{"title":"Risk of venous thromboembolism greatest within two weeks of long-haul flight","authors":"Fabrice Paganin MD,PhD (Commentary Author)","doi":"10.1016/j.ehbc.2004.03.017","DOIUrl":"https://doi.org/10.1016/j.ehbc.2004.03.017","url":null,"abstract":"<div><h3>Question</h3><p>After a long haul flight, when are people at greatest risk of developing deep vein thrombosis?</p></div><div><h3>Study design</h3><p>Retrospective review and record linkage study.</p></div><div><h3>Main results</h3><p>Of the 13,184 people admitted to a Western Australia hospital during 1981–1999 with a primary diagnosis of venous thromboembolism, 5408 (41%) had arrived on an international flight sometime during the same 18 year period. Of these, 153 Australian citizens and 438 non-Australian citizens were admitted within 100 days of flight arrival (see Table 1). Venous thromboembolism was significantly more likely within the first 14 days of flight arrival for both Australian and non-Australian citizens, compared with the number of events expected under the assumption of a uniform distribution across 100 days (<em>P</em><0.001 for both comparisons). However, these results may have limited generalisability (see notes).<span><div><div><table><tbody><tr><td><strong>Table 1</strong> Observed and expected venous thromboembolism events by time (days) since flight arrival.</td></tr><tr><td>Citizenship</td><td>Days since most recent flight arrival</td></tr><tr><td></td><td>0–14</td><td>15–30</td><td>31–60</td><td>61–100</td><td>Total</td></tr><tr><td><em>Australian</em></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Observed</td><td>46</td><td>23</td><td>32</td><td>52</td><td>153</td></tr><tr><td>Expected<sup>*</sup></td><td>102.6</td><td>113.2</td><td>212.3</td><td>283.0</td><td>711.1</td></tr><tr><td><em>Non-Australian</em></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Observed</td><td>200</td><td>69</td><td>78</td><td>91</td><td>438</td></tr><tr><td>Expected<sup>†</sup></td><td>105.3</td><td>116.2</td><td>217.9</td><td>290.5</td><td>729.9</td></tr><tr><td><sup>*</sup>Estimated from the total number of arrivals of Australian citizens in Western Australia (4.8 million) and the age- and sex-specific baseline rates for venous thromboembolism in the Western Australian population. There were consistently fewer observed venous thromboembolism events than expected events, suggesting a ‘healthy traveller effect’.</td></tr><tr><td><sup>†</sup>Also estimated from the baseline rates for venous thromboembolism in the Western Australian population.</td></tr></tbody></table></div></div></span></p></div><div><h3>Authors’ conclusions</h3><p>There appears to be an increased risk of venous thromboembolism for 2 weeks after arrival from a long-haul flight.</p></div>","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"8 3","pages":"Pages 133-135"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehbc.2004.03.017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71829088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biennial screening mammography is cost effective in healthy women aged over 65 years","authors":"Patricia A Carney PhD (Commentary Author)","doi":"10.1016/j.ehbc.2004.03.015","DOIUrl":"https://doi.org/10.1016/j.ehbc.2004.03.015","url":null,"abstract":"<div><h3>Question</h3><p>What is the cost-effectiveness of screening mammography in women over 65 years old?</p></div><div><h3>Study design</h3><p>Systematic review with narrative synthesis.</p></div><div><h3>Main results</h3><p>Ten studies, out of 115 identified, met inclusion criteria. Studies had similar cost-effectiveness findings; extending biennial screening to ages 75–80 years cost, on average, $34,000–$88,000 per life year gained compared with stopping screening at age 65 (adjusted to 2002 US dollars). Two studies found breast cancer screening less effective at reducing mortality in women with significant comorbidities (dementia, congestive heart failure, or hypertension), thus reducing the cost-effectiveness of screening in this population. No study fully adjusted for potential harms of screening.</p></div><div><h3>Authors’ conclusions</h3><p>In women aged over 65 years without serious comorbidity, biennial breast cancer screening reduces mortality at reasonable costs.</p></div>","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"8 3","pages":"Pages 142-144"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehbc.2004.03.015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71829106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Breast-feeding has little effect on blood pressure in later life","authors":"Undurti N Das MD, FAMS (Commentary Author)","doi":"10.1016/j.ehbc.2004.03.011","DOIUrl":"https://doi.org/10.1016/j.ehbc.2004.03.011","url":null,"abstract":"<div><h3>Question</h3><p>Is breast feeding, compared with bottle feeding with formula milk, associated with lower mean blood pressure in later life?</p></div><div><h3>Study design</h3><p>Systematic review with meta-analysis.</p></div><div><h3>Main results</h3><p>Twenty four studies were identified (12 cross-sectional studies, 11 cohort studies and one randomised controlled trial). Average systolic blood pressure was significantly lower in people who were breast fed as an infant compared with infants that were bottle fed (−1.10<!--> <!-->mmHg, 95% CI -1.78 to -0.42<!--> <!-->mmHg). There was no significant difference in diastolic blood pressure between feeding groups. However, there was significant heterogeneity across studies (see Notes), so these results should be interpreted with caution.</p></div><div><h3>Authors’ conclusions</h3><p>Breast feeding in infancy has at best, a modest effect on systolic blood pressure in later life compared with bottle feeding.</p></div>","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"8 3","pages":"Pages 145-147"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehbc.2004.03.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71829107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addition of artesunate to standard antimalarial drugs reduces treatment failure","authors":"T. Davis","doi":"10.1016/J.EHBC.2004.03.020","DOIUrl":"https://doi.org/10.1016/J.EHBC.2004.03.020","url":null,"abstract":"","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"15 1","pages":"156-158"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82506168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Length of hospital stay for elderly people is substantially higher in the NHS compared with Kaiser Permanente and US Medicare programmes","authors":"D. Sklar","doi":"10.1016/J.EHBC.2004.03.016","DOIUrl":"https://doi.org/10.1016/J.EHBC.2004.03.016","url":null,"abstract":"","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"63 1","pages":"113-115"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81470340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Magnesium sulphate given before birth does not significantly reduce death or cerebral palsy in premature babies, but may improve motor dysfunction☆","authors":"A. Gunn, L. Bennet","doi":"10.1016/J.EHBC.2004.03.003","DOIUrl":"https://doi.org/10.1016/J.EHBC.2004.03.003","url":null,"abstract":"","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"47 1","pages":"162-164"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73829737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A community-based disease management program for postmyocardial infarction reduces hospital readmissions compared with usual care","authors":"Jalal K Ghali MD (Commentary Author)","doi":"10.1016/j.ehbc.2004.03.013","DOIUrl":"https://doi.org/10.1016/j.ehbc.2004.03.013","url":null,"abstract":"<div><h3>Question</h3><p>Do community-based disease management programs for patients recovering from myocardial infarction reduce hospital readmissions compared with usual care?</p></div><div><h3>Study design</h3><p>Randomized controlled trial.</p></div><div><h3>Main results</h3><p>Disease management programme-based care (DMP) significantly reduced hospital re-admission days compared with usual care in patients recovering from myocardial infarction (number of readmission days for angina, congestive heart failure and chronic obstructive pulmonary disease per follow-up days: <span><math><mtext>114</mtext><mtext>30,823</mtext></math></span> with DMP vs. <span><math><mtext>200</mtext><mtext>34,021</mtext></math></span> with usual care; incidence density ratio<span><sup>∗</sup></span> (IDR): 1.59, 95% CI 1.27 to 2.00; <em>P</em><0.001; number of all-cause hospital readmission days: <span><math><mtext>483</mtext><mtext>30,823</mtext></math></span> with DMP vs. <span><math><mtext>814</mtext><mtext>34,021</mtext></math></span> with usual care; IDR: 1.53, 95% CI 1.37 to 1.71; <em>P</em><0.001). There was no significant difference in mortality after discharge between groups (8 with DMP vs. 11 with usual care; <em>P</em>>0.05).</p></div><div><h3>Authors’ Conclusions</h3><p>A community-based disease management program successfully reduced hospitalisation days for patients recovering from myocardial infarction compared with usual care.</p></div>","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"8 3","pages":"Pages 119-121"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehbc.2004.03.013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71829089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of unilateral visual impairment in preschool children modestly improves visual acuity","authors":"Maria S Castanes MPH (Commentary Author)","doi":"10.1016/j.ehbc.2004.03.002","DOIUrl":"https://doi.org/10.1016/j.ehbc.2004.03.002","url":null,"abstract":"<div><h3>Question</h3><p>How effective is treatment for unilateral visual impairment detected by preschool vision screening?</p></div><div><h3>Study design</h3><p>Multicentre randomised controlled trial.</p></div><div><h3>Main Results</h3><p>Glasses plus patch treatment slightly but significantly improved visual acuity (both uncorrected and best corrected) compared with no treatment in children with mild to moderate unilateral visual impairment at 52 weeks (see Table 1; see notes). Glasses alone modestly improved best corrected visual acuity compared with no treatment; however there was no significant difference in uncorrected visual acuity between these groups.<span><div><div><table><tbody><tr><td><strong>Table 1</strong> LogMAR visual acuity scores by treatment group at 52 weeks.</td></tr><tr><td>Visual acuity</td><td>No treatment</td><td>Glasses alone</td><td>Glasses plus Patch</td></tr><tr><td></td><td>Mean logMAR</td><td>Mean logMAR</td><td>Mean difference (95% CI) from no treatment</td><td>Mean logMAR</td><td>Mean difference (95% CI) from no treatment</td></tr><tr><td>Uncorrected</td><td>0.424</td><td>0.381</td><td>0.043 (-0.05 to 0.013)</td><td>0.336</td><td>0.088 (0.01 to 0.17)</td></tr><tr><td>Best corrected</td><td>0.301</td><td>0.216</td><td>0.085 (0.02 to 0.15)</td><td>0.193</td><td>0.109 (0.05 to 0.17)</td></tr></tbody></table></div></div></span></p></div><div><h3>Authors’ conclusions</h3><p>Treatment with glasses alone or in combination with patches can modestly improve visual acuity in children with mild to moderate unilateral visual impairment, compared with no treatment.</p></div>","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"8 3","pages":"Pages 174-175"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehbc.2004.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71829105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Universal screening does not reduce the prevalence of visual impairment in older people","authors":"Robert W Enzenauer MD, MPH (Commentary Author)","doi":"10.1016/j.ehbc.2004.03.009","DOIUrl":"https://doi.org/10.1016/j.ehbc.2004.03.009","url":null,"abstract":"<div><h3>Question</h3><p>Does targeted or universal screening for visual acuity improve visual outcomes in older people?</p></div><div><h3>Study design</h3><p>Cluster randomised controlled trial.</p></div><div><h3>Main results</h3><p>There was no significant difference in the proportion of people with poor visual acuity with universal screening compared with targeted screening at follow-up (median follow-up 3.9 years; absolute risk for acuity <6/18 in either eye: 37.0% (339/978) with universal screening vs. 34.7% (307/829) with targeted screening; RR 1.07, 95% CI 0.84 to 1.36; <em>P</em>=0.58). There was no significant difference in visual function between groups at follow up (mean composite NEI score: 86.0 with universal screening vs. 85.6 with targeted screening; mean difference: 0.4, 95% CI –1.7 to 2.5; <em>P</em>=0.69).</p></div><div><h3>Authors’ conclusions</h3><p>Universal screening for visual impairment in older people as part of multidimensional screening programme did not significantly decrease the overall prevalence of visual impairment.</p></div>","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"8 3","pages":"Pages 150-152"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehbc.2004.03.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71829108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk of AIDS increases in children aged 2 years and older with CD4 T cell percentage less than 15","authors":"W. Moss, D. Persaud","doi":"10.1016/J.EHBC.2004.03.019","DOIUrl":"https://doi.org/10.1016/J.EHBC.2004.03.019","url":null,"abstract":"","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"6 1","pages":"168-170"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86202631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}