Boletín Médico Del Hospital Infantil de México (English Edition)最新文献

{"title":"Omics techniques and biobanks to find new biomarkers for the early detection of acute lymphoblastic leukemia in middle-income countries: a perspective from Mexico","authors":"William Alejandro Aguirre-Guillén ,&nbsp;Tania Angeles-Floriano ,&nbsp;Briceida López-Martínez ,&nbsp;Hortensia Reyes-Morales ,&nbsp;Albert Zlotnik ,&nbsp;Ricardo Valle-Rios","doi":"10.1016/j.bmhime.2017.11.031","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.031","url":null,"abstract":"<div><p>Acute lymphoblastic leukemia (ALL) affects the quality of life of many children in the world and particularly in Mexico, where a high incidence has been reported. With a proper financial investment and with well-organized institutions caring for those patients, together with solid platforms to perform high-throughput analyses, we propose the creation of a Mexican repository system of serum and cells from bone marrow and blood samples derived from tissues of pediatric patients with ALL diagnosis. This resource, in combination with omics technologies, particularly proteomics and metabolomics, would allow longitudinal studies, offering an opportunity to design and apply personalized ALL treatments. Importantly, it would accelerate the development of translational science and will lead us to further discoveries, including the identification of new biomarkers for the early detection of leukemia.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 3","pages":"Pages 227-232"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138322722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omics-based biomarkers: current status and potential use in the clinic","authors":"Héctor Quezada ,&nbsp;Ana Laura Guzmán-Ortiz ,&nbsp;Hugo Díaz-Sánchez ,&nbsp;Ricardo Valle-Rios ,&nbsp;Jesús Aguirre-Hernández","doi":"10.1016/j.bmhime.2017.11.030","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.030","url":null,"abstract":"<div><p>In recent years, the use of high-throughput omics technologies has led to the rapid discovery of many candidate biomarkers. However, few of them have made the transition to the clinic. In this review, the promise of omics technologies to contribute to the process of biomarker development is described. An overview of the current state in this area is presented with examples of genomics, proteomics, transcriptomics, metabolomics and microbiomics biomarkers in the field of oncology, along with some proposed strategies to accelerate their validation and translation to improve the care of patients with neoplasms. The inherent complexity underlying neoplasms combined with the requirement of developing well-designed biomarker discovery processes based on omics technologies present a challenge for the effective development of biomarkers that may be useful in guiding therapies, addressing disease risks, and predicting clinical outcomes.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 3","pages":"Pages 219-226"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138322721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between time of permanence in the early education program (nurseries program) and developmental level for children in poverty situation","authors":"Antonio Rizzoli-Córdoba ,&nbsp;Laura Ibernia Vargas-Carrillo ,&nbsp;Jorge Rodrigo Vásquez-Ríos ,&nbsp;Hortensia Reyes-Morales ,&nbsp;Miguel Ángel Villasís-Keever ,&nbsp;Gabriel O'Shea-Cuevas ,&nbsp;Daniel Aceves-Villagrán ,&nbsp;Onofre Muñoz-Hernández ,&nbsp;José Alberto García-Aranda","doi":"10.1016/j.bmhime.2017.11.024","DOIUrl":"10.1016/j.bmhime.2017.11.024","url":null,"abstract":"<div><h3>Background</h3><p>The nurseries program (NP) was created to support parents with 1 to 3-year-old children living in poverty situation in Mexico, and includes education and child daycare for 8<!--> <!-->hours five days per week. The objective of this study was to evaluate the association between length of stay in the NP and the level of development in children.</p></div><div><h3>Methods</h3><p>Cross-sectional, population-based study conducted in two Mexican states. All children aged between 12 to 48 months enrolled in NP from November 2014 to January 2015 were included. The Child Development Evaluation (CDE) test was used to screen early development. Normal early development prevalence odds ratio (OR) was calculated and adjusted for gender, impairment, and state, using as a reference those children with less than 30 days in the program.</p></div><div><h3>Results</h3><p>The study included 3,387 children from 177 NP nurseries, 53% were male; age by group was divided in 12-24 months (22.3%), 25-36 months (37.6%) and 37-42 months (40.1%). Normal development adjusted OR by age were 1.9 (CI95%: 1.30-2.78) for 6-11 months, 2.36 (95%IC: 1.60-3.50) for 12-17 months, 2.78 (95%IC: 1.65-4.65) for 18-23 months and 3.46 (95%IC: 2.13-5.60) for &gt; 24 months. Regarding area of development, a greater probability of having a normal result for language and social areas was observed after six months in the program, and for the motor (both gross and fine) and knowledge areas after 12 months.</p></div><div><h3>Conclusion</h3><p>The length of the stay in the NP after six months significantly and progressively increases the probability of normal development regardless of gender and age.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 2","pages":"Pages 98-106"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47719104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child care centers and child development in Mexico: progress and challenges","authors":"Rafael Pérez-Escamilla","doi":"10.1016/j.bmhime.2017.01.002","DOIUrl":"10.1016/j.bmhime.2017.01.002","url":null,"abstract":"","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 2","pages":"Pages 84-85"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54311171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The jibarization of logos: how medical reductionism can kill","authors":"Juan Emilio Sala","doi":"10.1016/j.bmhime.2017.11.021","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.021","url":null,"abstract":"<div><p>In recent decades, a disciplinary and sub disciplinary proliferation has been triggered both in the medical fields and science in general. This trend may be partially explained by two diachronic, dialectically interconnected facts: the deepening of the technical, social and international division of labor in the globalized capitalist world, and the triumph of the reductionist program, mainly developed by the logical empiricism of the Vienna Circle. This paper aims to deepen the debate on the intricate links between medicine, biology, philosophy, reductionism, and complex thought, by using two examples: a current clinical case report and the situation experienced by a famous American scientist, Stephen Jay Gould, about his first cancer, an abdominal mesothelioma. We have witnessed how the two above-mentioned historical facts have been operating as a super-structure like a pair of “tweezers”, dismembering and compressing at the same moment the object of knowledge, the theories that allow their study, and the subject that receives the knowledge. This <em>jibarization of knowledge</em> is a real problem for public health, from the moment that it impacts, omnipresent, in the actual hegemonic medical model, leading to potentially dangerous attitudes in the various components of health systems.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 2","pages":"Pages 154-163"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137288554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evans syndrome in infants","authors":"Olivia Alejandra Flores-Montes ,&nbsp;Martha Cecilia Escobar-Orduño ,&nbsp;Mónica Lozano-Garcidueñas ,&nbsp;Jaime Guadalupe Valle-Leal","doi":"10.1016/j.bmhime.2017.01.001","DOIUrl":"10.1016/j.bmhime.2017.01.001","url":null,"abstract":"<div><h3>Background</h3><p>Evans’ syndrome is characterized by the reduction of at least two blood cell lines in the absence of other diagnoses; it was previously described as the simultaneous or sequential development of autoimmune hemolytic anemia and immune thrombocytopenia with unknown etiology. Incidence of 37% and mortality rate of 10% have been reported for Evans’ syndrome.</p></div><div><h3>Clinical cases</h3><p>We report the clinical presentation and evolution of Evans’ syndrome in two infants who were initially diagnosed with immune thrombocytopenia. The clinical diagnosis was supported by complementary studies and hematological disorders were corroborated. Both cases received treatment with steroids and intravenous immunoglobulin.</p></div><div><h3>Conclusions</h3><p>Other cell line disorders must be looked for when approaching children with thrombocytopenia. In the present cases, we found autoimmune hemolytic anemia and monocytosis. Therefore, infectious and immunological studies must be included. The treatment of choice are steroids, and intravenous immunoglobulin should be considered if severe immune thrombocytopenia is associated, as observed in these cases.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 2","pages":"Pages 141-146"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47405251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education in our time: competency or aptitude? The case for medicine. Part I","authors":"Leonardo Viniegra-Velázquez","doi":"10.1016/j.bmhime.2017.11.023","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.023","url":null,"abstract":"<div><p>This paper on the role that education plays at our time begins with a statement: to be able to understand the education's core; it is necessary to characterize its society. Distinctive features of today's world, lead us to perceive it as the ruin of civilization. Based on the limitless financial gain, education has a passive quality, responsible for maintaining the <em>status quo</em> as well as preserving the degrading attributes of actual societies: individualism, passivity, competitiveness, consumerism and high vulnerability to control and manipulation. Competency or aptitude are not synonyms; they are concepts pertaining radically different approaches to the practice and understanding of education. Competency represents the current tendency of passive education, where knowledge is just about acquiring and retaining information. Aptitude refers to participatory education, described in the second part of this essay. Passive education is present in the professional competencies model, specified in curricula, profiles, levels, school activities, evaluation, the concept of progress and social consequences. The argument is that this paradigm does not foster real progress defined as the primacy of values sustaining spiritual, intellectual and moral development- and is instead accomplice of the civilization's collapse.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 2","pages":"Pages 164-172"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137288555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytological features of childhood acute leukemia at the Hospital de Especialidades Pediátricas, Chiapas, Mexico","authors":"José Luis Lepe-Zúñiga ,&nbsp;Francisco Javier Jerónimo-López ,&nbsp;Jorge Gregorio Hernández-Orantes","doi":"10.1016/j.bmhime.2016.12.001","DOIUrl":"10.1016/j.bmhime.2016.12.001","url":null,"abstract":"<div><h3>Background</h3><p>Childhood acute leukemia cytological features are unknown in Chiapas, Mexico. Defining these features is important because this is a relatively isolated population with high consanguinity index, and these aspects could determine differences in the response to treatment and outcome.</p></div><div><h3>Methods</h3><p>Eighty-one childhood acute leukemia cases treated at the Hospital de Especialidades Pediátricas (HEP) in Chiapas were characterized by morphology, immunophenotype, genotype, initial risk assignment and status at the time of the study. Results were compared with national and international relevant information.</p></div><div><h3>Results</h3><p>The following proportion of acute leukemia types was found: B-cell, 75.3%; myeloid, 16%; T-cell, 3.7%; B-M, 3.7% and NK cells, 1.2%. Genetic alterations were present in 40.6% of B-cell and 69% of myeloid. The genetic alteration was related to the patient's short-term evolution in type B leukemias but not in myeloid. In B-cell leukemia, the cases with the altered MLL gene died in less than one month; cases with t(1;19) (q23;p13) translocation had a good evolution, and those with t(12;21) (p13;q22) translocation had a poor evolution in the medium term. Hyperdiploidy occurred in 20% of B-cell cases; 83% of them remained in remission 1 to 12 months after diagnosis and 69% of the cases with myeloid leukemias died or abandoned the treatment at relapse after 15 days to 37 months of diagnosis.</p></div><div><h3>Conclusions</h3><p>The proportion of different types of acute leukemia treated at the HEP is similar to that found in other parts of the country. Their behavior and outcome are related to the presence or absence of specific and non-specific genetic alterations.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 2","pages":"Pages 122-133"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2016.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48488568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital cellulitis complicated by subperiosteal abscess due to Streptococcus pyogenes infection","authors":"José Daniel Ruiz Carrillo ,&nbsp;Edwin Vázquez Guerrero ,&nbsp;Mónica Cecilia Mercado Uribe","doi":"10.1016/j.bmhime.2017.11.020","DOIUrl":"10.1016/j.bmhime.2017.11.020","url":null,"abstract":"<div><h3>Background</h3><p>Orbital cellulitis is an infectious disease that is very common in pediatric patients, in which severe complications may develop. Etiological agents related to this disease are <em>Haemophilus influenzae</em> B, <em>Staphylococcus aureus</em>, <em>Streptococcus pneumoniae</em> and <em>Moraxella catarrhalis</em>, 95% of the cases. <em>Streptococcus beta-hemolytic</em> and anaerobic microorganisms may also be present and cause &lt;<!--> <!-->5% of the cases. We present an uncommon case of orbital cellulitis complicated by a subperiosteal abscess caused <em>Streptococcus pyogenes</em>.</p></div><div><h3>Case Report</h3><p>A 9-year-old male patient with a history of attention deficit disorder and hyperactivity disorder since he was five years old. His illness started with erythema on the outer edge of the right eye, increase in the peri-orbicular volume with limitation of eyelid opening, progression to proptosis, pain with eye movements and conjunctival purulent discharge. Image studies reported a subperiosteal and pre-septal right abscess with extraocular cellulitis. Empirical antibiotic treatment was started, surgical drainage was performed, and <em>Streptococcus pyogenes</em> was isolated from the culture of the obtained purulent material.</p></div><div><h3>Conclusions</h3><p>Due to the implementation of vaccination schemes against <em>H. influenza</em> and <em>S. pneumoniae</em> since the 90s, the cases by these pathogens have decreased, causing new bacteria to take place as the cause of the infection. The importance of considering <em>S. pyogenes</em> as an etiology of orbital cellulitis comes from its rapid progression to abscess formation, and the few cases described in the literature.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 2","pages":"Pages 134-140"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54312376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in early childhood development: from neurons to large scale programs","authors":"Rafael Pérez-Escamilla ,&nbsp;Antonio Rizzoli Córdoba ,&nbsp;Aranzazú Alonso Cuevas ,&nbsp;Hortensia Reyes Morales","doi":"10.1016/j.bmhime.2017.11.022","DOIUrl":"10.1016/j.bmhime.2017.11.022","url":null,"abstract":"<div><p>Early childhood development (ECD) is the foundation of countries’ economic and social development and their ability to meet the Sustainable Development Goals (SDGs). Gestation and the first three years of life are critical for children to have adequate physical, psychosocial, emotional and cognitive development for the rest of their lives. Nurturing care and protection of children during gestation and early childhood are necessary for the development of trillions of neurons and synapses necessary for healthy development. ECD requires access to good nutrition and health services from gestation, responsive caregiving according to the child's developmental stage, social protection, child welfare, and early stimulation and learning opportunities. Six actions are recommended to improve national ECD programs: expand political will and funding; create a supportive, evidence-based policy environment; build capacity through inter-sectoral coordination; ensure fair and transparent governance of programs and services; increase support for multidisciplinary research, and promote the development of leaders. Mexico has made significant progress under the leadership of the Health Ministry but still faces major challenges. The recent creation of a national inter-sectoral framework to enable ECD with the support of international organizations and the participation of civil society organizations can help overcome these difficulties.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 2","pages":"Pages 86-97"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54312382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}