Chemical record最新文献

{"title":"Controlling Chemo- and Site-Selectivity Through the Formation of Radicals Adjacent to a sp² Carbon.","authors":"Anil Rajendra Paraskar, Rupali Dasharath Shinde, Sukalyan Bhadra","doi":"10.1002/tcr.70231","DOIUrl":"https://doi.org/10.1002/tcr.70231","url":null,"abstract":"<p><p>Achieving high chemo- and site-selectivity is crucial in organic synthesis. High selectivity directly minimizes undesired by-products, thereby increasing the atom economy and eliminating the wasteful purification steps. While the control of chemoselectivity is precisely achieved by the reactivity variation between two different functional groups, that of site-selectivity is a challenging task. Historically, substrate-directed approaches have played a key role in realizing site-selective transformations. On contrary, modern site-selective approaches are rather dependent on radical chemistry. In this context, transformations via metal-catalyzed SET-induced formation of radical intermediates arguably represent a powerful strategy that has received considerable attention within last two decades. Among the various classes, a radical intermediate adjacent to a C_sp ² center is relatively stabilized compared to the corresponding alkyl radical species, which is attributed to the resonance delocalization of the unpaired electron into the adjacent system. By engaging those radical intermediates, numerous approaches that have been accomplished proceed with amazingly perfect chemo- and site-selectivity. Noteworthy instances include transformations via the formation of carboxylate radicals and α-carbonyl radicals from carboxylic acids, ketones, etc. In this account, we describe developments on this area that have emanated primarily from our original research together with a few instances of closely related works by others.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e70231"},"PeriodicalIF":8.9,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serendipitous Emergence of Pyrrolo[2,3,4-kl]acridin-1(2H)-one Derivatives: From Unexpected Discovery to Synthetic Development.","authors":"Swadhin Swaraj Acharya, Rudranarayan Sutar, Subhakalyani Nayak, Bibhuti Bhusan Parida","doi":"10.1002/tcr.70239","DOIUrl":"https://doi.org/10.1002/tcr.70239","url":null,"abstract":"<p><p>Serendipitous discoveries have often opened new doors in organic synthesis for the synthesis of unknown reaction paths and molecular frameworks. The well-known method to synthesize acridine derivatives is the classical multicomponent condensation of amines, carbonyl compounds, and 1,3-dicarbonyl compounds. In 2012, Kefayati and coworkers reported the remarkable unprecedented synthesis of pyrrolo[2,3,4-kl]acridin-1(2H)-one derivatives from a multicomponent reaction combining isatin, dimedone, and aniline derivatives. The complex pyrroloacridine scaffold, a motif associated with many natural products and bioactive molecules, was directly synthesized by this unexpected transformation, which was distinct from the traditional synthesis of acridines. Significant advancements have been made in the design of several synthetic approaches for pyrroloacridine derivatives since this landmark discovery. This comprehensive review summarizes the advances covering synthetic approaches, mechanistic insights, and future perspectives.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e70239"},"PeriodicalIF":8.9,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxaziridines: Versatile Reagents in Modern Organic Synthesis.","authors":"Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida","doi":"10.1002/tcr.70232","DOIUrl":"https://doi.org/10.1002/tcr.70232","url":null,"abstract":"<p><p>Oxaziridines are three-membered heterocyclic compounds containing a carbon, an oxygen, and a nitrogen atom. Along with high regio-, chemo-, enantio-, and diastereoselectivity, oxaziridines have gained more interest in modern organic synthesis due to their unique structural and electronic features that allow O-atom and N-group/atom transfer reactions. The reactions of oxaziridines can be performed both stoichiometrically and catalytically. Their applications include selective α- and γ-hydroxylation/amination of carbonyl compounds, epoxidation of olefins and oxidation of thiols, sulfides and sulfoxides, etc. In addition, oxaziridines have been explored for ring-opening, rearrangement, and fragmentation, which produce amides, nitrones, imines, and other useful synthetic intermediates. Notably, oxaziridines undergo cycloaddition with alkenes, alkynes, ketenes, nitriles, etc., and offer structurally diverse heterocyclic frameworks such as isoxazolines, isoxazoles, oxadiazolines, oxadiazoles, etc. Among various oxaziridines, N-sulfonyl oxaziridines are known as Davis reagents, which are widely used for selective oxidations and synthesis of heterocycles. Chiral oxaziridines and oxaziridinium salts have found a broad spectrum of applications in asymmetric synthesis, enabling enantioselective oxygen-transfer reactions and the synthesis of complex molecules. This review collates the synthesis, structural features, mechanistic aspects, reactivity patterns, and synthetic applications of oxaziridines, including their roles in oxidation chemistry, cycloadditions, rearrangements, and synthesis of heterocyclics, natural products, and pharmaceutical drugs.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e70232"},"PeriodicalIF":8.9,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyrimidine-Based Hybrids for Epidermal Growth Factor Receptor Targeting: Structure-Activity Relationships and Comparative Activity Profiling.","authors":"Ankush Kumar, Rajwinder Kaur, Rohit Bhatia","doi":"10.1002/tcr.70234","DOIUrl":"https://doi.org/10.1002/tcr.70234","url":null,"abstract":"<p><p>Pyrimidine has become an important scaffold for designing anticancer drugs because of its planar aromatic structure, synthetic versatility, and ability to establish key interactions with its target. This heterocyclic scaffold is an essential component of nucleic acids and many biologically active molecules, which makes it highly relevant for therapeutic application. In recent years, significant attention has been directed toward pyrimidine-based hybrid molecules, in which the pyrimidine core is integrated with other bioactive scaffolds to enhance the anticancer activity. The present review encompasses a wide range of such hybrids, including pyrimidine-quinoline, pyrimidine-indole, pyrimidine-triazole, pyrimidine-chalcone, pyrimidine-pyrazole, pyrimidine-imidazole, pyrimidine-thiazole, and pyrimidine-oxadiazole derivatives. This hybridization strategy facilitates the development of multitargeted agents capable of modulating key signaling pathways in cancer. Among these, epidermal growth factor receptor (EGFR) has gained particular importance due to its central role in tumor growth, survival, and metastasis. This review focuses on the last 2 years' advancements (from Jan 2025 to early 2026) in the development of pyrimidine-containing hybrid molecules as EGFR inhibitors. Different hybridization techniques involving pyrimidine linked or fused with another moiety are comprehensively discussed. Furthermore, the present review summarizes the structure-activity relationship (SAR), mechanistic pathway, and molecular interactions responsible for their anticancer potential, with a specific emphasis on their EGFR inhibitory activity, including effects on mutant EGFR. Notably, compounds 16a and 16b (pyrazolo[3,4-d]pyrimidine-sulfonamide hybrids) were identified as the most active EGFR inhibitors with IC₅₀ of 0.069 and 0.064 µM, respectively. Additionally, pyrimidine-based anticancer agents under clinical investigation as EGFR inhibitors are briefly highlighted. Overall, pyrimidine-based hybrids represent a promising direction as next-generation anticancer therapeutics.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e70234"},"PeriodicalIF":8.9,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances of Metal-Organic Frameworks-Based Sensors for Food Safety and Environmental Monitoring.","authors":"Nizi Chang, Jingran Ma, Sidra Tul Muntaha, Zhengling Wang, Ming Xie, Naoufel Ben Hamadi, Abul Kalam, Wajahat Ali, Muhammad Mateen, Salamat Ali","doi":"10.1002/tcr.70235","DOIUrl":"https://doi.org/10.1002/tcr.70235","url":null,"abstract":"<p><p>Metal-organic frameworks (MOFs) are versatile porous materials increasingly used in sensing for food safety and environmental monitoring, where on-site detection is critical. Compared to traditional methods, MOF-based sensors offer higher surface areas, tunable pores, abundant active sites, and versatile functionalization, significantly enhancing sensitivity and selectivity. This review systematically covers recent advances in MOF-based sensors, focusing on their physicochemical properties, synthesis routes, and functional modifications. It explores how pore architecture, metal nodes, and organic linkers influence sensing performance, and discusses applications in detecting chemical contaminants, spoilage indicators, and hazardous environmental gases. Emerging trends such as multifunctional integration, portable devices, and intelligent sensing systems are also highlighted. A dedicated section addresses the trade-offs in sensor selection to guide platform choice for specific analytical needs, while another examines scientific limitations, practical advantages over conventional materials, and translational challenges. Despite notable progress, issues persist regarding long-term stability, reproducibility, scalable manufacturing, and user-friendliness. Future research should prioritize material robustness, standardization, and the incorporation of advanced technologies to facilitate real-world deployment. Overall, MOF-based sensors represent a promising frontier for next-generation analytical tools, with substantial potential in smart packaging, environmental surveillance, and sustainable sensing systems.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e70235"},"PeriodicalIF":8.9,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundamental Insights Toward Efficient Hydrogen Storage: Materials Design Considerations in Nanostructured and Polymer-Hybrid Systems.","authors":"Fatimah Y Alomari, Mohsin Ejaz, Shahid Ali, Safyan Akram Khan, Amal AlFawaz, Muhammad Nawaz Tahir, Muhammad Mansha","doi":"10.1002/tcr.70236","DOIUrl":"https://doi.org/10.1002/tcr.70236","url":null,"abstract":"<p><p>Hydrogen is a promising alternative energy source as the world moves toward decarbonization by reducing reliance on traditional fossil fuels. This review encompasses a comprehensive study of emerging materials for hydrogen storage, beginning with the physical and thermodynamic properties of hydrogen and the need for effective hydrogen storage solutions. Solid-state storage has attracted considerable attention because of its greater capacity and improved safety. Advancements in materials design have yielded many hydrogen storage candidates, including nanostructured materials, carbon-based nanostructures, metal-organic frameworks, porous carbon, MXenes, metal halides, functional polymers, and porous organic polymers. These materials offer many advantages but also pose important concerns, such as limited storage capacity, slow response, and ongoing structural deterioration. Moreover, the combination of polymers and nanostructured materials has emerged as an attractive solution to address these concerns. This type of hybrid material improves surface chemistry, pore architecture, stability, and enhances hydrogen uptake and kinetics. The potential implementation of hydrogen storage and its associated limitations have been thoroughly discussed.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e70236"},"PeriodicalIF":8.9,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolution of Cyclic Carbonate-Functionalized Polymers: From Fundamental Chemistry to Comprehensive Applications.","authors":"Bungo Ochiai","doi":"10.1002/tcr.70233","DOIUrl":"https://doi.org/10.1002/tcr.70233","url":null,"abstract":"<p><p>This review provides a comprehensive overview of polymers bearing five-membered cyclic carbonate (5CC) moieties, highlighting their role in advancing CO₂ utilization and their unique applications based on 5CC moieties. 5CC structures are highly promising due to their unique chemical properties and the fact that their synthesis typically requires milder conditions than most of CO₂ conversion processes. The synthetic methodologies are categorized into three primary routes: polymerization of 5CC functional monomers, postpolymerization modification using CO₂ or 5CC compounds, and polymerization accompanied by CO₂ fixation. While (meth)acrylates are the most extensively developed platform, the exploration of other backbones-including styrene, vinyl ether, siloxane, and cyclic ethers-has realized a diverse array of polymer architectures. Furthermore, this review explores how the distinctive characteristics of 5CC functional polymers-such as high polarity and specific reactivity-lead to various applications, including high-performance adhesives, coatings, energy storage devices, colorimetric sensors, and optical materials. Finally, the current challenges and future perspectives for the development of sustainable, high-functionality 5CC-based materials are addressed.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e70233"},"PeriodicalIF":8.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable Synthesis and Biological Aspects of Pyrrolobenzodiazepine Derivatives: An Insight Into Current Developments, Structure-Activity Relationships, and Clinical Studies","authors":"Anshita Paliwal,&nbsp;Shivangi Jaiswal,&nbsp;Kanika Verma,&nbsp;Diksha Bareth,&nbsp;Sonia Zeba Hashmi,&nbsp;Sarvesh Paliwal,&nbsp;Swapnil Sharma,&nbsp;Jaya Dwivedi","doi":"10.1002/tcr.202500179","DOIUrl":"10.1002/tcr.202500179","url":null,"abstract":"<p>Pyrrolobenzodiazepine is tricyclic ring system containing five-, six-, and seven-membered nitrogen heterocycles in the molecular framework. This is a privileged pharmacophore found in pharmaceutical drugs and natural products. However, researchers worldwide are exploring green synthetic methods to develop novel bioactive agents to curb undesirable health effects in humans and aquatic animals. In view of this, various sets of pyrrolobenzodiazepines were synthesized by modulating the ring position or by adding other pharmacophores to enhance the molecules’ efficacy. This review is primarily concerned with retrosynthetic, functionalization, and green synthesis of pyrrolobenzodiazepines (1965–2025), followed by an in-depth discussion of their various biological properties, highlighting structure–activity relationships, molecular docking, and in vitro and in vivo studies on pyrrolobenzodiazepines. This review provides an overview of the synthesis, structural characteristics, and diverse spectrum of biological properties, which will surely open a new window for the design and development of potent pyrrolobenzodiazepine-based drugs in future research.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 8","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalytic Transformations of Aza-Cyclobutenes, Fused Cyclobutenes, and Cyclobutenones","authors":"Asad Aziz,&nbsp;Zhanhui Yang","doi":"10.1002/tcr.70176","DOIUrl":"10.1002/tcr.70176","url":null,"abstract":"<p>Cyclobutenes, four-membered cyclic compounds with a carbon–carbon double bond, are valuable intermediates in organic synthesis, offering unique reactivity due to their ring strain. This review focuses on three major types including aza-cyclobutene<b>,</b> fused cyclobutene, and cyclobutenone<b>,</b> highlighting their synthetic versatility and reactivity. Aza-cyclobutenes enable diverse functionalization strategies for constructing complex N-heterocyclic structures. Fused cyclobutenes with their bicyclic nature are explored for applications in stereoselective chemical transformations, polymer, and materials science, while cyclobutenones, with their electrophilic carbonyl group, serve as key intermediates in polyfunctionalized frameworks. We discuss recent advancements in catalysis, including transition metal- and photoredox-mediated transformations, which enable selective, enantioselective, and regioselective reactions. The review also addresses emerging challenges and future directions, emphasizing the scalability of these methods for industrial applications. This comprehensive overview underscores the transformative potential of cyclobutenes in synthetic organic chemistry.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 8","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nickel Foam Electrodes—A Versatile, Powerful, and Readily Available Tool in Electro-Organic Synthesis","authors":"Rok Narobe,&nbsp;Johannes Schneider,&nbsp;Siegfried R. Waldvogel","doi":"10.1002/tcr.70152","DOIUrl":"10.1002/tcr.70152","url":null,"abstract":"<p>For more than 50 years, nickel foam electrodes have served in electrosynthesis as powerful and readily available electrode materials. Due to their inexpensive nature and easy handling, they have been widely employed. Their application as an active anode material, which generates a conductive and insoluble layer of NiOOH in alkaline media, gives access to a selective oxidizing system. While using NiOOH anodes as an electrocatalyst has already emerged in the past and was rediscovered lately, the use of nickel foam electrodes as a highly active cathode material for the reduction of organic compounds has strongly evolved only within the last decade. Electroreductions on nickel foam can be carried out in both alkaline and acidic media, as well as under protic and aprotic conditions, enabling a broad range of transformations. The affordability, high electrical conductivity, large electrode surface area, and specific electrocatalytic features are in combination unique and unmatched by any other electrode material. The developments and, in particular, recent breakthroughs for this electrode material in electro-organic synthesis are surveyed.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 8","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tcr.70152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}