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Cover Feature: Increasing the Lewis Acidity of Pyramidal Boranes: Cationic 9-Bora-1-Azatriptycenes as Strong Boron Lewis Superacids (ChemistryEurope 5/2025) 封面特征：增加锥体硼烷的刘易斯酸度：阳离子9-硼-1-氮杂三烯作为强硼刘易斯超强酸（化学欧洲5/2025）
ChemistryEurope Pub Date : 2025-09-23 DOI: 10.1002/ceur.70076
Nicolas Niessen, Loïc Mineur, Aurélien Chardon, Arnaud Osi, Abel Idrice Adjieufack, Damien Mahaut, Nikolay Tumanov, Johan Wouters, Benoît Champagne, Guillaume Berionni
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引用次数: 0
Cover Feature: Magneto-Optical Correlations in a High Symmetry Dysprosium Complex Reveal an Almost “Ideal Non-SMM” and Orange-to-Red DyIII-Based Emitter (ChemistryEurope 5/2025) 封面特写：高对称镝配合物中的磁光相关性揭示了几乎“理想的非smm”和橙色到红色的dyiii基发射器（ChemistryEurope 5/2025）
ChemistryEurope Pub Date : 2025-09-23 DOI: 10.1002/ceur.70078
Nimisha Jain, Gregoire David, Marie Cordier, Yan Suffren, Boris Le Guennic, Yann Sarazin, Kevin Bernot
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引用次数: 0
Cover Feature: Increasing the Lewis Acidity of Pyramidal Boranes: Cationic 9-Bora-1-Azatriptycenes as Strong Boron Lewis Superacids (ChemistryEurope 5/2025) 封面特征：增加锥体硼烷的刘易斯酸度：阳离子9-硼-1-氮杂三烯作为强硼刘易斯超强酸（化学欧洲5/2025）
ChemistryEurope Pub Date : 2025-09-23 DOI: 10.1002/ceur.70076
Nicolas Niessen, Loïc Mineur, Aurélien Chardon, Arnaud Osi, Abel Idrice Adjieufack, Damien Mahaut, Nikolay Tumanov, Johan Wouters, Benoît Champagne, Guillaume Berionni
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引用次数: 0
Cover Feature: Magneto-Optical Correlations in a High Symmetry Dysprosium Complex Reveal an Almost “Ideal Non-SMM” and Orange-to-Red DyIII-Based Emitter (ChemistryEurope 5/2025) 封面特写：高对称镝配合物中的磁光相关性揭示了几乎“理想的非smm”和橙色到红色的dyiii基发射器（ChemistryEurope 5/2025）
ChemistryEurope Pub Date : 2025-09-23 DOI: 10.1002/ceur.70078
Nimisha Jain, Gregoire David, Marie Cordier, Yan Suffren, Boris Le Guennic, Yann Sarazin, Kevin Bernot
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引用次数: 0
Front Cover: Activation of Allenes by Diferrocenylphosphenium Ion: Isolation of a Wheland Intermediate of Ferrocene (ChemistryEurope 5/2025) 封面：二茂铁基磷离子对烯的活化：二茂铁惠兰中间体的分离（ChemistryEurope 5/2025）
ChemistryEurope Pub Date : 2025-09-23 DOI: 10.1002/ceur.70077
Corina Stoian, Carolin Exner, Pim Puylaert, Moritz Hornig, Serhiy Demeshko, Malte Fischer, Emanuel Hupf, Jens Beckmann
{"title":"Front Cover: Activation of Allenes by Diferrocenylphosphenium Ion: Isolation of a Wheland Intermediate of Ferrocene (ChemistryEurope 5/2025)","authors":"Corina Stoian,&nbsp;Carolin Exner,&nbsp;Pim Puylaert,&nbsp;Moritz Hornig,&nbsp;Serhiy Demeshko,&nbsp;Malte Fischer,&nbsp;Emanuel Hupf,&nbsp;Jens Beckmann","doi":"10.1002/ceur.70077","DOIUrl":"https://doi.org/10.1002/ceur.70077","url":null,"abstract":"<p><b>The Front Cover</b> shows a round-bottomed flask containing a burgundy solution of diferrocenylphosphenium ion [Fc<sub>2</sub>P][B(C<sub>6</sub>F<sub>5</sub>)<sub>4</sub>], which was used in this work to activate various allenes. Dropwise addition to 2-(trimethylsilyl) penta-2,3-diene yields a bright red solution of a stable Wheland intermediate of ferrocene, whose solid-state structure is depicted as a ball-and-stick model. In front lies Saint Peter’s Key, a prominent feature of the City of Bremen’s coat of arms, representing the unlocked potential of highly reactive main group species. More information can be found in the Research Article by E. Hupf, J. Beckmann and co-workers (DOI: 10.1002/ceur.202500031).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Feature: Small Molecule Activation by Metallylenes and their Follow-Up Reactions (ChemistryEurope 5/2025) 封面专题：小分子的聚乙烯活化及其后续反应（ChemistryEurope 5/2025）
ChemistryEurope Pub Date : 2025-09-23 DOI: 10.1002/ceur.70079
Eveline H. Tiekink, Matthijs W. Kragtwijk, Trevor A. Hamlin
{"title":"Cover Feature: Small Molecule Activation by Metallylenes and their Follow-Up Reactions (ChemistryEurope 5/2025)","authors":"Eveline H. Tiekink,&nbsp;Matthijs W. Kragtwijk,&nbsp;Trevor A. Hamlin","doi":"10.1002/ceur.70079","DOIUrl":"https://doi.org/10.1002/ceur.70079","url":null,"abstract":"<p><b>Blurring the boundaries</b> between main-group and transition metal chemistry, Group 14 metallylenes offer a tunable, earth-abundant platform for catalysis. Once the domain of d-block elements, transition metal-like reactivity is now within reach—unlocking new avenues for sustainable small-molecule activation and follow-up reactions through ligand optimization and quantum chemical design. More information can be found in the Review by T. A. Hamlin and co-workers (DOI: 10.1002/ceur.202500119).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Feature: Small Molecule Activation by Metallylenes and their Follow-Up Reactions (ChemistryEurope 5/2025) 封面专题：小分子的聚乙烯活化及其后续反应（ChemistryEurope 5/2025）
ChemistryEurope Pub Date : 2025-09-23 DOI: 10.1002/ceur.70079
Eveline H. Tiekink, Matthijs W. Kragtwijk, Trevor A. Hamlin
{"title":"Cover Feature: Small Molecule Activation by Metallylenes and their Follow-Up Reactions (ChemistryEurope 5/2025)","authors":"Eveline H. Tiekink,&nbsp;Matthijs W. Kragtwijk,&nbsp;Trevor A. Hamlin","doi":"10.1002/ceur.70079","DOIUrl":"https://doi.org/10.1002/ceur.70079","url":null,"abstract":"<p><b>Blurring the boundaries</b> between main-group and transition metal chemistry, Group 14 metallylenes offer a tunable, earth-abundant platform for catalysis. Once the domain of d-block elements, transition metal-like reactivity is now within reach—unlocking new avenues for sustainable small-molecule activation and follow-up reactions through ligand optimization and quantum chemical design. More information can be found in the Review by T. A. Hamlin and co-workers (DOI: 10.1002/ceur.202500119).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: Activation of Allenes by Diferrocenylphosphenium Ion: Isolation of a Wheland Intermediate of Ferrocene (ChemistryEurope 5/2025) 封面：二茂铁基磷离子对烯的活化：二茂铁惠兰中间体的分离（ChemistryEurope 5/2025）
ChemistryEurope Pub Date : 2025-09-23 DOI: 10.1002/ceur.70077
Corina Stoian, Carolin Exner, Pim Puylaert, Moritz Hornig, Serhiy Demeshko, Malte Fischer, Emanuel Hupf, Jens Beckmann
{"title":"Front Cover: Activation of Allenes by Diferrocenylphosphenium Ion: Isolation of a Wheland Intermediate of Ferrocene (ChemistryEurope 5/2025)","authors":"Corina Stoian,&nbsp;Carolin Exner,&nbsp;Pim Puylaert,&nbsp;Moritz Hornig,&nbsp;Serhiy Demeshko,&nbsp;Malte Fischer,&nbsp;Emanuel Hupf,&nbsp;Jens Beckmann","doi":"10.1002/ceur.70077","DOIUrl":"https://doi.org/10.1002/ceur.70077","url":null,"abstract":"<p><b>The Front Cover</b> shows a round-bottomed flask containing a burgundy solution of diferrocenylphosphenium ion [Fc<sub>2</sub>P][B(C<sub>6</sub>F<sub>5</sub>)<sub>4</sub>], which was used in this work to activate various allenes. Dropwise addition to 2-(trimethylsilyl) penta-2,3-diene yields a bright red solution of a stable Wheland intermediate of ferrocene, whose solid-state structure is depicted as a ball-and-stick model. In front lies Saint Peter’s Key, a prominent feature of the City of Bremen’s coat of arms, representing the unlocked potential of highly reactive main group species. More information can be found in the Research Article by E. Hupf, J. Beckmann and co-workers (DOI: 10.1002/ceur.202500031).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bistable and Water-Operable Hemiindigo Photoswitches Allow Optical Control of Acetylcholinesterase Activity with Visible Light 双稳态和可水操作的半靛蓝光开关允许用可见光光学控制乙酰胆碱酯酶活性
ChemistryEurope Pub Date : 2025-09-09 DOI: 10.1002/ceur.202500221
Leticia M. Lazinski, Morane Beaumet, Frédérique Loiseau, Cyril Goudet, Martial Boggio-Pasqua, Guy Royal, Romain Haudecoeur
{"title":"Bistable and Water-Operable Hemiindigo Photoswitches Allow Optical Control of Acetylcholinesterase Activity with Visible Light","authors":"Leticia M. Lazinski,&nbsp;Morane Beaumet,&nbsp;Frédérique Loiseau,&nbsp;Cyril Goudet,&nbsp;Martial Boggio-Pasqua,&nbsp;Guy Royal,&nbsp;Romain Haudecoeur","doi":"10.1002/ceur.202500221","DOIUrl":"https://doi.org/10.1002/ceur.202500221","url":null,"abstract":"<p>While photopharmacology enables precise spatiotemporal control over drug activity, its widespread reliance on UV-responsive molecules often hinders preclinical and clinical advancements. Thus, alternative scaffolds can offer promising advantages over the commonly used azobenzene family. In this study, we introduce the first hemiindigo-based photopharmacological agents, which are capable of isomer-dependent human acetylcholinesterase inhibition in the nanomolar range. These hemiindigo photoswitches exhibit highly favorable properties: They are fully functional in aqueous medium with good photoisomerization quantum yields, respond exclusively to blue-to-orange visible light (415–590 nm), and maintain high stability in their metastable form, even in physiological buffers. Notably, indoxyl <i>N</i>-methylation emerged as a key structural feature for optimizing photophysical properties, as demonstrated through crystallography and a theoretical model describing the photochemical pathways governing photoisomerization. Overall, this study paves the way for broader exploration and future applications of the largely overlooked hemiindigo scaffold in photopharmacology.</p>","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.202500221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bistable and Water-Operable Hemiindigo Photoswitches Allow Optical Control of Acetylcholinesterase Activity with Visible Light 双稳态和可水操作的半靛蓝光开关允许用可见光光学控制乙酰胆碱酯酶活性
ChemistryEurope Pub Date : 2025-09-09 DOI: 10.1002/ceur.202500221
Leticia M. Lazinski, Morane Beaumet, Frédérique Loiseau, Cyril Goudet, Martial Boggio-Pasqua, Guy Royal, Romain Haudecoeur
{"title":"Bistable and Water-Operable Hemiindigo Photoswitches Allow Optical Control of Acetylcholinesterase Activity with Visible Light","authors":"Leticia M. Lazinski,&nbsp;Morane Beaumet,&nbsp;Frédérique Loiseau,&nbsp;Cyril Goudet,&nbsp;Martial Boggio-Pasqua,&nbsp;Guy Royal,&nbsp;Romain Haudecoeur","doi":"10.1002/ceur.202500221","DOIUrl":"https://doi.org/10.1002/ceur.202500221","url":null,"abstract":"<p>While photopharmacology enables precise spatiotemporal control over drug activity, its widespread reliance on UV-responsive molecules often hinders preclinical and clinical advancements. Thus, alternative scaffolds can offer promising advantages over the commonly used azobenzene family. In this study, we introduce the first hemiindigo-based photopharmacological agents, which are capable of isomer-dependent human acetylcholinesterase inhibition in the nanomolar range. These hemiindigo photoswitches exhibit highly favorable properties: They are fully functional in aqueous medium with good photoisomerization quantum yields, respond exclusively to blue-to-orange visible light (415–590 nm), and maintain high stability in their metastable form, even in physiological buffers. Notably, indoxyl <i>N</i>-methylation emerged as a key structural feature for optimizing photophysical properties, as demonstrated through crystallography and a theoretical model describing the photochemical pathways governing photoisomerization. Overall, this study paves the way for broader exploration and future applications of the largely overlooked hemiindigo scaffold in photopharmacology.</p>","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.202500221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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