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Drug-induced liver injury: An overview and update 药物性肝损伤:综述与最新进展
Gastroenterology & Endoscopy Pub Date : 2023-04-01 DOI: 10.1016/j.gande.2022.11.005
Yujie Wang, Wen Xie
{"title":"Drug-induced liver injury: An overview and update","authors":"Yujie Wang,&nbsp;Wen Xie","doi":"10.1016/j.gande.2022.11.005","DOIUrl":"https://doi.org/10.1016/j.gande.2022.11.005","url":null,"abstract":"<div><p>Drug-induced liver injury (DILI) is a relatively rare but important adverse event for a variety of commonly used drugs, herbal and dietary supplements, illegal drugs and novel agents. The actual epidemiology of DILI is difficult to evaluate and varies between different countries. Many risk factors have been identified for DILI but the exact and detailed mechanisms of DILI still remain largely unknown. DILI has been typically classified as direct or idiosyncratic, but indirect injury has been recognized as the third type of DILI. It is difficult to predict and prevent DILI due to the lack of acute diagnosis tools. Many novel serum biomarkers have been identified for DILI and need further study in the clinic. For management, discontinuation of suspicious drugs is the first and important step. Effective drugs treatment is limited but novel drugs have been explored. Novel drugs, such as immune checkpoint inhibitors and monoclonal antibodies, have emerging as important causative agents of DILI. This paper reviewed the epidemiology, risk factors, pathogenesis, clinical presentation, causative agents, diagnosis and management of DILI.</p></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"1 2","pages":"Pages 102-109"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49885375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prediction of esophageal varices in patients with hepatitis B-associated liver cirrhosis by non-invasive markers 用无创标志物预测乙型肝炎相关肝硬化患者食管静脉曲张
Gastroenterology & Endoscopy Pub Date : 2023-04-01 DOI: 10.1016/j.gande.2023.02.002
Lili Gao, Yijin Zhang, Xuesong Gao, Li Xu, Xuefei Duan
{"title":"Prediction of esophageal varices in patients with hepatitis B-associated liver cirrhosis by non-invasive markers","authors":"Lili Gao,&nbsp;Yijin Zhang,&nbsp;Xuesong Gao,&nbsp;Li Xu,&nbsp;Xuefei Duan","doi":"10.1016/j.gande.2023.02.002","DOIUrl":"https://doi.org/10.1016/j.gande.2023.02.002","url":null,"abstract":"<div><h3>Aims</h3><p>To assess the non-invasive markers for diagnosing and grading esophageal varices(EV) in hepatitis B-associated liver cirrhosis by non-invasive method.</p></div><div><h3>Methods</h3><p>A total of 209 treatment-naive patients with hepatitis B-associated liver cirrhosis were included in this study. These patients were divided into no EV, large grade EV and any grade EV groups according to electronic gastroscope (EGD) results. Blood tests, physical examination, and abdominal ultrasound scan (USS) were measured. The non-invasive indexes for predicting esophageal varices were screened, and non conditional logistic regression model was established. Performance was expressed as sensitivity, specificity, positive, and negative predictive values (PPV, NPV), accuracy, and area under the curve (AUC).</p></div><div><h3>Results</h3><p>In the 209 patients, 155 (74.2%) EV and 106(50.7%) large EV were found. There were significant differences in spleen-length (SL), portal vein diameter (PVD), platelet blood cell (PLT) and white blood cell (WBC) between patients with any grade or large and without EV by univariate analysis. The logistic regression model was Y=-2.083-0.011∗PLT+0.101∗PVD+0.013∗SL with any grade EV, the prediction formula is Y= ​0.427-0.013∗PLT -0.861∗WBC+0.008∗SL with large EV.</p></div><div><h3>Conclusions</h3><p>Spleen-length, portal vein diameter, platelet and white blood cell can predict esophageal varices and large esophageal varices in hepatitis B-associated liver cirrhosis.</p></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"1 2","pages":"Pages 87-90"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49885376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: Chronic hepatitis C with anti-HCV positive and serum HCV RNA negative 病例报告:慢性丙型肝炎，抗HCV阳性，血清HCV RNA阴性
Gastroenterology & Endoscopy Pub Date : 2023-04-01 DOI: 10.1016/j.gande.2022.11.004
Huihui Lu , Wen Deng , Yao Lu , Lu Zhang , Yao Xie , Minghui Li
{"title":"Case report: Chronic hepatitis C with anti-HCV positive and serum HCV RNA negative","authors":"Huihui Lu ,&nbsp;Wen Deng ,&nbsp;Yao Lu ,&nbsp;Lu Zhang ,&nbsp;Yao Xie ,&nbsp;Minghui Li","doi":"10.1016/j.gande.2022.11.004","DOIUrl":"https://doi.org/10.1016/j.gande.2022.11.004","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"1 2","pages":"Pages 120-123"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49860257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenesis and endoscopic treatment of gastroparesis 胃轻瘫的发病机制及内镜治疗
Gastroenterology & Endoscopy Pub Date : 2023-04-01 DOI: 10.1016/j.gande.2022.11.008
Ying Wu, Ni Xie, Yineng Yu, Baiwen Li
{"title":"Pathogenesis and endoscopic treatment of gastroparesis","authors":"Ying Wu,&nbsp;Ni Xie,&nbsp;Yineng Yu,&nbsp;Baiwen Li","doi":"10.1016/j.gande.2022.11.008","DOIUrl":"https://doi.org/10.1016/j.gande.2022.11.008","url":null,"abstract":"<div><p>Gastroparesis is a common functional disorder characterized by chronic upper gastrointestinal symptoms and objective evidence of non-mechanically obstructive delayed gastric emptying. Oxidative stress and inflammation are the core mechanisms of gastroparesis, and it has pathological changes such as loss of Interstitial Cajal Cell (ICC), decreased innervation, immune infiltration, and myofibrosis. In recent years, there has been innovation and development in endoscopic treatment of gastroparesis, among which G-POEM has shown good clinical efficacy. Other endoscopic treatments, such as gastric electrical stimulation, intra-pyloric botulinum toxin injection, pyloric stenting, gastrostomy or anastomosis, also contribute to improving delayed gastric emptying and alleviating symptoms of gastroparesis. This article reviews the physiological changes and pathological mechanisms of gastroparesis and the latest progress in treatment. The review aims to evaluate the effectiveness of current endoscopic therapies and explore possible improvements in the treatment of gastroparesis.</p></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"1 2","pages":"Pages 110-117"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49860258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A tale of gastroenterology & endoscopy: It was the best of times 胃肠病学和内窥镜检查的故事:那是最好的时代
Gastroenterology & Endoscopy Pub Date : 2023-01-01 DOI: 10.1016/j.gande.2022.12.001
Lianyong Li, Jun Cheng
{"title":"A tale of gastroenterology & endoscopy: It was the best of times","authors":"Lianyong Li,&nbsp;Jun Cheng","doi":"10.1016/j.gande.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.gande.2022.12.001","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"1 1","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49698829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Curing the disease and recovering as Before”：Super minimally invasive surgery “治病如初”:超微创手术
Gastroenterology & Endoscopy Pub Date : 2023-01-01 DOI: 10.1016/j.gande.2023.02.001
Shuai Zhang , Ningli Chai , Yingdi Liu
{"title":"“Curing the disease and recovering as Before”：Super minimally invasive surgery","authors":"Shuai Zhang ,&nbsp;Ningli Chai ,&nbsp;Yingdi Liu","doi":"10.1016/j.gande.2023.02.001","DOIUrl":"https://doi.org/10.1016/j.gande.2023.02.001","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"1 1","pages":"Page 11"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49698842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The diagnostic utility of endocytoscopy for the detection of esophageal lesions: A systematic review and meta-analysis 内吞镜检查在食管病变诊断中的应用:一项系统综述和荟萃分析
Gastroenterology & Endoscopy Pub Date : 2023-01-01 DOI: 10.1016/j.gande.2023.01.002
Lu Wang , Bofu Tang , Feifei Liu, Zhenyu Jiang, Xianmei Meng
{"title":"The diagnostic utility of endocytoscopy for the detection of esophageal lesions: A systematic review and meta-analysis","authors":"Lu Wang ,&nbsp;Bofu Tang ,&nbsp;Feifei Liu,&nbsp;Zhenyu Jiang,&nbsp;Xianmei Meng","doi":"10.1016/j.gande.2023.01.002","DOIUrl":"https://doi.org/10.1016/j.gande.2023.01.002","url":null,"abstract":"<div><h3>Objective</h3><p>To systematically evaluate the value of endocytoscopy (ECS) in the diagnosis of early esophageal cancer (EC).</p></div><div><h3>Methods</h3><p>Pubmed, Ovid and EMbase databases were searched to collect diagnostic tests of ECS assisted diagnosis of early EC. The retrieval time was from the establishment of the database to August 2022. Review manager 5.4, Stata 16.0 and Meta-Disc 1.4 were used for meta-analysis after two researchers independently screened literature, extracted data and evaluated the bias risk of included studies.</p></div><div><h3>Results</h3><p>A total of 7 studies were included, including 520 lesions. Meta-analysis results showed that the combined sensitivity (SE), specificity (SP), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and positive posterior probability (PPP) of ECS screening for early EC were 0.95 [95%<em>CI</em>: 0.84, 0.98], 0.92 [95%<em>CI</em>: 0.83, 0.96], 11.8 [95%<em>CI</em>: 5.3, 26.1], 0.06 [95%<em>CI</em>: 0.02, 0.18], 203 [95%<em>CI</em>: 50, 816], and 75%, respectively. The area (AUC) under the summary receiver Operating Characteristic curve (SROC) was 0.98 [95%<em>CI</em>: 0.96, 0.99].</p></div><div><h3>Conclusions</h3><p>Current evidence suggests that ECS can be used as an effective screening tool for early EC. Due to the limited number and quality of included studies, it is imperative to conduct more high-quality studies to verify the above conclusions.</p></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"1 1","pages":"Pages 12-17"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49698847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Super minimally invasive surgery: New directions and new goals 超微创手术：新方向、新目标
Gastroenterology & Endoscopy Pub Date : 2023-01-01 DOI: 10.1016/j.gande.2022.11.002
Enqiang Linghu
{"title":"Super minimally invasive surgery: New directions and new goals","authors":"Enqiang Linghu","doi":"10.1016/j.gande.2022.11.002","DOIUrl":"https://doi.org/10.1016/j.gande.2022.11.002","url":null,"abstract":"<div><p>The advancement of medicine is changing with each passing day, and the surgical mode is constantly bringing forth the new. At present, the surgical mode is developing from traditional open surgery and minimally invasive surgery (MIS) to super minimally invasive surgery (SMIS). Treatment concept of traditional surgery is based on the removal of the lesions and partial or complete involved organs, and the reconstruction of normal anatomical structure is bound to have an important negative impact on human body. Under the guidance of SMIS, the lesions are removed while the integrity of organ anatomy is preserved, so as to achieve the goal of \"curing the disease and recovering as before\". SMIS points out the direction for the development of surgery in the future.</p></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"1 1","pages":"Pages 3-4"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49698825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Recent progress in gut microbiota 肠道微生物群研究进展
Gastroenterology & Endoscopy Pub Date : 2023-01-01 DOI: 10.1016/j.gande.2022.11.001
Danying Cheng, Huichun Xing
{"title":"Recent progress in gut microbiota","authors":"Danying Cheng,&nbsp;Huichun Xing","doi":"10.1016/j.gande.2022.11.001","DOIUrl":"https://doi.org/10.1016/j.gande.2022.11.001","url":null,"abstract":"<div><p>There are hundreds of millions of microorganisms in the human intestines, and the unity of the interaction between intestinal microbiota and their hosts is called intestinal microecology. Intestinal microecology involves in many physiological processes, such as metabolism and immune regulation, directly affecting human health. Besides digestive tract diseases, the imbalance in intestinal microecology has also been identified as closely associated with the occurrence and development of liver diseases, tumors, cardiovascular diseases, metabolic-related diseases, and neurological and psychiatric diseases. Microecological therapeutic strategies targeting intestinal microbiota are a potential novel treatment for various chronic diseases. This paper reviewed the research progress in intestinal microecology in recent years.</p></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"1 1","pages":"Pages 27-31"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49698860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hepatic amyloidosis accompanied with massive ascites and kidney impairment: A case report 肝淀粉样变伴大量腹水及肾脏损害1例
Gastroenterology & Endoscopy Pub Date : 2023-01-01 DOI: 10.1016/j.gande.2022.11.003
Huihui Lu , Tingting Jiang , Lu Zhang , Yao Xie , MingHui Li
{"title":"Hepatic amyloidosis accompanied with massive ascites and kidney impairment: A case report","authors":"Huihui Lu ,&nbsp;Tingting Jiang ,&nbsp;Lu Zhang ,&nbsp;Yao Xie ,&nbsp;MingHui Li","doi":"10.1016/j.gande.2022.11.003","DOIUrl":"https://doi.org/10.1016/j.gande.2022.11.003","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"1 1","pages":"Pages 24-26"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49779360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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