Dermatological Reviews最新文献

{"title":"Dupilumab Efficacy and Safety Assessment in the Treatment of Atopic Dermatitis in Pediatric Patients: A Systematic Review","authors":"Valeria Antoniou,&nbsp;Elena Thomaidou,&nbsp;Ekatherine Prokopiou","doi":"10.1002/der2.70002","DOIUrl":"https://doi.org/10.1002/der2.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background/Objectives</h3>\u0000 \u0000 <p>Atopic dermatitis (AD) is a chronic inflammatory skin condition, commonly first occurring in early childhood. Although many treatments have currently been established, their effectiveness often varies, and it is not always adequate. The first biologic agent approved in the pediatric population, in severe AD cases, is dupilumab. In this review we aim to present the current data on dupilumab effectiveness and safety in the pediatric population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Systematic search was conducted throughout PubMed, ScienceDirect, and clinicaltrials.gov, from which three clinical trials and four real-life studies were included. The studies were analyzed in terms of drug effectiveness (using EASI, IGA and SCORAD scoring systems) and safety profile (presence and occurrence of adverse events).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>EASI, SCORAD, and IGA scores were significantly improved in patients receiving dupilumab treatment irrespective of dosage. Conjunctivitis was the most consistently and commonly reported adverse event in both clinical trials (relative risk; RR = 2.4, 95% confidence interval [CI] [1.20, 4.84], <i>p</i> = 0.01) and real-life studies (10.8% of patients). Injection-site reactions and nasopharyngitis demonstrated an increased, yet nonsignificant RR. Compared to placebo, dupilumab exhibited a reduced RR of 36% in AD exacerbations (95% CI [0.43, 0.94], <i>p</i> = 0.0234) and 44% in skin infections (95% CI [0.36, 0.88], <i>p</i> = 0.0106).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dupilumab appears to be a promising drug in the treatment of moderate to severe AD in pediatric population, with noticeable improvement in outcome scores. Among the adverse events, conjunctivitis is the most common; however, no long-term or life-threatening events were reported.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eczematous Drug Eruptions: Identification and Management of Pharmacological Culprits in Primary Care","authors":"Joseph Gofman,&nbsp;Darcy Tocci,&nbsp;Daniel L. Fischer,&nbsp;Charles Gropper","doi":"10.1002/der2.70004","DOIUrl":"https://doi.org/10.1002/der2.70004","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Eczematous drug eruptions (EDEs) can mimic common skin conditions like eczema or psoriasis, complicating diagnosis and treatment. These eruptions often present as papular or vesicular lesions, sometimes pruritic, with scaling and crusting. EDEs can manifest anywhere from days to years after initiating medications commonly prescribed in the primary care setting such as calcium channel blockers, ACE inhibitors, ARBs, thiazides, and statins. Misdiagnosis can lead to prolonged patient discomfort and unnecessary treatments. This review emphasizes the importance of accurate differentiation between EDEs and other dermatoses for improved patient outcomes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This review aims to aid clinicians in the differentiation of EDEs from clinically similar conditions, such as eczema and psoriasis. It focuses on identifying commonly prescribed medications in primary care settings that trigger EDEs, discusses diagnostic strategies, and explores effective treatment options for managing these eruptions.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A comprehensive literature review was conducted using databases such as PubMed, Google Scholar, and the Cochrane Library, covering the period from January 1980 to January 2023. The search included terms like “eczematous,” “drug eruption,” “medication,” “drug induced,” “skin reactions,” “adverse cutaneous,” and “side effects.” Studies selected for review included literary reviews, systematic reviews, case reports, and case series focusing on the pharmacological agents responsible for EDEs. Articles were selected based on their focus on primary care medications and their connection to EDEs.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The review identified a broad spectrum of medications implicated in EDEs, including calcium channel blockers, ACE inhibitors, ARBs, thiazides, and statins. Among these, calcium channel blockers were the most frequently associated with chronic, diffuse, and pruritic scaly papules and plaques. Other common offenders include ACE inhibitors and ARBs, which primarily trigger eczema-like rashes in elderly patients. Thiazide diuretics were associated with photosensitivity reactions leading to eczematous eruptions. Statins were found to compromise the skin barrier, contributing to the development of eczematous reactions, particularly in older individuals. The histopathological findings across cases frequently showed spongiosis, eosinophilic infiltrates, and acanthosis, complicating the differentiation from eczema without a thorough medication history.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;sec","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction—Dermatological Reviews—October 2024","authors":"Michael H. Gold","doi":"10.1002/der2.70007","DOIUrl":"https://doi.org/10.1002/der2.70007","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide “Ozempic” Face and Implications in Cosmetic Dermatology","authors":"Karen Montecinos,&nbsp;Barbara Kania,&nbsp;David J. Goldberg","doi":"10.1002/der2.70003","DOIUrl":"https://doi.org/10.1002/der2.70003","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Semaglutide, a glucagon-like peptide-1 receptor agonist, has been utilized for the treatment of type 2 diabetes. Recently, it has gained popularity for its ability to aid in weight loss. However, rapid weight loss induced by semaglutide has been shown to lead to noticeable facial volume loss and the appearance of a prematurely aged face referred to as “Ozempic face.” As this term gains more popularity and increasingly more nondiabetic patients seek rapid weight loss options, there is growing concern among patients and healthcare providers regarding using semaglutide for weight loss as it may have a negative impact on facial esthetics.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The purpose of this paper is to investigate the semaglutide face phenomenon associated with GLP-1 agonist use for the treatment of obesity.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A comprehensive search on PubMed was conducted to identify the available information related to semaglutide regarding Ozempic face. The search was conducted using a combination of keywords, including “semaglutide,” “semaglutide face,” and “Ozempic face.”&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;“Semaglutide face” is recognized as having similar characteristics to a naturally occurring aging face. However, the characteristics of an Ozempic face occur in people much younger than what is seen with the natural aging process. While some believe that this phenomenon is attributed to acute weight loss at a faster rate than normal, many physicians argue that the semaglutide face phenomenon is more likely to occur with the amount of weight lost overall rather than whether that individual used a semaglutide medication to achieve the weight reduction or not. Overall, the semaglutide face phenomenon is characterized by elastin and collagen loss, fat and muscle volume loss, and excessive sagging skin.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The semaglutide face phenomenon highlights the esthetic implications of using semaglutide for the promotion of accelerated weight loss. While this term is not medically recognized, the hollow or sunken look following rapid weight loss sheds light on the effect of semaglutide in facial fat redistribution and volume loss. The metabolic changes induced by GLP-1 agonists can impact adipose and muscle tissue, which can lead to changes in facial contour and overall appearance. While semaglutide-induced facial changes may resemble signs of premature aging, they are distinct in their rapid onset and association with signi","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uses of Dupilumab in Dermatology: A Systematic Review of the Randomized Controlled Trials","authors":"Asmaa Enad Alenazy,&nbsp;Yasmeen Mohammed Alanazi,&nbsp;Sumayyah Inad Alanazi,&nbsp;Nehal Hassan Alrohaimi","doi":"10.1002/der2.70005","DOIUrl":"https://doi.org/10.1002/der2.70005","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Dupilumab has shown promise as a therapeutic option in dermatology, particularly in conditions like atopic dermatitis (AD), prurigo nodularis, and alopecia areata. This systematic review aimed to analyze the efficacy, safety, and benefits of dupilumab based on findings from placebo-controlled trials in dermatological conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study Aim</h3>\u0000 \u0000 <p>The objective was to systematically review placebo-controlled trials evaluating dupilumab in dermatological conditions and analyze the outcomes related to efficacy, safety, and patient-reported outcomes (PROs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>A comprehensive search was conducted in electronic databases (PubMed/MEDLINE, Embase, Cochrane Library, Scopus, and Web of Science) using keywords related to “dupilumab,” “dermatology,” “randomized controlled trial,” and “placebo.” Inclusion criteria encompassed randomized controlled trials comparing dupilumab against placebo, reporting relevant outcomes, and excluding non-randomized studies or those with interventions other than dupilumab.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The review included nine placebo-controlled trials with a total sample size of 6797 participants. Dupilumab demonstrated significant improvements in clinical severity, PROs, anxiety/depression symptoms, and health-related quality of life (HRQoL) compared to placebo in patients with moderate-to-severe AD. In prurigo nodularis, dupilumab showed significant improvements in pruritus and nodule reduction compared to placebo. Promising results were observed in alopecia areata, particularly in patients with high baseline IgE levels, with improvements in SALT scores and hair regrowth. PROs such as itch, sleep, mental health, and overall quality of life were improved with dupilumab, especially with the 300 mg dose regimens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings from placebo-controlled trials support the efficacy and safety of dupilumab in dermatological conditions, including AD, prurigo nodularis, and alopecia areata. Dupilumab appears to be a valuable therapeutic option, with potential benefits in improving clinical outcomes and PROs. Further research is warranted to explore its efficacy in other conditions and optimize dosing regimens for personalized treatment approaches.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What's New in Diode Laser Hair Removal?","authors":"Rahul Pillai,&nbsp;Jisha Pillai","doi":"10.1002/der2.253","DOIUrl":"https://doi.org/10.1002/der2.253","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Laser hair removal remains one of the most common procedures in cosmetic dermatology. It has always been challenging because of the higher competing epidermal melanocyte as the targeted hair chromophore is also melanin. As a result, to avoid unwanted side effects from laser therapy while maintaining high efficacy levels, the use of the right laser device, appropriate settings, and customized pre and posttreatment care are crucial. With more efficient versions of existing lasers in the market, the safety profile has been taken care of without compromising the efficacy. Diode lasers along with long pulsed Nd:YAG and alexandrite are considered as the safest hair removal lasers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To summarize recent developments in diode laser hair reduction focusing on improvements in efficiency, safety, and patient compliance with recent innovations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A review of recent literature updates in diode laser hair reduction technology focusing on multiwavelength systems, safety profiles, and innovations in laser device was searched using keywords diode laser hair removal and mutliwavelength diode laser devices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Currently, 810 nm diode laser is the most extensively used technology for the long term elimination of unwanted hair, thus establishing itself as an efficacious and safe modality. The rapid multiple pass in motion technique with lesser fluence and gradual heating of the skin epidermis was more well tolerated in patients than the higher fluence single shot method. Most popular combination of triple wavelength was 755, 810, and 1064 nm, which is considered most effective with least complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Diode lasers still remain the gold standard in laser hair removal especially on darker skin types. Recent innovations in diode laser have significantly improved the efficacy, safety, and patient compliance with hair reduction. Multiwavelength platforms seems to be the way forward, however the basic principles and certain problems like minimal pain, treating thin hair, paradoxical hair growth, white hair removal still remains a challenge.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRP, Exosomes, and Stem Cells: An International Perspective","authors":"Nupur Singh,&nbsp;Angela N. Brown,&nbsp;Michael H. Gold","doi":"10.1002/der2.70000","DOIUrl":"https://doi.org/10.1002/der2.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Regenerative medicine is a novel, developing field centered on efforts to repurpose the body's own molecular makeup to target specific problems. Specifically, the use of stem cells, platelet-rich plasma, and exosomes is rapidly expanding. Internationally, there remain different guidelines and a variety of medical uses, encouraging an exploration into the medical and cosmetic benefits offered.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aims to investigate current literature on the international perspectives of PRP, stem cells, and exosomes to present a global review on how these are obtained and utilized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature search was conducted on PubMed reviewing PRP, exosomes, and stem cells, among other related topics, and their applications in medical, pharmacologic, and dermatologic fields. Research produced by various global regions was examined to identify similarities and differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Stem cells have been successfully implemented in the oncology and dermatology realms as a result of their plasticity and ability to quickly replicate and divide. Platelet-rich plasma is of strong interest due to platelets' extracellular vesicles and their unmatched abilities. Exosomes are actively being studied in the fields of neurology and rheumatology, among others. International guidelines are reviewed based on regulations of these materials. Potential ethical barriers of isolation and source utilization are explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The perspectives and findings considered here stress the potential expanding uses of PRP, stem cells, and exosomes on a global scale. We highlight the need for further clinical studies and international collaboration among varying guidelines to best utilize these tools in the field of dermatology and medicine.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiosyncratic Reaction of Isotretinoin: A Review","authors":"Kar Wai Alvin Lee,&nbsp;Lisa Kwin Wah Chan,&nbsp;Cheuk Hung Lee,&nbsp;Jovian Wan,&nbsp;Kyu-Ho Yi","doi":"10.1002/der2.70001","DOIUrl":"https://doi.org/10.1002/der2.70001","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Isotretinoin is widely recognized for its efficacy in treating severe acne. However, its use is associated with a variety of idiosyncratic reactions that can affect multiple organ systems and bodily functions, necessitating vigilant monitoring and appropriate management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this review is to raise awareness of the broad spectrum of adverse effects linked to isotretinoin therapy, thereby enhancing the ability of healthcare providers to identify at-risk individuals and improve patient outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive review of current literature was conducted to explore the range of idiosyncratic reactions associated with isotretinoin. The focus was on identifying the types of adverse effects reported and the necessary monitoring strategies to mitigate these risks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Isotretinoin has been linked to a wide array of adverse effects, including, but not limited to, psychiatric issues (e.g., depression and suicidal behavior), hematological complications (e.g., neutropenia and agranulocytosis), gastrointestinal disturbances, cardiovascular effects, dermatological manifestations, hepatobiliary issues, ophthalmological changes, and orthopedic concerns. These reactions highlight the importance of careful patient monitoring during isotretinoin therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Healthcare professionals prescribing isotretinoin must be aware of the potential for diverse idiosyncratic reactions and should implement appropriate monitoring protocols to ensure patient safety. By understanding and anticipating these adverse effects, healthcare providers can better manage the risks associated with isotretinoin use, ultimately improving the quality of care for patients undergoing treatment for severe acne.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages and Disadvantages of Using AI in Dermatology","authors":"Nasim Gholizadeh,&nbsp;Ghasem Rahmatpour Rokni,&nbsp;Mahsa Babaei","doi":"10.1002/der2.248","DOIUrl":"https://doi.org/10.1002/der2.248","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Artificial intelligence (AI) in dermatology is both promising and challenging. This is important for clinicians to recognize most up-to-date knowledge and advancements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Advantages include timely detection and diagnosis, enhanced accuracy, efficient triage, workflow automation, personalized treatment, outcome prediction, education support, telemedicine aid, research facilitation, cost-efficiency, scalability, and drug development. However, limitations include generalizability issues, image quality variations, data requirements, interpretability concerns, patient acceptance, liability, multidisciplinary coordination challenges, data bias risks, lack of explainability, potential loss of clinical skills, security and privacy risks, resource intensiveness, integration challenges, validation and regulation gaps, and limited clinical assessment. Bridging these gaps requires robust ethical frameworks, interdisciplinary collaboration, education, regulation focusing on patient safety and privacy, standardized data sets, transparency, and human oversight.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite the challenges, AI holds significant potential to revolutionize dermatology practice, improving patient outcomes, healthcare accessibility, and research advancements. Further research and interdisciplinary collaboration are crucial to maximize AI's benefits and address its limitations effectively.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.248","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intense Pulsed Light Hair Removal","authors":"Hector Leal-Silva,&nbsp;Sebastián Leal-Delgado","doi":"10.1002/der2.252","DOIUrl":"https://doi.org/10.1002/der2.252","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The use of intense pulsed light (IPL) for hair removal has proven to be quite effective for conditions such as hypertrichosis and hirsutism, as well as other skin conditions related to the pilosebaceous unit. IPL was developed in the 1990s and uses a broad spectrum of light to penetrate the skin and reach the hair follicle, enabling treatment for various skin types and hair colors. This review covers the history, mechanism of action, effectiveness, patient selection, and clinical applications of IPL hair removal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To conduct this review, a comprehensive literature search was conducted to identify relevant peer-reviewed articles in English discussing the clinical use or application-based outcomes of this technology specifically for hair removal. The search covered the period from January 1990 to May 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The review of 33 peer-reviewed articles shows that IPL has significantly advanced hair removal treatment since its inception. A popular choice in clinical practice due to its efficacy, safety, and versatility, IPL hair removal has been successfully used in patients with skin conditions like acne, folliculitis, rosacea, and hyperpigmentation, offering additional benefits compared to laser hair removal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>IPL hair removal is a safe and effective option for reducing unwanted hair and improving skin appearance. It can also treat multiple skin conditions simultaneously with a low risk of side effects. Additionally, it's less painful than laser hair removal, making it an attractive option for long-lasting hair removal, especially for patients with co-existing dermatological conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142041708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}