Boletín Médico Del Hospital Infantil de México (English Edition)最新文献_第10页

Alveolar rhabdomyosarcoma: origin and prognostic implications of molecular findings 肺泡横纹肌肉瘤:分子发现的起源和预后意义

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.039

Pilar Eguía-Aguilar , Briceida López-Martínez , Carmen Retana-Contreras , Mario Perezpeña-Diazconti

引用次数: 0

Participation of mesenchymal stem cells in the regulation of immune response and cancer development 间充质干细胞参与免疫反应和癌症发展的调节

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.036

Marta Elena Castro-Manrreza

{"title":"Participation of mesenchymal stem cells in the regulation of immune response and cancer development","authors":"Marta Elena Castro-Manrreza","doi":"10.1016/j.bmhime.2017.11.036","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.036","url":null,"abstract":"<div><p>The relevance of the microenvironment in the initiation, promotion, and progression of cancer has been postulated. Mesenchymal stem cells (MSCs) have been identified as important components of the tumor stroma, which are capable of affecting the development of cancer through various mechanisms. In particular, MSCs immunosuppressive properties play an important role. It has been shown that bone marrow-derived and other healthy tissues-derived MSCs are capable of regulating the immune response by affecting the activation, maturation, proliferation, differentiation, and effector function of cells of the immune system, such as neutrophils, macrophages, dendritic cells, natural killer cells (NK) and T-lymphocytes. Similar mechanisms have been identified in MSCs associated with different types of tumors, where they generate an immunosuppressive microenvironment by decreasing the cytotoxic activity of T-lymphocytes and NK cells, skew macrophage differentiation towards an M2 phenotype, and decrease the secretion of Th1-type cytokines. Also, the cytokines, chemokines, and factors secreted by the transformed cells or other cells from the tumor stroma are capable of modulating the functions of MSCs.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 6","pages":"Pages 380-387"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138305167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of diets rich in omega-3 and omega-6 in the development of cancer 富含omega-3和omega-6的饮食在癌症发展中的作用

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.043

Sara Huerta-Yépez , Ana B. Tirado-Rodriguez , Oliver Hankinson

{"title":"Role of diets rich in omega-3 and omega-6 in the development of cancer","authors":"Sara Huerta-Yépez , Ana B. Tirado-Rodriguez , Oliver Hankinson","doi":"10.1016/j.bmhime.2017.11.043","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.043","url":null,"abstract":"<div><p>Over the past decade, some studies have addressed the therapeutic effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and the opposite effects of omega-6 (ω-6) PUFAs on several diseases, including cardiovascular disorders, diabetes, neurodegenerative diseases, and cancer. Research demonstrates the safety of these naturally occurring ingredients. Of particular interest, several studies have shown that ω-3 PUFAs possess a therapeutic role against certain types of cancer. It is also known that ω-3 PUFAs can improve the efficacy and tolerability of chemotherapy. Previous reports have indicated that suppression of nuclear factor-κB, activation of AMPK/SIRT1, modulation of cyclooxygenase (COX) activity, and up-regulation of novel anti-inflammatory lipid mediators such as protectins, maresins, and resolvins, are the main mechanisms of the antineoplastic effect of ω-3 PUFAs. In contrast, several studies have demonstrated that ω-6 PUFAs induce progression in certain types of cancer. In this review, we discuss epidemiological and experimental studies addressing the relationship between the development of some types of cancer, including colon and colorectal carcinoma, breast cancer, prostate cancer, lung cancer and neuroblastoma, and the ingestion to ω-3 and ω-6 (PUFAs). We also discuss the clinical data, addressing the therapeutic role of omega-3 PUFA against different types of cancer.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 6","pages":"Pages 446-456"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138397645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is there something else besides the proapoptotic AVPI-segment in the Smac/DIABLO protein? 在Smac/DIABLO蛋白中，除了促凋亡的avpi节段外，是否还有别的什么?

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.034

Georgina Victoria-Acosta , Marlet Martínez-Archundia , Liliana Moreno-Vargas , Jorge Meléndez-Zajgla , Gustavo Ulises Martínez-Ruiz

{"title":"Is there something else besides the proapoptotic AVPI-segment in the Smac/DIABLO protein?","authors":"Georgina Victoria-Acosta , Marlet Martínez-Archundia , Liliana Moreno-Vargas , Jorge Meléndez-Zajgla , Gustavo Ulises Martínez-Ruiz","doi":"10.1016/j.bmhime.2017.11.034","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.034","url":null,"abstract":"<div><p>In mammals, apoptosis is the main mechanism to eliminate unwanted cells, securing tissue homeostasis and consequently maintaining the health in the organism. Classically, apoptosis culminates with the activation of caspases, which are enzymes that display cysteine protease activity to degrade specific substrates implied in essential cellular processes. This process is highly regulated. A key regulation mechanism is mediated by the Inhibitor of Apoptosis Proteins (IAPs) family members, which inhibit the activated forms of caspases through physical interaction with them. Smac/DIABLO, a mitochondrial protein that is translocated to the cytoplasm in apoptotic conditions, derepresses the IAP-mediated caspase inhibition through physical interaction with IAPs. The first four amino acids (AVPI) of Smac/DIABLO mediate the interaction with IAPs and subsequent apoptosis induction. This interaction has lead to the creation of small molecules mimicking the AVPI segment for potential anticancer therapy. Nevertheless, several studies have pointed out the existence of AVPI-independent functions of Smac/DIABLO. The aim of this review was to provide a landscape of these underestimated AVPI-independent biological functions that have been observed using different approaches, such as the study of endogenous splice variant isoforms and truncated and mutated artificial proteins.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 6","pages":"Pages 365-371"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138305164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody-mediated targeting of the transferrin receptor in cancer cells 癌细胞中转铁蛋白受体的抗体介导靶向

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.035

Rosendo Luria-Pérez , Gustavo Helguera , José A. Rodríguez

{"title":"Antibody-mediated targeting of the transferrin receptor in cancer cells","authors":"Rosendo Luria-Pérez , Gustavo Helguera , José A. Rodríguez","doi":"10.1016/j.bmhime.2017.11.035","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.035","url":null,"abstract":"<div><p>Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes. TfR1 is a single pass type-II transmembrane protein expressed at basal levels in most tissues. High expression of TfR1 is typically associated with rapidly proliferating cells, including various types of cancer. TfR1 is targeted by experimental therapeutics for several reasons: its cell surface accessibility, constitutive endocytosis into cells, essential role in cell growth and proliferation, and its overexpression by cancer cells. Among the therapeutic agents used to target TfR1, antibodies stand out due to their remarkable specificity and affinity. Clinical trials are being conducted to evaluate the safety and efficacy of agents targeting TfR1 in cancer patients with promising results. These observations suggest that therapies targeting TfR1 as direct therapeutics or delivery conduits remain an attractive alternative for the treatment of cancers that overexpress the receptor.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 6","pages":"Pages 372-379"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138305165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New perspectives on the computational characterization of the kinetics of binding-unbinding in drug design: implications for novel therapies 药物设计中结合-解结合动力学计算表征的新视角:对新疗法的影响

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.041

Liliana M. Moreno-Vargas , Diego Prada-Gracia

引用次数: 0

Why computational methods for the study of biological macromolecules and their effectors? 为什么要用计算方法来研究生物大分子及其效应器?

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2016.10.002

Rachid C. Maroun

引用次数: 0

Seventy years of life and validity of a legendary scientific article of universal resonance 七十年的生命和有效性的传奇性科学文章的普遍共鸣

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-09-01 DOI: 10.1016/j.bmhime.2017.11.009

Silvestre Félix Frenk y Freund

引用次数: 0

Malnutrition 营养不良

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-09-01 DOI: 10.1016/j.bmhime.2017.11.008

Federico Gómez Santos

引用次数: 0

Guidelines for complementary feeding in healthy infants 健康婴儿补充喂养指南

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-09-01 DOI: 10.1016/j.bmhime.2017.11.007

Enrique Romero-Velarde , Salvador Villalpando-Carrión , Ana Berta Pérez-Lizaur , Ma. de la Luz Iracheta-Gerez , Carlos Gilberto Alonso-Rivera , Gloria Elena López-Navarrete , Andrea García-Contreras , Erika Ochoa-Ortiz , Flora Zarate-Mondragón , Gerardo Tiburcio López-Pérez , Clío Chávez-Palencia , Manuel Guajardo-Jáquez , Salvador Vázquez-Ortiz , Beatriz Adriana Pinzón-Navarro , Karely Noemy Torres-Duarte , José Domingo Vidal-Guzmán , Pedro Luis Michel-Gómez , Iris Nallely López-Contreras , Liliana Verenice Arroyo-Cruz , Pamela Almada-Velasco , José Luis Pinacho-Velázquez

{"title":"Guidelines for complementary feeding in healthy infants","authors":"Enrique Romero-Velarde , Salvador Villalpando-Carrión , Ana Berta Pérez-Lizaur , Ma. de la Luz Iracheta-Gerez , Carlos Gilberto Alonso-Rivera , Gloria Elena López-Navarrete , Andrea García-Contreras , Erika Ochoa-Ortiz , Flora Zarate-Mondragón , Gerardo Tiburcio López-Pérez , Clío Chávez-Palencia , Manuel Guajardo-Jáquez , Salvador Vázquez-Ortiz , Beatriz Adriana Pinzón-Navarro , Karely Noemy Torres-Duarte , José Domingo Vidal-Guzmán , Pedro Luis Michel-Gómez , Iris Nallely López-Contreras , Liliana Verenice Arroyo-Cruz , Pamela Almada-Velasco , José Luis Pinacho-Velázquez","doi":"10.1016/j.bmhime.2017.11.007","DOIUrl":"10.1016/j.bmhime.2017.11.007","url":null,"abstract":"<div><p>A proper nutrition during the first two years of life is critical to reach the full potential of every human being. To the present day, this period is recognized as a <em>critical window</em> for promoting optimal growth, development, and good health. Therefore, adequate feeding at this stage of life has an impact on health, nutritional status, growth and development of children; not only in the short term but in the medium and long term. This paper provides recommendations on complementary feeding (CF) presented as questions or statements that are important for those who take care for children during this stage of life. For example: When to start complementary feedings; Exposure to potentially allergenic foods; Introduction of sweetened beverages; Use of artificial sweeteners and light products; Food introduction sequence; Food consistency changes according to neurological maturation; Number of days to test acceptance and tolerance to new foods; Amounts for each meal; Inadequate complementary feeding practices; Myths and realities of complementary feeding; Developmental milestones; Practice of Baby Led Weaning or vegetarianism.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 5","pages":"Pages 338-356"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54311963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13