Gastroenterology & Endoscopy最新文献

{"title":"Multimodal learning in gastrointestinal diseases","authors":"Luwen Zhang ,&nbsp;Yubing Shen ,&nbsp;Wentao Gu ,&nbsp;Peng Wu","doi":"10.1016/j.gande.2025.10.001","DOIUrl":"10.1016/j.gande.2025.10.001","url":null,"abstract":"<div><div>Gastrointestinal diseases represent a significant global health challenge, with current diagnostic and management approaches constrained by the integration of heterogeneous multimodal data. This review synthesizes the development prospects of multimodal applications in gastroenterology. By summarizing recent literatures, we demonstrate how multimodal integration can facilitate gastrointestinal disease screening, enable more accurate staging, support treatment decision-making, and optimize clinical workflows. Feature-level fusion serves as the dominant technique in current implementations, while hybrid approaches combining multiple fusion levels are increasingly adopted to enhance flexibility in complex clinical scenarios. Despite these advances, retrospective performance does not guarantee clinical success. Persistent challenges, including data heterogeneity, modality incompleteness, and barriers to clinical translation, remain to be addressed. Overall, this review underscores the transformative potential of multimodal learning to advance precision gastroenterology through integrated diagnostic and therapeutic.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 4","pages":"Pages 251-258"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145332467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of artificial intelligence in ultrasonographic diagnosis of liver cancer: Current status and future perspectives","authors":"Yubing Shen ,&nbsp;Luwen Zhang ,&nbsp;Peng Wu","doi":"10.1016/j.gande.2025.09.002","DOIUrl":"10.1016/j.gande.2025.09.002","url":null,"abstract":"<div><div>With the rapid advancement of artificial intelligence (AI) technologies, ultrasonography has undergone transformative progress in the diagnosis of liver cancer. This review summarizes the latest developments of AI-assisted ultrasonographic diagnosis of liver cancer, including commonly used ultrasound modalities (such as B-mode ultrasound and contrast-enhanced ultrasound) and their applicability across different patient populations. AI models have demonstrated superior performance in tasks such as distinguishing malignant from benign lesions, tumor subtyping, and multitask learning. They are particularly proficient in detecting small lesions, extracting quantitative imaging features, and minimizing subjective bias. Technological advancements in this field have evolved from traditional machine learning to deep learning and further to multimodal fusion approaches. The focus has shifted from static image analysis to dynamic video processing, from single-task models to multitask frameworks, and from model-centric development to clinical integration. Although many AI models have outperformed traditional diagnostic methods and even expert radiologists in performance, their clinical translation remains hindered by several challenges. These include the scarcity of high-quality annotated data, absence of standardized protocols, limited model interpretability, and complexities in multimodal data integration. Future directions should concentrate on establishing standardized multicenter databases, advancing privacy-preserving federated learning techniques, strengthening interdisciplinary collaboration, and conducting prospective clinical validation and real-world studies. As a non-invasive and efficient tool, AI-assisted ultrasonographic diagnosis of liver cancer holds great promise in the era of precision medicine.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 4","pages":"Pages 241-250"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145332466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to missing informed consent forms","authors":"","doi":"10.1016/j.gande.2025.06.002","DOIUrl":"10.1016/j.gande.2025.06.002","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 4","pages":"Page 230"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to previously published articles regarding missing conflict-of-interest disclosures","authors":"","doi":"10.1016/j.gande.2025.06.003","DOIUrl":"10.1016/j.gande.2025.06.003","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 4","pages":"Page 231"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized controlled trials evaluating large language models in digestive diseases: a scoping review","authors":"Peng Wu ,&nbsp;Fuxiao Li ,&nbsp;Yuanxi Jia ,&nbsp;Jiaqian Yin ,&nbsp;Yubing Shen ,&nbsp;Yanxiao Gao ,&nbsp;Ying Li ,&nbsp;Feng Sha ,&nbsp;Zhirong Yang ,&nbsp;Jinling Tang","doi":"10.1016/j.gande.2025.09.003","DOIUrl":"10.1016/j.gande.2025.09.003","url":null,"abstract":"<div><div>This scoping review summarizes the current landscape of randomized controlled trials (RCTs) evaluating the use of large language models (LLMs) in digestive diseases. We conducted a systematic search of PubMed, Web of Science, Scopus, and CENTRAL for published RCTs, and of ClinicalTrials.gov and the International Clinical Trials Registry Platform (ICTRP) for ongoing trials. We included RCTs on digestive diseases in which LLMs were the primary intervention. A total of four published and ten ongoing RCTs were identified. Most trials were conducted in China and the United States, primarily as single-country, single-center studies. Gastrointestinal diseases were the main focus, followed by hepatobiliary conditions. The assessed LLM applications predominantly supported clinical decision-making and patient education, with question answering emerging as the most common natural language processing task. Notably, the trials were relatively balanced in their use of general-purpose versus domain-specific LLMs, reflecting diverse strategies in model deployment. The most common study design involved comparisons between LLM-assisted and unassisted approaches, with primary outcomes centered on various aspects of care management. The main limitation of this review is the relatively small number of available studies. Despite this, the identified trials highlight the promising potential of LLM applications in digestive diseases. Further international, multicenter, well-reported RCTs with a focus on real patient outcomes are urgently needed to confirm the usefulness of LLMs in clinical practice.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 4","pages":"Pages 232-240"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145332465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The possibility of artificial intelligence in the management of H. pylori infection","authors":"Zivarifar Hamidreza,&nbsp;Khosravi Manizhe,&nbsp;Keikha Masoud","doi":"10.1016/j.gande.2025.08.002","DOIUrl":"10.1016/j.gande.2025.08.002","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 4","pages":"Pages 221-223"},"PeriodicalIF":0.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Errata regarding missing abstracts in previously published articles","authors":"","doi":"10.1016/j.gande.2025.05.008","DOIUrl":"10.1016/j.gande.2025.05.008","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 193-194"},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The frequency and characteristics of inflammatory bowel disease in pediatric patients with Hirschsprung's disease: A case-control study","authors":"Naghi Dara ,&nbsp;Niloofar Ziba ,&nbsp;Leily Mohajerzadeh ,&nbsp;Yasaman Zarinfar ,&nbsp;Arshia Dara ,&nbsp;Amirhossein Hosseini ,&nbsp;Saleheh Tajalli ,&nbsp;Nathalia Sernizon Guimarães ,&nbsp;Mohammadreza Esmaeili Dooki ,&nbsp;Mahmoud Hajipour ,&nbsp;Farid Imanzadeh","doi":"10.1016/j.gande.2025.06.001","DOIUrl":"10.1016/j.gande.2025.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Hirschsprung disease is associated with enterocolitis and inflammatory bowel disease (IBD) as it affects bowel innervation from birth. This study is about the evaluation of IBD in children with diagnosed Hirschsprung disease.</div></div><div><h3>Methods</h3><div>A case-control study was designed between 2012 and 2021, including patients diagnosed with Hirschsprung disease and IBD (case group) and without IBD (control group). Patients were randomly allocated within each group in a ratio of 4 to 1. The 4:1 ratio of controls to cases was chosen to increase the statistical power of the analysis, given the relatively small number of IBD cases within our Hirschsprung's disease patient population at our center. A checklist was used in the collection of clinical and demographic data, and the data were analyzed using SPSS version 25.</div></div><div><h3>Results</h3><div>This study consisted of 87 patients diagnosed with Hirschsprung's disease, which included 17 patients diagnosed with Hirschsprung's disease and IBD (case group) and 70 controls without IBD (control group). The frequency of IBD among diagnosed Hirschsprung patients is 19.5 ​%. The age of all patients at presentation averaged 20.2 ​± ​33.7 months, with more males noted (62.1 ​%). Typical symptoms preceding diagnosis were constipation (76.7 ​%) and abdominal swollen belly (15.1 ​%). In the IBD population, 17.3 ​% were diagnosed with ulcerative colitis and 2.3 ​% with Crohn's disease at a mean age of 47.9 ​± ​45.7 months. Vomiting (31.3 ​%) and constant watery stools (31.3 ​%) were symptoms of IBD. Mean Age, Failure to thrive, and Diarrhea were the only two variables that were statistically significant in females, p ​&lt; ​0.05.</div></div><div><h3>Conclusion</h3><div>The present study showed very significant differences in the clinical features of Hirschsprung disease patients with and without inflammatory bowel disease and highlighted the importance of timely IBD diagnosis and intervention in children to prevent the worsening of the condition.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 4","pages":"Pages 224-229"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of clinical trials for novel therapeutic approaches in celiac disease","authors":"Anmar AL-Taie,&nbsp;Amina Murodalieva,&nbsp;Maryam Abdullah,&nbsp;Nawaz Khoshnaw","doi":"10.1016/j.gande.2025.05.007","DOIUrl":"10.1016/j.gande.2025.05.007","url":null,"abstract":"<div><div>Celiac disease (CD) is a chronic a multifactorial immune-mediated systemic inflammatory disease of the small intestine caused by genetic and environmental factors, elicited by the ingestion of dietary gluten products and related prolamines. This was to provide a broad overview of the completed clinical trials of various novel treatment approaches that are emerging in the current literature, summarising the latest clinical advances of published work from these clinical trials, as well as the possibilities for using them in future clinical practice for CD treatment. A systematic literature search was carried out using PRISMA guidelines and searching through different databases of the clinical trials of novel treatment approaches for CD treatment. Most of the retrieved publications were concerning latiglutenase and larazotide as the two drugs currently undergoing most of the clinical trials to mitigate gluten sensitisation. On the other hand, the results of blocking IL-15 with PRN15 were somewhat disappointing and may have significant adverse effects. Patients who are inevitably suffering from dietary limitations may find hope in these innovative therapies, although it is yet unclear how effective, in the long run, these medications will be useful in treating CD-related extraintestinal symptoms and disorders.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 170-183"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of sleep apnea amongst the population of Saudi Arabia","authors":"Muazzam Sheriff Maqbul ,&nbsp;Lina Mohammad Haytham Mawardi ,&nbsp;Reem Khalid bin Brik ,&nbsp;Leen Abdulkareem Fida ,&nbsp;Hala Ramzi Alsaedi ,&nbsp;Shuroq Saleh Basawaidan ,&nbsp;Amira Musaeed Mohammed ,&nbsp;Ashjan Nasser Abdurabu Bamarhool ,&nbsp;Moayad Abdulraouf Ahmed ,&nbsp;Rghad Mazen Aloufi ,&nbsp;Noura Majdy Abdulghani ,&nbsp;Hala Marwan Shaaban ,&nbsp;Abdulrahman Ismail Maqbool Ahmed ,&nbsp;Omar Hussain Mohsin Alsaggaf ,&nbsp;Fatimah Bandar Bawazir","doi":"10.1016/j.gande.2025.05.006","DOIUrl":"10.1016/j.gande.2025.05.006","url":null,"abstract":"<div><h3>Introduction</h3><div>This cross-sectional study aimed to assess the prevalence of sleep apnea among the gastritis population in Saudi Arabia and explore its associations with sociodemographic factors, health conditions, and lifestyle habits.</div></div><div><h3>Method</h3><div>A total of 696 participants aged 18 years and older with gastritis were recruited from diverse regions within Saudi Arabia. Data collection included a structured questionnaire to evaluate symptoms of sleep apnea, gastritis health conditions, and lifestyle factors.</div></div><div><h3>Results</h3><div>The findings revealed a significant prevalence of sleep apnea, particularly among older adults, males, and individuals with gastritis health conditions along with hypertension, diabetes, and obesity. Notably, 40 ​% of respondents reported gastritis health issues with high blood pressure and obesity showing strong correlations with sleep apnea prevalence due to gastritis. Despite high rates of sleep-related symptoms—such as difficulty sleeping and frequent awakenings—only 15 ​% of participants had received a formal diagnosis, and even fewer were undergoing treatment.</div></div><div><h3>Conclusion</h3><div>The results reveal a significant gap in healthcare access and awareness of sleep apnea, highlighting the need for better screening and diagnosis. Recommendations include public health campaigns, enhanced healthcare training, and improved access to sleep specialists to address this public health issue in Saudi Arabia and the broader Middle East region.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 125-134"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}