Archives of Gerontology and Geriatrics Plus最新文献

{"title":"Tools to reduce inappropriate drug use in geriatric patients: PRISCUS 2.0 list updates","authors":"Şeyma Handan Akyön ,&nbsp;Kamile Sılay ,&nbsp;Petra A. Thürmann","doi":"10.1016/j.aggp.2024.100052","DOIUrl":"10.1016/j.aggp.2024.100052","url":null,"abstract":"<div><h3>Introduction</h3><p>Polypharmacy, the concurrent use of multiple medications, poses significant risks to geriatric patients due to increased susceptibility to side effects and interactions. This narrative review addresses the challenges posed by polypharmacy in older adults, emphasizing the importance of reducing adverse effects. The article examines explicit, implicit, and mixed assessment tools used to identify potentially inappropriate medications (PIMs) and minimize adverse effects in geriatric populations.</p></div><div><h3>Conclusion</h3><p>The article underscores the critical need for accurate assessment and intervention to mitigate the negative consequences of polypharmacy in geriatric patients. The PRISCUS 2.0 List, an extensively updated version of the original PRISCUS list, emerges as a comprehensive tool to aid healthcare professionals in identifying PIMs. Its expanded medication list, incorporation of new evaluation criteria, disease-specific considerations, and enhanced classification system contribute to better identification of inappropriate medications. When we compared with other PIM criteria in previous studies, the EU(7)-PIM list was one of the most comprehensive, and with the PRISCUS 2.0 list update, it was determined that it contains partially more drugs that are inappropriate for the elderly in the Turkish pharmaceutical market. Comparisons between various criteria reveal their varying detection rates and strengths, highlighting the significance of using multiple criteria for a more holistic assessment. Additionally, the advent of online applications offers accessible solutions by consolidating multiple explicit criteria into a single platform, aiding practitioners in making well-informed decisions. The study emphasizes the need for ongoing updates, validation, and suitability assessments for these tools in diverse healthcare settings to ensure their effectiveness.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000493/pdfft?md5=852d9e280818336d66957d25c461faa8&pid=1-s2.0-S2950307824000493-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of supervision ratio on functional physical performance and cellular health to collective multicomponent training in untrained adults aged","authors":"Ewertton de Souza Bezerra ,&nbsp;Andreza dos Santos Silva ,&nbsp;Jéssica Naveca De Abreu ,&nbsp;Rômulo de Oliveira Sena ,&nbsp;Luis Mochizuki","doi":"10.1016/j.aggp.2024.100053","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100053","url":null,"abstract":"<div><p>In pragmatic settings, involving elderly individuals in physical activity programs typically does not require individualized training. Thus, the aim of this study was to assess the impact on functional physical performance and cellular health resulting from a high (10 participants to 1 supervisor) versus low (20 participants to 1 supervisor) supervision ratio in a group-based multicomponent training program for older women. The experimental procedure presented three phases: a) pre-assessment (physical functional performance and cellular health); b) multicomponent training program (2 sessions/week); c) post-assessment. Performance variables were normalized with a t-score and the statistical analysis was based on the individual relative position in the t-score. After the collective multicomponent training intervention, 55 % of participants were above the mean t-score; however, low supervision ratio group (20:1) did not change functional physical performance and cellular health. A high supervision ratio is an important condition to improve individual older women response during a collective multicomponent training program.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295030782400050X/pdfft?md5=8703ecfe9ee006a0ef7ee1ceb8ef53d7&pid=1-s2.0-S295030782400050X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141326153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the interplay between control beliefs, cortisol levels and depression in old age: Is feeling in control always beneficial?","authors":"F.M. Kabia MD ,&nbsp;A.A.L. Kok PhD ,&nbsp;D. Rhebergen MD PhD ,&nbsp;N. Rius Ottenheim MD PhD ,&nbsp;A.T.F. Beekman MD PhD","doi":"10.1016/j.aggp.2024.100050","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100050","url":null,"abstract":"<div><h3>Objectives</h3><p>We investigated the relationship between levels of mastery/conscientiousness and cortisol response in older adults, considering depression status. Based on former research we hypothesized that high and low and not intermediate levels of mastery/conscientiousness would correlate with high cortisol response, particularly in depressed individuals.</p></div><div><h3>Methods</h3><p>Data from the Netherlands Study of Depression in Older Persons (NESDO) were analyzed. Respondents were categorized into low, intermediate, and high mastery/conscientiousness groups. Regression analyses examined associations between mastery/conscientiousness and evening cortisol (N=412) and cortisol awakening response (N=370), stratified by depression status. Histograms were created to visualize the results.</p></div><div><h3>Results</h3><p>No significant associations were found between mastery/conscientiousness and cortisol response, irrespective of depression status.</p></div><div><h3>Conclusions</h3><p>Our findings do not suggest that low or high levels of mastery/conscientiousness increase stress in depressed older adults compared to those with intermediate levels, nor do they differ from non-depressed individuals.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295030782400047X/pdfft?md5=7f6adff7f38c8af0a08ba5dfdc002838&pid=1-s2.0-S295030782400047X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141326152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health and cognitive function: Insights from longitudinal ageing study in India (LASI) - A cross-sectional analysis","authors":"Sakthi Kiruthika K ,&nbsp;Akshata Rao ,&nbsp;Abhijith Rajaram Rao,&nbsp;Bhawana Painkra,&nbsp;Akash Jaiswal,&nbsp;Pramod Kumar,&nbsp;Nidhi Soni,&nbsp;Naveet Wig,&nbsp;Prasun Chatterjee,&nbsp;Avinash Chakrawarty","doi":"10.1016/j.aggp.2024.100049","DOIUrl":"10.1016/j.aggp.2024.100049","url":null,"abstract":"<div><h3>Introduction</h3><p>The oral cavity is related to nervous system diseases, and oral issues have a bidirectional correlation with cognitive dysfunction. Thus, this study aims to explore the association between oral health problems and cognitive dysfunction in community-dwelling Indian older adults.</p></div><div><h3>Materials and Methods</h3><p>Utilizing data from LASI, a nationally representative cohort study, this study involved 30,726 participants aged ≥60 years. The oral health problems of study participants were self-reported. Cognitive impairment was assessed using composite score, and a score of less than -1.5 SD was defined as the presence of cognitive impairment.</p></div><div><h3>Results</h3><p>In univariate analysis, significant associations were observed between oral health problems (loss of some natural teeth, OR: 1.33, 95 % CI: 1.15–1.52, <em>p</em> &lt; 0.001; lost all natural teeth, OR: 2.33, 95 % CI: 1.97–2.76, <em>p</em> &lt; 0.001) and ease of chewing solid food [Fairly well (OR: 1.51, 95 % CI: 1.33–1.71, <em>p</em> &lt; 0.001) and not at all (OR: 2.37, 95 % CI: 2.11–2.67, <em>p</em> &lt; 0.001)] with cognitive impairment. In multivariate analysis, adjusted for various factors, a significant association persisted between loss of all natural teeth (OR: 1.62, 95 % CI: 1.34–1.95, <em>p</em> &lt; 0.001) and the ability to chew solid food. Specifically, individuals reporting chewing solid food “Fairly well” (OR: 1.34, 95 % CI: 1.16–1.52, <em>p</em> &lt; 0.001) and those unable to chew at all (OR: 1.73, 95 % CI: 1.51–1.97, <em>p</em> &lt; 0.001) with cognitive impairment.</p></div><div><h3>Conclusion</h3><p>The findings of this study underscore a compelling connection between oral health issues and cognitive impairment. Consequently, it is imperative to proactively identify and address oral health problems in older adults.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000468/pdfft?md5=e8e9dc1193ca557229bea752a808e755&pid=1-s2.0-S2950307824000468-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant decrease in the incidence of osteoporotic hip fracture in patients with higher leisure-time physical activity: A case-control study","authors":"Haldor Andrés Rojas Hitschfeld ,&nbsp;Isidora Catalina Fernández Contreras ,&nbsp;Marco Antonio Grandón Solís ,&nbsp;Constanza Tatiana Von Plessing Pierry ,&nbsp;Carolina Andrea Frías Leiva ,&nbsp;Lizandro Ismael Jaque González ,&nbsp;Samuel Antonio Parra Aguilera ,&nbsp;Carlos Enrique Chandia Aguilera ,&nbsp;Erik Iván Quevedo Langenegger","doi":"10.1016/j.aggp.2024.100043","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100043","url":null,"abstract":"<div><h3>Introduction</h3><p>The principal group of people who suffer from fragility hip fractures is the elderly population, gaining relevance given the increase in the average median age of the Chilean and European populations. This fracture risk is associated with a decreased bone density. Physical activity is a protective factor in the risk of falls and a determinant of bone resistance.</p></div><div><h3>Objectives</h3><p>Determine the impact of physical activity on the probability of suffering a fragility hip fracture in a population ≥ 60 years of age in a public trauma hospital in Chile.</p></div><div><h3>Materials and methods</h3><p>It was conducted a relational analytical study of cases and controls. A total of 147 patients participated, the case group with osteoporosis hip fracture formed for 72 patients, and the control group without hip fracture 75 patients formed for 75 patients. To quantify physical activity was applied the instrument Global Physical Activity Questionnaire in the control group, and a designed version to assess pre-fracture physical activity in the case group.</p></div><div><h3>Results</h3><p>There is a significant statistical difference between the incidence of hip fractures and physical activity during leisure time, both for vigorous physical activity (p = 0.002, p &lt; 0.05), moderate physical activity (p &lt; 0.001, p &lt; 0.05), and for moderate physical activity at work (p = 0.016, p &lt; 0.05).</p></div><div><h3>Conclusions</h3><p>Physical activity during leisure time and moderate physical activity at work showed to be factors associated with a significant decrease in the incidence of fragility hip fractures.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 3","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000407/pdfft?md5=b13177660b78bb5bccb3ee716bc24482&pid=1-s2.0-S2950307824000407-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insight into functional decline assessment in older adults: A physiotherapist's perspective","authors":"Alhadi M. Jahan","doi":"10.1016/j.aggp.2024.100048","DOIUrl":"10.1016/j.aggp.2024.100048","url":null,"abstract":"<div><p>This paper aims to examine the concept of functional decline in older adults from a physiotherapist's perspective. Throughout this paper, the author will shed some light on the conceptualization, identification, and assessment of functional decline among older adults. Also, a reflection on the role of physiotherapists in promoting healthy aging and how prepared they are to meet the changing demographic landscape will be discussed. A narrative literature review methodology was used to search for and analyze relevant articles that have been published in the past three decades. The reviewed materials included peer-reviewed publications that examined the assessment of physical functional decline in older adults. The assessment of functional decline in older adults is commonly done through one assessment measure at a time. Furthermore, assessments for functional decline often happen in emergency rooms when something catastrophic has taken place, such as a fall injury. The findings also suggest that multi-domain assessments are more useful than single-domain assessments in this population. One promising assessment tool for the identification of older adults who are at risk of developing functional decline that is specific to physiotherapy practice was identified and discussed. There is a need for further research to refine the assessment process, and to develop interventions to prevent or mitigate functional decline. Overall, this paper provides valuable insights into current assessment measures of functional decline in older adults relevant to physiotherapy practice and suggests potential areas for future research.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000456/pdfft?md5=4a4af408323ff97f604b98654d9197c9&pid=1-s2.0-S2950307824000456-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic shifts and health dynamics: Exploring the impact of aging rates on health outcomes in Brazilian capitals","authors":"Samuel C. Dumith ,&nbsp;Natan Feter","doi":"10.1016/j.aggp.2024.100044","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100044","url":null,"abstract":"<div><h3>Objectives</h3><p>We aimed to examine the association between population aging and the prevalence of non-communicable diseases and risk factors in the Brazilian population.</p></div><div><h3>Study design</h3><p>An ecological study using secondary data from 2010 to 2023 of the Surveillance System of Risk and Protective Factors for Chronic Diseases by Telephone Survey (VIGITEL).</p></div><div><h3>Methods</h3><p>We estimated the aging rate in 2010 and 2022 as the ratio of people aged 65 or older to those younger than 15 using the 2010 and 2022 Brazilian censuses. We calculated the absolute differences in the prevalence of non-communicable diseases (hypertension, diabetes) and their risk factors (smoking, excessive alcohol consumption, physical inactivity, obesity) and negative health perceptions in 2010 and 2023 for the 26 Brazilian states and the Federal District. Linear regression assessed the relationship between aging rate and health outcomes. We stratified the analyses to explore the differences by sex.</p></div><div><h3>Results</h3><p>Brazil's aging rate was higher among women than men (average of 0.20 and 0.31, respectively). The increased number of older adults was associated with a higher prevalence of excess weight and diabetes in men. In women, the aging rate was associated with a higher prevalence of smoking, excessive alcohol consumption, obesity, hypertension, and diabetes.</p></div><div><h3>Conclusions</h3><p>Our findings show a sex-specific association between population aging and the prevalence of health conditions in the Brazilian population. By discerning the sex-specific nuances and untangling the multifactorial influences, this research aspires to contribute valuable insights to the burgeoning field of public health in the face of evolving demographic landscapes.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 3","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000419/pdfft?md5=7425a831205f93a3bdacd16b61c3d6a1&pid=1-s2.0-S2950307824000419-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of a Japanese version of life-space assessment in institutionalized settings","authors":"Tomoyuki Shinohara PhD ,&nbsp;Shota Saito MS ,&nbsp;Ayumi Maruyama ,&nbsp;Yuta Yabana ,&nbsp;Yosuke Tomita PhD ,&nbsp;Klaus Hauer PhD","doi":"10.1016/j.aggp.2024.100040","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100040","url":null,"abstract":"<div><h3>Purpose</h3><p>A reduction in life space (LS) is associated with a negative impact on medical and functional status during hospitalization, with potential consequences after discharge. A validated version of an evaluation tool for assessing LS in Japanese individuals in an institutionalized setting is lacking. This study developed and validated a Japanese version of the Life-Space Assessment in Institutionalized Settings (LSA-IS-J).</p></div><div><h3>Material and methods</h3><p>The LSA-IS-J was developed using a specified process. This study included 30 inpatients admitted to the rehabilitation ward. The Timed Up and Go Test, Berg Balance Scale scores, 10-meter walking time, Functional Independence Measure, and Falls Efficacy Scale-International were used to assess construct validity. For test-retest reliability, the same assessor evaluated the LSA-IS-J within two days. Correlation coefficients were calculated to determine the construct validity.</p></div><div><h3>Results</h3><p>The mean LSA-IS-J total score mean was 37.7 (standard deviation: 7.4), with skewness of -0.17 and kurtosis of -1.39. No ceiling or floor effects are observed. The test-retest reliability was excellent for the total and subtests, with intraclass correlations ranging from 0.78 to 0.99. The LSA-IS-J showed significant correlations with almost all variables related to motor status and concerns about falling, indicating high construct validity. In contrast, more generic variables were not significantly associated.</p></div><div><h3>Conclusions</h3><p>The LSA-IS-J demonstrated broad feasibility for assessing LS without ceiling or floor effects among patients undergoing ward-based rehabilitation. The LSA-IS-J also demonstrated excellent test-retest reliability and adequate construct validity for constructs with a high impact on LS.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000377/pdfft?md5=fa2325cea25a137bab607dbd21f4e905&pid=1-s2.0-S2950307824000377-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141291987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of transcranial direct current stimulation on dual-task performance in older and young adults: A systematic review and meta-analysis","authors":"Jibrin Sammani USMAN,&nbsp;Thomson Wai-Lung WONG,&nbsp;Shamay Sheung Mei NG","doi":"10.1016/j.aggp.2024.100047","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100047","url":null,"abstract":"<div><h3>Background</h3><p>The ability to successfully perform various physical and cognitive tasks simultaneously is a required goal for older adults (OA). Brain areas such as the dorsolateral prefrontal cortex (DLPFC) are involved in cognitive processing during walking and balance tasks, with transcranial direct current stimulation (tDCS) used in modulating the excitability of brain cortical areas such as the DLPFC.</p></div><div><h3>Objectives</h3><p>To evaluate the available scientific evidence on the effects of tDCS on dual-task (DT) Performance (PF) in older and young adults.</p></div><div><h3>Methods</h3><p>Databases of PEDro, Web of Science, PubMed, Embase, and Cochrane Library were searched from inception until December 2023. RCTs were included. The risk of bias (ROB) and methodological quality of the included RCTs were assessed with the appropriate Cochrane ROB assessment tool, and PEDro scale respectively. Both narrative and quantitative synthesis were used for data analysis.</p></div><div><h3>Results</h3><p>The result revealed that real tDCS significantly reduced: dual-task cost (DTC) on gait speed (MD = 3.68, 95 %CI-1.04 to 6.33, P = 0.006), DTC on postural sway (PS) velocity (MD = -25.49, P &lt; 0.00001), DTC on PS area (MD = -53.96, P &lt; 0.00001), and significantly improved DT PS velocity (SMD = -0.61, P = 0.02), with low certainty of evidence post- experiment compared to sham tDCS in OA. However, in young adults, there was no significant difference post-experiment between real and sham tDCS on DT stride time variability (P = 0.18) and DTC on stride time variability (P = 0.34) with low certainty of evidence.</p></div><div><h3>Conclusions</h3><p>tDCS especially anodal tDCS to the DLPFC significantly improved DT PS velocity and area, and also significantly reduced DTC on gait speed, PS velocity, and area in OA.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000444/pdfft?md5=45203de40251ed8dac976aa4f9c4ab2a&pid=1-s2.0-S2950307824000444-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141294236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation, muscle health and aging: Calf circumference as a cost-effective diagnostic indicator of Sarcopenia","authors":"Sharon P Rose ,&nbsp;Anju Srinivas ,&nbsp;Akila Prashant ,&nbsp;Prathiba Periera ,&nbsp;Suma M Nataraj ,&nbsp;Kusuma K Shivashankar","doi":"10.1016/j.aggp.2024.100046","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100046","url":null,"abstract":"<div><h3>Background</h3><p>This study aims to investigate the levels of interleukin6(IL6), interleukin 10(IL10), the IL6:IL10 ratio, and various anthropometric measurements in different stages of sarcopenia among older individuals.</p></div><div><h3>Methodology</h3><p>Conducted as a one-year cross-sectional study using purposive sampling, involving individuals aged 58–85 years, screened for sarcopenia based on the AWGS-2019 criteria. Case-finding methods included the SARC<img>CalF questionnaire, handgrip strength(HGS), and chair-stand tests(CST). Anthropometric measurementswere recorded for all participants, allowing for the calculation of body mass index(BMI), waist-to-hip ratio(WHR), and appendicular skeletal muscle mass index(ASMI). Additionally, IL6 and IL10levels were estimated using Sandwich-ELISA.</p></div><div><h3>Results</h3><p>Among the 130participants, 33 were free from sarcopenia, 35 exhibited pre-sarcopenia, 29 had sarcopenia, and 33 presented severe-sarcopenia. A majority (63 %) of the participants were male, and a substantial portion (77 %) had both diabetes and sarcopenia. The study's findings revealed that the SARC<img>CalF questionnaire demonstrated a lower mean score in the non-sarcopenia group, with an increasing trend from pre-sarcopenia to severe-sarcopenia groups. HGS, CST results, and ASMI exhibited a reverse trend. Post-Hoc Tukey's tests revealed that IL6, IL10, IL6:IL10, and Calf Circumference(CC) exhibited significant differences between the study groups. Furthermore, ROC analysis demonstrated that IL6, IL10, IL6:IL10, and CC possessed an AUC ranging between 0.7 and 0.9, showcasing good sensitivity and specificity in distinguishing between non-sarcopenia and pre-sarcopenia.</p></div><div><h3>Conclusion</h3><p>This study highlights the utility of IL6, IL10, IL6:IL10, and CC in the early identification of pre-sarcopenia among older individuals, offering valuable insights for clinicians to intervene promptly and enhance their quality of life.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 3","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000432/pdfft?md5=ce65b32677e231a9d2d444cb9453f476&pid=1-s2.0-S2950307824000432-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141286032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}