iLIVER最新文献

{"title":"Radiomic features on contrast-enhanced images of the remnant liver predict the prognosis of hepatocellular carcinoma after partial hepatectomy","authors":"Meilong Wu ,&nbsp;Liping Liu ,&nbsp;Xiaojuan Wang ,&nbsp;Ying Xiao ,&nbsp;Shizhong Yang ,&nbsp;Jiahong Dong","doi":"10.1016/j.iliver.2024.100079","DOIUrl":"10.1016/j.iliver.2024.100079","url":null,"abstract":"<div><h3>Background and aims</h3><p>Radiomic features extracted from preoperative contrast-enhanced computed tomography (CT) images have been shown to predict the prognosis of hepatocellular carcinoma (HCC). However, the prognostic role of radiomic features obtained from postoperative contrast-enhanced CT images of the remnant liver remains unclear. This study explored the prognostic value of radiomic features extracted from postoperative contrast-enhanced CT images in patients with HCC.</p></div><div><h3>Methods</h3><p>Robust radiomic features were obtained from postoperative contrast-enhanced CT images for 78 patients with primary HCC and used to construct a radiomics score. A clinical model and a combined model that integrated clinicopathological indicators and the radiomics score were established. The predictive performance of the model was assessed using the concordance index and net reclassification index.</p></div><div><h3>Results</h3><p>The postoperative radiomics score for the remnant liver was an independent prognostic factor for disease-free survival (DFS) and overall survival (OS). The combined model was not inferior to the clinical model in predicting DFS but was superior in predicting OS. The net reclassification index confirmed that the combined model was more accurate and efficient in predicting OS and DFS. The radiomics score for DFS was significantly associated with tumor thrombus in the portal vein and the postoperative neutrophil-lymphocyte ratio. The radiomics score for OS was associated with multiple tumors, microvascular invasion, and tumor thrombus in the portal vein.</p></div><div><h3>Conclusion</h3><p>Postoperative contrast-enhanced CT radiomic features of the remnant liver were valuable prognostic indicators that could potentially reflect tumor burden and postoperative inflammatory status and provide more information for clinical decision-making.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"3 1","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947824000045/pdfft?md5=c065aba55254c61a1225a54fc0d41961&pid=1-s2.0-S2772947824000045-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139820567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma: Review and bibliometric","authors":"Pamela Scarlett Espinoza Loyola ,&nbsp;Diana Laura Muratalla Bautista ,&nbsp;Karen Adela Hernández Bautista ,&nbsp;Elizabeth Gil White ,&nbsp;José Antonio González Moreno ,&nbsp;Daniel Angel Torres del Real ,&nbsp;Víctor Manuel Páez Zayas ,&nbsp;Carla Escorza-Molina ,&nbsp;Fernando Mondragón Rodríguez ,&nbsp;Omar Vásquez Gómez ,&nbsp;Luis Jorge Fernández López ,&nbsp;Paul Santiago Mogrovejo Vázquez ,&nbsp;Isidoro Aczel Sánchez-Cedillo ,&nbsp;Víctor Jose Visag Castillo","doi":"10.1016/j.iliver.2024.100077","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100077","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) is one of the most common cancers in the world and is one of the leading indications for liver transplantation, liver transplantation is the gold standard treatment for end stage liver disease. Diagnosis is based up on radiological characteristics and rarely biopsy results. However treatment must be individualized to each patient to improve recurrences and outcomes. In this article, we focus on the different selection criteria for liver transplantation. This study aimed to investigate the distribution laws and research frontiers of international literature, so as to present holistic bibliometric evaluation of the studies on 5-year survival and disease-free recurrence in 5 years, according to hepatocarcinoma criteria for liver transplantation. The paper aims to review and analyze 5-year survival and disease-free recurrence based on hepatocarcinoma criteria for liver transplantation. It systematically examines and summarizes distribution characteristics and research frontiers through bibliometric analysis. A bibliographic search was implemented in PubMed/Medline, Clinical Key, Science Direct and Index Medicus with MESH terms, from the year 1996–2022. Patients selected for transplantation using the Metroticket 2.0 (MT2) criteria had the highest overall survival along with patients selected for transplantation using the Milan Criteria had the best 5-year disease-free recurrence. The Metroticket 2.0 criteria (MT2) and Milan Criteria (MC) have shown the most favorable post-transplant outcomes for patients with hepatocellular carcinoma (HCC). However, MC demonstrated the best 5-year disease-free recurrence rate, underscoring the significance of taking into account tumor morphology and biology when determining the eligibility of HCC patients for liver transplantation. The distribution characteristics and research frontiers by bibliometrics concerning prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma the collaborations are sufficient to reach a consensus that the Milan criteria are the best criteria.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"3 1","pages":"Article 100077"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947824000021/pdfft?md5=9a6497898d12245cd13ea8b00292d9d2&pid=1-s2.0-S2772947824000021-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140042498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging role of molecular diagnosis and personalized therapy for hepatocellular carcinoma","authors":"Ming-Da Wang ,&nbsp;Yong-Kang Diao ,&nbsp;Lan-Qing Yao ,&nbsp;Zhong-Qi Fan ,&nbsp;Ke-Chun Wang ,&nbsp;Han Wu ,&nbsp;Li-Hui Gu ,&nbsp;Jia-Hao Xu ,&nbsp;Chao Li ,&nbsp;Guo-Yue Lv ,&nbsp;Tian Yang","doi":"10.1016/j.iliver.2024.100083","DOIUrl":"10.1016/j.iliver.2024.100083","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) is a prevalent malignancy worldwide, ranking as the sixth most common malignancy and the third leading cause of cancer-related mortality. Late diagnosis, limited management options, and its complex etiology contribute to the poor prognosis and high mortality rates. Recent advances in understanding the molecular mechanisms of HCC and innovations in high-throughput sequencing technologies have led to the development of molecular diagnostics and personalized therapies for this challenging malignancy. This review provides a comprehensive overview of research on the molecular diagnosis and individualized treatment for HCC. We highlight key advances and potential future directions and discuss the application of next-generation sequencing technologies to identify and characterize genetic and epigenetic alterations in HCC patients. These technologies may aid in the selection of targeted therapies, prediction of treatment response, and monitoring disease progression. Furthermore, we explore the role of liquid biopsy in HCC diagnosis, prognosis prediction, and treatment monitoring, focusing on circulating tumor cells, circulating tumor DNA, and extracellular vesicles. We also explore the evolving landscape of personalized therapy for HCC, including targeted therapies against key oncogenic signaling pathways, immune checkpoint inhibitors, tumor-agnostic therapies, and innovative cell-based therapies. We discuss the challenges and opportunities that lie ahead in the quest to improve HCC patient outcomes through the integration of molecular diagnostics and individualized precision therapies. We emphasize the need for multi-interdisciplinary collaboration, refinement of predictive and prognostic biomarkers, and the development of more effective combination strategies for HCC management in the new area of precision medicine.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"3 1","pages":"Article 100083"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947824000082/pdfft?md5=bd51dc230c2eaf9accdb3562d7e30e85&pid=1-s2.0-S2772947824000082-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139873264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-based pathological analysis of liver cancer: Current advancements and interpretative strategies","authors":"Guang-Yu Ding ,&nbsp;Jie-Yi Shi ,&nbsp;Xiao-Dong Wang ,&nbsp;Bo Yan ,&nbsp;Xi-Yang Liu ,&nbsp;Qiang Gao","doi":"10.1016/j.iliver.2024.100082","DOIUrl":"10.1016/j.iliver.2024.100082","url":null,"abstract":"<div><p>In recent years, significant advances have been achieved in liver cancer management with the development of artificial intelligence (AI). AI-based pathological analysis can extract crucial information from whole slide images to assist clinicians in all aspects from diagnosis to prognosis and molecular profiling. However, AI techniques have a “black box” nature, which means that interpretability is of utmost importance because it is key to ensuring the reliability of the methods and building trust among clinicians for actual clinical implementation. In this paper, we provide an overview of current technical advancements in the AI-based pathological analysis of liver cancer, and delve into the strategies used in recent studies to unravel the “black box” of AI's decision-making process.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"3 1","pages":"Article 100082"},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947824000070/pdfft?md5=066fabb4fd4ae8d1a5a1663b2066d90e&pid=1-s2.0-S2772947824000070-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139875057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in 3D bioprinting and biomaterials for liver tissue engineering: Paving the way for tissue-engineered liver","authors":"Qi Wang ,&nbsp;Yutian Feng ,&nbsp;Anqi Wang ,&nbsp;Yuelei Hu ,&nbsp;Yannan Cao ,&nbsp;Jingjing Zheng ,&nbsp;Yinpeng Le ,&nbsp;Juan Liu","doi":"10.1016/j.iliver.2024.100080","DOIUrl":"10.1016/j.iliver.2024.100080","url":null,"abstract":"<div><p>The liver is a pivotal organ that maintains internal homeostasis and actively participates in multiple physiological processes. Liver tissue engineering (LTE), by which <em>in vitro</em> biomimetic liver models are constructed, serves as a platform for disease research, drug screening, and cell replacement therapies. 3D bioprinting is used in tissue engineering to create microenvironments that closely mimic authentic tissues with carefully selected functional biomaterials. Ideal functional biomaterials exhibit characteristics such as high biocompatibility, mechanical strength, flexibility, processability, and tunable degradability. Biomaterials can be categorized into natural and synthetic biomaterials, each with its own advantages and limitations, and their combinations serve as a primary source of 3D bioprinting materials. It is noteworthy that the liver decellularized extracellular matrix (dECM), obtained by removing cellular components from tissues, possesses traits such as bioactivity, biocompatibility, and non-immunogenicity, making it a common choice among functional biomaterials. Furthermore, crosslinking of biomaterials significantly impacts the mechanical strength, physicochemical properties, and cellular behavior of the printed structures. This review covers the current utilization of biomaterials in LTE, focusing on natural and synthetic biomaterials as well as the selection and application of crosslinking methods. The aim is to enhance the fidelity of <em>in vitro</em> liver tissue models by providing a comprehensive coverage of functional biomaterials, thereby establishing a versatile platform for tissue-engineered livers.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"3 1","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947824000057/pdfft?md5=65053d389a689ac1379d75200952feb4&pid=1-s2.0-S2772947824000057-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139830212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role of extracellular vesicles as hepatic diagnostic and therapeutic tools: Can the dream come true?","authors":"Nourhan Badwei","doi":"10.1016/j.iliver.2024.100078","DOIUrl":"10.1016/j.iliver.2024.100078","url":null,"abstract":"<div><p>Chronic liver disease of various aetiologies with underlying cirrhosis is a serious cause of liver-related morbidity and mortality globally. The emerging role of non-invasive diagnostic/therapeutic tools in different stages of liver disease represents a challenge and an area of great interest for many researchers, which could differ in the clinical outcome of liver disease patients. Over a decade, several studies have evaluated the emerging role of circulating extracellular vesicles (EVs) as biomarkers and therapeutic targets in different liver diseases; They are small membrane-encapsulated particles that can act as potent vehicles via their cargos between different hepatic cell types and also between organs, because of their ability to transfer proteins, lipids, and nucleic acids to affect the recipient cells' related physiological functions. Hence, the issues related to the potential use of EVs as biomarkers in liver disease diagnosis, prognosis, and even to assess the response to treatment, have been handled in our review concluding that EVs have shown promising results as potential diagnostic tools and for further evaluation as therapeutic targets.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"3 1","pages":"Article 100078"},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772947824000033/pdfft?md5=e2a429e7cf7c88e97b724fa454068312&pid=1-s2.0-S2772947824000033-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139831606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting up an integrated service for PSC-IBD patients: A quality improvement project","authors":"Sreelakshmi Kotha,&nbsp;Ioannis Koumoutsos,&nbsp;Ben Warner,&nbsp;Eleni Theocharidou,&nbsp;Joel Mawdsley,&nbsp;Philip Berry","doi":"10.1016/j.iliver.2024.100076","DOIUrl":"10.1016/j.iliver.2024.100076","url":null,"abstract":"<div><h3>Background and aims</h3><p>Primary sclerosing cholangitis (PSC) often co-exists with inflammatory bowel disease (IBD) and together they are associated with increased risk of complications, including cancer (hepatobiliary, colorectal, gallbladder) and death. Guidelines for follow up and surveillance vary, but our local guidelines advise annual surveillance with magnetic resonance cholangiopancreatography (MRCP), colonoscopy and ultrasound (US) (6 monthly if cirrhotic). We aimed to assess the quality of care in our PSC-IBD patients, including adherence to local surveillance guidelines, and resultant detection of complications, before and after the introduction of an integrated PSC and IBD out-patient service.</p></div><div><h3>Methods</h3><p>Data on management of PSC-IBD patients was collected retrospectively before, and prospectively following, the introduction of an integrated service. Descriptive comparisons of diagnoses, adherence to planned surveillance and outcomes were made between cohorts pre- and post-service redesign.</p></div><div><h3>Results</h3><p>Prior to the service re-design there was significant variability in care and poor adherence to guidelines. Introduction of an integrated PSC-IBD service led to 89 referrals with possible PSC-IBD at 36 months after service re-design. Detailed review led to appropriate identification of 68 PSC-IBD patients. There was significant improvement in surveillance with annual colonoscopy in 90%, MRI/MRCP in 81%, US in 35%, compared to 55%, 55% and 7% respectively in the baseline cohort. This translated to diagnosis and appropriate treatment of colonic dysplasia in 4 patients, colorectal cancer (CRC) in 4 patients and cholangiocarcinoma (CCA) in 2 patients.</p></div><div><h3>Conclusion</h3><p>Establishment of an integrated out-patient service for PSC-IBD patients results in better compliance with guidelines, effective detection of complications, and appropriate management.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"3 2","pages":"Article 100076"},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277294782400001X/pdfft?md5=35c1c6c9dd0795abd3cb099d97232389&pid=1-s2.0-S277294782400001X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139831646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomic features on contrast-enhanced images of the remnant liver predict the prognosis of hepatocellular carcinoma after partial hepatectomy","authors":"Meilong Wu, Liping Liu, Xiaojuan Wang, Ying Xiao, Shizhong Yang, Jiahong Dong","doi":"10.1016/j.iliver.2024.100079","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100079","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"23 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139880292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-based pathological analysis of liver cancer: Current advancements and interpretative strategies","authors":"Guang-Yu Ding, Jieyi Shi, Xiao-Dong Wang, Bo Yan, Xi-Yang Liu, Qiang Gao","doi":"10.1016/j.iliver.2024.100082","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100082","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"46 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139815267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role of extracellular vesicles as hepatic diagnostic and therapeutic tools: Can the dream come true?","authors":"Nourhan Badwei","doi":"10.1016/j.iliver.2024.100078","DOIUrl":"https://doi.org/10.1016/j.iliver.2024.100078","url":null,"abstract":"","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"64 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139891489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}