{"title":"Self-assembly of Tyrosine Scaffolds in Aqueous Media: Complex Molecular Architectures from Simple Building Blocks","authors":"Dineshkumar Bharathidasan, Dr. Chandan Maity","doi":"10.1002/tcr.202500005","DOIUrl":null,"url":null,"abstract":"<p>Mimicking natural systems, self-assembly has been employed for constructing highly stable and well-ordered supramolecular structures. Amino acids are frequently used as building blocks in the self-assembly process due to their advantageous characteristics including easy availability, easy functionalization, tunable mechanical property, and biodegradability. <i>In situ</i> generation of active building blocks to obtain complex materials via self-assembly has enhanced their application in biomedical fields including bio-imaging, therapeutics. Single amino acid as the small building-block can provide artificial supramolecular materials with unique properties. In this review, we summarize the self-assembly of tyrosine-derivatives as single amino acid-based building blocks providing supramolecular assemblies and provide perspectives on their potential impact. Finally, we discuss the ongoing challenges for future research.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"25 6","pages":""},"PeriodicalIF":7.5000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical record","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/tcr.202500005","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Mimicking natural systems, self-assembly has been employed for constructing highly stable and well-ordered supramolecular structures. Amino acids are frequently used as building blocks in the self-assembly process due to their advantageous characteristics including easy availability, easy functionalization, tunable mechanical property, and biodegradability. In situ generation of active building blocks to obtain complex materials via self-assembly has enhanced their application in biomedical fields including bio-imaging, therapeutics. Single amino acid as the small building-block can provide artificial supramolecular materials with unique properties. In this review, we summarize the self-assembly of tyrosine-derivatives as single amino acid-based building blocks providing supramolecular assemblies and provide perspectives on their potential impact. Finally, we discuss the ongoing challenges for future research.
期刊介绍：
The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields.
TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
