Archives of Gerontology and Geriatrics Plus最新文献

{"title":"Sex differences in risk factors associated with Alzheimer’s dementia patients with irritability and anger","authors":"Philip Cole Brewer ,&nbsp;Timi Kehinde Ojo ,&nbsp;Killian Joseph Bucci ,&nbsp;Connor John O-Brien ,&nbsp;Dami Taiwo Ojo ,&nbsp;Emmanuel I. Nathaniel ,&nbsp;Nathan Gerhard Faulstich ,&nbsp;Adebobola Imeh-Nathaniel ,&nbsp;Richard Goodwin ,&nbsp;Thomas I Nathaniel","doi":"10.1016/j.aggp.2025.100184","DOIUrl":"10.1016/j.aggp.2025.100184","url":null,"abstract":"<div><h3>Background</h3><div>The objective of this study is to identify risk factors that contribute to sex differences in Alzheimer dementia (AD) patients that also present with irritability and anger (ADIA) and determine whether these factors are different between male and female patients with ADIA.</div></div><div><h3>Method</h3><div>We used data from the of database for AD with a history of irritability and collected from a large academic center from 2016 to 2020. A total of 128,769 patients with AD were identified: 72,896 females and 55,873 males. Univariate was used to stratified risk factors base on sex and presence or absence of anger and irritability among AD patients. The adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) for each risk factor or demographic were used to predict the odds of a specific risk factors being associated with male or female ADIA.</div></div><div><h3>Result</h3><div>In the adjusted analysis, male ADIA patients were more likely to present with hypertension (OR = 2.894, 95 % CI, 2.079–4.028), insomnia (OR = 1.736, 95 % CI, 1.132–2.663), dyslipidemia (OR = 1.974, 95 % CI, 1.119–3.482), and peripheral vascular disease (OR = 44.135, 95 % CI, 4.344–448.364). Females were more likely to present with osteoporosis (OR = 0.002, 95 % CI, 0.001–0.023), gait dysfunction (OR = 0.034, 95 % CI, 0.003–0.452), anxiety (OR = 0.634, 95 % CI, 0.472–0.852), urinary tract infection (OR = 0.157, 95 % CI, 0.063–0.393), headaches (OR = 0.121, 95 % CI, 0.052–0.282) and pneumonia (OR = 0.209, 95 % CI, 0.114–0.384).</div></div><div><h3>Conclusion</h3><div>This study reveals key sex differences in ADIA patients. A population-based approach that tackles inequalities in risk factors may offer population-based healthcare and care of male and female ADIA patients.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive-impairment-free life expectancy (CIFLE) among older adults in India: A gender and residence based study","authors":"Madhurima Sharma,&nbsp;Abdul Fathah,&nbsp;Indrajit Goswami","doi":"10.1016/j.aggp.2025.100182","DOIUrl":"10.1016/j.aggp.2025.100182","url":null,"abstract":"<div><h3>Background</h3><div>While cognitive impairment (CI) and dementia are among the most severe morbid conditions in later life, life expectancies free from CI have been much less investigated than measures of physical functioning. This study aimed to determine the health expectancies in middle aged and older adults in India, considering cognitive status as a health indicator.</div></div><div><h3>Methods</h3><div>We estimated Cognitive Impairment-free life expectancy (CIFLE) in India for people aged 45 and older using data from Longitudinal Ageing Study in India (LASI), 2017-18. Mortality data has been derived from the Sample Registration System (SRS), 2016-20. Sullivan’s method is used to estimate the average number of years a person can expect to live with and without cognitive impairment.</div></div><div><h3>Results</h3><div>The prevalence of CI among Indian adults 45 and above is 10.28 %, increasing from 4.34 % (45–49) to 47 % (85+). Higher rates in females (13.65 % vs 6.42 % in males) and rural areas (12.39 % vs 6.38 % urban). The results indicate that after attaining age 60, males are expected to live 15 more years as cognitive impairment-free, which is only 12 years for females; though life expectancy for females is higher than that of males. Older adults in rural areas are expected to have fewer cognitive impairment-free years than in urban areas.</div></div><div><h3>Conclusion</h3><div>Longer life does not extend cognitive health. CI reduces quality of life and increases care needs, aligning with global trends. The disparities in CI-free life expectancy between genders and rural-urban areas highlight the need for targeted interventions and policies to address cognitive health inequalities in India.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung ultrasound (LUS) as a predictor of delirium in elderly patients with COVID-19 during hospitalization: A geriatric vulnerability-stress model","authors":"Thomas Fraccalini MD ,&nbsp;Isa Rita Bergoglio MD, PhD ,&nbsp;Gianfranco Fonte MD, PhD ,&nbsp;Andrea Trogolo MD ,&nbsp;Alessandro Maraschi MD ,&nbsp;Thomas Roberts ,&nbsp;Beatrice Tarozzo PsyD ,&nbsp;Beatriz Vitorino MS ,&nbsp;Julia Michelin Vecchini MS ,&nbsp;Santoro Mariangela MD ,&nbsp;Monica Traversa MD, PhD ,&nbsp;Teresa Crea MD ,&nbsp;Luciano Cardinale MD, PhD ,&nbsp;Giuseppe Maina MD ,&nbsp;Valerio Ricci MD, PhD ,&nbsp;Elisa Binello CNO ,&nbsp;Reald Turja NU ,&nbsp;Federico Mallamaci NU ,&nbsp;Giovanni Volpicelli MD","doi":"10.1016/j.aggp.2025.100186","DOIUrl":"10.1016/j.aggp.2025.100186","url":null,"abstract":"<div><h3>Introduction</h3><div>Delirium, an acute confusional state, is common in elderly hospitalized COVID-19 patients and is linked to poor outcomes. Despite this, underdiagnosis persists due to symptom overlap with dementia. This study investigates whether lung ultrasound (LUS) and cognitive screening can predict delirium risk in elderly COVID-19 patients.</div></div><div><h3>Methods</h3><div>A prospective study at San Luigi Hospital enrolled 64 COVID-19 patients (mean age 82.6). Pulmonary involvement was assessed using the LUS Extension Score (LUSext), while cognition was evaluated via MMSE and 4AT tests. Clinical data, including comorbidities and inflammatory markers, were analyzed. ROC curves and multivariate regression identified delirium predictors.</div></div><div><h3>Results</h3><div>Delirium occurred in 61.4 % (35/57). Univariate analysis linked delirium to pre-existing dementia (<em>p</em> = 0.03), higher LUS scores (<em>p</em> = 0.004), and lower MMSE scores (<em>p</em> = 0.0002). A LUS score &gt;3 (sensitivity 74 %, specificity 82 %) best predicted delirium. Multivariate analysis confirmed LUS &gt;3 (OR=4.22, <em>p</em> = 0.023) and lower MMSE (OR=0.87, <em>p</em> = 0.007) as independent risk factors.</div></div><div><h3>Discussion</h3><div>LUS and cognitive impairment are strong predictors of delirium in elderly COVID-19 patients. The LUSext score provides an objective, rapid bedside measure of lung pathology severity, with a score &gt;3 indicating significantly elevated delirium risk. The link between low MMSE and delirium underscores cognitive vulnerability.</div></div><div><h3>Conclusion</h3><div>While delirium is multifactorial, integrating LUS into routine assessment may improve early detection and management in resource-limited settings, effectively identifying high-risk patients using an accessible bedside investigation. A LUS score &gt;3 and low MMSE should prompt preventive measures. Further studies should validate these findings and explore pathophysiology.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of intergenerational programmes on older adults for active ageing. A systematic review","authors":"Victoria Sánchez-Cazalla ,&nbsp;Tamara Gutiérrez-Domingo","doi":"10.1016/j.aggp.2025.100176","DOIUrl":"10.1016/j.aggp.2025.100176","url":null,"abstract":"<div><h3>Introduction</h3><div>Ageing is a process that covers the entire life cycle of a human being and that, around old age, is usually accompanied by negative stereotypes, social isolation and a feeling of loneliness, resulting in a rupture between diverse generations. Intergenerational programs have been used to address this concern to pursue active ageing.</div></div><div><h3>Objetive</h3><div>Analyze the impact of intergenerational programs on the ageing process to achieve cohesive societies for all ages and thus promote the active ageing model.</div></div><div><h3>Material and methods</h3><div>A systematic review has been prepared, the search of which was carried out in the Pubmed, Web of Science, Scopus, PsycINFO, and Cochrane Libary databases, that included studies published between 2014 and 2025. A total of 3.144 articles were identified, of which 290 underwent selection according to title and abstract, leaving 72 that were evaluated for eligibility, according to the inclusion criteria.</div></div><div><h3>Results</h3><div>A total of 8 articles were valid for inclusion. The methodological quality of the studies was low to moderate, although most research reported improvements in participants' well-being after participation in an intergenerational program.</div></div><div><h3>Conclusions</h3><div>Intergenerational programs provided biopsychosocial benefits to generations of different ages, which helped enhance the pursuit of active ageing in order to establish strong connections in the community.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translating inflammaging: The bidirectional relationship between oral and systemic health in geriatric prosthodontics","authors":"Olga Naka,&nbsp;Panagiota Chatzidou,&nbsp;Katia Sarafidou,&nbsp;Vassiliki Anastassiadou","doi":"10.1016/j.aggp.2025.100192","DOIUrl":"10.1016/j.aggp.2025.100192","url":null,"abstract":"<div><div>The aging population presents complex challenges to oral health, particularly due to inflammaging, a chronic, low-grade systemic inflammation linked to tissue degeneration and frailty syndrome. Despite its relevance, inflammaging remains underexplored in geriatric prosthodontics. This scoping review aimed to systematically examine and classify existing literature on oral-systemic inflammaging, with emphasis on diagnostic biomarkers, therapeutic strategies, and interdisciplinary integration. Bloom’s cognitive taxonomy was used to structure the evidence according to levels of complexity and clinical application. Following the PRISMA-ScR guidelines, 1686 records were screened across four databases (PubMed, Scopus, Web of Science, and Embase), and 49 studies met the inclusion criteria. The review employed a dual framework: the PICO model for clinical relevance and Bloom’s instructional taxonomy to categorize evidence from recall-level biological markers to higher-order insights, such as senotherapeutics, multi-omics diagnostics, and digital integration. Findings highlighted strong correlations between systemic inflammatory markers and oral aging conditions. Novel interventions, including senolytics, mTOR inhibitors, and microbiome-targeted therapies, showed translational promise. However, gaps persist in standardized biomarker panels, long-term clinical trials, and integration of frailty metrics into prosthodontic care. In conclusion, inflammaging offers a compelling biological perspective for transitioning prosthodontic strategies from mechanical approaches to precision-based methodologies. Integrating concepts including geroscience, salivary diagnostics, and personalized biomaterials can enhance outcomes and resilience in older adults. Future research should prioritize biologically informed protocols, interdisciplinary collaboration, and AI-supported predictive tools to align prosthodontics with the broader goals of healthy aging.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of non-exercise physical activity with sarcopenia compared with that of exercise habits among community-dwelling older adults: A 7-year follow-up from the Kashiwa Cohort Study","authors":"Weida Lyu ,&nbsp;Tomoki Tanaka ,&nbsp;Bo-Kyung Son ,&nbsp;Yasuyo Yoshizawa ,&nbsp;Katsuya Iijima","doi":"10.1016/j.aggp.2025.100188","DOIUrl":"10.1016/j.aggp.2025.100188","url":null,"abstract":"<div><h3>Aim</h3><div>This study investigated the relationship of moderate-to-vigorous-intensity non-exercise physical activity (NEPA) and exercise habits (EH) with sarcopenia in community-dwelling older adults.</div></div><div><h3>Methods</h3><div>A 7-year longitudinal analysis was conducted using data of 863 older adults from the Kashiwa Cohort Study in Japan, with baseline assessment in 2014 and follow-up in 2016, 2018, and 2021. Sarcopenia was assessed using the Asian Working Group for Sarcopenia 2019 criteria. NEPA status and EH were evaluated using the Global Physical Activity Questionnaire and a self-reported questionnaire according to the Japanese National Health and Nutrition Survey, respectively.</div></div><div><h3>Results</h3><div>Cox regression analysis identified baseline NEPA and EH as predictors of cumulative sarcopenia incidence. The incidence of new-onset sarcopenia and adjusted hazard ratios (95 % confidence interval [CI]) were 10.7 % and 0.49 (0.25–0.94) for NEPA only, 9.6 % and 0.44 (0.23–0.85) for EH only, and 8.0 % and 0.40 (0.22–0.72) for both, respectively, compared with 18.9 % for the neither NEPA nor EH group. Generalized estimating equations (GEE) analysis revealed that the odds of sarcopenia were significantly lower in the NEPA only, EH only, and both NEPA and EH groups, with adjusted odds ratios (95 % CI) of 0.52 (0.28–0.96), 0.48 (0.24–0.95), and 0.36 (0.20–0.63), respectively.</div></div><div><h3>Conclusions</h3><div>Both NEPA and EH were independently associated with a lower sarcopenia incidence. Therefore, NEPA may be a practical alternative to structured exercises for older adults.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing frailty and functional decline assessment","authors":"Liang-Kung Chen MD, PhD","doi":"10.1016/j.aggp.2025.100190","DOIUrl":"10.1016/j.aggp.2025.100190","url":null,"abstract":"","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and delirium: A fatal combination in older adults","authors":"Jay Acharya ,&nbsp;Radcliffe Lisk ,&nbsp;Rashid Mahmood ,&nbsp;Amir Manzoor ,&nbsp;Francesca Young ,&nbsp;Mitveer Gill ,&nbsp;Keefai Yeong ,&nbsp;Kevin Kelly ,&nbsp;Jonathan Robin ,&nbsp;David Fluck ,&nbsp;Christopher Henry Fry ,&nbsp;Thang Sieu Han","doi":"10.1016/j.aggp.2025.100180","DOIUrl":"10.1016/j.aggp.2025.100180","url":null,"abstract":"<div><h3>Background</h3><div>Frailty and delirium commonly coexist in acutely ill older adults, but they are variably measured. The Clinical Frailty Scale (CFS) and the 4AT scores are advocated as standardised tools to assess these conditions. We have developed risk categories based on these scales to predict mortality.</div></div><div><h3>Methods</h3><div>Two-graph ROC curve analysis derived thresholds at 5.5 for CFS and 1 for 4AT for predicting mortality, from which three composite <em>Risk-Categories</em> were created: “<em>Low-Risk</em>” represents low scores for both CFS (1–6) and 4AT (0); <em>Intermediate-Risk”</em> represents either high CFS (7–9) or high 4AT (1–12) scores; and <em>High-Risk</em>” represents both high CFS and 4AT scales. These <em>Risk-Categories</em> were used to predict in-hospital or 30-day mortality using logistic regression, and up to 27 months since admission using Cox regression; adjusted for age, sex, Charlson comorbidity index, anticholinergic burden and polypharmacy.</div></div><div><h3>Results</h3><div>There were 1192 patients (57.1 % women) of mean age 86.1 yr (SD=7.1) consecutively admitted to a hospital. Compared to those in the “<em>Low-Risk</em>” category (reference), in-hospital mortality odds-ratios (ORs; 95 %CI) were greater for those in the “<em>Intermediate-Risk”</em> category: OR=1.74 (1.11–2.72), and “<em>High-Risk</em>” category: OR=2.72 (1.47–5.02). Corresponding values for within 30-day mortality were: OR=1.75 (1.18–2.60) and OR=3.03 (1.76–5.21). Risk of death within 27 months of admission was increased in the “<em>High-Risk</em>” category: hazard ratio=1.46 (1.14–1.87). The association of CFS and mortality was partially mediated by 4AT.</div></div><div><h3>Conclusion</h3><div>Mortality in hospital was approximately doubled in “<em>Intermediate-Risk</em>” and tripled in “<em>High-Risk</em>” patients, which persisted after discharge. These risk categories are a useful tool for identifying high-risk patients.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty assessment as a predictor of postoperative complications and life space in Indian older adults undergoing elective major orthopaedic surgery: A prospective study from a tertiary care centre","authors":"Abhijith Rajaram Rao ,&nbsp;Sumitab Singh ,&nbsp;Baburao Gudeti ,&nbsp;Pramod Kumar Mehta ,&nbsp;Rajesh Malhotra ,&nbsp;Avinash Chakrawarty ,&nbsp;Aparajit Ballav Dey ,&nbsp;Prasun Chatterjee","doi":"10.1016/j.aggp.2025.100198","DOIUrl":"10.1016/j.aggp.2025.100198","url":null,"abstract":"<div><h3>Introduction</h3><div>Preoperative risk assessment is important, and the traditional evaluation is ineffective in identifying frail older patients. We intend to report the association between frailty, as diagnosed using the National Surgical Quality Improvement Program (NSQIP) modified frailty index, and immediate and one-month postoperative outcome in older adults undergoing elective orthopaedic surgery.</div></div><div><h3>Methods</h3><div>This prospective study was conducted in the inpatient department of a tertiary care centre. The preoperative data along with comorbidity, frailty and other geriatric syndromes were collected from 100 older adults, undergoing elective orthopaedic surgery. The outcomes were day 3 postoperative complications such as delirium, electrolyte imbalance, acute kidney injury, pulmonary embolism, intensive care unit admission and infection. Mobility, and mortality were assessed on 30^th post-operative day.</div></div><div><h3>Results</h3><div>The mean age of the study population was 67.8±6.75 years, 80 % were between the age of 60-74 years, 55 (55 %) were females, 28 patients were frail. Hypertension (<em>n =</em> 48) was the most prevalent comorbidity, followed by diabetes (<em>n =</em> 29). Among the immediate post-operative complications, frail patients had higher risk of hyponatremia (OR: 39.44; CI: 4.84-1734.41), acute kidney injury (OR: 6.8; CI: 1.58-33.37), delirium (OR: 23; CI: 5.23-134.84), and infection (OR: 9.44; CI: 2.32-44.87). At 30-day post-operative day frail patients had poor mobility (18.05±8.4 vs 24.45±5.6).</div></div><div><h3>Conclusion</h3><div>Frailty is an important predictor of immediate and short-term post-operative complications in older adults undergoing major elective orthopaedic surgery. Pre-operative screening for frailty could help focus care towards vulnerable patients and prevent adverse events during post-operative period.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can targeted cognitive intervention improve rehabilitation outcome in hip fracture patients: a randomized controlled trial","authors":"Yedida Borow,&nbsp;Renata Efrati,&nbsp;Noa Doron,&nbsp;Michal Tzin,&nbsp;Yaara Ginsburg,&nbsp;Daniela Gesner,&nbsp;Avital Hershkovitz","doi":"10.1016/j.aggp.2025.100193","DOIUrl":"10.1016/j.aggp.2025.100193","url":null,"abstract":"<div><h3>Background</h3><div>Hip fractures lead to disability, loss of independence, and a decline in quality of life. Rehabilitation success depends on various factors, such as, age, pre-fracture function, level of cognitive function, nutritional status, comorbidity, and family support. Most studies exploring the question of whether cognitive-based interventions can lead to functional improvement were conducted on community-dwelling elderly individuals with acquired brain injury, dementia, and cognitive impairments. Our aim was to compare targeted cognitive intervention with conventional occupational therapy in improving rehabilitation outcomes amongst post-acute hip fracture patients.</div></div><div><h3>Methods</h3><div>A randomized controlled single blinded study. Eighty patients were randomly assigned to two groups: group A (intervention) received targeted cognitive intervention, based on concepts from \"The multi-context approach to cognitive rehabilitation of executive dysfunction\" and group B (controls) received conventional occupational therapy. T-test and chi-square tests assessed significant differences between demographic, clinical, functional variables. ANOVA with repeated measures assessed significant improvement in cognitive/functional test scores in the two groups.</div></div><div><h3>Results</h3><div>43 patients were assigned to the intervention group; 37 to the controls. All patients significantly improved in their cognitive tests. No significant differences were found between the groups regarding discharge scores of the cognitive test, degree of cognitive improvement, functional outcomes and patient reported outcome measures questions.</div></div><div><h3>Conclusions</h3><div>Targeted cognitive intervention did not lead to a better outcome in hip fracture patients. As most were cognitively impaired, further research is warranted in order to explore whether different cognitive interventions might improve their rehabilitation outcomes.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100193"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}