Archives of Gerontology and Geriatrics Plus最新文献

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Coronary heart disease racial disparities among older adults in the U.S.: Systematic review, 2000-2024 美国老年人冠心病的种族差异:2000-2024年的系统回顾
Archives of Gerontology and Geriatrics Plus Pub Date : 2025-09-01 Epub Date: 2025-08-05 DOI: 10.1016/j.aggp.2025.100194
Sanggon Nam
{"title":"Coronary heart disease racial disparities among older adults in the U.S.: Systematic review, 2000-2024","authors":"Sanggon Nam","doi":"10.1016/j.aggp.2025.100194","DOIUrl":"10.1016/j.aggp.2025.100194","url":null,"abstract":"<div><h3>Background</h3><div>Coronary heart disease (CHD) remains a leading cause of morbidity and mortality among older U.S. adults, with significant racial and ethnic disparities in prevalence, treatment, and outcomes. This systematic review synthesizes evidence from 44 studies published between 2000 and 2024 to examine these disparities among adults aged ≥65, focusing on prevalence, access to care, treatment quality, outcomes, contributing factors, and effective interventions.</div></div><div><h3>Methods</h3><div>The review adhered to PRISMA 2020 guidelines. A comprehensive search was conducted across six databases: PubMed, Embase, Scopus, Web of Science, CINAHL, and the Cochrane Library. Studies were included if they examined racial/ethnic differences in CHD among U.S. adults aged ≥65. Two independent reviewers screened titles and abstracts, followed by full-text review, with disagreements resolved by a third reviewer. Inter-rater reliability was assessed using Cohen’s kappa (0.85 for title/abstract, 0.90 for full-text). Quality assessment used the Newcastle-Ottawa Scale (NOS; high quality ≥7 points, moderate 4–6 points, low ≤3 points) for observational studies and the Cochrane Risk of Bias tool for randomized trials. Due to heterogeneity, a narrative synthesis was conducted, with subgroup analyses for key outcomes.</div></div><div><h3>Results</h3><div>The 44 included studies revealed persistent disparities in CHD prevalence, access, treatment, and outcomes, particularly affecting Black, Hispanic, and American Indian/Alaska Native (AI/AN) older adults. Minority groups exhibited higher CHD prevalence and risk factors (e.g., hypertension, diabetes), lower access to guideline-directed therapies, and worse outcomes, including higher readmission and mortality rates. Structural racism, socioeconomic factors, and systemic biases were key drivers. Interventions like policy reforms, community-based programs, and telehealth showed promise in reducing disparities.</div></div><div><h3>Conclusions</h3><div>Despite progress in acute care, significant disparities persist in long-term CHD management among minority older adults. Addressing social determinants, improving access to equitable care, and implementing culturally competent interventions are essential for health equity.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health on the move: cardiovascular disease risk among ageing male migrants in India 流动中的健康:印度老年男性移民患心血管疾病的风险
Archives of Gerontology and Geriatrics Plus Pub Date : 2025-09-01 Epub Date: 2025-08-08 DOI: 10.1016/j.aggp.2025.100196
Vasim Ahamad , Ujjwal Das
{"title":"Health on the move: cardiovascular disease risk among ageing male migrants in India","authors":"Vasim Ahamad ,&nbsp;Ujjwal Das","doi":"10.1016/j.aggp.2025.100196","DOIUrl":"10.1016/j.aggp.2025.100196","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality globally, with a growing burden in low- and middle-income countries such as India. Rapid urbanization, lifestyle changes, and demographic shifts have made internal migration a critical determinant of health. The present study aims to investigate the association between migration and CVD among older males in India.</div></div><div><h3>Methods</h3><div>Data were drawn from the Longitudinal Aging Study in India (LASI Wave-1), including 29,944 male respondents aged 45 years and above. Descriptive statistics, multivariate logistic regression, and Fairlie decomposition analysis were employed to analyze the association between migration and self-reported CVD. Migration streams were categorized as rural–rural, rural–urban, urban–rural, and urban–urban.</div></div><div><h3>Results</h3><div>Migrants had significantly higher odds of CVD compared to non-migrants (Adjusted OR: 1.12, 95% CI: 1.05–1.19). Migration streams involving urban exposure (rural–urban and urban–urban) were associated with a higher CVD risk. Longer duration of stay at the destination, inter-state and early-life migration were also associated with increased CVD risk. Urban residence, higher education, better economic status, and being unemployed were independently associated with elevated CVD risk. Fairlie decomposition showed that 81% of the CVD disparity between migrants and non-migrants could be explained by observed factors, with place of residence (50.25%), education (18.85%), and MPCE quintile (9.23%) being the major contributors.</div></div><div><h3>Conclusion</h3><div>Migration, particularly to or within urban areas, is significantly associated with increased CVD risk among older Indian males. The findings underscore the need for public health policies that address urban lifestyle risks and improve health monitoring and preventive care for migrant populations.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global research trends on subtypes of Parkinson's disease: A visual bibliometric analysis 帕金森氏病亚型的全球研究趋势:视觉文献计量分析
Archives of Gerontology and Geriatrics Plus Pub Date : 2025-09-01 Epub Date: 2025-05-07 DOI: 10.1016/j.aggp.2025.100166
Yan Su , Sheng Cai , Yang Xu , Xianwen Chen
{"title":"Global research trends on subtypes of Parkinson's disease: A visual bibliometric analysis","authors":"Yan Su ,&nbsp;Sheng Cai ,&nbsp;Yang Xu ,&nbsp;Xianwen Chen","doi":"10.1016/j.aggp.2025.100166","DOIUrl":"10.1016/j.aggp.2025.100166","url":null,"abstract":"<div><h3>Object</h3><div>Parkinson's disease (PD) is a neurodegenerative disease with different subtypes. More accurate subtype classification is significant for understanding the pathogenesis of PD, predicting disease progression, and selecting effective treatment methods. A bibliometric analysis of relevant research on PD subtypes is presented in this study.</div></div><div><h3>Methods</h3><div>Original research and review articles related to PD subtypes from January 1, 2015 to December 31, 2024 were retrieved from the Web of Science Core Collection (WOSCC) database. After screening, 2213 articles were obtained. Statistical analysis and visualization of country, institution, author, journal, and keyword information contained in the studies were performed using CiteSpace (v6.2. R4) and VOSviewer (v1.6.20.0) software to identify research hotspots and trends in the field.</div></div><div><h3>Result</h3><div>The 2213 articles used in this study were from 11740 authors from 3117 institutions in 93 countries and published in 481 journals. From the analysis, it was found that the number of annual publications in this field has been increasing year by year in the past 10 years. The United States contributed the most to this research direction, with the largest number of publications (604) and citations (31, 284), and the strongest connection with other countries. 'Motor disorder ' is the most frequently cited journal, and ' Parkinson 's disease-related disorder ' is the most frequently published journal. \"Parkinson's Disease\", \"Dementia\", \"Subtypes\", and \"Progress\" are frequently used keywords, while \"Rem sleep\", \"networs\", and \"machine learning\" are the focus of research in recent years.</div></div><div><h3>Conclusion</h3><div>The bibliometric analysis offers a comprehensive insight into present research focal points and evolving patterns associated with PD subtypes. High-frequency keywords pinpointed underscore dynamic research fields encompassing methodologies, mechanisms, and engaged populations. These findings can provide guidance for future research on PD subtypes.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining early adversities, demographic, health and psychosocial factors associated with lifetime depression among older Canadians: Findings from a nationally representative study 调查与加拿大老年人终生抑郁相关的早期逆境、人口、健康和社会心理因素:一项具有全国代表性的研究结果
Archives of Gerontology and Geriatrics Plus Pub Date : 2025-09-01 Epub Date: 2025-07-12 DOI: 10.1016/j.aggp.2025.100187
Megha Goel , Esme Fuller-Thomson
{"title":"Examining early adversities, demographic, health and psychosocial factors associated with lifetime depression among older Canadians: Findings from a nationally representative study","authors":"Megha Goel ,&nbsp;Esme Fuller-Thomson","doi":"10.1016/j.aggp.2025.100187","DOIUrl":"10.1016/j.aggp.2025.100187","url":null,"abstract":"<div><h3>Purpose</h3><div>Depression among older adults is associated with greater negative physical health, social, and economic outcomes than in younger populations. The objective of this study was to examine factors associated with lifetime depression in a nationally representative sample of Canadian older adults, highlighting characteristics linked to both vulnerability and resilience.</div></div><div><h3>Methods</h3><div>Secondary analysis of the 2022 Mental Health Access to Care Survey (MHACS) was conducted to estimate the prevalence and factors associated with lifetime depression among adults aged 55 and older (<em>n</em> = 3,535). The MHACS measured depression using the World Health Organization’s Composite International Diagnostic Interview (WHO-CIDI). Multivariable logistic regression of lifetime depression was conducted analyzing demographic and socioeconomic variables, adverse childhood experiences, physical health measures, health behaviors, and protective psychosocial factors.</div></div><div><h3>Results</h3><div>One in eleven older adults (9.2%) had experienced depression at some point in their lives. Middle-aged adults (55–64 years) compared to older respondents, and females compared to males had twice the odds of lifetime depression. Other factors associated with depression included childhood physical or sexual abuse, higher educational attainment, history of substance use disorders, multiple chronic physical health conditions, lower sense of life meaning, and higher spirituality.</div></div><div><h3>Conclusion</h3><div>Lifetime depression in older adults is associated with a complex interplay of risk and protective factors. Identifying these factors can support early recognition and targeted intervention, potentially improving outcomes and quality of life in this population.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The scope of frailty assessment tools in the middle east: unraveling gaps and trends 中东脆弱性评估工具的范围:揭示差距和趋势
Archives of Gerontology and Geriatrics Plus Pub Date : 2025-09-01 Epub Date: 2025-05-17 DOI: 10.1016/j.aggp.2025.100168
Sulaiman Alshakhs M.D., Sara Mohamed, Ibtihal Kamal, Sa'ad Laws, Mai A. Mahmoud MBBS, MEHP
{"title":"The scope of frailty assessment tools in the middle east: unraveling gaps and trends","authors":"Sulaiman Alshakhs M.D.,&nbsp;Sara Mohamed,&nbsp;Ibtihal Kamal,&nbsp;Sa'ad Laws,&nbsp;Mai A. Mahmoud MBBS, MEHP","doi":"10.1016/j.aggp.2025.100168","DOIUrl":"10.1016/j.aggp.2025.100168","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is a multidimensional syndrome associated with increased risk of adverse health outcomes in older adults. As Middle Eastern populations age, validated frailty assessment tools (FATs) are essential to inform care planning. However, regional uptake and validation remain unclear.</div></div><div><h3>Objective</h3><div>This scoping review aimed to map the use and validation of FATs among adults aged 55 and above in the Middle East, identify research gaps, and explore cross-country trends.</div></div><div><h3>Methods</h3><div>Following PRISMA-ScR guidelines, a comprehensive literature search was conducted in May 2022 and updated in December 2024 across PubMed, Embase, Web of Science, and Scopus. Search terms targeted “frailty,” “geriatric,” and 17 Middle Eastern countries. Inclusion criteria comprised primary studies using or discussing FATs among adults aged 55+, conducted in or including a Middle Eastern country. Non-English/Arabic texts, non-primary literature, and studies lacking frailty definitions or tools were excluded. In total, 103 studies were included.</div></div><div><h3>Results</h3><div>The Clinical Frailty Scale (CFS) and Fried Frailty Phenotype (FFP) were the most commonly used tools, appearing in 36 and 32 studies respectively. However, only 12 studies reported tool validation, and just 7 conducted cultural adaptation. Research output was highest in Turkey (28 studies), Iran (17), and Saudi Arabia (14), while 6 countries had no studies. Most studies used FATs in hospital settings.</div></div><div><h3>Conclusion</h3><div>Frailty research is growing in the Middle East but remains fragmented and under-validated. Standardized tools adapted to local contexts are urgently needed. Strengthening clinical care and policy will require greater regional collaboration and investment in culturally relevant research</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflections of those who have lived: Phenomenological perspectives from adults at end-of-life from an Eriksonian lens 对那些曾经生活过的人的反思:从埃里克森的视角看成年人在生命末期的现象学视角
Archives of Gerontology and Geriatrics Plus Pub Date : 2025-09-01 Epub Date: 2025-06-04 DOI: 10.1016/j.aggp.2025.100175
Brittany Stahnke , Roxxi Davis , Morgan Cooley , Porsha Farmer
{"title":"Reflections of those who have lived: Phenomenological perspectives from adults at end-of-life from an Eriksonian lens","authors":"Brittany Stahnke ,&nbsp;Roxxi Davis ,&nbsp;Morgan Cooley ,&nbsp;Porsha Farmer","doi":"10.1016/j.aggp.2025.100175","DOIUrl":"10.1016/j.aggp.2025.100175","url":null,"abstract":"<div><div>There is little research focused on the knowledge that those in the last stage of their lives can offer. The last phase of life brings with it unique wisdom and life advice that can be used to guide all people in their journeys. The purpose of this study was to provide scholarship detailing advice and learnings of those in this unique and final life stage. Nine participants were interviewed in the year 2021, and transcripts were analyzed in an interpretative phenomenological manner. Main themes of life suffering and values presented with sub-themes including illness, loss, family, faith, and purpose. The importance of choice in the lives we live, as well as hard work supports the abilities to succeed in valued areas. Family was stated to be the most important part of these lives; however, with or without family, one also benefits from a sense of accomplishment and pride in themselves.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A UK study: Menopausal and perimenopausal women’s biopsychosocial experiences, understanding of treatment options, and thoughts towards their future lives 英国的一项研究:绝经期和围绝经期妇女的生物心理社会经历,对治疗方案的理解,以及对未来生活的看法
Archives of Gerontology and Geriatrics Plus Pub Date : 2025-09-01 Epub Date: 2025-07-27 DOI: 10.1016/j.aggp.2025.100191
Mandy Simpson, Cynthia Tuuli, Elizabeth Eate
{"title":"A UK study: Menopausal and perimenopausal women’s biopsychosocial experiences, understanding of treatment options, and thoughts towards their future lives","authors":"Mandy Simpson,&nbsp;Cynthia Tuuli,&nbsp;Elizabeth Eate","doi":"10.1016/j.aggp.2025.100191","DOIUrl":"10.1016/j.aggp.2025.100191","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to draw attention and give voice to women’s experiences, knowledge, future thoughts and general understanding of perimenopause and menopause, exploring this natural event holistically through a biopsychosocial lens.</div></div><div><h3>Methods</h3><div>One focus group of four self-identified perimenopausal or menopausal women was conducted to gather data. Purposive sampling was used to recruit the participants through a social media campaign. Interpretative Phenomenological Analysis provided a framework to study this important topic through exploring and examining lived experiences in a small group sample size, using the framework’s seven-step data analysis to identify key themes within the data.</div></div><div><h3>Results</h3><div>Four main group experiential themes were highlighted through analysis of the participants' responses: (1) onset and impact of symptoms, (2) menopause and relationships, (3) the knowledge gap, and (4) future thoughts: a desire for change. A prominent overarching theme involved the participants showing less concern for how they were being personally affected by their climacteric experience but demonstrating greater concern for the impact of their perimenopause or menopause experience upon others. This overarching theme was evident within all four group experiential themes.</div></div><div><h3>Conclusions</h3><div>The participants were deeply concerned about how their symptoms affected others. They had limited knowledge when their own symptoms started, but after seeking support, particularly from people with lived experiences rather than academic literature, they became inspired to be a part of bringing about change for the next generation, so that in the future menopause experiences would not occur so unexpectedly for others.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender differences in disability among older persons in India: Evidence from the longitudinal ageing study in India (LASI) 印度老年人残疾的性别差异:来自印度纵向老龄化研究的证据
Archives of Gerontology and Geriatrics Plus Pub Date : 2025-09-01 Epub Date: 2025-06-21 DOI: 10.1016/j.aggp.2025.100183
Kinkar Mandal PhD (Assistant Professor) , Lekha Subaiya PhD (Professor)
{"title":"Gender differences in disability among older persons in India: Evidence from the longitudinal ageing study in India (LASI)","authors":"Kinkar Mandal PhD (Assistant Professor) ,&nbsp;Lekha Subaiya PhD (Professor)","doi":"10.1016/j.aggp.2025.100183","DOIUrl":"10.1016/j.aggp.2025.100183","url":null,"abstract":"<div><h3>Background</h3><div>Older women experience higher rates of disability compared to men. This gender disparity is linked to varying risk factors. The objective of this study is to investigate gender differences in disability among older adults in India</div></div><div><h3>Methods</h3><div>For this study, we used Longitudinal Ageing Study of India, Wave 1 (2017–2018) data, a nationally representative dataset of older persons age 60 years and above. Both descriptive and inferential statistics are used to analysis the data.</div></div><div><h3>Results</h3><div>Our findings indicate that older women report higher rates of vision, hearing, difficulty in chewing solid food, and physical disabilities, contributing to the observed gender differences in disability. Among these, vision impairment is the most prevalent. Notably, women with fewer years of schooling and those living in households in the lower wealth quintiles exhibit the highest levels of disability. Additionally, older individuals who are of advanced age, widowed, living in urban areas or alone, currently employed, or who experienced poor childhood health are more likely to report disabilities.</div></div><div><h3>Conclusion</h3><div>The higher prevalence of disability among women is the result of a combination of demographic and socioeconomic factors. These findings serve as a wake-up call for researchers and policymakers to prioritize gender-sensitive interventions aimed at preventing disability among older adults.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid-stimulating hormone and cognitive impairment in non-depressed non-demented multiethnic middle-aged and older US adults: Assessing sex-specific risk prediction 促甲状腺激素和非抑郁非痴呆多种族美国中老年成人的认知障碍:评估性别特异性风险预测
Archives of Gerontology and Geriatrics Plus Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.aggp.2025.100195
Asma Hallab , Alzheimer’s Disease Neuroimaging Initiative
{"title":"Thyroid-stimulating hormone and cognitive impairment in non-depressed non-demented multiethnic middle-aged and older US adults: Assessing sex-specific risk prediction","authors":"Asma Hallab ,&nbsp;Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.aggp.2025.100195","DOIUrl":"10.1016/j.aggp.2025.100195","url":null,"abstract":"<div><h3>Background</h3><div>Understanding the particularities of thyroid-cognition interactions in older adults is crucial in assessing the risks and evaluating therapeutic options.</div></div><div><h3>Methods</h3><div>Cross-sectional analyses where participants from Alzheimer’s Disease Neuroimaging Initiative (ADNI) with mild cognitive impairment (MCI) and healthy controls (HC), with complete neurocognitive tests, thyroid stimulating hormone (TSH) &lt;10 µIU/mL, and geriatric depression scale (GDS) &lt;5, were eligible. Linear and logistic regression models, including testing for non-linearity, were performed. Sex strata were explored.</div></div><div><h3>Results</h3><div>Of the total 1845 multiethnic US-participants, with a median age of 73 (IQR: 68, 78); 887 (48 %) were females, and 1056 (57 %) had MCI. The median TSH level was 1.70 µIU/mL (IQR: 1.15, 2.40); significantly lower in MCI than HC (1.66 vs. 1.74 µIU/mL, <em>p</em>-value=0.02). There was a significant association between TSH and overall cognition only in males (adj. <em>ß</em><sub>Males</sub>=-0.40[-0.74, -0.07], <em>p</em>-value=0.019). The odds of being diagnosed with MCI at baseline decreased with higher TSH levels in the total study population (adj. OR<sub>Total</sub>=0.87[0.79, 0.95], <em>p</em>-value=0.002) and in males (adj. OR<sub>Males</sub>=0.80[0.70, 0.92], <em>p</em>-value=0.001).</div></div><div><h3>Conclusions</h3><div>There was a sex-specific, statistically significant association between TSH levels and cognition in multiethnic middle-aged and older ADNI adults. Lower TSH levels and worse global cognition were statistically associated only in males. To precisely delineate the chronological onset of these disorders, longitudinal clinical studies are needed.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-communicable diseases and risk factors profiling among geriatric population residing in Hyderabad city, India 印度海得拉巴市老年人口的非传染性疾病和风险因素分析
Archives of Gerontology and Geriatrics Plus Pub Date : 2025-06-01 Epub Date: 2025-03-31 DOI: 10.1016/j.aggp.2025.100153
Karthikeyan Ramanujam, Joyeeta Thakur, Rajitha Triveni Koralla, JJ Babu Geddam, Samarasimha Reddy N
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