Chemical Engineering Research & Design最新文献

{"title":"Selective adsorption of phosphate by 2D thin-bladed ZIF-L in phosphate mining wastewater: An investigation of single phosphorus and phosphorus-chromium composite systems","authors":"Dongming Li ,&nbsp;Peicong Zhang ,&nbsp;Jinhua Luo ,&nbsp;Yi Huang ,&nbsp;Jialin He ,&nbsp;Jinshu Zhang ,&nbsp;Yubin Li ,&nbsp;Chengye Yang","doi":"10.1016/j.cherd.2025.09.040","DOIUrl":"10.1016/j.cherd.2025.09.040","url":null,"abstract":"<div><div>The Yangtze River basin is the primary region for phosphate resource distribution in China, and pollution from phosphorus and chromium during phosphate mining poses a significant danger to the local water environment and soil safety. 2D ZIF-L, a novel zinc-based ZIF material, demonstrates substantial potential for water pollution remediation owing to its distinctive leaf-like shape and superior hydrophilicity. Currently, there are no reports regarding the research of this substance inside the phosphorus-chromium composite pollution system. This paper presents the preparation of ZIF-L materials exhibiting superior synergistic adsorption capabilities for phosphorus and chromium, utilising zinc nitrate as the zinc source and 2-methylimidazole as the organic ligand through a precipitation method under conditions of low molar ratio and low water usage, achieving a saturated phosphorus adsorption capacity of 192.9 mg/g. Acidic conditions enhanced the removal of phosphorus and chromium by ZIF-L; the initial concentration of phosphorus was a key factor in determining the ability of chromium to inhibit or promote the total adsorption capacity of ZIF-L; and the presence of chromium augmented the adsorption rate of phosphate by ZIF-L. The adsorption of phosphate by ZIF-L in the single phosphorus/phosphorus-chromium composite contaminated solution was consistent with the Langmuir model and the quasi-second-order kinetic model, which belonged to the adsorption of a monomolecular layer and was dominated by chemical adsorption. The adsorption mechanism primarily involved both electrostatic attraction and ligand exchange. To summarise, ZIF-L has extensive potential for remediating phosphate mining pollutants.</div></div>","PeriodicalId":10019,"journal":{"name":"Chemical Engineering Research & Design","volume":"223 ","pages":"Pages 209-219"},"PeriodicalIF":3.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient adsorption of typical antibiotics by petroleum coke-based ultra-large surface porous carbon materials: Mechanism and cost analysis","authors":"Di Zhang ,&nbsp;Xinyu Yang ,&nbsp;Tongtong Wang ,&nbsp;Huixia Wang ,&nbsp;Shumiao Cao ,&nbsp;Hui Shi","doi":"10.1016/j.cherd.2025.09.035","DOIUrl":"10.1016/j.cherd.2025.09.035","url":null,"abstract":"<div><div>The misuse and residues of typical antibiotics cause serious threats to the aquatic environment, especially for non-biodegradable pollutants such as chloramphenicol (CAP) and norfloxacin (NOR). Currently, traditional adsorbents have limited effectiveness in treating this type of wastewater, and there is an urgent need to develop efficient and low-cost adsorbent materials balanced with green economy objectives. This study used petroleum coke, a common chemical waste, as a precursor to prepare ultra-large surface area porous carbon (UC) through multiple processes of “carbonization-oxidation-expansion-activation”. The adsorption characteristics and mechanisms were deeply analyzed by various characterization techniques, batch experiments, and classical adsorption models. The results showed that the specific surface area of UC was as high as 2569.43 m²·g⁻¹ with a multistage pore structure dominated by micropores. The theoretical maximum adsorption capacity of CAP and NOR by UC was 437.47 mg·g⁻¹ and 362.27 mg·g⁻¹, respectively. The adsorption is consistent with the Langmuir and Pseudo-second-order kinetic models. This adsorption mechanism is dominated by the single-molecule-layer physical interactions, mainly including surface adsorption and ion exchange, assisted by hydrogen bonding and π-π interactions. The full life cycle assessment of UC showed that its preparation cost is low, approximately 13.86 USD·kg⁻¹ (40.12 % of the raw material), and its performance was significantly better than that of the popular adsorbents. This work provides an economical and efficient technological approach for preparing high-performance adsorbents from petroleum coke resources, which is of great value for antibiotic wastewater treatment.</div></div>","PeriodicalId":10019,"journal":{"name":"Chemical Engineering Research & Design","volume":"222 ","pages":"Pages 557-572"},"PeriodicalIF":3.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small-gain based distributed Model Predictive Control of nonlinear continuous processes","authors":"Yi Zheng,&nbsp;Qibo Liu,&nbsp;Qingchun Zhao,&nbsp;Yanye Wang,&nbsp;Shaoyuan Li","doi":"10.1016/j.cherd.2025.09.026","DOIUrl":"10.1016/j.cherd.2025.09.026","url":null,"abstract":"<div><div>This paper proposes a distributed Model Predictive Control (MPC) for continuous nonlinear systems composed of interconnected subsystems. The proposed distributed MPC builds upon Lyapunov-based MPC by incorporating the small-gain theorem to ensure stability. Specifically, a stability constraint is designed to limit the derivative of the subsystem-based ISS-Lyapunov function of each subsystem under the action of the designed subsystem-based MPC to be less than that under an existing controller. Sufficient conditions are derived to ensure that the states of the closed-loop system converge to a small region around the equilibrium under the proposed method. The design of a certain subsystem-based MPC only relies on its dynamics and the resulting gain relationship with its associated subsystems, and each subsystem-based MPC operates with neighbor-to-neighbor communication. These keep the structural flexibility of the control system. The designed DMPC does not require that all subsystem-based Lyapunov functions decrease simultaneously. This positively impacts the performance of the entire system. Finally, an application of the proposed method to a chemical process demonstrates its effectiveness.</div></div>","PeriodicalId":10019,"journal":{"name":"Chemical Engineering Research & Design","volume":"223 ","pages":"Pages 177-184"},"PeriodicalIF":3.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An optimisation framework for minimising power consumption, dead volume, and shear rate of mixing tanks containing shear-thinning fluids utilising CFD","authors":"Liam Merrick Boston,&nbsp;Jos Derksen,&nbsp;Aniruddha Majumder","doi":"10.1016/j.cherd.2025.09.025","DOIUrl":"10.1016/j.cherd.2025.09.025","url":null,"abstract":"<div><div>A hydrodynamic model of a laminar mixing tank containing a shear-thinning power-law fluid stirred by a helical ribbon impeller is created using the Lattice Boltzmann Method and used to train regression models to predict power number, percentage of dead volume, and shear rate statistics. A Reduced Gradient Algorithm is used to maximise a Composite Desirability Function, composed of the regression models, to optimise impeller geometry for selected flow behaviour indices following a Design of Experiments methodology. The regression models are trained on sixty simulations, and validated on eight separate simulations. The range of deviation between regression models and each output response are as follows: impeller power number = 0.047<!--> <!-->% to 18<!--> <!-->%, percentage of tank dead volume = 0.34<!--> <!-->% to 18<!--> <!-->%, average shear rate = 0.56<!--> <!-->% to 9.0<!--> <!-->%, maximum shear rate = 0.46<!--> <!-->% to 11<!--> <!-->%, and standard deviation of shear rate = 0.69<!--> <!-->% to 5.5<!--> <!-->%. This is found to be an efficient methodology for optimising mixing conditions, when only a hydrodynamic model is available.</div></div>","PeriodicalId":10019,"journal":{"name":"Chemical Engineering Research & Design","volume":"223 ","pages":"Pages 263-279"},"PeriodicalIF":3.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the combined role of gravity and rheology in thermocapillary-driven droplet spreading","authors":"Soumen Chakraborty ,&nbsp;Antarip Poddar ,&nbsp;Vishnu Teja Mantripragada","doi":"10.1016/j.cherd.2025.08.042","DOIUrl":"10.1016/j.cherd.2025.08.042","url":null,"abstract":"<div><div>The complex rheology of biofluids and industrial fluids is a decisive factor in their deformation and spreading on a heated substrate. However, the intervening role of gravity forces remains unexplored. Here, we apply the lubrication approximation to the momentum equation and the power-law constitutive relation for inelastic non-Newtonian fluids, with the intermolecular forces being accounted for within the continuum hypothesis. The derived evolution equation for droplet height has been solved numerically using the finite element method. The Marangoni stress dominates the conjoining–disjoining pressure in the ‘Marangoni film regime’. The gravity effect causes a significant curvature of the rear edge, leading to a pancake-like droplet shape and reduced capillary ridge height near advancing fronts. Furthermore, increasing capillary ridge height with shear-thinning and faster-moving advancing fronts with either enhanced Marangoni stress or shear-thickening are both dampened by gravity. The droplet regime, previously observed in microgravity conditions, no longer exists under gravity. The drop deviates from its initial shape as dictated by its rheology but maintains the same shape afterwards, leading to a new regime named ‘transition without breakup.’ The gravity effect weakens after initial deformation, and the dominant conjoining–disjoining pressure results in a constant migration speed without further deformation. The ‘transition with breakup regime’, where droplets break apart into smaller droplets, is influenced by a critical interaction between Marangoni stress, intermolecular force, and gravity force. The onset of rupture strongly depends on the fluid rheology and the thermocapillary strength. The presented regime maps provide the critical parameters for switching regimes and highlight exclusive spreading states under gravity. These insights on the critical interaction between gravity, shear-dependent rheology, and thermocapillary actuation for partially wetting droplets could lead to more versatile microfluidic devices for handling complex biofluids.</div></div>","PeriodicalId":10019,"journal":{"name":"Chemical Engineering Research & Design","volume":"222 ","pages":"Pages 544-556"},"PeriodicalIF":3.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic hydrogen production performance of ZnCdS-encapsulated bimetallic NiMoO4 rod-like heterojunctions in the reforming of lignin model compounds","authors":"Jianxu Zhang ,&nbsp;Jingwei Li ,&nbsp;Linjing Ye ,&nbsp;Weisheng Guan","doi":"10.1016/j.cherd.2025.09.028","DOIUrl":"10.1016/j.cherd.2025.09.028","url":null,"abstract":"<div><div>Biomass photoreforming for hydrogen production is a promising approach that utilizes solar energy to facilitate the reaction between biomass and water, achieving efficient conversion of both solar and biomass energy into hydrogen. In this study, ZnCdS (ZCS) nanoparticles were loaded onto NiMoO₄ (NMO) nanorods via calcination and hydrothermal methods to construct ZCS/NMO S-scheme heterojunctions. The resultant composites were systematically characterized for physicochemical properties. Among the prepared catalysts, ZCS/NMO-10 % demonstrated the highest hydrogen evolution activity, with hydrogen production rates of 600.27 μmol·g⁻¹·h⁻¹ and 165.54 μmol·g⁻¹·h⁻¹ using a lignin model compound and sodium lignosulfonate as substrates, respectively. The introduction of the bimetallic oxide effectively accelerated the hydrogen evolution reaction. This improved photocatalytic performance is ascribed to the formation of the heterojunction, which not only enhances charge separation but also preserves strong redox capabilities. Additionally, liquid phase analysis of the lignin model compound (PP-ol) solution after catalysis revealed that PP-ol was oxidized into three high-value chemicals during the oxidation half-reaction, with a maximum conversion rate of up to 89.10 %. A possible catalytic reaction mechanism is also proposed. Overall, this work provides a promising strategy for mitigating energy shortages and environmental pollution.</div></div>","PeriodicalId":10019,"journal":{"name":"Chemical Engineering Research & Design","volume":"222 ","pages":"Pages 486-499"},"PeriodicalIF":3.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of poly (lactic-Co-glycolic acid) nanoparticles of retinol using supercritical fluid technology: Factorial design-based optimization, physicochemical characterization and cell viability assessment","authors":"Milind Velhal ,&nbsp;Shriya Pande ,&nbsp;Ritesh Fule ,&nbsp;Nitin Dumore ,&nbsp;Md Ali Mujtaba ,&nbsp;Ali F. Almutairy ,&nbsp;Ameeduzzafar Zafar ,&nbsp;Mohammad Khalid","doi":"10.1016/j.cherd.2025.09.033","DOIUrl":"10.1016/j.cherd.2025.09.033","url":null,"abstract":"<div><div>Retinol acetate (RA) has potential antineoplastic and chemo-preventive activities. However, RA is highly hydrophobic, which decreases its bioavailability and limits its therapeutic potential. Therefore, this study aimed to develop and characterize poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) using supercritical fluid technology (SFT). Additionally, the therapeutic effectiveness of RA-loaded PLGA-NPs was evaluated using cytotoxicity assay. In the present investigation, we have explored novel, green technology for preparing PLGA-NPs, which is the modified rapid expansion of supercritical solution (RESS) with mixing and sonication. Preoptimization feasibility studies were taken into consideration when choosing dependent and independent factors. 2³ full factorial design was applied to quantify the effect of dependent factors on independent factors. The optimized RA-loaded PLGA-NPs formulation was characterized by various parameters. The average particle size, polydispersity index, and zeta potential of optimized PLGA-NPs were 100.8 ± 10 nm, 0.412 ± 0.08, and −17.6 mV, respectively. The drug content was observed to be 82 ± 5 % and % entrapment efficiency was found to be 99.6 ± 0.32 %. The XRD and DSC of NPs showed that the drug is in a non-crystalline state. FTIR spectroscopy confirmed the effective incorporation of RA into the PLGA-NPs. SEM and TEM studies exhibit uniform-shaped particles of 70–100 nm size. The release of the drug from RA-PLGA nanoparticles was regulated by the initial diffusion of RA and later by the degradation of the biodegradable polymer. MTT assay revealed that the RA-loaded PLGA-NPs were superior in arresting cell growth as compared to free RA. In summary, RA-encapsulated PLGA-NPs, prepared by the SFT, have great potential as a drug delivery system for clinical applications in anti-cancer treatment.</div></div>","PeriodicalId":10019,"journal":{"name":"Chemical Engineering Research & Design","volume":"222 ","pages":"Pages 500-515"},"PeriodicalIF":3.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of CaO-based thermochemical storage particles through SiC doping and calcination strategy: Toward enhanced thermal conductivity and mechanical properties","authors":"Xiang Li,&nbsp;Zhongli He,&nbsp;Hongchuan Jiang,&nbsp;Guodong Zhang,&nbsp;Cai Liang","doi":"10.1016/j.cherd.2025.09.032","DOIUrl":"10.1016/j.cherd.2025.09.032","url":null,"abstract":"<div><div>Calcium oxide (CaO) is a promising material for thermochemical energy storage, but its poor mechanical properties and cycling stability remain a major challenge. In this study, CaO-based composite particles with different SiC doping ratio (0–20 wt%) were prepared and subjected to forming calcination at 700°C, 850°C, and 1000°C. The effects of doping ratio and forming calcination temperature on thermal conductivity, reaction stability, and mechanical properties were systematically evaluated. The results show that 10 wt% SiC doping significantly improves thermal conductivity (up to 0.971 W·m⁻¹·K⁻¹), improves strength (still 14.5 N after 20 cycles), and reduces attrition loss to 0.31 wt% after 20 cycles. However, over-doping (≥15 wt%) leads to a decrease in strength during cycling. The energy storage density and conversion rate also decrease slightly with increasing doping ratio. Particles doped with 10 wt% SiC and subjected to calcination above 850 °C showed superior overall performance in both thermal and mechanical aspects.</div></div>","PeriodicalId":10019,"journal":{"name":"Chemical Engineering Research & Design","volume":"222 ","pages":"Pages 404-414"},"PeriodicalIF":3.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental and CFD analysis of two-phase flow in a ceramic porous media under plasma-assisted wastewater treatment conditions","authors":"Masoud Haghshenasfard ,&nbsp;Stefan Schönekerl ,&nbsp;Gisa Scale ,&nbsp;Christel Pfefferkorn ,&nbsp;Daniela Haase ,&nbsp;Sarah Trepte ,&nbsp;Hossein Mehdipour ,&nbsp;André Lerch","doi":"10.1016/j.cherd.2025.09.030","DOIUrl":"10.1016/j.cherd.2025.09.030","url":null,"abstract":"<div><div>This study investigates hydrodynamic parameters governing pollutant degradation in a low-temperature plasma (LTP) reactor utilizing porous alumina ceramic media. A validated 3D Volume of Fluid (VOF) model simulated air–water two-phase flow to resolve film thickness, wettability, wetting area, residence time, and liquid hold-up across varying flow rates. Experimental measurements confirmed the CFD predictions and showed that increasing the flow rate led to a sharp decline in degradation efficiency due to reduced residence time and increased film thickness. Notably, maximum degradation (∼33.4 mg/L) occurred at intermediate flow conditions (Q ≈ 7.0 L/h, RT ≈ 6.1 s), whereas degradation stagnated at higher flow rates due to shortened treatment time and possible side reactions indicated by conductivity shifts. Kinetic analysis of the experimental data confirmed a zero-order degradation mechanism, with a strong linear correlation between residence time and indigo carmine removal (R² = 0.997). Regression and desirability-based optimisation identified 10.97 L/h as the ideal flowrate, balancing surface wetting and residence time for effective degradation (∼31.2 mg/L). Sensitivity analysis confirmed that film thickness and residence time were the most influential factors. The study offers a quantitative framework for optimising LTP reactors by integrating CFD, experiments, and multi-criteria optimisation.</div></div>","PeriodicalId":10019,"journal":{"name":"Chemical Engineering Research & Design","volume":"223 ","pages":"Pages 160-176"},"PeriodicalIF":3.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved magnesium sulphate crystallization using ultrasonic horn","authors":"Yagna S. Hirpara,&nbsp;Parag R. Gogate","doi":"10.1016/j.cherd.2025.09.031","DOIUrl":"10.1016/j.cherd.2025.09.031","url":null,"abstract":"<div><div>The current study explored the use of an ultrasonic horn to improve the crystallization of magnesium sulphate, also employing response surface methodology (RSM) for optimizing the parameters governing particle size reduction, striving to attain the smallest possible particle size and a narrow particle size distribution (PSD). The optimal conditions identified using the model fitting included an ultrasonic power of 136 W, an applied ultrasound time of 10 min, a duty cycle of 70 % and stirring at 1110 rpm. Under the optimized ultrasonic conditions, the particle size was reduced to about 72.9 % of that found in conventional samples. The reduction in particle size during sonication was attributed to shear forces induced by cavitation, along with acoustic streaming and microjet effects. The X-ray diffraction analysis revealed that the sonication affected particle size, with minimal perturbations to the crystal lattice. Fourier-transform infrared (FTIR) spectroscopy confirmed that the functional groups remained unchanged after ultrasonic treatment, while SEM images displayed smaller, and fragmented crystals of magnesium sulphate. Overall, the study demonstrated the advantages of ultrasound in achieving smaller crystals with improved morphology, without compromising crystal quality.</div></div>","PeriodicalId":10019,"journal":{"name":"Chemical Engineering Research & Design","volume":"222 ","pages":"Pages 516-531"},"PeriodicalIF":3.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}