authors":"Guang-Yu Ding, Jieyi Shi, Xiao-Dong Wang, Bo Yan, Xi-Yang Liu, Qiang Gao","doi":"10.1016/j.iliver.2024.100082","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100082","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"46 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139815267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role of extracellular vesicles as hepatic diagnostic and therapeutic tools: Can the dream come true?","authors":"Nourhan Badwei","doi":"10.1016/j.iliver.2024.100078","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100078","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"64 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139891489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in 3D bioprinting and biomaterials for liver tissue engineering: Paving the way for tissue-engineered liver","authors":"Qi Wang, Yutian Feng, Anqi Wang, Yuelei Hu, Yannan Cao, Jingjing Zheng, Yinpeng Le, Juan Liu","doi":"10.1016/j.iliver.2024.100080","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100080","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"25 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139890135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting up an integrated service for PSC-IBD patients: A quality improvement project","authors":"S. Kotha, Ioannis Koumoutsos, Ben Warner, Eleni Theocharidou, Joel Mawdsley, Philip Berry","doi":"10.1016/j.iliver.2024.100076","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100076","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"60 9-10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139891507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for esophagogastric variceal-related poor outcomes in primary biliary cholangitis: A prospective cohort study","authors":"Lin Han, Huan Xie, Xue-Mei Ma, Xiao-Long Lu, Jun Zhao, Qing-Sheng Liang, Zheng-Sheng Zou, Jing-Feng Bi, Bo Jin, Ying Sun","doi":"10.1016/j.iliver.2024.100081","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100081","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"24 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139873882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging role of molecular diagnosis and personalized therapy for hepatocellular carcinoma","authors":"Ming-Da Wang, Yongkang Diao, Lan-Qing Yao, Zhonghong Fan, Ke-Chun Wang, Han Wu, Li-Hui Gu, Jia-Hao Xu, Chao Li, Guoyue Lv, Tian Yang","doi":"10.1016/j.iliver.2024.100083","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100083","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"32 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139813451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine diagnosis and treatment based on systematics","authors":"Zhanhong Wang ,&nbsp;Danli Wang ,&nbsp;Wen Liu ,&nbsp;Zhongxia Wang","doi":"10.1016/j.iliver.2023.08.004","DOIUrl":"10.1016/j.iliver.2023.08.004","url":null,"abstract":"<div><h3>Background</h3><p>Traditional Chinese Medicine (TCM) is a well-established medical system with a long history. However, the overall concept and systematic thinking in TCM are not comprehensively understood and applied in its inheritance and development.</p></div><div><h3>Objective</h3><p>This study aims to provide a basic theory for TCM diagnosis using systematics as the guiding principle. Using modern scientific and technological achievements, we aim to explore a new TCM diagnosis method.</p></div><div><h3>Methods</h3><p>We analyzed previous studies on TCM diagnosis and treatment, and reviewed clinical research on TCM diagnosis and treatment from the viewpoint of systematics. We propose a new process model based on systematics for TCM diagnosis and treatment. This is a generalized model that summarizes the process of “establishing an image to express meaning”.</p></div><div><h3>Results</h3><p>The proposed model was implemented in the clinical practice of TCM. We monitored the detailed treatment process of patients in the Department of Liver Diseases at Beijing Hospital. One patient underwent a treatment program that lasted 1 year and 45 days, consisting of 12 iterative cycles, each guided by the proposed diagnostic model and tailored to the patient's evolving condition. This case study validates the effectiveness of the proposed model in the diagnosis and treatment of liver disease in TCM. The therapeutic efficacy has been validated through the examination of both TCM indicators and Western medical auxiliary parameters. Among these, the TCM indicators consist of 2 components: tongue diagnosis and pulse diagnosis. Meanwhile, the Western medical auxiliary indicators encompass a range of assessments, including whole blood cell analysis, professional liver function examination, a series of liver function assessments, a high-sensitivity hepatitis B pentathlete test, as well as color Doppler ultrasound evaluations of the liver, bile duct, pancreas, spleen, and assessments of liver elasticity, among other related examination parameters. In conclusion, it is evident that the syndrome of liver depression and spleen deficiency has significantly diminished, and the viral load has decreased to levels below the detectable threshold, thereby confirming the restoration of normal liver function. These findings indicate that the disease is now under control.</p></div><div><h3>Conclusions</h3><p>In this study, we applied the guiding principle of systematics to the study of TCM diagnosis and treatment, and combined it with modern medical technology. We proposed a TCM diagnosis and treatment process model, and a TCM model to establish an image, which can effectively support the diagnosis and treatment of TCM diseases. We illustrated the effectiveness of these models by applying them to TCM liver disease.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 4","pages":"Pages 181-187"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277294782300035X/pdfft?md5=cee617f900a16d95c3527195f1503ac8&pid=1-s2.0-S277294782300035X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91298095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}