Biotechnology Notes最新文献_第4页

Unraveling current breakthroughs in Scorodocarpus borneensis phytochemical therapeutics: A systematic review 黄芩生理化学疗法中的电流断裂：系统回顾

Biotechnology Notes Pub Date : 2024-01-01 DOI: 10.1016/j.biotno.2024.05.001

Muhammad Hamizan Zawawi , Siti Azhani-Amran , Zuraidah Abdullah , Sabreena Safuan

{"title":"Unraveling current breakthroughs in Scorodocarpus borneensis phytochemical therapeutics: A systematic review","authors":"Muhammad Hamizan Zawawi , Siti Azhani-Amran , Zuraidah Abdullah , Sabreena Safuan","doi":"10.1016/j.biotno.2024.05.001","DOIUrl":"10.1016/j.biotno.2024.05.001","url":null,"abstract":"<div><p><em>Scorodocarpus borneensis</em>, also known as the Kulim tree or Garlic tree, has been consumed by the local communities in Southeast Asia as traditional spice using its old leaves, stem bark, and seeds. The locals also used Kulim tree parts as conventional alternative to treat many diseases such as hemorrhoids, leprosy, diabetes, and diarrhea. However, there was limited scientific evidence to support these traditional claims. Therefore, this systematic review aims to present and evaluate a detailed overview of the phytochemical constituents of <em>S. borneensis</em> from previous existing studies, shedding light on their chemical composition, bioactivity, and potential applications. In addition, current studies regarding <em>S. borneensis</em> are still on a fundamental level. Hence, we aim that this review will reveal the research gap from the previous literature and provide an insight to implement a new research approach in the future. A literature search was conducted using four databases: ScienceDirect, Scopus, Web of Science, and PubMed. The articles were screened and data were extracted based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline. 8 studies satisfied the inclusion criteria that focused on the phytochemicals from <em>S. borneensis</em>. The major phytochemical compound reported was phenolic compound. S. borneensis also exhibits several therapeutic outcomes such as antioxidant, antimicrobial, and anticancer but current studies are not enough to support the claims regarding <em>S. borneensis</em> health benefit. In conclusion, this review highlights the current understanding of <em>S. borneensis’</em> phytochemical composition and its therapeutic applications which are important in preventing human diseases especially non-communicable diseases.</p></div>","PeriodicalId":100186,"journal":{"name":"Biotechnology Notes","volume":"5 ","pages":"Pages 100-110"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665906924000084/pdfft?md5=2778f6f37bfba7a5ed673fe883e37908&pid=1-s2.0-S2665906924000084-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Chlorella vulgaris and Chlorella sorokiniana as sustainable organisms to bioconvert glucosamine into valuable biomass 将小球藻和小球藻确定为将氨基葡萄糖生物转化为有价值生物质的可持续生物体

Biotechnology Notes Pub Date : 2024-01-01 DOI: 10.1016/j.biotno.2024.01.003

Hosam Elhalis , Mohamed Helmy , Sherilyn Ho , Sharon Leow , Yan Liu , Kumar Selvarajoo , Yvonne Chow

{"title":"Identifying Chlorella vulgaris and Chlorella sorokiniana as sustainable organisms to bioconvert glucosamine into valuable biomass","authors":"Hosam Elhalis , Mohamed Helmy , Sherilyn Ho , Sharon Leow , Yan Liu , Kumar Selvarajoo , Yvonne Chow","doi":"10.1016/j.biotno.2024.01.003","DOIUrl":"https://doi.org/10.1016/j.biotno.2024.01.003","url":null,"abstract":"<div><p>Chitin is a major component of various wastes such as crustacean shells, filamentous fungi, and insects. Recently, food-safe biological and chemical processes converting chitin to glucosamine have been developed. Here, we studied microalgae that can uptake glucosamine as vital carbon and nitrogen sources for valuable alternative protein biomass. Utilizing data mining and bioinformatics analysis, we identified 29 species that contain the required enzymes for glucosamine to glucose conversion. The growth performance of the selected strains was examined, and glucosamine was used in different forms and concentrations. Glucose at a concentration of 2.5 g/L was required to initiate glucosamine metabolic degradation by <em>Chlorella vulgaris</em> and <em>Chlorella sorokiniana</em>. Glucosamine HCl and glucosamine phosphate showed maximum cell counts of about 8.5 and 9.0 log/mL for C. <em>sorokiniana</em> and <em>C. vulgaris</em> in 14 days, respectively. Enzymatic hydrolysis of glucosamine increased growth performance with <em>C. sorokiniana</em> by about 3 folds. The adapted strains were fast-growing and could double their dry biomasses during the same incubation time. In addition, adapted <em>C. sorokiniana</em> was able to tolerate three times glucosamine concentration in the medium. The study illustrated possible strategies for employing <em>C. sorokiniana</em> and <em>C. vulgaris</em> to convert glucosamine into valuable biomass in a more sustainable way.</p></div>","PeriodicalId":100186,"journal":{"name":"Biotechnology Notes","volume":"5 ","pages":"Pages 13-22"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665906924000035/pdfft?md5=2d02dd1a924a37191fa8804cbe12d15c&pid=1-s2.0-S2665906924000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139494007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Therapeutic advancements in nanomedicine: The multifaceted roles of silver nanoparticles" "纳米医学的治疗进展：银纳米粒子的多方面作用"

Biotechnology Notes Pub Date : 2024-01-01 DOI: 10.1016/j.biotno.2024.05.002

Karthik K Karunakar , Binoy Varghese Cheriyan , Krithikeshvaran R , Gnanisha M , Abinavi B

{"title":"\"Therapeutic advancements in nanomedicine: The multifaceted roles of silver nanoparticles\"","authors":"Karthik K Karunakar , Binoy Varghese Cheriyan , Krithikeshvaran R , Gnanisha M , Abinavi B","doi":"10.1016/j.biotno.2024.05.002","DOIUrl":"10.1016/j.biotno.2024.05.002","url":null,"abstract":"<div><p>Nanotechnology has the advantages of enhanced bioactivity, reduced toxicity, target specificity, and sustained release and NPs can penetrate cell membranes. The small size of silver nanoparticles, AgNPs, large surface area, and unique physicochemical properties contribute to cell lysis and increased permeability of cell membranes used in the field of biomedicine. Functional precursors integrate with phytochemicals to create distinctive therapeutic properties and the stability of the nanoparticles can be enhanced by Surface coatings and encapsulation methods, The current study explores the various synthesis methods and characterization techniques of silver nanoparticles (AgNPs) and highlights their intrinsic activity in therapeutic applications, Anti-cancer activity noted at a concentration range of 5–50 μg/ml and angiogenesis is mitigated at a dosage range of 10–50 μg/ml, Diabetes is controlled within the same concentration. Wound healing is improved at concentrations of 10–50 μg/ml and with a typical range of 10–08 μg/ml for bacteria with antimicrobial capabilities. Advancement of silver nanoparticles with a focus on the future use of AgNPs-coated wound dressings and medical devices to decrease the risk of infection. Chemotherapeutic drugs can be administered by AgNPs, which reduces adverse effects and an improvement in treatment outcomes. AgNPs have been found to improve cell proliferation and differentiation, making them beneficial for tissue engineering and regenerative medicine. Our study highlights emerging patterns and developments in the field of medicine, inferring potential future paths.</p></div>","PeriodicalId":100186,"journal":{"name":"Biotechnology Notes","volume":"5 ","pages":"Pages 64-79"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665906924000096/pdfft?md5=e8e08526b06a4c8603d010ed4bfdd106&pid=1-s2.0-S2665906924000096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141229774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered microbial consortia for next-generation feedstocks 用于下一代原料的工程微生物联合体

Biotechnology Notes Pub Date : 2024-01-01 DOI: 10.1016/j.biotno.2024.01.002

Gazi Sakir Hossain , Yuanmei Liang , Jee Loon Foo , Matthew Wook Chang

引用次数: 0

A comprehensive study on anaerobic digestion of organic solid waste: A review on configurations, operating parameters, techno-economic analysis and current trends 有机固体废物厌氧消化综合研究：关于配置、运行参数、技术经济分析和当前趋势的综述

Biotechnology Notes Pub Date : 2024-01-01 DOI: 10.1016/j.biotno.2024.02.001

D.Jaya Prasanna Kumar , Ranjeet Kumar Mishra , Sampath Chinnam , Prakash Binnal , Naveen Dwivedi

{"title":"A comprehensive study on anaerobic digestion of organic solid waste: A review on configurations, operating parameters, techno-economic analysis and current trends","authors":"D.Jaya Prasanna Kumar , Ranjeet Kumar Mishra , Sampath Chinnam , Prakash Binnal , Naveen Dwivedi","doi":"10.1016/j.biotno.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.biotno.2024.02.001","url":null,"abstract":"<div><p>The excessive discharge and accumulation of solid organic waste into the environment is of severe concern across the globe. Thus, an efficient waste management system is important to mitigate health risks to humans, minimize harmful impacts on the environment, and ensure a sustainable ecosystem. The organic waste is converted into value-added products either using microorganisms or heat energy; these methods are commonly known as biochemical and thermochemical techniques. The biochemical process has the advantage of higher selectivity of the products and lower processing temperatures. The principal conversion processes of this category are fermentation and anaerobic digestion (AD). This review article focuses on AD, a potential method for treating organic waste and creating a variety of products with added value. Here we present the digestibility of various organic wastes, the role of microorganisms, the decomposition process, co-substrates, digester designs, biogas yields, by-products, environmental impacts, and overall techno-economical effectiveness of the process. Further, this review offers insights into new directions for AD for waste treatment and future research without compromising the overall feasibility and environmental sustainability.</p></div>","PeriodicalId":100186,"journal":{"name":"Biotechnology Notes","volume":"5 ","pages":"Pages 33-49"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665906924000047/pdfft?md5=697f3bc9004f1454bf22f245f86a3bf8&pid=1-s2.0-S2665906924000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140016320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and bioactive component analysis of filamentous bacterium XJ-16 丝状细菌XJ-16的鉴定及活性成分分析

Biotechnology Notes Pub Date : 2023-01-01 DOI: 10.1016/j.biotno.2023.03.001

Ke Jiang , Ruoxuan Bai , Xianglian Luo , Ting Gao , Fangxu Xu , Hongxin Zhao , Dianpeng Zhang

{"title":"Characterization and bioactive component analysis of filamentous bacterium XJ-16","authors":"Ke Jiang , Ruoxuan Bai , Xianglian Luo , Ting Gao , Fangxu Xu , Hongxin Zhao , Dianpeng Zhang","doi":"10.1016/j.biotno.2023.03.001","DOIUrl":"https://doi.org/10.1016/j.biotno.2023.03.001","url":null,"abstract":"<div><p>Actinomycetes, which can produce a variety of bioactive compounds in the metabolic process, is one of the important sources of novel drugs, enzymes, anti-tumor drugs and enzyme inhibitors. It has been the focus of researchers to find and develop <em>Actinomycetes</em> with special characters. Strain XJ-16 is a blue alkali-resistant filamentous bacterium with high antimicrobial activity isolated from saline-alkali land of Xinjiang. Based on the classification, the enzyme production, metabolite antibacterial activity, and antibacterial substance isolation of XJ-16 were explored. which showed that XJ-16 belongs to the blue group of <em>Streptomyces</em> sp, and it can secrete cellulase, lipase, urease, protease, catalase and oxidase during metabolism. In addition, the bacteriostatic substance secreted by the strain XJ-16 showed inhibitory effects against both Gram-positive and Gram-negative bacteria, as well as the yeast <em>Candida albicans</em>. Then it was found that the bacteriostasis produced by XJ-16 has strong tolerance to acid, weak tolerance to alkali, and easy to be inactivated. After tested by HPLC, the retention time of antimicrobial substance was 13.261 min. This study provides new research ideas and theoretical support for searching for new antibacterial compounds and further developing the blue alkaline <em>Actinomycete</em> XJ-16.</p></div>","PeriodicalId":100186,"journal":{"name":"Biotechnology Notes","volume":"4 ","pages":"Pages 49-57"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49731575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suitability evaluation of toehold switch and EXPAR for cell-free MicroRNA biosensor development 支点开关和EXPAR在无细胞MicroRNA生物传感器开发中的适用性评价

Biotechnology Notes Pub Date : 2023-01-01 DOI: 10.1016/j.biotno.2023.11.003

Caroline E. Copeland , Yong-Chan Kwon

{"title":"Suitability evaluation of toehold switch and EXPAR for cell-free MicroRNA biosensor development","authors":"Caroline E. Copeland , Yong-Chan Kwon","doi":"10.1016/j.biotno.2023.11.003","DOIUrl":"https://doi.org/10.1016/j.biotno.2023.11.003","url":null,"abstract":"<div><p>The development of a robust and cost-effective sensing platform for microRNA (miRNA) is of paramount importance in detecting and monitoring various diseases. Current miRNA detection methods are marred by low accuracy, high cost, and instability. The toehold switch riboregulator has shown promising results in detecting viral RNAs integrated with the freeze-dried cell-free system (CFS). This study aimed to leverage the toehold switch technology and portability to detect miRNA in the CFS and to incorporate the exponential amplification reaction (EXPAR) to bring the detection to clinically relevant levels. We assessed various EXPAR DNA templates under different conditions to enhance the accuracy of the sensing platform. Furthermore, different structures of toehold switches were tested with either high-concentration synthetic miRNA or EXPAR product to assess sensitivity. Herein, we elucidated the mechanisms of the toehold switch and EXPAR, presented the findings of these optimizations, and discussed the potential benefits and drawbacks of their combined use.</p></div>","PeriodicalId":100186,"journal":{"name":"Biotechnology Notes","volume":"4 ","pages":"Pages 83-89"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665906923000090/pdfft?md5=61d37cf4a5204994790dfb4c07164302&pid=1-s2.0-S2665906923000090-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138439364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2023 The 1st National Competition of “Bloomag Cup” in CO2 capture, conversion, and utilization 2023 年首届 "布鲁马格杯 "全国二氧化碳捕获、转化和利用竞赛

Biotechnology Notes Pub Date : 2023-01-01 DOI: 10.1016/j.biotno.2023.12.001

Ziman Chen, Dan Wang, Zhenyi Wu, Yongqin Lv

{"title":"2023 The 1st National Competition of “Bloomag Cup” in CO2 capture, conversion, and utilization","authors":"Ziman Chen, Dan Wang, Zhenyi Wu, Yongqin Lv","doi":"10.1016/j.biotno.2023.12.001","DOIUrl":"https://doi.org/10.1016/j.biotno.2023.12.001","url":null,"abstract":"<div><p>The inaugural National Competition for Carbon Dioxide Capture, Conversion and Utilization Innovation (“Bloomag Cup”) was successfully held on July 30, 2023 in Beijing. This competition was initiated by Professor Tianwei Tan and Prof. Yongqin Lv from Beijing University of Chemical Technology (BUCT), and jointly organized by BUCT and Chongqing University. The competition is slated for annual recurrence, with a rotational hosting arrangement involving various academic institutions. The ongoing competition underscores the primacy of pioneering and exploratory facets inherent to technological innovation. Its principal objective is to catalyze the development of foundational and cutting-edge technological competencies within the realm of CO<sub>2</sub> capture, conversion, and utilization. The overarching goals encompass identifying promising technological breakthroughs, fostering emerging talent in scientific and technological innovation, facilitating high-quality sustainable economic growth within China, and actively contributing to global efforts towards peak carbon emissions and achieving sustainable development goals for humanity. This inaugural Bloomag Cup saw wide participation from students and researchers, generating fruitful discussions that advance the nascent field. It is hoped this competition will continue cultivating solutions that help mitigate anthropogenic climate change through innovative carbon dioxide technologies.</p></div>","PeriodicalId":100186,"journal":{"name":"Biotechnology Notes","volume":"4 ","pages":"Pages 112-117"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665906923000132/pdfft?md5=e434bed0478aec98b2cd4b2862b56c4d&pid=1-s2.0-S2665906923000132-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138564404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential application of menadione for antimicrobial coating of surgical sutures 甲萘醌在外科缝合线抗菌涂层中的潜在应用

Biotechnology Notes Pub Date : 2023-01-01 DOI: 10.1016/j.biotno.2023.02.001

Cheng Hong Yap , See Khai Lim , Yun Li Chan , Chin Fei Chee , Sun Tee Tay

{"title":"Potential application of menadione for antimicrobial coating of surgical sutures","authors":"Cheng Hong Yap , See Khai Lim , Yun Li Chan , Chin Fei Chee , Sun Tee Tay","doi":"10.1016/j.biotno.2023.02.001","DOIUrl":"https://doi.org/10.1016/j.biotno.2023.02.001","url":null,"abstract":"<div><p>Staphylococcal-associated surgical site infections (SSI) are common nosocomial infections in healthcare facilities worldwide. The use of antiseptic-coated sutures has been recommended to minimise the risk of SSI in clinical settings. However, as there has been a growing concern over antibiotic resistance resulting from antiseptic usage, development of antimicrobial sutures using alternative compounds is necessary. In this study, menadione (2-methyl-1,4-napthoquinone), also known as Vitamin K<sub>3,</sub> was evaluated as a potential antimicrobial compound for suture coating. The anti-staphylococcal activity of menadione was assessed using microbroth dilution method and biofilm inhibition assays. The low menadione minimum biofilm inhibitory concentration values against both methicillin-susceptible and -resistant <em>S. aureus</em> strains indicate its inhibitory activity against staphylococcal biofilm. Menadione-coated sutures were prepared by dip-coating surgical sutures in slurries containing poly(D,L-lactide-co-glycolide) polymers (either 65:35 or 75:25) and calcium stearate. Zone of inhibition assays showed dose-dependent antimicrobial effects of the sutures up to four days. A ∼3 log10 colony forming unit/ml reduction of adherent bacteria (p < 0.05) on the sutures was demonstrated via bacterial adherence assays. The integrity and tensile strength of the sutures were unaffected by the coating procedure. In view of the increased antibiotic resistance and limited antimicrobials, menadione may be potentially useful for antimicrobial coating of surgical sutures.</p></div>","PeriodicalId":100186,"journal":{"name":"Biotechnology Notes","volume":"4 ","pages":"Pages 20-27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49757647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthetic biology in Indonesia: Potential and projection in a country with mega biodiversity 印度尼西亚的合成生物学:在一个拥有巨大生物多样性的国家的潜力和预测

Biotechnology Notes Pub Date : 2023-01-01 DOI: 10.1016/j.biotno.2023.02.002

Immanuel Sanka , Ali Budhi Kusuma , Faustina Martha , Andre Hendrawan , Ihsan Tria Pramanda , Adhityo Wicaksono , Afif Pranaya Jati , Maulida Mazaya , Ari Dwijayanti , Nurul Izzati , Muhammad Farhan Maulana , Aulia Reski Widyaningrum

引用次数: 1