Gastroenterology & Endoscopy最新文献

{"title":"The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective","authors":"Sheng Chen ,&nbsp;Min Wang ,&nbsp;Shuai Zhang ,&nbsp;Xin Huang ,&nbsp;Xinke Sui ,&nbsp;Dou Li ,&nbsp;Changqing Zhong ,&nbsp;Wei Wu","doi":"10.1016/j.gande.2024.12.003","DOIUrl":"10.1016/j.gande.2024.12.003","url":null,"abstract":"<div><div>Gastroesophageal airway reflux disease (GARD) refers to a class of diseases in which the contents of the digestive system reflux into esophagus, the upper and lower airways, mouth, ear and nose et al., causing uncomfortable symptoms. It covers gastroesophageal reflux disease and extra-esophageal reflux disease. GARD is one of the most common diseases in clinical practice. The main cause of GARD-related clinical symptoms and signs of GARD is the structural damage and functional disability, which were caused by repeated contact between the mucous epithelium of the reflux tract and the acidic and non-acidic components of the reflux. Over the years, major progress has been made in the understanding of the molecular pathogenesis of reflux associated mucosal inflammation, suggesting a complex and multifactorial pathogenesis and immune-mediated effects. Thus, we reviewed the clinical and pathophysiological characteristics of GARD and probe the complexity of the pathogenesis of GARD-related mucosal inflammation from the aspects of microscopic changes and specific molecular mediators. New drug therapies for the mucosal injuries in the reflux tract were also reviewed. From bench to bedside, these novel molecular findings might provide new perspectives and therapeutic approaches for GARD.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 1","pages":"Pages 39-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of mortality for stomach cancer during the past 20 years in the US","authors":"Camilla Mattiuzzi,&nbsp;Giuseppe Lippi","doi":"10.1016/j.gande.2024.09.002","DOIUrl":"10.1016/j.gande.2024.09.002","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 1","pages":"Pages 10-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver lobes and cirrhosis: Diagnostic insights from lobar ratios","authors":"Kriti Pandey ,&nbsp;Debabrata Dash ,&nbsp;Raj Kumar Koiri","doi":"10.1016/j.gande.2024.10.002","DOIUrl":"10.1016/j.gande.2024.10.002","url":null,"abstract":"<div><div>Liver cirrhosis is the formation of abnormal nodular structure and fibrosis. Globally it accounts for 4 ​% of all deaths. Alcohol, viral hepatitis, and non-alcoholic fatty liver disease are the most common cause of cirrhosis. Cirrhosis progresses from the compensated stage to the decompensated stage. It is end-stage liver disease. Anatomically, the liver is divided into four lobes, the right lobe, the left lobe, the caudate lobe, and the quadrate lobe. This lobe varies in size and location within the liver, the right lobe being the largest. Cirrhosis primarily causes portal hypertension which has a varying impact on the four lobes. The right lobe undergoes atrophy due to its acentric location from a central vein and the caudate lobe undergoes hypertrophy due to its central location from the central vein. Preferential perfusion occurs in the caudate lobe and there is a decrease in perfusion in the right lobe. The early non-invasive diagnosis of cirrhosis is required for safe and curable treatment of early-stage cirrhosis. The size variability induced by cirrhosis plays a significant role in its diagnosis. Two key ratios for early cirrhosis detection are the caudate-to-right lobe ratio and the right-to-left lobe ratio, with the former being more substantial. The caudate-to-right-lobe ratio (C/RL) is a key morphological marker for evaluating liver changes in cirrhosis. A C/RL ratio above 0.65 suggests the presence of cirrhosis, making it a valuable tool in diagnosing the condition. These measurements are non-invasive, safe, and crucial for early diagnosis of cirrhosis.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 1","pages":"Pages 1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of peptic ulcer disease and its associated factors in Jeddah Saudi Arabia","authors":"Muazzam Sheriff Maqbul ,&nbsp;Reem Saleh Alzaki ,&nbsp;Reema Sami Meeralam ,&nbsp;Norah Abdulmajeed Alqutami ,&nbsp;Bayan Mohammed Alturki ,&nbsp;Lina Sultan Alhazmi ,&nbsp;Reem Mamdouh Alaseeri ,&nbsp;Lama Saad Alghamdi ,&nbsp;Reem Khalid bin Brik ,&nbsp;Shaima Tariq Mansoor Beig ,&nbsp;Muath Saeed Alamri ,&nbsp;Wjood Abdullah A. Alshehri ,&nbsp;Turki Ayed Almutairi ,&nbsp;Maha Abdullah Alqurashi ,&nbsp;Ahmed Jamal Nasef","doi":"10.1016/j.gande.2024.09.001","DOIUrl":"10.1016/j.gande.2024.09.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Peptic ulcer disease's (PUD) global significance, emphasizing its health burdens and associations with factors like <em>Helicobacter pylori</em> infection and lifestyle habits. The need for comprehensive approaches to prevention and management. Despite global research, there's a gap in understanding PUD in Jeddah, Saudi Arabia, necessitating this study to inform healthcare policies and interventions in the region. The study aims to investigate PUD prevalence, associated factors, healthcare-seeking behavior, and knowledge levels in Jeddah's population to provide insights for public health strategies and clinical practices.</div></div><div><h3>Methodology</h3><div>This cross-sectional study investigated the prevalence of peptic ulcer disease (PUD) and its associated factors in Jeddah, Saudi Arabia, using a validated questionnaire covered demographic details, knowledge, psychosocial aspects, symptoms, healthcare-seeking behavior, and medical history. It was translated into Arabic, culturally adapted, and validated through expert review and pilot testing. A sample size of 561 participants was determined using an online sample calculator, targeting a 95 ​% confidence level. Ethical approval was obtained from the Institutional Research Review Board (IRRB-02-03,092,023). Data was collected through an online survey using convenience sampling and analyzed with SPSS and Excel, employing both descriptive and inferential statistical methods.</div></div><div><h3>Result</h3><div>The survey in Jeddah, Saudi Arabia, examined peptic ulcer disease (PUD) prevalence and associated factors. Demographic analysis showed 561 participants, almost evenly split by gender (269 males, 292 females), with varying ages and educational backgrounds. Symptoms like abdominal pain were prevalent (398 respondents), as were lifestyle factors such as spicy food consumption (456 respondents) and stress (496 respondents). The study revealed a high PUD prevalence, with 463 respondents (82.53 ​%) reporting a history of the disease, primarily gastric ulcers (256 cases, 45.63 ​%) and duodenal ulcers (207 cases, 36.89 ​%). Treatment mainly involved outpatient antibiotic use (419 respondents, 74.68 ​%), while 44 respondents (7.84 ​%) required hospitalization. Reported well-being levels ranged from 1 to 10, with various satisfaction levels among respondents.</div></div><div><h3>Conclusions</h3><div>The study highlighted a substantial prevalence of PUD, primarily gastric ulcers, among participants. The findings advocate for tailored interventions, including education, screening, and treatment optimization, to alleviate the PUD burden and enhance healthcare outcomes. The study offers crucial insights into PUD epidemiology, guiding evidence-based prevention and management strategies.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 1","pages":"Pages 13-21"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Effective non-surgical treatment of hemorrhoids with sclerosing foam and novel injection device” [Gastroenterol Endoscop 2, (4) (2024), 176–180]","authors":"Juan Cabrera Garcia-Olmedo ,&nbsp;Gonzalo López González","doi":"10.1016/j.gande.2025.01.001","DOIUrl":"10.1016/j.gande.2025.01.001","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 1","pages":"Page 53"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The best beginning, a smooth process, and a bright future of gastroenterology & endoscopy","authors":"Lianyong Li ,&nbsp;Jun Cheng","doi":"10.1016/j.gande.2024.12.004","DOIUrl":"10.1016/j.gande.2024.12.004","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 1","pages":"Page A1"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human umbilical cord derived-mesenchymal stem cells alleviate lipid metabolism disturbances of hepatocytes via mitochondrial transport","authors":"Jing Xue ,&nbsp;Xiangnan Hu ,&nbsp;Suying Xia ,&nbsp;Pengfei Ren ,&nbsp;Aihong Wang","doi":"10.1016/j.gande.2024.12.001","DOIUrl":"10.1016/j.gande.2024.12.001","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the effect and mechanism of human umbilical cord derived-mesenchymal stem cells (UC-MSCs) on improving lipid metabolism disorders in vitro.</div></div><div><h3>Methods</h3><div>Human liver cancer cell line HepG2 cells were divided into three groups: normal group, oleic acid treatment group (OA group), and OA ​+ ​MSCs group. Evaluate lipid deposition in HepG2 cells using oil red staining. Use a reagent kit to detect the triglyceride content in HepG2 cells. Evaluate the mitochondrial transport of MSCs to HepG2 cells using immunofluorescence staining and flow cytometry. Perform immunofluorescence staining to observe the formation of intercellular tunnel nanotubes (TNT). Evaluate the effect of UC-MSCs on HepG2 cells after the formation of TNT was inhibited by cytochalasin D (CytoD).</div></div><div><h3>Results</h3><div>Compared with the OA group, the OA ​+ ​MSCs group showed a decrease in lipid deposition and triglyceride content in HepG2 cells. MitoTracker Red dye was used to label MSCs mitochondria, and flow cytometry showed that over 90 ​% of HepG2 cells had MitoTracker Red positive mitochondria, indicating a significant transfer of mitochondria from UC-MSCs to HepG2 cells. Immunofluorescence staining showed the formation of TNT structures between MSCs and HepG2 cells, and identified the transport of UC-MSCs mitochondria through TNT structures. After inhibiting TNT formation using CytoD, the effect of UC-MSCs on improving HepG2 lipid metabolism was weakened.</div></div><div><h3>Conclusion</h3><div>UC-MSCs improve lipid metabolism in HepG2 cells through TNT mediated mitochondrial transport, indicating that mitochondria transfer-based therapies may be an innovative and promising therapeutic strategy for NAFLD.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 1","pages":"Pages 47-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The digestive system under microgravity environment: Changes, mechanisms and the prospects of the future","authors":"Peiming Sun ,&nbsp;Xiaopei Gao ,&nbsp;Dan Wei ,&nbsp;Jun Ge ,&nbsp;Xiangling Deng ,&nbsp;Hongyang Chen ,&nbsp;Heming Yang ,&nbsp;Junfeng Gao ,&nbsp;Jianwu Yang","doi":"10.1016/j.gande.2024.12.002","DOIUrl":"10.1016/j.gande.2024.12.002","url":null,"abstract":"<div><div>In recent years, the space industry has continued to improve and develop, and human beings have been staying in space for longer periods while facing the challenges of microgravity to human life. The normal functioning of the digestive system is an important prerequisite for astronauts in carrying out their missions. Microgravity can have a wide range of effects on the digestive system. In this article, we summarized the literature of recent years and provided an overview of the research progress around the effects of weightlessness on the digestive system and microgravity medicine at the cellular, molecular, and metabolic levels. We aim to provide some guidance for the development of aerospace medicine.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 2","pages":"Pages 108-115"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of knowledge and awareness about Helicobacter pylori infection among urban population of Kingdom of Saudi Arabia","authors":"Muazzam Sheriff Maqbul ,&nbsp;Wjood Abdullah A. Alshehri ,&nbsp;Shaima Tariq Mansoor Beig ,&nbsp;Reem Khalid bin Brik ,&nbsp;Abrar Hassan Alshehri ,&nbsp;Muath Saeed Alamri ,&nbsp;Abdulrahman Adel Abdulrahman Obaid ,&nbsp;Mohammed Shafiq Omar Badhdouh ,&nbsp;Sidra Azhar Khan ,&nbsp;Noor Khalid Salah Hamo ,&nbsp;Asma Ahmed Omar Al-Attas ,&nbsp;Ahmed Mahmoud i hassan","doi":"10.1016/j.gande.2024.08.001","DOIUrl":"10.1016/j.gande.2024.08.001","url":null,"abstract":"<div><h3>Introduction</h3><div>This cross-sectional study investigates the prevalence of knowledge and awareness of <em>Helicobacter pylori (H. pylori)</em> infection among the urban population of the Kingdom of Saudi Arabia (KSA). The study is motivated by the need to understand the specific demographic segments within the urban setting and their awareness levels of this prevalent bacterial infection affecting the digestive system.</div></div><div><h3>Methodology</h3><div>The cross-sectional study, employing a purposive sampling method and involving 840 participants from major cities in the KSA, utilized a structured survey questionnaire to gather data on demographic factors, awareness levels, attitudes, and experiences related to <em>H. pylori</em> infection, with subsequent statistical analysis and adherence to ethical guidelines for participant confidentiality and privacy protection.</div></div><div><h3>Result</h3><div>The study involved 840 participants from major cities, revealing that 59.16 ​% were aware of <em>H. pylori</em>. Demographic variations included higher participation from Jeddah and Riyadh, with the majority being females aged 18–25, Saudi nationals, and individuals with undergraduate education. About 57.02 ​% reported experiencing suspected <em>H. pylori</em> symptoms, and 49.16 ​% had prior infections, with varying severity. Hesitancy toward screening (42.61 ​%), but 72.97 ​% believed in preventability. Limited awareness of treatments (15.35 ​%) and identification of factors like water and food were noted. Participants perceived the seriousness of <em>H. pylori</em> in the mid-range (5–7).</div></div><div><h3>Conclusion</h3><div>The findings shed light on variations in awareness, knowledge gaps, and attitudes, emphasizing the need for targeted public health interventions, educational campaigns, and policy measures to address the challenges associated with <em>H. pylori</em> infections in urban areas.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"2 4","pages":"Pages 196-204"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949752324000438/pdfft?md5=ae4aa6849f47429912392f1e3d0eaaf3&pid=1-s2.0-S2949752324000438-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of BoozLiv™ as an add on therapy in patients with alcoholic liver disease: An open-label, randomized controlled trial","authors":"Mohammad Nezamuddin Khan ,&nbsp;Balavigneshwaran A ,&nbsp;Priyadharshini Ananthathandavan ,&nbsp;Vijayakumar T M ,&nbsp;Rajesh N A ,&nbsp;Pavithra A ,&nbsp;Sumitha A","doi":"10.1016/j.gande.2024.07.007","DOIUrl":"10.1016/j.gande.2024.07.007","url":null,"abstract":"<div><h3>Background</h3><p>Alcoholic Liver Disease (ALD) poses a significant global health threat, contributing to millions of deaths each year. Despite the well-established link between chronic alcohol consumption and liver damage, treatment options remain limited, emphasizing the need for innovative approaches.</p></div><div><h3>Methods</h3><p>An open-label, randomized controlled trial was conducted in India, involving 68 adult ALD patients over a 12-week period. The patients were randomized into two groups: one receiving standard therapy and the other receiving standard therapy along with BoozLiv™ syrup. Liver function tests, Model for End-Stage Liver Disease (MELD) scores, and safety parameters were assessed at various intervals.</p></div><div><h3>Results</h3><p>The study demonstrated that BoozLiv™ syrup, as an add-on therapy, significantly reduced total bilirubin, direct bilirubin, SGOT, SGPT, ALP, and GGT levels compared to standard therapy alone (<em>p ​&lt; ​0.05</em>). The MELD score, indicative of liver function, showed a substantial improvement in the BoozLiv™ group (<em>p ​&lt; ​0.01</em>). Safety analysis revealed that BoozLiv™ was well-tolerated, with only minor adverse effects such as nausea and vomiting reported.</p></div><div><h3>Conclusion</h3><p>BoozLiv™ syrup, used in conjunction with standard therapy, showed promising results in improving liver function and reducing liver damage markers in ALD patients. The safety profile was favorable and no patient has withdrawn their consent due to adverse events. Further long-term studies in larger populations are warranted to validate these findings and establish BoozLiv™ as a potential therapeutic option for ALD.</p></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"2 4","pages":"Pages 168-175"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949752324000426/pdfft?md5=0601f47ce2b8b601a087aa7a88ad0a35&pid=1-s2.0-S2949752324000426-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}