hLife最新文献

{"title":"Ten scientific questions on regional immunity in the pulmonary and respiratory mucosal systems","authors":"778th Xiangshan Science Conference Expert Panel","doi":"10.1016/j.hlife.2025.07.004","DOIUrl":"10.1016/j.hlife.2025.07.004","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 12","pages":"Pages 569-572"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145772004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACE2-using coronaviruses: A global concern","authors":"Zepeng Xu , André Costa Lobato , Kefang Liu , George Fu Gao","doi":"10.1016/j.hlife.2025.09.005","DOIUrl":"10.1016/j.hlife.2025.09.005","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 12","pages":"Pages 615-617"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145772007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From spectrum to species: A new era of medical microbiology with AI-powered Raman spectroscopy","authors":"Ziyi Zhang , Yu Vincent Fu","doi":"10.1016/j.hlife.2025.06.004","DOIUrl":"10.1016/j.hlife.2025.06.004","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 11","pages":"Pages 527-530"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic and therapeutic itaconate treatment alleviates COVID-19-associated lung injury","authors":"Yao Jiang ,&nbsp;Peida Yang ,&nbsp;Bo Yao ,&nbsp;Liang Zhang ,&nbsp;Man Yang ,&nbsp;Yiyi Chen ,&nbsp;Lunzhi Yuan ,&nbsp;Junyu Chen ,&nbsp;Jinhang He ,&nbsp;Xing Lei ,&nbsp;Feng Chen ,&nbsp;Mingxi Yue ,&nbsp;Siping Yan ,&nbsp;Tong Cheng ,&nbsp;Yixin Chen ,&nbsp;Quan Yuan ,&nbsp;Jun Zhang ,&nbsp;Shuhai Lin ,&nbsp;Tianying Zhang ,&nbsp;Ningshao Xia","doi":"10.1016/j.hlife.2025.06.006","DOIUrl":"10.1016/j.hlife.2025.06.006","url":null,"abstract":"<div><div>Itaconate (ITA), an immunomodulatory metabolite with known anti-inflammatory properties, has underexplored therapeutic or prophylactic potential against coronavirus disease 2019 (COVID-19). Using an interanimal transmission golden hamster model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced acute lung injury, we first assessed ITA changes in dNS1-RBD-vaccinated hamsters <em>via</em> metabolomic profiling. Then, we evaluated prophylactic intranasal (20 mg/kg at 9, 6, and 3 days before SARS-CoV-2 infection) and therapeutic intraperitoneal (100 mg/kg at 6, 24, and 48 hours post-infection) ITA administration, assessed by histopathology, transcriptomic, and metabolomic profiling, followed by multi-omics integration, including gene expression clustering, pathway enrichment, and cytokine/chemokine–metabolites correlation analyses. Public bronchoalveolar lavage fluid (BALF) single-cell RNA-sequencing (scRNA-seq) datasets from COVID-19 patients were re-analyzed to explore macrophage heterogeneity. Intranasal dNS1-RBD vaccine upregulated ITA levels, prompting further exploration of its immunomodulatory role. Both prophylactic and therapeutic ITA treatments significantly mitigated weight loss and improved lung pathology. Correlation analyses implied a potential regulatory crosstalk between fatty acid β-oxidation (FAO) and reduced inflammatory response. Re-analysis of BALF scRNA-seq dataset highlighted transcriptional networks involving <em>PPARG</em>, <em>RARA</em>, <em>BHLHE41</em>, <em>TCF7L2</em>, and <em>ESRRA</em>—genes linked to macrophage self-renewal and metabolic homeostasis, which appeared to be preserved in ITA-treated hamsters. These findings underscore ITA's role in modulating immunometabolic responses, particularly through FAO-driven macrophage reprogramming, to attenuate SARS-CoV-2-induced lung damage. Together, this study provides insights into host-directed therapies targeting metabolic reprogramming to mitigate COVID-19 severity.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 11","pages":"Pages 551-564"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence serves as a research aide in biology but never eclipses humanity as a successor","authors":"Wei Yang ,&nbsp;Qi Sun ,&nbsp;Yihao Zhang ,&nbsp;Jingshu Yang ,&nbsp;Feng Gao ,&nbsp;Congchao Cheng ,&nbsp;Yu Sun","doi":"10.1016/j.hlife.2025.05.009","DOIUrl":"10.1016/j.hlife.2025.05.009","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 11","pages":"Pages 534-537"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational design of human CD26 receptor for a strong neutralizing ability against MjHKU4r-CoV-1 and MERS-CoV","authors":"Yalei Zhang ,&nbsp;Mingxiong Tian ,&nbsp;Yanjun Han ,&nbsp;Junqing Sun ,&nbsp;Wenwei Li ,&nbsp;Chongzhi Bai ,&nbsp;Chao Su ,&nbsp;Pengcheng Han","doi":"10.1016/j.hlife.2025.05.005","DOIUrl":"10.1016/j.hlife.2025.05.005","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 11","pages":"Pages 565-568"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forging trust in AI-assisted disease diagnosis","authors":"Yangzhihao Zhang ,&nbsp;Mengjie Fang ,&nbsp;Xin Feng ,&nbsp;Xu-Yao Zhang ,&nbsp;Xuebin Xie ,&nbsp;Di Dong","doi":"10.1016/j.hlife.2025.05.011","DOIUrl":"10.1016/j.hlife.2025.05.011","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 11","pages":"Pages 531-533"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The terra incognita in microbiology for artificial intelligence and where to go next","authors":"Siqi Guo ,&nbsp;Jun Wang","doi":"10.1016/j.hlife.2025.06.002","DOIUrl":"10.1016/j.hlife.2025.06.002","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 11","pages":"Pages 524-526"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enabling manufacture and access to advanced therapy medicinal products in low- and middle-income countries","authors":"Antonio Carlos Campos de Carvalho ,&nbsp;Camile Giaretta Sachetti ,&nbsp;Marco Aurélio Krieger","doi":"10.1016/j.hlife.2025.07.001","DOIUrl":"10.1016/j.hlife.2025.07.001","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 11","pages":"Pages 521-523"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell transcriptome analysis reveals mechanism of phosphodiesterase inhibitor in neonatal mouse infection-associated liver injury treatment","authors":"Xixi Chen ,&nbsp;Yanhui Xu ,&nbsp;Huifang Ren ,&nbsp;Xiaolei Wang ,&nbsp;Andrew M. Lew ,&nbsp;Yuxia Zhang ,&nbsp;Zhe Wen","doi":"10.1016/j.hlife.2025.04.002","DOIUrl":"10.1016/j.hlife.2025.04.002","url":null,"abstract":"<div><div>Virus-induced neonatal liver failure remains a critical health challenge with poorly understood mechanisms. This study employed a comprehensive approach to investigate the pathological role of phosphodiesterase 4B (PDE4B) in rotavirus-associated liver injury. In this study, we utilized a mouse model of virus-induced liver injury model through the intraperitoneal injection of rhesus rotavirus (RRV) into newborn BALB/c mice, and applied dipyridamole as treatment strategy. We performed single cell sequencing and high-resolution immune landscape exploration on liver samples (<em>n</em> = 3 per group) from control (50 μL phosphate-buffered saline [PBS]), RRV-infected mice (50 μL PBS with 1.5 × 10⁶ plaque-forming units of RRV on the first day), and dipyridamole-treated mice (RRV-injected mice with 2.5 mg/kg/day dipyridamole for 12 days). We showed that dipyridamole-mediated inhibition of phosphodiesterases (PDEs) restored the differentiation trajectory of neutrophils by suppressing their activation and promoting clearance. In addition, dipyridamole suppressed the activation of autoreactive B cells and cytotoxic lymphocytes, which collectively ameliorated liver pathology and improved neonatal survival following RRV infection. In summary, we demonstrated that inhibition of phosphodiesterase signaling alleviates liver failure in murine models of neonatal rotavirus infection, thereby revealing a candidate strategy to treat rotavirus-associated diseases in neonates.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 11","pages":"Pages 538-550"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}