Boletín Médico Del Hospital Infantil de México (English Edition)最新文献_第9页

A case-series analysis of tuberculosis in pediatric patients treated in a tertiary level hospital 某三级医院小儿肺结核病例系列分析

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2017-01-01 DOI: 10.1016/j.bmhime.2017.11.017

José Guillermo Vázquez Rosales , Cynthia Acosta Gallegos , María Guadalupe Miranda Novales , Yazmín Del Carmen Fuentes Pacheco , María Guadalupe Labra Zamora , Daniel Octavio Pacheco Rosas , Fortino Solórzano Santos

{"title":"A case-series analysis of tuberculosis in pediatric patients treated in a tertiary level hospital","authors":"José Guillermo Vázquez Rosales , Cynthia Acosta Gallegos , María Guadalupe Miranda Novales , Yazmín Del Carmen Fuentes Pacheco , María Guadalupe Labra Zamora , Daniel Octavio Pacheco Rosas , Fortino Solórzano Santos","doi":"10.1016/j.bmhime.2017.11.017","DOIUrl":"10.1016/j.bmhime.2017.11.017","url":null,"abstract":"<div><h3>Background</h3><p>Tuberculosis (TB) remains a challenge because severe forms occur most frequently in children under five years old and the diagnosis is complex. The objective of this paper was to describe the clinical presentation, frequency, methods used to make the diagnosis and response to treatment in children with TB treated at a tertiary level hospital.</p></div><div><h3>Methods</h3><p>The study was retrospective and descriptive of a cohort of consecutive cases treated from January 2010 to December 2013. Ninety-three medical records of children diagnosed with TB according to the definition of the NOM-006-SSA2-2013 were reviewed. The analysis was performed using descriptive statistics.</p></div><div><h3>Results</h3><p>From 93 children, 58% were male (mean age of 7 years), 97% with a history of BCG vaccination, and 6% had contact with a TB case. The most frequent clinical forms were pulmonary (30.1%), lymph node (24.7%), miliary/disseminated (16.1%), meningeal (13%), and osteal TB (7.5%). The most common symptoms were fever and weight loss (50% and 40%, respectively). AFB stain and culture were positive in 26% and 7% of all cases, respectively. The histopathological study was conclusive in 90% of the cases. The treatment was successful in 94.6%, with not associated mortality.</p></div><div><h3>Conclusions</h3><p>The association of clinical symptoms with alterations in chest radiography and positive PPD is useful in establishing the presumptive diagnosis and an early and appropriate treatment.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"74 1","pages":"Pages 27-33"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54312369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Pediatric tuberculosis 小儿结核病

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2017-01-01 DOI: 10.1016/j.bmhime.2017.11.010

Mercedes Macías Parra

引用次数: 0

Fitting parameters for cochlear implant 人工耳蜗拟合参数

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2017-01-01 DOI: 10.1016/j.bmhime.2017.11.016

Rosa Isela Banda González , Salvador Castillo Castillo , Graciela Roque Lee

引用次数: 2

Perspectives in cancer: molecular findings, computational-designed drugs, and patient care 癌症的观点:分子发现、计算设计药物和病人护理

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.033

Sara Huerta-Yepez

引用次数: 0

Medical interventions for cancer treatment-induced symptoms in children: an overview 儿童癌症治疗诱发症状的医学干预:综述

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.045

Leticia A. Barajas-Nava , Juan Garduño-Espinosa

{"title":"Medical interventions for cancer treatment-induced symptoms in children: an overview","authors":"Leticia A. Barajas-Nava , Juan Garduño-Espinosa","doi":"10.1016/j.bmhime.2017.11.045","DOIUrl":"10.1016/j.bmhime.2017.11.045","url":null,"abstract":"<div><h3>Background</h3><p>Childhood cancer accounts for 0.5 to 4.6% of the total number of cases in any population. According to the treatment, some side effects are present. Most adverse reactions can cause severe consequences for the survival of the patient. The more effective interventions for the management and the prevention of treatment-induced symptoms (TIS) in children with cancer are necessary to know. The objective of this review was to identify and describe available scientific evidence on the efficacy and safety of interventions used for the management and prevention of TIS in children with cancer.</p></div><div><h3>Methods</h3><p>We conducted a systematic review of the literature on studies that evaluated or described the effectiveness of interventions used for the management and prevention of TIS in children with cancer in some of the major electronic databases. Results were qualitative synthesized and presented as evidence tables.</p></div><div><h3>Results</h3><p>We identified eight systematic reviews. The revisions included experimental studies. All participants, including children and adults, were patients diagnosed with some cancer about to receive or that received treatment.</p></div><div><h3>Conclusions</h3><p>The results showed only a reduced number of clinical trials that have evaluated the interventions for the management of TIS in children with cancer. In addition, the available evidence was limited and of poor quality. It is necessary to conduct more clinical trials with good methodological quality and high statistical power.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 6","pages":"Pages 467-483"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"94281649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis 利用公共数据库分析评估TRPM2通道作为乳腺癌的生物标志物

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.038

Adriana Sumoza-Toledo , Mario Iván Espinoza-Gabriel , Dvorak Montiel-Condado

{"title":"Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis","authors":"Adriana Sumoza-Toledo , Mario Iván Espinoza-Gabriel , Dvorak Montiel-Condado","doi":"10.1016/j.bmhime.2017.11.038","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.038","url":null,"abstract":"<div><h3>Background</h3><p>Breast cancer is one of the most common malignancies affecting women. Recent investigations have revealed a major role of ion channels in cancer. The transient receptor potential melastatin-2 (TRPM2) is a plasma membrane and lysosomal channel with important roles in cell migration and cell death in immune cells and tumor cells.</p></div><div><h3>Methods</h3><p>In this study, we investigated the prognostic value of TRPM2 channel in breast cancer, analyzing public databases compiled in Oncomine™ (Thermo Fisher, Ann Arbor, MI) and online Kaplan-Meier Plotter platforms.</p></div><div><h3>Results</h3><p>The results revealed that TRPM2 mRNA overexpression is significant <em>in situ</em> and invasive breast carcinoma compared to normal breast tissue. Furthermore, multi-gene validation using Oncomine™ showed that this channel is coexpressed with proteins related to cellular migration, transformation, and apoptosis. On the other hand, Kaplan-Meier analysis exhibited that low expression of TRPM2 could be used to predict poor outcome in ER- and HER2+ breast carcinoma patients.</p></div><div><h3>Conclusions</h3><p>TRPM2 is a promising biomarker for aggressiveness of breast cancer, and a potential target for the development of new therapies.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 6","pages":"Pages 397-404"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138305168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of computational methods for anticancer drug discovery, design, and optimization 计算方法在抗癌药物发现、设计和优化中的应用

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.040

Diego Prada-Gracia , Sara Huerta-Yépez , Liliana M. Moreno-Vargas

{"title":"Application of computational methods for anticancer drug discovery, design, and optimization","authors":"Diego Prada-Gracia , Sara Huerta-Yépez , Liliana M. Moreno-Vargas","doi":"10.1016/j.bmhime.2017.11.040","DOIUrl":"10.1016/j.bmhime.2017.11.040","url":null,"abstract":"<div><p>Developing a novel drug is a complex, risky, expensive and time-consuming venture. It is estimated that the conventional drug discovery process ending with a new medicine ready for the market can take up to 15 years and more than a billion USD. Fortunately, this scenario has recently changed with the arrival of new approaches. Many novel technologies and methodologies have been developed to increase the efficiency of the drug discovery process, and computational methodologies have become a crucial component of many drug discovery programs. From hit identification to lead optimization, techniques such as ligand- or structure-based virtual screening are widely used in many discovery efforts. It is the case for designing potential anticancer drugs and drug candidates, where these computational approaches have had a major impact over the years and have provided fruitful insights into the field of cancer. In this paper, we review the concept of rational design presenting some of the most representative examples of molecules identified by means of it. Key principles are illustrated through case studies including specifically successful achievements in the field of anticancer drug design to demonstrate that research advances, with the aid of <em>in silico</em> drug design, have the potential to create novel anticancer drugs.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 6","pages":"Pages 411-423"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77349538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 60

Bactofection of sequences encoding a Bax protein peptide chemosensitizes prostate cancer tumor cells 细菌感染编码Bax蛋白肽的序列可使前列腺癌肿瘤细胞化学致敏

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.037

Marco Antonio Hernández-Luna , Ricardo Díaz de León-Ortega , Daniel Dimitri Hernández-Cueto , Ricardo Gaxiola-Centeno , Raúl Castro-Luna , Leonel Martínez-Cristóbal , Sara Huerta-Yépez , Rosendo Luria-Pérez

{"title":"Bactofection of sequences encoding a Bax protein peptide chemosensitizes prostate cancer tumor cells","authors":"Marco Antonio Hernández-Luna , Ricardo Díaz de León-Ortega , Daniel Dimitri Hernández-Cueto , Ricardo Gaxiola-Centeno , Raúl Castro-Luna , Leonel Martínez-Cristóbal , Sara Huerta-Yépez , Rosendo Luria-Pérez","doi":"10.1016/j.bmhime.2017.11.037","DOIUrl":"10.1016/j.bmhime.2017.11.037","url":null,"abstract":"<div><h3>Background</h3><p>Tumor cell resistance to chemotherapy agents is one of the main problems in the eradication of different neoplasias. One of the mechanisms of this process is the overexpression of anti-apoptotic proteins such as Bcl-2 and Bcl-<sub>XL</sub>; blocking the activity of these proteins may contribute to the sensitization of tumor cells and allow the adequate effects of chemotherapeutic drugs.</p></div><div><h3>Methods and results</h3><p>This study adressed the transfection of prostate cancer cells (PC3) with a plasmid encoding a recombinant protein with an antagonist peptide from the BH3 region of the Bax protein fused to the GFP reporter protein (BaxGFP).</p><p>This protein induced apoptosis of these tumor cells; further, selective transport of this plasmid to the tumor cell with <em>Salmonella enterica</em> serovar Typhimurium (strain SL3261), a live-attenuated bacterial vector, can induce sensitization of the tumor cell to the action of drugs such as cisplatin, through a process known as <em>bactofection</em>.</p></div><div><h3>Conclusions</h3><p>These results suggest that <em>Salmonella enterica</em> can be used as a carrier vector of nucleotide sequences encoding heterologous molecules used in antitumor therapy.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 6","pages":"Pages 388-396"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54312394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Instruments to measure the quality of life in patients with oral mucositis undergoing oncological treatment: a systematic review of the literature 测量接受肿瘤治疗的口腔黏膜炎患者生活质量的仪器:文献的系统回顾

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.044

Rosaura Gutiérrez-Vargas , María Luisa Díaz-García , Miguel Ángel Villasís-Keever , Javier Portilla-Robertson , Marta Zapata-Tárres

{"title":"Instruments to measure the quality of life in patients with oral mucositis undergoing oncological treatment: a systematic review of the literature","authors":"Rosaura Gutiérrez-Vargas , María Luisa Díaz-García , Miguel Ángel Villasís-Keever , Javier Portilla-Robertson , Marta Zapata-Tárres","doi":"10.1016/j.bmhime.2017.11.044","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.044","url":null,"abstract":"<div><h3>Background</h3><p>Oral mucositis (OM) is an inflammatory reaction of the oropharyngeal mucosa to cumulative chemotherapy (CT) and radiation therapy (RT), affecting one or more parts of the digestive tract along with the quality of life (QoL) of the patient. The goal of this study was to identify valid and reliable tools to evaluate QoL related to OM.</p></div><div><h3>Methods</h3><p>A systematic review of the literature was conducted up to May 2016. Articles were selected by peers using the PubMed database through a search following the inclusion and exclusion criteria and STAndards for the Reporting of Diagnostic accuracy studies (STARD) checklist with a cut-off point ≥ 70%.</p></div><div><h3>Results</h3><p>We identified four relevant articles that described instruments to assess the QoL related to OM in patients undergoing cancer treatment.</p></div><div><h3>Conclusions</h3><p>The evaluation of the QoL in patients with OM is a difficult scenario because of its multiple variables. The knowledge of this relationship is limited because general instruments of oral health or cancer therapy are commonly used for evaluation. However, valid instruments are already available for estimating the impact of OM on the QoL from the patient's perspective.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 6","pages":"Pages 457-466"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138305170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergies: diseases closely related to cancer 过敏:与癌症密切相关的疾病

Boletín Médico Del Hospital Infantil de México (English Edition) Pub Date : 2016-11-01 DOI: 10.1016/j.bmhime.2017.11.042

Belén Tirado-Rodríguez , Sara Huerta-Yépez

{"title":"Allergies: diseases closely related to cancer","authors":"Belén Tirado-Rodríguez , Sara Huerta-Yépez","doi":"10.1016/j.bmhime.2017.11.042","DOIUrl":"https://doi.org/10.1016/j.bmhime.2017.11.042","url":null,"abstract":"<div><p>Allergies are hypersensitivity reactions that occur through specific type Th2 immunological mechanisms characterized by different soluble mediators, as well as specific cells of the immune system. In recent decades, evidence has emerged relating this disease with cancer development. However, most of the results of epidemiology studies have been controversial and contradictory. There are mainly two trends. While the first indicates that allergies can reduce the risk of cancer, the other indicates that they may increase this risk. The first trend can be explained by the immunosurveillance hypothesis, which states that the increased immune surveillance after the immune hyper-responsiveness can inhibit or exert a protective effect against the development of cancer. Similarly, the prophylaxis hypothesis suggests that the physical effects of allergy symptoms can prevent cancer by removing potential carcinogens.</p><p>In contrast, the opposing hypothesis propose that there is a deviation of the immune response toward Th2, which favors the development of cancer, or that the process of chronic inflammation favors the generation of mutations, and therefore the development of cancer.</p><p>With the purpose of understanding more about these two hypotheses, the main soluble and cellular factors of allergic diseases that could be playing a key role in the development or inhibition of cancer were considered in this review.</p></div>","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"73 6","pages":"Pages 432-445"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bmhime.2017.11.042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138305169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0