Gastroenterology & Endoscopy最新文献

{"title":"Errata regarding missing abstracts in previously published articles","authors":"","doi":"10.1016/j.gande.2025.05.008","DOIUrl":"10.1016/j.gande.2025.05.008","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 193-194"},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of clinical trials for novel therapeutic approaches in celiac disease","authors":"Anmar AL-Taie,&nbsp;Amina Murodalieva,&nbsp;Maryam Abdullah,&nbsp;Nawaz Khoshnaw","doi":"10.1016/j.gande.2025.05.007","DOIUrl":"10.1016/j.gande.2025.05.007","url":null,"abstract":"<div><div>Celiac disease (CD) is a chronic a multifactorial immune-mediated systemic inflammatory disease of the small intestine caused by genetic and environmental factors, elicited by the ingestion of dietary gluten products and related prolamines. This was to provide a broad overview of the completed clinical trials of various novel treatment approaches that are emerging in the current literature, summarising the latest clinical advances of published work from these clinical trials, as well as the possibilities for using them in future clinical practice for CD treatment. A systematic literature search was carried out using PRISMA guidelines and searching through different databases of the clinical trials of novel treatment approaches for CD treatment. Most of the retrieved publications were concerning latiglutenase and larazotide as the two drugs currently undergoing most of the clinical trials to mitigate gluten sensitisation. On the other hand, the results of blocking IL-15 with PRN15 were somewhat disappointing and may have significant adverse effects. Patients who are inevitably suffering from dietary limitations may find hope in these innovative therapies, although it is yet unclear how effective, in the long run, these medications will be useful in treating CD-related extraintestinal symptoms and disorders.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 170-183"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of sleep apnea amongst the population of Saudi Arabia","authors":"Muazzam Sheriff Maqbul ,&nbsp;Lina Mohammad Haytham Mawardi ,&nbsp;Reem Khalid bin Brik ,&nbsp;Leen Abdulkareem Fida ,&nbsp;Hala Ramzi Alsaedi ,&nbsp;Shuroq Saleh Basawaidan ,&nbsp;Amira Musaeed Mohammed ,&nbsp;Ashjan Nasser Abdurabu Bamarhool ,&nbsp;Moayad Abdulraouf Ahmed ,&nbsp;Rghad Mazen Aloufi ,&nbsp;Noura Majdy Abdulghani ,&nbsp;Hala Marwan Shaaban ,&nbsp;Abdulrahman Ismail Maqbool Ahmed ,&nbsp;Omar Hussain Mohsin Alsaggaf ,&nbsp;Fatimah Bandar Bawazir","doi":"10.1016/j.gande.2025.05.006","DOIUrl":"10.1016/j.gande.2025.05.006","url":null,"abstract":"<div><h3>Introduction</h3><div>This cross-sectional study aimed to assess the prevalence of sleep apnea among the gastritis population in Saudi Arabia and explore its associations with sociodemographic factors, health conditions, and lifestyle habits.</div></div><div><h3>Method</h3><div>A total of 696 participants aged 18 years and older with gastritis were recruited from diverse regions within Saudi Arabia. Data collection included a structured questionnaire to evaluate symptoms of sleep apnea, gastritis health conditions, and lifestyle factors.</div></div><div><h3>Results</h3><div>The findings revealed a significant prevalence of sleep apnea, particularly among older adults, males, and individuals with gastritis health conditions along with hypertension, diabetes, and obesity. Notably, 40 ​% of respondents reported gastritis health issues with high blood pressure and obesity showing strong correlations with sleep apnea prevalence due to gastritis. Despite high rates of sleep-related symptoms—such as difficulty sleeping and frequent awakenings—only 15 ​% of participants had received a formal diagnosis, and even fewer were undergoing treatment.</div></div><div><h3>Conclusion</h3><div>The results reveal a significant gap in healthcare access and awareness of sleep apnea, highlighting the need for better screening and diagnosis. Recommendations include public health campaigns, enhanced healthcare training, and improved access to sleep specialists to address this public health issue in Saudi Arabia and the broader Middle East region.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 125-134"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic marginal assessment of fixed colorectal polyps accurately predicts complete resection after cold snare polypectomy:a prospective single-center observational study","authors":"Xianzong Ma ,&nbsp;Changwei Duan ,&nbsp;Yuli Liu ,&nbsp;Hua Jin ,&nbsp;Mingjie Zhang ,&nbsp;Jianqiu Sheng ,&nbsp;Peng Jin ,&nbsp;Yufen Tang ,&nbsp;Lang Yang ,&nbsp;Yuqi He","doi":"10.1016/j.gande.2025.05.003","DOIUrl":"10.1016/j.gande.2025.05.003","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to ascertain the effectiveness of using fixed cold snare polypectomy (CSP) specimens, accompanied by endoscopic assessment, in predicting complete resection outcomes.</div></div><div><h3>Methods</h3><div>In this prospective, single-center, observational investigation, patients with colorectal polyps measuring 5–15 ​mm were enrolled, who underwent CSP between August 2018 and January 2020. Following resection, the specimens were procured and fixed. The primary focus was on evaluating the accuracy of endoscopic margin appraisal of the fixed specimens in forecasting complete resection. The generalized estimating equation model was employed to delve into the potential risk factors contributing to false-positive endoscopic margin assessments of these fixed specimens.</div></div><div><h3>Results</h3><div>A cohort of 150 patients, presenting with 260 polyps, were included in the analysis. The CSP procedure achieved a remarkable complete resection rate of 98.5 ​%. In assessing the accuracy of endoscopic evaluation for complete resection in fixed specimens with negative margins, we observed a sensitivity of 100.0 ​%, specificity of 87.1 ​%, an area under the curve (AUC) of 93.6 ​%, and an overall accuracy of 87.3 ​%. Crucial insights from the multivariate regression analysis unveiled sessile serrated lesions (SSL) as an independent risk factor for generating false-positive results during endoscopic margin assessments of fixed specimens, with an odds ratio of 3.5 (95 ​% CI: 1.3–9.3, P ​= ​0.011).</div></div><div><h3>Conclusions</h3><div>Endoscopic assessment's negative lateral margin could accurately predict complete resection in fixed specimens. The fixed specimens of SSL are not suitable for margin assessment by endoscopy after fixation.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 152-158"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the gut Speaks: The hidden toll of irritable bowel syndrome on body and mind","authors":"Yasser Fakri Mustafa","doi":"10.1016/j.gande.2025.05.002","DOIUrl":"10.1016/j.gande.2025.05.002","url":null,"abstract":"<div><div>Irritable bowel syndrome (IBS) is a multifaceted gastrointestinal disorder that transcends the gut, affecting the physical, psychological, and social well-being of millions worldwide. Despite its prevalence, IBS remains enigmatic, with no single biomarker or diagnostic test providing clarity. This review explores the intricate interplay of genetic, dietary, and psychological factors that contribute to IBS, revealing its profound impact on both individual lives and society at large. From debilitating gastrointestinal symptoms to comorbid anxiety and depression, the disorder imposes substantial personal and economic burdens. New research shows that the gut-brain axis is a key player in the pathophysiology of IBS, connecting microbial dysbiosis and changes caused by stress. New dietary approaches, like the low FODMAP diet, have shown promise in managing symptoms, but the fact that different patients react differently demonstrates how complicated this condition is. Pharmacological treatments offer limited relief, while psychological therapies, such as cognitive behavioral therapy, address the psychosomatic dimensions of IBS, fostering resilience and coping. This article advocates for a multidisciplinary approach to IBS management, integrating dietary guidance, stress reduction, pharmacotherapy, and psychological support to improve patient outcomes. It also emphasizes the need for future research to unravel IBS's molecular underpinnings and develop targeted therapies. By bridging gaps in understanding and care, this review aims to shed light on the hidden toll of IBS, inspiring innovation and compassion in its treatment.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 135-151"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper GI endoscopy in children with Helicobacter pylori Infection: Insights from a six-year retrospective review","authors":"Rafia Rashid,&nbsp;Salahuddin Mahmud,&nbsp;Madhabi Baidya,&nbsp;Ahmed Rashidul Hasan,&nbsp;Tanzila Farhana,&nbsp;Syed Shafi Ahmed","doi":"10.1016/j.gande.2025.05.005","DOIUrl":"10.1016/j.gande.2025.05.005","url":null,"abstract":"<div><h3>Purpose</h3><div><em>Helicobacter pylori</em> (<em>H. pylori</em>) is a prevalent bacterial infection acquired primarily during childhood, particularly in regions with poor sanitation and overcrowding. In Bangladesh, limited data exists on pediatric <em>H. pylori</em> infections and their endoscopic findings. This study aimed to evaluate the clinical presentations, endoscopic features, and histopathological findings of children with <em>H. pylori</em> infection in a tertiary care center.</div></div><div><h3>Methods</h3><div>This retrospective study was conducted at Bangladesh Shishu Hospital &amp; Institute between July 2018 and September 2024. A total of 1145 upper gastrointestinal (GI) endoscopies were performed, with 241 children included based on positive Rapid Urease Test (RUT) or Campylobacter-like Organism (CLO) test results. Demographic data, clinical symptoms, and endoscopic findings in the esophagus, stomach, and duodenum were recorded. Biopsies were taken for histopathological examination. Data analysis was descriptive, with results presented as frequencies.</div></div><div><h3>Results</h3><div>Among the 241 patients, 58 ​% were male, with a mean age of 8.6 years. The common presenting symptom was recurrent abdominal pain (62 ​%), followed by vomiting (15 ​%) and hematemesis/melena (12 ​%). Endoscopic findings revealed multiple erythematous lesions in the stomach in 88 ​% of cases, with nodular lesions present in 7 ​% of duodenal cases. Histopathological examination confirmed chronic gastritis in 82 ​% of patients and chronic gastritis with duodenitis in 15 ​%.</div></div><div><h3>Conclusion</h3><div>Recurrent abdominal pain and erythematous gastric lesions were the predominant clinical and endoscopic findings in children with <em>H. pylori</em> infection. Chronic gastritis was the most common histopathological diagnosis. Early diagnosis through upper GI endoscopy is crucial in managing pediatric <em>H. pylori</em> infections to prevent complications. To further refine management strategies and enhance generalizability, future studies should incorporate multicenter cohorts, include <em>H. pylori</em>-negative controls, and assess antibiotic resistance patterns.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 159-164"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of key genes and pathways in the following pancreatic ductal adenocarcinoma (PDAC) using integrated bioinformatics analysis","authors":"Manish Shukla ,&nbsp;Jai Chand Patel ,&nbsp;Meenakshi Shukla","doi":"10.1016/j.gande.2025.05.004","DOIUrl":"10.1016/j.gande.2025.05.004","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, and understanding its molecular mechanisms is critical for improving diagnosis and treatment. This study analyzed microarray datasets (GSE16515, GSE28730, GSE62165, and GSE91035) from the Gene Expression Omnibus to identify differentially expressed genes (DEGs) in PDAC. A total of 1917 upregulated and 1003 downregulated genes were identified across 323 PDAC and matched normal samples. Hierarchical clustering analysis revealed four distinct clusters, with Cluster 2 exhibiting higher gene expression changes. Further analysis identified 23 significantly upregulated genes, including AHNAK2, CDH3, CEACAM1, CEACAM5, COL10A1, FN1, KRT19, MMP11, and TRIM29. Functional enrichment analysis indicated that these genes were involved in processes such as cell adhesion, extracellular matrix (ECM) structural constituents, and receptor-ligand interactions. Key pathways included pancreatic secretion, protein digestion, absorption, and ECM-receptor interactions. Survival analysis revealed that high expression levels of AHNAK2, CDH3, CEACAM6, COL17A1, CXCL5, and others were associated with poor prognosis. Validation confirmed overexpression of these genes in PDAC tissues. These findings highlight the potential role of genes from the AHNAK2, Laminin family (LAMC2, LAMB3), and fibronectin (FN1) in PDAC progression. The study provides valuable insights into the molecular mechanisms underlying PDAC and identifies potential biomarkers for prognosis and therapeutic targets.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 195-210"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ilaprazole: Distinctive pharmacokinetic and pharmacodynamic properties among proton pump inhibitors","authors":"Hubert Igno Castus,&nbsp;Bhuvaneshwar Amanan,&nbsp;Hariharan Murugadoss,&nbsp;Priyadharshini Ananthathandavan","doi":"10.1016/j.gande.2025.04.001","DOIUrl":"10.1016/j.gande.2025.04.001","url":null,"abstract":"<div><div>Ilaprazole is a new proton pump inhibitor (PPI) that provides effective and sustained intragastric acid suppression. As PPIs are foundational medications in the treatment of acid-related disorders, the introduction of new PPIs into clinical practice is encouraged. Despite dose and frequency adjustments of standard PPIs, 15–30 ​% of Gastroesophageal reflux disease (GERD) patients remain resistant to acid suppression therapy. Persistent symptoms may result from inadequate acid inhibition or other causes, such as non-acid reflux. Most existing benzimidazole PPIs, such as omeprazole, lansoprazole, and pantoprazole, have a short plasma half-life (less than 2 ​h), leading to the need for new medications that provide consistent and prolonged acid suppression. This study aims to highlight the unique pharmacokinetic and pharmacodynamic characteristics of ilaprazole. Unlike other PPIs, ilaprazole does not exhibit genetic polymorphism effects on drug metabolism. Incorporating ilaprazole into standard triple therapy for <em>Helicobacter pylori</em> infection enhances eradication rates and improves clinical outcomes. Studies have shown that ilaprazole possesses superior <em>H. pylori</em> eradication and ulcer-healing properties. Additionally, this study examines how drug interactions with ilaprazole differ from those of other PPIs. Initial findings indicate that ilaprazole has fewer interactions compared to commonly used PPIs. This review suggests that ilaprazole could be a better alternative compared to other PPI.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 184-192"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic efficacy of computed tomography angiography for acute gastrointestinal bleeding","authors":"Joseph Atarere ,&nbsp;Thilini Delungahawatta ,&nbsp;Boniface Mensah ,&nbsp;Ramya Vasireddy ,&nbsp;Ted O. Akhiwu ,&nbsp;Yakubu Bene-Alhasan ,&nbsp;Sarah Rimm ,&nbsp;Jose Mari Parungao ,&nbsp;Dana Sloane ,&nbsp;Christopher Haas ,&nbsp;David Weisman ,&nbsp;Haider Naqvi","doi":"10.1016/j.gande.2025.03.004","DOIUrl":"10.1016/j.gande.2025.03.004","url":null,"abstract":"<div><h3>Background and aims</h3><div>Computed tomography angiography (CTA) is the radiologic test for acute gastrointestinal bleeding (GIB). We aimed to (1) identify the clinical factors associated with (a) positive CTA findings, (b) positive esophagogastroduodenoscopy (EGD) findings after a negative CTA, and (2) compare bleeding severity on EGD by CTA findings.</div></div><div><h3>Methods</h3><div>Using data from a retrospective cohort of patients, we examined the factors associated with positive CTA findings and those associated with bleeding on EGD after a negative CTA. We examined the severity of upper GIB on EGD by findings on CTA and compared bleeding severity with the Glasgow Blatchford Score (GBS). We also evaluated the factors associated with high-grade bleeding lesions on EGD.</div></div><div><h3>Results</h3><div>A total of 1677 patients were included in this study, of which 229 (13.7 ​%) had positive CTA findings. A history of GIB, hematochezia on presentation and any length of stay in the ICU were associated with positive CTA findings. Among patients with negative CTA results, hematemesis on presentation [OR 2.94; 95 ​% CI (1.53, 5.64)] and high-risk GBS [OR 5.19; 95 ​% CI (2.02, 13.35)] were associated with finding upper GIB on EGD. ICU admission for 4+ days was associated with higher-grade bleeding lesions. Those with positive CTA findings had a higher proportion of Forrest 1 lesions (10.8 ​% vs 3.7 ​%).</div></div><div><h3>Conclusion</h3><div>Our findings support a low threshold for EGD among patients with extended ICU stays (4+ days) even after a negative CTA. The GBS, validated for risk stratification in upper GIB, remains a useful predictive tool even in the context of a negative CTA.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 2","pages":"Pages 116-124"},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacotherapy challenges in HIV patient with Plummer-Vinson Syndrome","authors":"Priya Manirajan,&nbsp;Palanisamy Sivanandy","doi":"10.1016/j.gande.2025.03.003","DOIUrl":"10.1016/j.gande.2025.03.003","url":null,"abstract":"<div><div>Plummer-Vinson Syndrome (PVS) is a rare condition characterized by the classic triad of dysphagia, iron-deficiency anemia or long-standing anemia, and esophageal web. We present a case of a 38-year-old man who was diagnosed with human immunodeficiency virus, underwent antiretroviral therapy, and faced challenges starting Highly Active Antiretroviral Therapy (HAART) medications due to their size. An esophagogastroduodenoscopy revealed that the patient has Plummer-Vinson Syndrome. Healthcare providers encountered difficulties in optimizing his therapy and initiating HAART medication for his HIV treatment. We present this case due to its rarity.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 3","pages":"Pages 165-169"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}