中华妇产科杂志最新文献

{"title":"[Guidelines for standardized diagnostic procedures of common vaginitis (2025)].","authors":"","doi":"10.3760/cma.j.cn112141-20250814-00378","DOIUrl":"10.3760/cma.j.cn112141-20250814-00378","url":null,"abstract":"","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"61 2","pages":"89-96"},"PeriodicalIF":0.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Utility of digital pathology image analysis in micropapillary serous borderline ovarian tumor].","authors":"X Xu, H Y Meng, L Zhang, L Yuan, W Chen, W W Cheng","doi":"10.3760/cma.j.cn112141-20250909-00421","DOIUrl":"10.3760/cma.j.cn112141-20250909-00421","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the potential value of quantitative digital pathology analysis in predicting prognosis in micropapillary serous borderline ovarian tumor (MP-SBOT). <b>Methods:</b> Clinical and pathological data from 366 serous borderline ovarian tumor (BOT) patients who attended the First Affiliated Hospital of Nanjing Medical University between October 2012 and November 2023 were retrospectively reviewed. Patients were classified into MP-SBOT group and non-MP-SBOT group according to their pathological subtype. Within the MP-SBOT group, patients were further classified into recurrence and non-recurrence subgroups. Digital image analysis using QuPath was performed on 83 ovarian serous tumors with adequate tissue quality, including MP-SBOT (<i>n</i>=48), SBOT in the non-MP-SBOT group (<i>n</i>=9), serous cystadenoma (<i>n</i>=11), low-grade serous carcinoma (<i>n</i>=7) and high-grade serous carcinoma (<i>n</i>=8). Quantitative pathological features including nuclear area, cellular area, and nuclear-to-cytoplasmic ratio (N/C ratio) of tumor cells were extracted. Univariate and multivariate Cox regression analyses were used to identify factors associated with MP-SBOT recurrence. Kaplan-Meier method was applied to estimate progression-free survival (PFS) time. <b>Results:</b> (1) Compared with non-MP-SBOT group, MP-SBOT group patients exhibited higher median serum carbohydrate antigen 125 level (127.9 <i>vs</i> 36.5 kU/L), higher D-Dimer level (0.7 vs 0.3mg/L), higher proportion of bilateral ovarian tumors (60.4% vs 15.4%), higher proportion of invasive peritoneal implants (25.0% vs 3.1%), higher proportion of International Federation of Gynecology and Obstetrics (FIGO) stage Ⅱ-Ⅲ (54.1% vs 10.0%), higher proportion of mixed cystic-solid mass detected by imaging examination (88.1% vs 70.1%) and higher proportion of recurrence (33.3% vs 13.5%) with statistically significant differences (all <i>P</i><0.001). (2) Quantitative digital pathology revealed the distinct cellular morphologic characteristics in MP-SBOT. The tumor cell N/C ratio was significantly higher in MP-SBOT group than non-MP-SBOT group (0.48 vs 0.41; <i>P</i><0.05). The tumor cell N/C ratio increased progressively with tumor malignancy. (3) Univariate Cox analysis identified tumor cell N/C ratio>0.50 and conservative surgery as factors associated with recurrence in MP-SBOT group. Multivariate analysis confirmed that an elevated tumor cell N/C ratio was an independent risk factor for recurrence in MP-SBOT group (<i>HR</i>=7.278, 95%<i>CI</i>:1.940-27.307, <i>P</i>=0.003). (4) Kaplan-Meier survival analysis showed that patients with tumor cell N/C ratio>0.50 had a significantly shorter median PFS than those with the tumor cell N/C ratio≤0.50 (164.0 vs 35.0 months, <i>P</i><0.001). <b>Conclusions:</b> MP-SBOT display more aggressive clinical features. The elevated tumor cell N/C ratio shows potential clinical value in predicting recurrence in MP-SBOT patients.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"61 2","pages":"128-137"},"PeriodicalIF":0.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical analysis of pregnancy outcomes and prognosis for fetal ventriculomegaly].","authors":"J F Zhai, Y M Qi, J B Wu, H M Tao, J Liang, L B Pang, X M Fu, B Zhang","doi":"10.3760/cma.j.cn112141-20250704-00309","DOIUrl":"10.3760/cma.j.cn112141-20250704-00309","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the factors affecting the clinical outcomes of fetuses with ventriculomegaly (VM), and to provide help for the clinical management of fetuses with VM. &lt;b&gt;Methods:&lt;/b&gt; This was a retrospective study. A total of 208 singleton pregnant women diagnosed with fetal VM in Xuzhou Central Hospital from January 2017 to June 2025 were enrolled. According to the pregnancy outcome, the subjects were divided into induction group (63 cases) and live birth group (145 cases). The two groups were compared in terms of gravidity and parity, mode of conception, parental age at delivery, maternal body mass index (BMI) in early pregnancy, maternal education background, pregnancy complications, adverse pregnancy history, family expectations for the fetus, fetal VM combined intracranial and extracranial abnormalities, and prenatal diagnosis genetic abnormalities. Logistic regression was used to analyze the influencing factors of fetal VM pregnancy outcomes. The clinical outcomes and postnatal development of newborns were followed up. &lt;b&gt;Results:&lt;/b&gt; (1) There were no significant differences between induction group and live birth group in terms of gravidity, mode of conception, parental age at delivery, maternal BMI in early pregnancy, adverse pregnancy history, extracranial abnormalities, and high family expectations (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). (2) The proportions of moderate VM, severe VM, bilateral VM, asymmetric VM, intrauterine progressive VM, VM combined with intracranical abnormalities, fetal genetic abnormalities, pregnancy complications in the induction group were significantly higher than those in the live birth group, while the proportion of high maternal education level was lower than that in the live birth group (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). (3) Univariate logistic regression analysis showed that moderate to severe VM, bilateral VM, asymmetric VM, intrauterine progressive VM, VM combined with intracranial abnormalities and genetic abnormalities were risk factors for induction of labor in VM fetuses, while high maternal education level was a protective factor for live birth in VM fetuses (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). Multivariate logistic regression analysis showed that moderate to severe VM, bilateral VM, intrauterine progressive VM, and prenatal genetic abnormalities were independent risk factors for abortion of VM fetuses, and high maternal education level was an independent protective factor for live birth of VM fetuses (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). (4) Among the 145 live births, 5 were preterm births and 140 were term births. During the follow-up period (6 months to 7 years after birth), 139 cases were normal, 1 case died at 6 months after birth, 1 case had Crouzon syndrome, and 4 cases had motor and/or language development disorders. &lt;b&gt;Conclusions:&lt;/b&gt; Moderate to severe VM, bilateral VM, intrauterine progressive VM, genetic abnormalities, and high maternal education level are independent risk factors for fetal VM. Multidisciplinary team cooperatio","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"61 2","pages":"104-113"},"PeriodicalIF":0.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between maternal pre-pregnancy body mass index and clinical pregnancy outcomes and perinatal outcomes of single live birth in frozen-thawed embryo transfer cycles].","authors":"H Y Hao, Y G Xiang, X J Geng, N Jia, C L Zhang, M Li, S D Zhang","doi":"10.3760/cma.j.cn112141-20250423-00163","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20250423-00163","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the relationship between maternal pre-pregnancy body mass index (BMI) and clinical pregnancy outcomes and singleton live birth outcomes in frozen-thawed embryo transfer (FET) cycles. &lt;b&gt;Methods:&lt;/b&gt; A total of 45 856 patients who underwent FET in Henan Provincial People's Hospital and the Second Affiliated Hospital of Zhengzhou University from January 2013 to December 2023 were retrospectively analyzed, including 15 960 singleton live births. Based on the female's BMI, they were divided into the underweight group (BMI&lt;18.5 kg/m&lt;sup&gt;2&lt;/sup&gt;), the normal weight group (BMI 18.5-&lt;25.0 kg/m&lt;sup&gt;2&lt;/sup&gt;), the overweight group (BMI 25.0-&lt;30.0 kg/m&lt;sup&gt;2&lt;/sup&gt;), and the obese group (BMI≥30.0 kg/m&lt;sup&gt;2&lt;/sup&gt;). Multivariate linear models and logistic regression models were used to evaluate the effects of maternal pre-pregnancy BMI on clinical pregnancy outcomes and singleton live birth outcomes. Generalized additive model was used to fit the curve between maternal pre-pregnancy BMI and perinatal outcomes and to determine the threshold. &lt;b&gt;Results:&lt;/b&gt; (1) Among 45 856 FET patients, there were 2 390 cases (5.21%) in the underweight group, 30 177 cases (65.81%) in the normal weight group, 10 835 cases (23.63%) in the overweight group, and 2 454 cases (5.35%) in the obesity group. The early abortion rate of overweight and obesity group, the clinical pregnancy rate and live birth rate of underweight group, the clinical pregnancy rate of obesity group were higher than those of normal weight group, and the live birth rate of overweight group was lower than that of normal weight group, and the differences were statistically significant (all &lt;i&gt;P&lt;/i&gt;&lt;0.01). (2) Among the 15 960 singleton live birth FET patients, 926 (5.80%) were in underweight group, 10 620 (66.54%) were in normal weight group, 3 561 (22.31%) were in overweight group, and 853 (5.34%) were in obesity group. The incidences of preterm birth, extremely preterm birth, macrosomia and large for gestational age (LGA) in the overweight and obese groups were significantly higher than those in the normal weight group (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). The incidence of small for gestational age (SGA) infants in the underweight group was significantly higher than that in the normal weight group, while the incidences of preterm birth, macrosomia and LGA infants were all significantly lower than those in the normal weight group (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). (3) Maternal pre-pregnancy overweight and obesity were associated with early miscarriage (a&lt;i&gt;OR&lt;/i&gt;=1.20, 1.37), preterm birth (a&lt;i&gt;OR&lt;/i&gt;=1.49, 1.70), very preterm birth (a&lt;i&gt;OR&lt;/i&gt;=1.64, 2.09), macrosomia (a&lt;i&gt;OR&lt;/i&gt;=1.87, 2.57), and LGA (a&lt;i&gt;OR&lt;/i&gt;=1.55, 1.95), and the risks of live birth (a&lt;i&gt;OR&lt;/i&gt;=0.87, 0.80) and low birth weight infant (a&lt;i&gt;OR&lt;/i&gt;=0.65, 0.51) were significantly decreased (all &lt;i&gt;P&lt;/i&gt;&lt;0.01). Maternal pre-pregnancy underweight had no significant effect on early miscarriage, clinical pregnancy and live birth (all &lt;i&gt;P&lt;/","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"61 1","pages":"39-49"},"PeriodicalIF":0.0,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Value of self-sampling cervical exfoliated cells of HPV E6/E7 mRNA detection in cervical cancer screening: a multicenter clinical study].","authors":"F Y Xiao, R C Ma, Y X Wang, J W Zhou, J W Li, L Sui","doi":"10.3760/cma.j.cn112141-20250909-00420","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20250909-00420","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the clinical value of self-sampling cervical exfoliated cells of HPV E6/E7 mRNA detection in cervical cancer screening. <b>Methods:</b> A total of 778 participants from Obstetrics and Gynecology Hospital of Fudan University, the Second Affiliated Hospital of Zhejiang University School of Medicine, Lianyungang Maternity and Child Health Hospital of Jiangsu Province, Yancheng Maternity and Child Health Hospital of Jiangsu Province and Yangzhou Maternity and Child Health Hospital of Jiangsu Province who were volunteered to engage in the study of self-sampling cervical exfoliated cells of HPV E6/E7 mRNA detection were included from March 2023 to April 2024. Both self-collected and clinician-collected samples underwent HPV E6/E7 mRNA detection. Statistical analysis was performed to compare the detection consistency between the two methods, and a questionnaire survey was used to assess participants' acceptance of self-sampling. <b>Results:</b> Among 778 participants, the sensitivity between self-collected and clinician-collected samples was 90.8%, specificity was 97.8%, and the overall agreement rate was 96.5%. The Kappa value was 0.883 (<i>P</i><0.001), indicating high consistency between the two methods. Stratified analysis revealed that Kappa value>0.8, overall agreement >95.0% in different age groups and geographical regions. The questionnaire showed that 95.9% of participants preferred self-sampling, citing ease of use (43.6%), convenience (40.6%), and privacy (30.5%) as primary reasons. Additionally, 64.3% participants favored hospitals as the preferred location for self-sampling. <b>Conclusion:</b> Self-sampling demonstrates high consistency with clinician sampling for HPV E6/E7 mRNA testing and excellent acceptance, suggesting its potential as an effective tool to improve the coverage of cervical cancer screening.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"61 1","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Comparative analysis of clinicopathological and molecular characteristics between pure ovarian endometrioid carcinoma and synchronous endometrial and ovarian endometrioid carcinoma].","authors":"C Wang, X Y Zhao, Y Liu, Y X Wang, J Yang, Z X Song, C R Liu","doi":"10.3760/cma.j.cn112141-20250721-00330","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20250721-00330","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the differences in clinicopathological and molecular characteristics between pure ovarian endometrioid carcinoma (POEC) and synchronous endometrial and ovarian endometrioid carcinoma (SEOEC), aiming to provide a basis for their differential diagnosis and individualized treatment. &lt;b&gt;Methods:&lt;/b&gt; Clinical and pathological data were collected from ovarian endometrioid carcinoma patients and they were divided into POEC group (219 cases) and SEOEC group (169 cases) according to whether they had endometrioid endometrial carcinoma or not. Clinical data including the age at onset, reasons for medical consultation, maximum diameter of ovarian tumors and pathological examination results such as histologic grading of the lesions were collected. Additionally, follow-up outcomes and survival status of the patients were also recorded. Molecular subtyping results were obtained from 108 cases of POEC group and 109 cases of SEOEC group patients. Large-scale targeted sequencing using next-generation sequencing was performed on 76 POEC group samples (32 with matched peripheral blood) and 51 SEOEC group samples (46 with matched peripheral blood/normal tissue). The prognosis of POEC group and SEOEC group were analyzed. Moreover, SEOEC group were further stratified to high-risk group and low-risk group according to 2020 WHO classification of tumors and 2023 International Federation of Gynecology and Obstetrics (FIGO) staging of endometrial cancer. &lt;b&gt;Results:&lt;/b&gt; (1) Clinicopathological characteristics: compared to the SEOEC group, POEC group patients exhibited the following characteristics: younger age at diagnosis (50.0 years &lt;i&gt;vs&lt;/i&gt; 38.0 years, &lt;i&gt;P&lt;/i&gt;&lt;0.001), higher proportion presenting with typical ovarian cancer symptoms (45.7% &lt;i&gt;vs&lt;/i&gt; 92.1%, &lt;i&gt;P&lt;/i&gt;&lt;0.001), higher detection rates of ovarian endometriosis (14.9% &lt;i&gt;vs&lt;/i&gt; 56.2%, &lt;i&gt;P&lt;/i&gt;&lt;0.001) and uterine adenomyosis (23.0% &lt;i&gt;vs&lt;/i&gt; 37.0%, &lt;i&gt;P&lt;/i&gt;=0.021), higher proportion of low grade tumors (78.7% &lt;i&gt;vs&lt;/i&gt; 95.4%, &lt;i&gt;P&lt;/i&gt;&lt;0.001), lower proportion of mismatch repair deficiency subtype (23.9% &lt;i&gt;vs&lt;/i&gt; 3.7%, &lt;i&gt;P&lt;/i&gt;&lt;0.001). (2) Gene mutation profile: although the driver gene mutation profiles were similar between the two groups, POEC group patients had a significantly lower PTEN (22.4% &lt;i&gt;vs&lt;/i&gt; 64.0%, &lt;i&gt;P&lt;/i&gt;&lt;0.001) and CTNNB1 (22.4% &lt;i&gt;vs&lt;/i&gt; 48.0%, &lt;i&gt;P&lt;/i&gt;=0.014) mutation rates compared to SEOEC group. Also, POEC group had a higher KRAS mutation rate than SEOEC group patients (50.0% &lt;i&gt;vs&lt;/i&gt; 28.0%, &lt;i&gt;P&lt;/i&gt;=0.055). (3)Prognosis: survival analysis revealed that POEC group patients had a significantly shater progression free survival time compared to the low-risk SEOEC group patients(&lt;i&gt;P&lt;/i&gt;=0.046). However, their long-term survival outcomes (both overall survival and disease specific survival) were significantly better than those of the high-risk SEOEC group patients (&lt;i&gt;P&lt;/i&gt;=0.018 and &lt;i&gt;P&lt;/i&gt;=0.046, respectively). &lt;b&gt;Conclusions:&lt;/b&gt; POEC and SEOEC rep","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"61 1","pages":"50-59"},"PeriodicalIF":0.0,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Detection of fetal cardiac dysgenesis by SNP array technology and the variation hotspots of the local population].","authors":"L Ma, X Yang, R M Liu, H Wu, J Liu, C M Sun","doi":"10.3760/cma.j.cn112141-20250627-00301","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20250627-00301","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the application of single nucleotide polymorphism array (SNP array) in the detection of fetal cardiac dysplasia and to explore the characteristics of chromosomal variants associated with fetal cardiac dysplasia in the local population. &lt;b&gt;Methods:&lt;/b&gt; A total of 556 pregnant women who underwent SNP array examination in Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University from January 2021 to December 2024 because of abnormal soft index or structural malformations of fetal heart development by ultrasound examination were collected. According to the results of fetal ultrasound examination, they were divided into single abnormal soft markers group (237 cases), multiple abnormal soft index group (232 cases), soft index combined with cardiac structural abnormalities group (24 cases), isolated cardiac structural abnormalities group (47 cases), and cardiac structural abnormalities combined with other systemic abnormalities group (16 cases). According to the age of pregnant women, they were divided into ≤25 years old group (20 cases), 26-29 years old group (155 cases), 30-34 years old group (190 cases), 35-39 years old group (149 cases) and ≥40 years old group (42 cases). The differences in the detection of chromosomal abnormalities in pregnant women with different echocardiographic results and different ages were compared. &lt;b&gt;Results:&lt;/b&gt; (1) Among the 556 pregnant women who underwent SNP array for fetal cardiac anomalies, 110 cases of fetal chromosomal variations were detected, with a detection rate of 19.8% (110/556), including 72 cases of pathogenic variations (12.9%, 72/556) and 38 cases of variants of uncertain significance (VUS; 6.8%, 38/556). Pathogenic copy number variations (CNV) involved 9 chromosomes, with 3q29, 16p13.11, 17p13.3p13.2 and 22q11.21 being the most common. (2) Among the pregnant women with different ultrasound results, the highest detection rate of fetal chromosomal variation was in the group with cardiac structural abnormalities combined with other systemic abnormalities, with a detection rate of 10/16. The detection rates of single abnormal soft index group, multiple abnormal soft index group, soft index combined with cardiac structural abnormalities group and isolated cardiac structural abnormalities group were 17.3% (41/237), 18.1% (42/232), 41.7% (10/24) and 14.9% (7/47), respectively, and the differences were statistically significant (&lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=27.680, &lt;i&gt;P&lt;/i&gt;&lt;0.001). (3) In different age groups, the detection rate of chromosome aneuploidy increased with age, and the detection rate of ≥40 years old group (16.7%, 7/42) was the highest. There was no significant difference in the detection rate of pathogenic CNV, VUS and chromosomal abnormalities among different age groups (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). &lt;b&gt;Conclusions:&lt;/b&gt; SNP array technology has important application value in prenatal diagnosis of fetal cardiac anomalies. The study on the characteristics o","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"61 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy and safety of triptorelin acetate microspheres for injection versus triptorelin acetate for injection in Chinese patients with endometriosis: a multicenter, randomized, double-blind, phase Ⅲ non-inferiority clinical trial].","authors":"A M Zhao, Y Wang, W W Yang, Z Q Liang, F J Shen, C Z Li, Z T Wei, X J Sheng, W Yuan, Q Li, F Ming, Y H Zheng, X Y Lu, H Ye, J J Li, B Lye, H J Ruan, Y Z Zhang, Y X Li, W R Li, H K Yang, Y L Zheng, X J Dong, H Lu, S Y Hou, P Yan, Y Q Ge, J L Kang, L N Wang, H Y Zhang, Y Hu, R F Zhao, Y L Wang, S Y Zhang, L P Han, L Sang, M H Cui, J J Zhai, D Lu, Y Zheng, Y Z Guo, M L Chen, L P Sun, J Lu, S J Guo, X H Zhang, W Feng, L H Yang","doi":"10.3760/cma.j.cn112141-20250421-00161","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20250421-00161","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To evaluate the efficacy and safety of triptorelin acetate microspheres for injection compared with triptorelin acetate for injection in the treatment of endometriosis. &lt;b&gt;Methods:&lt;/b&gt; A total of 392 patients with endometriosis were prospectively enrolled from 47 research centers across China between October 25, 2021, and February 14, 2023. Participants were randomly assigned in a 1∶1 ratio to either the experimental group (&lt;i&gt;n&lt;/i&gt;=196) or the control group (&lt;i&gt;n&lt;/i&gt;=196). Both groups received intramuscular injections of the respective drugs once every 4 weeks for a total of 6 doses. The primary efficacy endpoint was the percentage of subjects with suppressed estradiol levels after treatment. Secondary endpoints included pain relief, amenorrhea rate, changes in ovarian endometrioma diameter, and adverse drug reactions. &lt;b&gt;Results:&lt;/b&gt; For the primary efficacy endpoint, the percentages of subjects with suppressed estradiol levels at week 12 in the experimental and control groups were 97.3% (177/182) and 98.4% (181/184), respectively. The rate difference was -1.1% (95%&lt;i&gt;CI&lt;/i&gt;: -4.8% to 2.3%), the lower limit of the 95%&lt;i&gt;CI&lt;/i&gt; for the rate difference was greater than the non-inferiority margin of -10%. Compared to baseline, visual analog scale (VAS) scores for dysmenorrhea and non-menstrual pelvic pain decreased at all post-treatment time points in both groups, with no statistically significant differences between two groups (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). Estradiol, luteinizing hormone, and follicle stimulating hormone levels significantly decreased from baseline at all post-treatment time points in both groups (all &lt;i&gt;P&lt;/i&gt;&lt;0.05), with no significant intergroup differences (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). No significant differences were observed in amenorrhea rates between two groups at week 8, 12, and 24 post-treatment (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). However, the time to menstruation recovery after drug discontinuation was significantly earlier in the experimental group than that in the control group (&lt;i&gt;P&lt;/i&gt;=0.003). Carbohydrate antigen 125 levels significantly decreased from baseline at week 12 and 24 post-treatment in both groups (all &lt;i&gt;P&lt;/i&gt;&lt;0.001), but no significant intergroup differences were found (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). In the experimental group, only the diameter of the right ovarian endometrioma showed a significant decrease from baseline at week 24 post-treatment (&lt;i&gt;P&lt;/i&gt;=0.016). In the control group, neither left nor right ovarian endometrioma diameters showed significant changes from baseline (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). The overall incidence of adverse drug reactions was similar between the experimental and control groups [77.6% (152/196) vs 78.6% (154/196), respectively; &lt;i&gt;P&lt;/i&gt;&gt;0.05]. &lt;b&gt;Conclusions:&lt;/b&gt; Triptorelin acetate microspheres for injection is an effective treatment for endometriosis. It could maintain low estrogen levels, consistently alleviate endometriosis-associated pain, achieve a high rate of amenorrhea during treatment, and ","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"61 1","pages":"30-38"},"PeriodicalIF":0.0,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of reproductive and psychological health of pregnant women with placenta accreta spectrum disorders after fertility-preserving treatment].","authors":"W R Zheng, B E Huang, X R Yang, J Yan, H X Yang","doi":"10.3760/cma.j.cn112141-20250824-00395","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20250824-00395","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the reproductive and psychological health status of pregnant women with placenta accreta spectrum disorders (PAS) after fertile-preserving surgery, and to follow up their subsequent pregnancy and delivery. <b>Methods:</b> A total of 269 cases of abnormally invasive placenta (AIP) who underwent pregnancy supervision and surgical treatment in Peking University First Hospital from January 2010 to August 2020 were collected as AIP group. A total of 300 pregnant women without other complications who underwent elective cesarean section due to cesarean section history in the same center and at the same time period were selected as the control group. Their clinical information was collected, and their menstruation, fertility and psychological health were followed up by telephone and online questionnaire. <b>Results:</b> (1) In AIP group, 222 (82.5%, 222/269) valid questionnaires were returned, of which 171 (77.0%, 171/222) completed the subjective scale. The control group returned 254 valid questionnaires (84.7%, 254/300), of which 191 (75.2%, 191/254) filled in the complete subjective scale. There was no significant difference in the demographic characteristics between AIP group and control group (all <i>P</i>>0.05), but the intraoperative blood loss, the incidence of short-term postoperative complications and the length of hospital stay in AIP group were higher than those in control group. (2) There were no differences in reproductive physiological health status, including the time to resume sexual life, menstruation, re-pregnancy, pelvic ultrasound manifestations and long-term complications between AIP group and control group. The fertility intention of AIP group was lower than that of control group [12.3% (25/204) vs 19.3% (49/254)]. (3) In AIP group, 17 women tried to get pregnant again, and 12 of them (12/17) had successful pregnancy and delivered, and no PAS occurred again. (4) FSFI scores of women undergoing hysterectomy (18 cases) were lower than those undergoing fertive-sparing surgery (204 cases) in AIP group, but there was no differences in the proportion of pelvic floor dysfunction and suspicious emotional disorder. <b>Conclusions:</b> The physiological function of pelvic organs in women with AIP can be restored after fertive-preserving surgery, which is similar to that of women with a history of cesarean section. The risk of pelvic floor dysfunction and emotional disorders is not significantly increased after hysterectomy, but the risk of sexual dysfunction is higher. Hysterectomy is not recommended as the first-line treatment for PAS. Women with fertility desire can get pregnant again and deliver by cesarean section, but PAS should be closely monitored for recurrence during pregnancy.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"61 1","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical analysis of 12 cases of pregnancy complicated with diffuse uterine leiomyomatosis].","authors":"W L Han, L Chen","doi":"10.3760/cma.j.cn112141-20250705-00310","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20250705-00310","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the clinical characteristics, diagnosis and treatment of pregnancy complicated with diffuse uterine leiomyomatosis (DUL), and to explore the treatment strategies for its complications during pregnancy and perinatal period. <b>Methods:</b> The clinical data of 12 pregnant women with DUL who delivered in Peking University Third Hospital from May 2017 to October 2024 were collected, and their complications during pregnancy and perinatal period, radiological features, and treatment strategies were analyzed. <b>Results:</b> The median age of 12 pregnant women with DUL was 32 years (range: 28 to 38 years), and all of them were primiparas with singleton pregnancy. Among the 12 pregnant women, only 7 cases (7/12) were suspected of DUL by imaging examination during pregnancy. Five cases (5/12) only showed multiple uterine fibroids by ultrasound and magnetic resonance imaging during pregnancy, which were finally diagnosed according to intraoperative exploration. Five cases (5/12) of DUL had signs of threatened abortion or threatened preterm birth such as uterine contraction and bleeding during pregnancy, including 3 cases of preterm birth (2 cases of spontaneous preterm birth and 1 case of iatrogenic preterm birth due to prenatal hemorrhage). Among the 12 pregnant women with DUL, 2 cases (2/12) had abnormal fetal position, 3 cases (3/12) had placental adhesion, and 1 case (1/12) had fibroid degeneration. Among the 12 pregnant women with DUL, 9 cases (9/12) were delivered by cesarean section, of which 3 cases were converted to cesarean section because of failed trial of labor, and 6 cases were directly terminated by cesarean section because of abnormal fetal position or previous myomectomy history. Postpartum hemorrhage occurred in 5 cases (5/12), including 4 cases of severe postpartum hemorrhage, and uterine tamponade had good hemostatic effect. Three cases (3/12) had fever after operation or postpartum. All the 12 pregnant women were discharged in a stable condition. Among the 12 neonates, 2 (2/12) were transferred to the department of pediatrics due to premature birth and finally discharged smoothly. <b>Conclusions:</b> Pregnancy complicated with DUL is a high-risk pregnancy, which increases the risk of complications during gestation, delivery and postpartum. Uterine cavity compression hemostasis may be an effective measure to deal with postpartum hemorrhage.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"60 12","pages":"926-933"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}