中华妇产科杂志最新文献

{"title":"[Exploration of CCL11 and sTNFR2 as potential biomarkers for the efficacy of lymphocyte immunotherapy in women with unexplained recurrent spontaneous abortion].","authors":"L Li, H Y Wang, J Qiao, R Li, P Liu","doi":"10.3760/cma.j.cn112141-20240511-00272","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20240511-00272","url":null,"abstract":"<p><p><b>Objective:</b> To explore biomarkers for the efficacy of lymphocyte immunotherapy (LIT) treating women with unexplained recurrent spontaneous abortion (URSA). <b>Methods:</b> Serum samples from 24 URSA potients who received LIT were collected at Peking University Third Hospital from December 2014 to June 2015. Semiquantitative sandwich-based antibody arrays containing 40 cytokines were used to screen target immune cytokines in the peripheral blood of URSA patients before and after LIT. Multifactor quantitative microsphere flow cytometry detection validated the levels of target cytokines. Based on the final pregnancy outcome after LIT, 24 URSA patients were divided into the full-term delivery group (15 cases) and the abortion group (9 cases). Furthermore, linear regression analysis were applied to evaluate the relationship between target cytokines and pregnancy outcomes. <b>Results:</b> Semiquantitative sandwich-based antibody arrays suggested that, among all 24 URSA patients included in this study, the intensities of the fluorescence signal were significantly lower post-LIT versus pre-LIT for the following cytokines: interleukin-15 (IL-15), monokine induced by γ-interferon (MIG), C-C motif chemokine ligand (CCL) 1 (all <i>P</i><0.05). In the full-term delivery group, the intensities of the fluorescence signal post-LIT were significantly lower than pre-LIT for the following cytokines: IL-15, CCL1, macrophage inflammatory protein (MIP) 1α (all <i>P</i><0.05). In the abortion group, the intensities of the fluorescence signal post-LIT were significantly lower than pre-LIT for the following cytokines: MIG, MIP-1δ (all <i>P</i><0.05). Linear regression analysis showed that the intensity of the fluorescence signal of CCL11 was increased and the intensity of the fluorescence signal of soluble tumor necrosis factor receptor 2 (sTNFR2) was decreased in the full-term delivery group after LIT, the differences were statistically significant (<i>P</i>=0.012, 0.029). Validation results of multifactor quantitative microsphere flow cytometry detection showed that the level of CCL11 was significantly increased (<i>P</i>=0.001) and the level of sTNFR2 was significantly decreased (<i>P</i>=0.001) in the full-term delivery group after LIT. <b>Conclusion:</b> CCL11 and sTNFR2 maybe serve as potential biomarkers that could predict pregnancy outcomes after LIT in women with URSA.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"60 1","pages":"24-33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Age-stratified association between preconception body mass index and risk of macrosomia at delivery].","authors":"S W Wu, N Zhang","doi":"10.3760/cma.j.cn112141-20240807-00439","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20240807-00439","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the impact of preconception body mass index (BMI) on neonatal birth weight and the risk of macrosomia in pregnant women across various age groups. &lt;b&gt;Methods:&lt;/b&gt; A cohort study was conducted, selecting pregnant women who underwent their initial prenatal assessment at Beijing Obstetrics and Gynecology Hospital from September 1st, 2018 to March 31st, 2020. Relevant data were collected from the hospital's electronic medical record system. Logistic regression nested cubic spline was used to analyze the nonlinear association between preconception BMI and neonatal birth weight. Binary logistic regression was also employed to assess the association between preconception BMI and macrosomia risk. &lt;b&gt;Results:&lt;/b&gt; (1) A total of 13 015 pregnant women were examined, revealing an incidence of macrosomia of 6.33% (824/13 015). The preconception BMI of pregnant women in the macrosomia group was significantly higher than that in the non-macrosomia group [(23.1±3.4) vs (21.6±3.1) kg/m&lt;sup&gt;2&lt;/sup&gt;], and the age was significantly higher than that in the non-macrosomia group [(32.1±3.6) vs (31.7±3.7) years], the differences were statistically significant (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). (2) Preconception BMI was positively correlated with neonatal birth weight. Pregnant women with preconception BMI of 15.0 kg/m&lt;sup&gt;2&lt;/sup&gt;, 20.0 kg/m&lt;sup&gt;2&lt;/sup&gt;, and 25.0 kg/m&lt;sup&gt;2&lt;/sup&gt; had decreased birth weight of 121 g (95%&lt;i&gt;CI&lt;/i&gt;: 35-183 g) and increased birth weights of 78 g (95%&lt;i&gt;CI&lt;/i&gt;: 54-102 g) and 182 g (95%&lt;i&gt;CI&lt;/i&gt;: 151-213 g), respectively, compared to those with a preconception BMI of 18.0 kg/m&lt;sup&gt;2&lt;/sup&gt;. (3) For each 1.0 kg/m&lt;sup&gt;2&lt;/sup&gt; increase in preconception BMI, the risk of macrosomia increased by 14% (&lt;i&gt;OR&lt;/i&gt;=1.14, 95%&lt;i&gt;CI&lt;/i&gt;: 1.11-1.16; &lt;i&gt;P&lt;/i&gt;&lt;0.001). When stratified by age, it was observed that elevated preconception BMI significantly increased the incidence of macrosomia in women aged 27-38 years. Among them, the risk of delivering macrosomia among 37 years old pregnant women was most affected by preconception BMI (&lt;i&gt;OR&lt;/i&gt;=1.33, 95%&lt;i&gt;CI&lt;/i&gt;: 1.17-1.51; &lt;i&gt;P&lt;/i&gt;&lt;0.001). (4) The stability and sensitivity analysis results showed that the preconception BMI of pregnant women with a preconception BMI of 18.0-&lt;25.0 kg/m&lt;sup&gt;2&lt;/sup&gt; had a significant impact on the risk of macrosomia (&lt;i&gt;OR&lt;/i&gt;=1.23, 95%&lt;i&gt;CI&lt;/i&gt;: 1.17-1.29; &lt;i&gt;P&lt;/i&gt;&lt;0.001), while the preconception BMI of other preconception BMI stratification pregnant women had no significant impact on the risk of macrosomia (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). Hypertension disorders in pregnancy, gestational diabetes mellitus and abnormal blood lipid during pregnancy were not the mediators associated with preconception BMI and macrosomia. After excluding three factors respectively, the impact of preconception BMI on the risk of macrosomia was the same as before (&lt;i&gt;OR&lt;/i&gt;=1.14, 95%&lt;i&gt;CI&lt;/i&gt;: 1.11-1.16; &lt;i&gt;P&lt;/i&gt;&lt;0.001). &lt;b&gt;Conclusions:&lt;/b&gt; Preconception BMI is linked to neonatal birth wei","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"60 1","pages":"11-17"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research advances of diagnosis and treatment of rectovaginal septum endometriosis].","authors":"E N Liu, F Miao, Y F Zhou","doi":"10.3760/cma.j.cn112141-20240805-00436","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20240805-00436","url":null,"abstract":"","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"60 1","pages":"66-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress in neoadjuvant therapy for epithelial ovarian cancer].","authors":"H Y Dong, L Li","doi":"10.3760/cma.j.cn112141-20240930-00532","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20240930-00532","url":null,"abstract":"","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"60 1","pages":"71-78"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Coexistence of development and expectation, balancing tasks and responsibilities].","authors":"J H Lang","doi":"10.3760/cma.j.cn112141-20241112-00601","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20241112-00601","url":null,"abstract":"","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"60 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on complex cesarean section (2024)].","authors":"","doi":"10.3760/cma.j.cn112141-20241014-00552","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20241014-00552","url":null,"abstract":"","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"60 1","pages":"3-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correlation between uterine volume and intrauterine adhesion: a propensity score matching analysis].","authors":"Q Xu, H Duan, Y Y An, L Gan","doi":"10.3760/cma.j.cn112141-20240814-00454","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20240814-00454","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the correlation between uterine volume and intrauterine adhesion (IUA). <b>Methods:</b> From June 2018 to November 2019, totally 7 007 patients who underwent hysteroscopy in outpatient operating rooms of Gynecological Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital were retrospectively analyzed<i>.</i> Patients of reproductive age with IUA without uterine fibroids and adenomyosis were selected as IUA group, and patients of reproductive age without uterine fibroids and adenomyosis without IUA during the same period were selected as the control group. The propensity score matching (PSM) method was used to perform 1∶1 matching for the two groups of patients, matching variables included age, height, weight, body mass index (BMI), gravidity, parity, and number of abortion curettage. Whether there was any difference in uterine volume between the two groups of patients was compared, and whether uterine volume was an influencing factor of IUA was explored. The patients in IUA group were also categorized into mild, moderate and severe to explore whether uterine volume influenced the severity of IUA. <b>Results:</b> (1) After inclusion and exclusion criteria, 351 patients were included in IUA group and 2 986 patients in the control group. With PSM, 327 patients in IUA group and 327 patients in the control group were finally enrolled in this study. There were no statistically significant differences in age, height, weight, BMI, gravidity, parity, and number of abortion curettage between the two groups of patients after matching (all <i>P></i>0.05). (2) After PSM, there was a significant difference between the uterine volume of IUA group (median: 44.23 cm³) and the uterine volume of the control group (median: 57.20 cm³; <i>P</i><0.001). (3) Reduced uterine volume (<i>OR</i>=0.961, 95%<i>CI</i>: 0.952-0.970) was an independent risk factor for IUA (<i>P</i><0.001). (4) Uterine volume had a significant effect on the severity of IUA (<i>P</i><0.001), the larger the uterine volume (<i>B</i>=-0.030, 95%<i>CI</i>: -0.044 to -0.017), the less severe the IUA. <b>Conclusions:</b> Reduced uterine volume is an independent risk factor for IUA, and uterine volume has a significant effect on the severity of IUA. In patients with small uterine volume size, primary and secondary prevention of IUA should be emphasized.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"60 1","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and prognosis of ovarian juvenile granulosa cell tumors].","authors":"X Ma, G Y Zhang, Z Li","doi":"10.3760/cma.j.cn112141-20240825-00256","DOIUrl":"https://doi.org/10.3760/cma.j.cn112141-20240825-00256","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To analyze the clinical characteristics, treatments, and prognosis of patients with ovarian juvenile granulosa cell tumor (JGCT). &lt;b&gt;Methods:&lt;/b&gt; Clinical and pathological data, and follow-up information of 34 patients diagnosed with JGCT from 2000 to 2021 were collected from the surveillance, epidemiology, and end results (SEER) database. A retrospective analysis was conducted to summarize the patients' clinical and pathological characteristics, treatments, and prognosis. Propensity score matching (PSM) was used to match the JGCT cases with adult granulosa cell tumor (AGCT) cases in SEER database. A total of 96 patients with ovarian granulosa cell tumor (OGCT), including 32 cases of JGCT and 64 cases of AGCT, were enrolled in a matched cohort analysis. Univariate and multivariate Cox regression analysis were performed on the matched cohort to explore the risk factors for overall survival. Kaplan-Meier curves and the log-rank test were used to compare the survival outcomes between JGCT and AGCT. &lt;b&gt;Results:&lt;/b&gt; (1) The median age at diagnosis for the 34 JGCT patients was 19.5 years (ranged: 1-48 years), with 3 patients aged ≤10 years, 16 patients aged 11-20 years, 11 patients aged 21-30 years, and 4 patients aged &gt;30 years. Tumors originated unilaterally in 33 patients, with only 1 case originating bilaterally. The maximum tumor diameter was recorded in 26 patients, with a median size of 12.4 cm (ranged: 3.5-40.0 cm). According to the 2014 International Federation of Gynecology and Obstetrics (FIGO) staging system, 19 patients were diagnosed with stage Ⅰ (including 10 cases with stage Ⅰa and 9 cases with stage Ⅰc), 4 patients with stage Ⅱ, 8 patients with stage Ⅲ, and 3 patients with stage Ⅳ. Two patients did not undergo surgery for the resection of lesions. Stage Ⅰ patients (15/19) underwent fertility-sparing surgery, while stage Ⅱ-Ⅲ patients underwent either fertility-sparing surgery or cytoreductive surgery (6 cases each). Stage Ⅳ patients underwent cytoreductive surgery (2 cases). Lymph node dissection was performed in 10 patients, among which only 1 patient with positive lymph nodes metastasis. None of the 34 patients received radiotherapy, while 18 patients received adjuvant chemotherapy (included neoadjuvant chemotherapy and postoperative adjuvant chemotherapy). The proportion of stage Ⅰ patients receiving adjuvant chemotherapy was relatively low, with only 4 out of 19 patients (including 2 out of 10 cases for stage Ⅰa and 2 out of 9 cases for stage Ⅰc). The proportions of patients receiving adjuvant chemotherapy for stages Ⅱ, Ⅲ and Ⅳ were 3 out of 4 cases, 8 out of 8 cases, and 3 out of 3 cases, respectively. The follow-up ended in December 2021, with 20 patients alive and 14 dead. The survival rate for ovarian JGCT patients was 59% (20/34). Among them, the survival rate for stage Ⅰ patients was 16/19, while for stage Ⅱ-Ⅳ patients, it was 4/15; there was a statistically significant difference (&lt;i&gt;P&lt;/i&gt;=0.002). Amon","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"60 1","pages":"34-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Guideline of cervical ripening and labor induction during the third trimester pregnancy (2024)].","authors":"","doi":"10.3760/cma.j.cn112141-20240707-00381","DOIUrl":"10.3760/cma.j.cn112141-20240707-00381","url":null,"abstract":"","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 11","pages":"819-828"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Potential of new self-crosslinked hyaluronic acid gel on the recovery of endometrium after artificial abortion: a multicenter, prospective randomized controlled trial].","authors":"C Y Li, L R Teng, Q Lin, L P Zhao, Y X Zhu, X Mi, Z N Wang, X Y Wang, L S Zhang, D Han, L L Ma, W P Bai, J M Wang, J Ni, H P Shen, Q F Chen, H M Xu, C C Ren, J Jiang, G Y Liu, P Peng, X Y Liu","doi":"10.3760/cma.j.cn112141-20240906-00493","DOIUrl":"10.3760/cma.j.cn112141-20240906-00493","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the impact of self-crosslinked hyaluronic acid (SCH) gel on endometrium recovery after artificial abortion. <b>Methods:</b> A multicenter, prospective randomized controlled trial was conducted across 18 hospitals from December 2021 to February 2023, involving 382 women who underwent artificial abortion. Participants were randomly allocated to receive either treatment with SCH gel (SCH group) or no treatment (control group) in a 1∶1 ratio. The primary outcome was endometrium thickness in 14 to 18 days after the first postoperative menstruation. Secondary outcomes included changes in menstrual volume during the first postoperative menstruation, menstruation resumption within 6 postoperative weeks, time to menstruation resumption, duration of the first postoperative menstruation, and incidence of dysmenorrhea. <b>Results:</b> Baseline characteristics of participants were comparable between the two groups (all <i>P</i>>0.05), with 95.3% (182/191) in SCH group and 92.7% (177/191) in the control group completed the study. The postoperative endometrial thickness in SCH group was significantly greater than that in the control group [(9.78±3.15) vs (8.95±2.32) mm; <i>P</i>=0.005]. SCH group also had significantly fewer participants with reduced menstrual volume [23 cases (12.6%, 23/182) vs 31 cases (17.5%, 31/177); <i>P</i>=0.038]. Although SCH group experienced less dysmenorrhea during the first postoperative menstrual period, this difference was not statistically significant [28.5% (51/179) vs 37.1% (65/175); <i>P</i>=0.083]. Outcomes were similar between SCH group and the control group regarding the proportion of participants who resumed menstruation within 6 weeks postoperatively, time to menstruation resumption, and duration of the first postoperative menstruation (<i>P</i>=0.792, 0.485, and 0.254, respectively). No serious adverse events were observed during the study period, and no adverse events were attributed to SCH gel treatment. <b>Conclusion:</b> The application of SCH gel after artificial abortion is safe and might aid in the recovery of the endometrium.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 11","pages":"864-870"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}