iGIE最新文献

{"title":"Practices and perceptions of advanced endoscopic imaging techniques for colorectal neoplasia detection in patients with inflammatory bowel disease: report of a survey among Canadian inflammatory bowel disease specialists","authors":"Lisa M.A. van Lierop MD, PhD,&nbsp;Rebecca Dang MSc,&nbsp;Talat Bessissow MD, MSc,&nbsp;Neeraj Narula MD, MPH,&nbsp;Timothy Ramsay PhD,&nbsp;Peter Greenstreet PhD,&nbsp;Frank Hoentjen MD, PhD,&nbsp;Sanjay K. Murthy MD, MSc","doi":"10.1016/j.igie.2026.02.006","DOIUrl":"10.1016/j.igie.2026.02.006","url":null,"abstract":"<div><h3>Background and Aims</h3><div>This study surveyed Canadian inflammatory bowel disease (IBD) specialists to understand their perceptions, preferences, and practices regarding image-enhancement modalities (including dye-spray chromoendoscopy [DCE], virtual chromoendoscopy [VCE], and artificial intelligence [AI]-aided endoscopy) for colorectal neoplasia (CRN) detection in IBD, to inform future studies and recommendations.</div></div><div><h3>Methods</h3><div>Developed collaboratively by IBD experts and methodologists, the survey assessed physicians' attitudes toward colonoscopy image-enhancement modalities for CRN surveillance in IBD, evaluating 5 domains: current practices, familiarity with advanced techniques, perceptions of AI-assisted endoscopy, barriers to adoption, and research priorities. It was distributed to IBD specialists affiliated with the Canadian IBD Research Consortium and conducted per The Strengthening the Reporting of Observational Studies in Epidemiology guidelines.</div></div><div><h3>Results</h3><div>Of 82 specialists invited, 33 responded (40.2%). Most worked in academic centers (90%); 39.4% managed large IBD practices. VCE was the most used advanced imaging modality (84.8%), followed by DCE (33.3%), high-definition white-light endoscopy (HD-WLE) plus nontargeted biopsies (33.3%), AI-assisted colonoscopy (18.2%), and HD-WLE alone (6.1%). Although 60.6% considered DCE and VCE similarly effective, drawbacks included bowel preparation (VCE: 26.6%; DCE: 24.1%) and poor visualization with inflammation (VCE: 26.6%; DCE: 12%). AI-assisted colonoscopy was seen as promising for CRN detection; 78.8% agreed randomized controlled trials are needed, and 39.4% would adopt AI if it improved CRN detection by 5% over HD-WLE.</div></div><div><h3>Conclusions</h3><div>This survey highlights a shift toward VCE over DCE, perceived drawbacks of chromoendoscopy, limited availability and uncertainty about AI-assisted colonoscopy, and a desire for research to demonstrate AI's utility for CRN detection in IBD.</div></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"5 2","pages":"Pages 173-181.e6"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the immune-mediated colitis endoscopic score using a retrospective cohort of patients with immune-mediated colitis","authors":"Malek Shatila MD,&nbsp;Carolina Colli Cruz MD,&nbsp;Krishnavathana Varatharajalu MD,&nbsp;Andres Caleb Urias Rivera MD,&nbsp;Kian Abdul-Baki MD,&nbsp;Kei Takigawa MD,&nbsp;Tanvi Gupta MD,&nbsp;Elliot Baerman MD,&nbsp;Linfeng Lu MD,&nbsp;Irene Jeong-Ah Lee MD,&nbsp;Hamza Salim MD,&nbsp;Raakhi Menon MD,&nbsp;Andrew Sullivan MD,&nbsp;Varun Vemulapalli MD,&nbsp;Cristina Natha MD,&nbsp;Ayesha Khan MD,&nbsp;Petros Grivas MD,&nbsp;David Faleck MD,&nbsp;Michael Dougan MD,&nbsp;Anusha Shirwaiker Thomas MD,&nbsp;Yinghong Wang MD, PhD","doi":"10.1016/j.igie.2025.09.002","DOIUrl":"10.1016/j.igie.2025.09.002","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Immune-mediated colitis (IMC) is a challenging adverse effect of immune checkpoint inhibitor therapy, often leading to treatment interruption or discontinuation. Current IMC endoscopic scoring systems were adapted from those used for inflammatory bowel disease but fail to fully capture IMC. The newly proposed IMC endoscopic score (IMCES) seeks to help guide prognosis and treatment. We aimed to validate IMCES and explore its association with IMC clinical severity and outcomes.</div></div><div><h3>Methods</h3><div>This single-center retrospective study included patients with IMC who received immune checkpoint inhibitors and underwent endoscopic evaluation. IMCESs were calculated on the basis of 10 gross endoscopic features, as previously reported. Patients were divided into those with IMCES &lt;4 and IMCES ≥4. Primary end points were selective immunosuppressive therapy (SIT) use, hospitalization, and clinical and endoscopic remission.</div></div><div><h3>Results</h3><div>We evaluated 807 patients, including the 308 previously used to develop IMCES, with 499 in a validation cohort. We found that IMCES ≥4 was associated with need for steroids and SIT (<em>P</em> &lt; .05). Patients with IMCES ≥4 also tended to be hospitalized more often and longer (<em>P</em> &lt; .05). Including ulceration as a criterion in IMCES strengthened these associations. Clinical symptoms had lower specificities for being associated with SIT use (26.8% for diarrhea, 64.6% for colitis) compared to IMCES ≥4 (91.5%).</div></div><div><h3>Conclusions</h3><div>IMCES ≥4 had a high specificity for the need for SIT and was associated with worse outcomes. Given the importance of risk stratification in the treatment of IMC to inform the early introduction of SIT, IMCES may be a powerful clinical tool to estimate prognosis and guide management but requires further validation.</div></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"5 2","pages":"Pages 136-144.e5"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13323902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence for pancreatic cyst dysplasia grading: a multicenter endoscopic ultrasound study","authors":"Miguel Mascarenhas Saraiva MD, PhD,&nbsp;Joana Mota MD,&nbsp;Belén Agudo MD,&nbsp;Francisco Mendes MD,&nbsp;Jessica Widmer DO,&nbsp;Tiago Ribeiro MD,&nbsp;António Pinto da Costa MD,&nbsp;Miguel Martins MD,&nbsp;Maria João Almeida MD,&nbsp;Daniel de la Iglesia MD,&nbsp;Carlos Esteban MD,&nbsp;Ana Garcia de Paredes MD,&nbsp;Maria Moris MD,&nbsp;Mateus F. de Carvalho MD,&nbsp;Marcos Lera MD,&nbsp;João Ferreira PhD,&nbsp;Filipe Vilas-Boas MD, PhD,&nbsp;Pedro Moutinho-Ribeiro MD, PhD,&nbsp;Susana Lopes MD, PhD,&nbsp;Mariano Gonzalez-Haba MD,&nbsp;Guilherme Macedo MD, PhD","doi":"10.1016/j.igie.2026.02.002","DOIUrl":"10.1016/j.igie.2026.02.002","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Pancreatic cystic lesions (PCLs) are increasingly detected because of the widespread use of imaging techniques. Among them, mucinous PCLs carry a higher malignancy risk, with intraductal papillary mucinous neoplasms (IPMNs) being the most frequent subtype. Accurate stratification based on the degree of dysplasia—low-grade dysplasia (LGD) versus high-grade dysplasia or carcinoma (HGD/C)—is essential to guide clinical management and avoid unnecessary surgical interventions. This study aimed to develop and evaluate a deep learning model for stratifying IPMNs into HGD/C and LGD using endoscopic ultrasound (EUS) images.</div></div><div><h3>Methods</h3><div>This multicenter study included EUS images collected from 5 centers across Spain, Brazil, and the United States. Ground truth classification of IPMNs was established through cytologic and biochemical analysis of cyst fluid, EUS-guided through-the-needle biopsy, or surgical specimens. A deep learning model was trained to distinguish LGD from HGD/C. Model performance was assessed on the basis of sensitivity, specificity, accuracy, and area under the precision–recall curve.</div></div><div><h3>Results</h3><div>A total of 51,046 EUS images were extracted from 30 examinations performed at 5 centers in Portugal, Spain, Brazil, and the United States. The model distinguished IPMNs with HGD/C from those with LGD with a sensitivity of 95.7%, a specificity of 88.7%, and an overall accuracy of 87.2%. The area under the receiver operating characteristic curve was 0.951.</div></div><div><h3>Conclusions</h3><div>To our knowledge, this is one of the first studies to evaluate the potential of an artificial intelligence model for dysplasia grading of IPMNs. Prospective validation of our model is necessary to ensure clinical benefit.</div></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"5 2","pages":"Pages 123-130.e1"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid growth of esophageal papilloma after chemoradiotherapy for esophageal cancer","authors":"Kentaro Kawamura MD,&nbsp;Yutaka Okagawa MD, PhD,&nbsp;Norito Suzuki MD,&nbsp;Masahiro Hirakawa MD, PhD,&nbsp;Kohichi Takada MD, PhD","doi":"10.1016/j.igie.2025.09.012","DOIUrl":"10.1016/j.igie.2025.09.012","url":null,"abstract":"","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"5 2","pages":"Pages 184-185"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When looks deceive: signet ring cell carcinoma masquerading as solitary pinpoint gastric erosion","authors":"Ashutosh Mohapatra MD, DM,&nbsp;Sonmoon Mohapatra MD","doi":"10.1016/j.igie.2026.01.017","DOIUrl":"10.1016/j.igie.2026.01.017","url":null,"abstract":"","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"5 2","pages":"Pages 201-202"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and ex vivo evaluation of a novel suction-based bile duct biopsy device","authors":"Luca J. Selaru,&nbsp;Jianing Li MD,&nbsp;Romina Roshanshad MD,&nbsp;Surya Evani MBBS,&nbsp;Venkata Akshintala MBBS,&nbsp;Stephen Belkoff PhD,&nbsp;Mouen Khashab MD, MASGE","doi":"10.1016/j.igie.2025.08.010","DOIUrl":"10.1016/j.igie.2025.08.010","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Histologic examination is considered the reference standard for diagnosing cancer. However, bile ducts and other narrow passages in the human body are difficult to biopsy. Current biopsy forceps collect tissue that is directly in front of and perpendicular to the instrument. In bile ducts, this is particularly challenging because angling the forceps is limited by tight spaces. This study presents a novel biopsy device and methodology capable of collecting tissue from areas parallel to the instrument.</div></div><div><h3>Methods</h3><div>We designed a biopsy device featuring a 4-lumen tube that can pass through the biopsy channel of an endoscope. The device includes several key components: a cutting blade, a mechanism to actuate the blade, a vacuum window for suction, and a tissue window for collecting samples. Testing was conducted using a bile duct phantom and a model constructed with porcine tissue.</div></div><div><h3>Results</h3><div>The device was successfully manufactured and tested in a controlled, ex vivo environment. It demonstrated the ability to navigate narrow conduits like bile ducts effectively. In addition, the device was able to suction tissue parallel to the instrument, cut it precisely, and retrieve it for histologic analysis.</div></div><div><h3>Conclusions</h3><div>This newly developed biopsy device offers the ability to obtain tissue samples from areas parallel to the biopsy instrument. The lateral biopsy window significantly expands the surface area for tissue collection, a critical feature for narrow conduits like bile ducts. This advancement is especially important for improving early cancer diagnosis in such areas, where delays can lead to worse prognosis.</div></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"5 2","pages":"Pages 99-103"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous gastric balloon hyperinflation causing renal infarct","authors":"Jeremy Yeo MD, BMedSt,&nbsp;Andrew Lane MBBS,&nbsp;Timothy Hanrahan MBBS, MPhil","doi":"10.1016/j.igie.2025.11.004","DOIUrl":"10.1016/j.igie.2025.11.004","url":null,"abstract":"","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"5 2","pages":"Pages 191-192"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13323897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zenker’s diverticulum in the era of third-space endoscopy: innovations, challenges, and adverse event management","authors":"Dimo Dimitrov MD,&nbsp;Dennis Yang MD,&nbsp;Peter V. Draganov MD","doi":"10.1016/j.igie.2026.01.011","DOIUrl":"10.1016/j.igie.2026.01.011","url":null,"abstract":"<div><div>Endoscopic management of Zenker’s diverticulum has rapidly evolved with the emergence of innovative therapeutic endoscopic approaches and the integration of novel devices. These techniques offer unprecedented precision and safety, although rare, adverse events can become catastrophic if not promptly recognized and managed. This narrative review explores recent innovations in third-space techniques and novel devices, with a focused, detailed discussion on recognizing and effectively managing adverse events.</div></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"5 2","pages":"Pages 241-248"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence detection of endoscopic moderate-to-severe ulcerative colitis: a novel tool to enhance clinical trial recruitment","authors":"Laurie B. Grossberg MD,&nbsp;Grace Geeganage BA,&nbsp;Aditya Mithal MD, PhD,&nbsp;Tina Deyhim MD,&nbsp;Andy Santisteban-Silva,&nbsp;Konstantinos Papamichael MD, PhD,&nbsp;Sami Elamin MD,&nbsp;Adam S. Cheifetz MD,&nbsp;Tyler M. Berzin MD,&nbsp;Loren G. Rabinowitz MD","doi":"10.1016/j.igie.2026.03.001","DOIUrl":"10.1016/j.igie.2026.03.001","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Artificial intelligence (AI) may detect endoscopically active ulcerative colitis (UC) and streamline clinical trial enrollment. Here, we investigate the performance of a commercially available AI model, autoinflammatory bowel disease (AutoIBD)-UC (Virgo Surgical Video Solutions, Inc, San Francisco, Calif, USA), to detect moderate-to-severe UC in colonoscopy videos collected as part of routine clinical practice.</div></div><div><h3>Methods</h3><div>AutoIBD-UC was applied to consecutive endoscopy videos between August 30, 2024, and October 17, 2024. Each video received an AutoIBD score (0-1); videos with scores above a predefined confidence threshold were flagged as possible moderate-to-severe UC. Flagged videos and medical records were reviewed to confirm UC diagnosis and grade Mayo endoscopic subscore (MES). Concurrently, research staff retrospectively reviewed all endoscopy reports to identify 3 cohorts: (1) 20 MES ≥2, (2) 20 non-UC inflammation, and (3) 20 screening colonoscopies. Sensitivity and specificity were calculated for all videos screened by AI. Median AutoIBD scores were compared by MES and disease extent.</div></div><div><h3>Results</h3><div>AutoIBD-UC was applied to 2273 endoscopy videos. Twenty-one videos were flagged, 10 of which had MES ≥2. AutoIBD-UC flagged 9 of 20 videos in cohort 1 and all MES 3 videos. More procedures with extensive (4 of 8) or left-sided disease (5 of 7) were flagged compared with those with proctitis (0 of 5). Median AutoIBD-UC scores differed between MES 2 (0.437; interquartile range [IQR], 0.270-0.571) and MES 3 (0.690; IQR, 0.607-0.765; <em>P</em> = .006), and by disease extent: proctitis (0.224; IQR, 0.193-0.270), left-sided (0.571; IQR, 0.554-0.603), and extensive (0.506; IQR, 0.408-0.598; <em>P</em> = .021). The sensitivity of AutoIBD-UC was 0.47, and the specificity was 0.99.</div></div><div><h3>Conclusions</h3><div>AutoIBD-UC accurately detects moderate-to-severe UC with moderate sensitivity and high specificity. Larger studies are necessary to evaluate AutoIBD-UC's utility as a recruitment aid compared to standard practice.</div></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"5 2","pages":"Pages 131-135"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound–guided fine-needle aspiration of an adrenal mass consistent with pheochromocytoma: a case report","authors":"Theodore W. James MD, MSc,&nbsp;Marek Skacel MD","doi":"10.1016/j.igie.2025.10.008","DOIUrl":"10.1016/j.igie.2025.10.008","url":null,"abstract":"<div><div>Pheochromocytomas are catecholamine-secreting adrenal tumors that are rarely biopsied due to the potential risk of hypertensive crisis and procedural adverse events. We report an unusual case of a 66-year-old woman with an enlarging left adrenal mass and elevated plasma and urine metanephrines. After multidisciplinary discussion, tissue diagnosis was deemed necessary for surgical planning, and she underwent endoscopic ultrasound (EUS)-guided fine-needle aspiration (EUS-FNA) before a planned cortical-sparing adrenalectomy. EUS revealed a 25-mm, well-encapsulated, homogeneous, isoechoic left adrenal lesion without vascularity. Two passes with a 22-gauge needle were performed under intensive hemodynamic monitoring, and there was no hemodynamic instability. Cytology and immunohistochemistry confirmed pheochromocytoma, and the patient subsequently underwent an uneventful laparoscopic adrenalectomy. Although biopsy of suspected pheochromocytoma is not standard practice, this case highlights that EUS-FNA may be a feasible and potentially safe diagnostic approach in select patients. Further study is needed to clarify its role in the evaluation of adrenal masses.</div></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"5 2","pages":"Pages 207-210"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13323926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}