Archives of Gerontology and Geriatrics Plus最新文献

{"title":"Social factors and nutritional health in aging","authors":"Liang-Kung Chen MD, PhD","doi":"10.1016/j.aggp.2025.100167","DOIUrl":"10.1016/j.aggp.2025.100167","url":null,"abstract":"","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring work and life satisfaction among older adults in India: Evidence from LASI","authors":"Priya Maurya ,&nbsp;Aparajita Chattopadhyay ,&nbsp;Aditi B. Prasad","doi":"10.1016/j.aggp.2025.100151","DOIUrl":"10.1016/j.aggp.2025.100151","url":null,"abstract":"<div><h3>Background</h3><div>Whether working in old age has a positive impact on overall life satisfaction of older people is a pertinent research question. This paper examined the role of work and occupational characteristics on life satisfaction among older adults in India.</div></div><div><h3>Data and methods</h3><div>This study utilised data from the first wave of the Longitudinal Ageing Study in India (2017–2018). It analysed 30771 older adults aged 60 and above. Descriptive statistics, bivariate analysis and linear regression analysis were applied.</div></div><div><h3>Results</h3><div>The mean score for life satisfaction was 23.74; slightly higher among men (24.09) than women (23.43). However, the findings from multivariable analysis shows that overall, women were more likely to have better life satisfaction than men after controlling for other characteristics. Never worked (aCoef=-0.55, SE=0.26, <em>p</em> &lt; 0.05; beta=-0.012) and currently working (aCoef=-0.43, SE=0.12, <em>p</em> &lt; 0.001; beta=-0.025) men were less likely to have better life satisfaction than men who are currently not working. Women who worked earlier and currently not engaged in work had better life satisfaction than men of the same class. Compared to men who were working on their farms, male agricultural labourers were less likely, and women engaged in their own or family farm were more likely to report higher life satisfaction. The study findings demonstrate that financially resourceful and working pensioners were capable of enjoying themselves in later life. Although gender differences exist in life satisfaction in the context of work, the effect sizes were small.</div></div><div><h3>Conclusion</h3><div>Women, better educated and wealthy, married, and healthy older adults are more likely to be satisfied in life. Encouraging saving practices among people, strengthening the land ownership rights and improving health and financial security among older adults through a life-course approach will contribute to a better quality of life in old age. The research underscores the importance of considering mediating mechanism of other factors while exploring the relationship between work, occupation and life satisfaction.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delirium in the emergency department: Incidence and risk factors in a Ligurian hospital","authors":"Thomas Fraccalini ,&nbsp;Andrea Trogolo ,&nbsp;Monica Traversa ,&nbsp;Beatrice Tarozzo ,&nbsp;Luciano Cardinale ,&nbsp;Giuseppe Maina ,&nbsp;Salvatore Di Gioia ,&nbsp;Davide Minniti ,&nbsp;Ivana Finiguerra ,&nbsp;Roberta Vacchelli ,&nbsp;Martina Battaglia ,&nbsp;Angelica Ruggeri ,&nbsp;Valerio Ricci ,&nbsp;Alessandro Maraschi ,&nbsp;Thomas Roberts ,&nbsp;Giovanni Volpicelli ,&nbsp;Luca Tagliafico","doi":"10.1016/j.aggp.2025.100165","DOIUrl":"10.1016/j.aggp.2025.100165","url":null,"abstract":"<div><h3>Background</h3><div>Delirium, a severe neuropsychiatric syndrome characterised by acute deficits in attention and self-awareness, is common among elderly inpatients, with incidence increasing with age and prolonged hospitalisation. This study examines the characteristics of geriatric patients developing delirium in the Emergency Medicine Department, focusing on the relationship between frailty at admission and delirium onset, and how these factors influence hospitalisation decisions and prognosis.</div></div><div><h3>Methods</h3><div>A prospective, observational study was conducted on patients aged 65+ admitted to the Emergency Department for over 24 hours. Comorbidities (e.g., dementia, cardiovascular diseases, diabetes, COPD, depression, Parkinson’s) and pharmacological therapies (e.g., antipsychotics, antidepressants) were recorded. Frailty was assessed using the Clinical Frailty Scale (CFS).</div></div><div><h3>Results</h3><div>Among 89 patients (mean age 83.94; 48 women, 41 men), 66.29 % developed delirium, 76.40 % required hospitalisation, and 31.46 % died during their stay. Significant associations were found between delirium and age (<em>p</em> = 0.0025), antipsychotic use (<em>p</em> &lt; 0.0001), CFS score (<em>p</em> = 0.014), and number of medications at admission (<em>p</em> = 0.009). Delirium was also significantly linked to Alzheimer’s disease (<em>p</em> = 0.0033), other dementias (<em>p</em> = 0.0021), anxiety-depressive disorders (<em>p</em> = 0.004), behavioural and psychological symptoms of dementia (BPSD) (<em>p</em> &lt; 0.0001), and mortality (<em>p</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>Frailty and delirium are critical factors influencing hospitalisation and prognosis in elderly patients. The study highlights the importance of early frailty assessment and medication review in the Emergency Department to mitigate delirium risk and improve outcomes.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing life expectancy in Saudi Arabia: insights from global best practices","authors":"Hala Alosaimi ,&nbsp;Haitham Alnouri ,&nbsp;Ibrahim Alasiri ,&nbsp;Saad Almushawah ,&nbsp;Mansour Mohammed ,&nbsp;Ameera Abdulrahman ,&nbsp;Rana A. Alotaibi ,&nbsp;Rasha Alfawaz ,&nbsp;Abdulaziz Abdulbaqi ,&nbsp;Weam Banjar ,&nbsp;Tareef Alaama ,&nbsp;Mariam M. AlEissa","doi":"10.1016/j.aggp.2025.100163","DOIUrl":"10.1016/j.aggp.2025.100163","url":null,"abstract":"<div><h3>Background</h3><div>Life expectancy is an important indicator of societal health and development. Social and economic determinants of health, political stability, and public policies frequently influence outcomes. Saudi Arabia has made significant strides in improving its population's life expectancy, and the overall trajectory is upwards and positive. Nevertheless, Saudi Arabia continues to face challenges related to controlling noncommunicable diseases. (NCDs), health disparities, and behavioral factors. This study aims to explore global best practices for improving life expectancy and establish recommendations for Saudi policy makers in the health industry and related stakeholders.</div></div><div><h3>Methodology</h3><div>A robust comparative analysis was used to evaluate the impact of global best practices with respect to the accessibility, efficiency and affordability of different national healthcare systems. It also addresses social determinants of health. Moreover, it looks at national health policies and preventative measures. The primary data sources used include peer-reviewed literature databases such as PubMed, the Lancet and Springer. The data were also derived from reports of global health organizations, such as the WHO, World Bank and OECD publications. The key indicators analysed included healthcare access, cultural/social awareness, education, nutrition, lifestyle, and socioeconomic factors. An online comprehensive questionnaire was sent to analyse data collected from people currently living in the Kingdom of Saudi Arabia.</div></div><div><h3>Results</h3><div>We introduce several recommendations after looking into countries with high longevity rates. <strong>We highlight</strong> the need to adopt evidence-based practices to increase life expectancy in Saudi Arabia. New strategies promoting healthy lifestyles through education, regulating unhealthy products, promoting regular physical activity, integrating mental health into primary health, encouraging plant-based diets and improving preventive healthcare are needed. To achieve a healthier and longer-living population aligning with the Kingdom's vision, cultural and socioeconomic barriers should be further addressed by incorporating stress management practices.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the risk of comorbid hypertension in multiple chronic diseases","authors":"Zihang Xiang,&nbsp;Handong Li","doi":"10.1016/j.aggp.2025.100135","DOIUrl":"10.1016/j.aggp.2025.100135","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is a common chronic disease in the elderly, with complex causes and multiple complications, making it a key comorbidity risk factor for chronic diseases.</div></div><div><h3>Method</h3><div>Using a hypothetical cohort from the CHARLS dataset (<em>n</em> = 19,283) and supplemented by CLHLS (<em>n</em> = 14,982), we employed a multi-state transition probability model to calculate hypertension incidence under various chronic disease conditions and its marginal impact on other chronic diseases.</div></div><div><h3>Results</h3><div>We ranked the conditional incidence of hypertension across 13 chronic disease combinations and identified key comorbidities. Additionally, we ranked the marginal impact of hypertension on other chronic diseases.</div></div><div><h3>Conclusions</h3><div>(1) Among common chronic diseases, hypertension poses the highest risk in healthy elderly individuals in healthy state. (2) In men, the highest risk factors for hypertension, in descending order, are memory-related diseases, stroke, diabetes, heart disease, and dyslipidemia. In women, these are cancer, stroke, diabetes, dyslipidemia, and heart disease. (3) Liver and stomach diseases “reduce” the risk of hypertension in men, while chronic lung disease, memory-related diseases, stomach disease, and kidney disease “reduce” the risk in women. (4) Hypertension in men does not significantly increase the risk of other chronic diseases, but it does in women. (5) Gender differences in hypertension among the elderly stem from differences in the types of comorbidities of chronic disease between men and women, rather than gender itself.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100135"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of healthy behaviors and physical activity on preventing cognitive impairment among older residents in Taipei","authors":"Wan-Yu Lin ,&nbsp;Yu-Kai Lin","doi":"10.1016/j.aggp.2025.100139","DOIUrl":"10.1016/j.aggp.2025.100139","url":null,"abstract":"<div><h3>Background</h3><div>With the rapid aging of the population, the prevalence of dementia among older adults has been increasing. This study aims to investigate the impact of healthy lifestyle behaviors and physical activity on the attenuation of cognitive decline in older adults.</div></div><div><h3>Methods</h3><div>This study longitudinally analyzed health examination data from older adults aged 65 and above in Taipei between 2005 and 2010. A total of 30,314 participants provided self-reported data through structured questionnaires on their health-related behaviors (tobacco use, alcohol consumption, vegetables and fruits intake, and milk consumption), engagement in physical activity and cognitive function. The Cox proportional hazards model was employed for data analysis.</div></div><div><h3>Results</h3><div>The findings indicated that older adults who occasionally consumed alcohol exhibited a 47 % (95 % CI: 0.42–0.68) lower risk of developing cognitive impairment. Individuals who did not consume vegetables and fruits daily had a 23 % (95 % CI: 1.06–1.43) higher risk of cognitive impairment compared to those with regular consumption. Furthermore, older adults who engaged in consistent physical activity demonstrated a reduced risk of cognitive impairment relative to their inactive counterparts. Specifically, individuals who exercised 1–2 times per week and those who were entirely sedentary exhibited an increased risk of 20 % (95 % CI: 1.04–1.38) and 84 % (95 % CI: 1.52–2.22), respectively.</div></div><div><h3>Conclusions</h3><div>This study provides empirical evidence that adherence to healthy lifestyle behaviors significantly contributes to mitigating cognitive decline in older adults. Moreover, these behaviors are feasible and adaptable in later life.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic stress in caregivers of adult patients with cancer: A scoping review","authors":"Elizaveta Klekovkina ,&nbsp;Maya A. Stern ,&nbsp;Carmine Malfitano ,&nbsp;Esme Fuller-Thomson","doi":"10.1016/j.aggp.2025.100141","DOIUrl":"10.1016/j.aggp.2025.100141","url":null,"abstract":"<div><h3>Objective</h3><div>The goal of this review was to critically review the research literature on traumatic stress in caregivers of adult cancer patients. Objectives included identifying the prevalence of significant traumatic stress symptoms, themes within the literature, and factors that are associated with traumatic stress in this population.</div></div><div><h3>Methods</h3><div>A search was conducted of APA PsycInfo, MEDLINE, Embase, and CINAHL. Two authors screened abstracts and full-texts and extracted data from included articles. A total of 1,150 unique titles and abstracts were identified, with 2f articles selected for full-text screening after title and abstract screening. There were 23 studies which were included in the review.</div></div><div><h3>Results</h3><div>Most studies reported a prevalence of PTSD of 15 % and above. The caregivers of newly diagnosed patients, those with recurrent cancer, and those on active treatment were the most distressed. Caregivers of patients who had completed treatment and those of longer-term survivors were less distressed. Significant associations were identified between caregiver traumatic stress and caregiver and patient psychological comorbidity, lower social support, higher caregiver burden, and patient's greater physical symptoms.</div></div><div><h3>Conclusion</h3><div>This scoping review reveals that a substantial proportion of caregivers of adult patients with cancer experience traumatic stress. However, the majority of published studies are cross-sectional, with small sample sizes, and a lack of racial and gender diversity. There is an urgent need for further research, including on proactive and tailored interventions provided at the time of diagnosis or recurrence of the disease.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing a Policy Model for Enhancing Social Health of the Elderly","authors":"Maryam Koosha ,&nbsp;Jafar Hezarjaribi ,&nbsp;Hesameddin Allameh ,&nbsp;Mohammad Amir Panahi ,&nbsp;Amir Lalegani","doi":"10.1016/j.aggp.2025.100149","DOIUrl":"10.1016/j.aggp.2025.100149","url":null,"abstract":"<div><h3>Introduction</h3><div>Given the significant increase in the elderly population in many countries, designing effective policy models to enhance the social health of this age group is essential. This article aims to present a comprehensive policy model focused on various dimensions of social health to improve the elderly's status. Its goal is to design efficient policies and offer recommendations to improve the living conditions of the elderly through practical and structural approaches.</div></div><div><h3>Method</h3><div>This study reviews documents, laws, guidelines, and government resolutions and analyzes case studies to identify effective models in elderly social health policymaking. The research employs theoretical frameworks of public policymaking, such as the life-cycle theory and structural approaches, to design efficient models.</div></div><div><h3>Findings</h3><div>The study findings highlight that challenges related to aging, across various aspects of social health, necessitate the formulation and implementation of comprehensive, coordinated policies. These policies should encompass institutional, financial, service-oriented, and cultural dimensions to effectively enhance elderly social health. Institutionally, policy formulation should be based on institutional mapping, fostering coordination among various sectors, strengthening executive structures, and enacting appropriate legal provisions to support the elderly. Financially, ensuring sustainable funding and reinforcing pension funds should be primary priorities. From a service perspective, designing elderly-friendly environments, expanding social services, and preventing health problems among the elderly are key focal points requiring careful planning and coordinated action.</div></div><div><h3>Discussion and Conclusion</h3><div>This study demonstrates that designing comprehensive, coordinated policies tailored to the specific needs of the elderly plays a pivotal role in improving their quality of life and social health. First, intersectoral collaboration between governmental, private, and civil society organizations is crucial for formulating and implementing effective policies. Second, leveraging modern technologies and digitizing services can enhance equitable and timely access to services for the elderly. Finally, adopting successful international experiences and localizing them, combined with a deep understanding of local challenges and opportunities, can result in policies that not only improve elderly social health but also strengthen social cohesion and reduce socioeconomic pressures in the long run.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of gait speed, grip strength, and depression on the risk of serious falls among older adults","authors":"Temam Beshir Raru ,&nbsp;Julie A. Pasco ,&nbsp;Mojtaba Lotfaliany ,&nbsp;Shiva Ganjali ,&nbsp;Malcolm Forbes ,&nbsp;Alice J. Owen ,&nbsp;Robyn L Woods ,&nbsp;Anna Barker ,&nbsp;Suzanne G. Orchard ,&nbsp;Joanne Ryan ,&nbsp;John J. McNeil ,&nbsp;Michael Berk ,&nbsp;Mohammadreza Mohebbi","doi":"10.1016/j.aggp.2025.100155","DOIUrl":"10.1016/j.aggp.2025.100155","url":null,"abstract":"<div><h3>Objective</h3><div>This study assessed the individual and combined associations of slow gait speed, weak grip strength, and depressive symptoms with the risk of serious falls in an aging population.</div></div><div><h3>Methods</h3><div>This study used data from the Aspirin in Reducing Events in the Elderly (ASPREE) trial, which collected adjudicated events on serious falls from Australian community-dwelling older adults (≥70 years). Cox proportional hazard models were employed to estimate adjusted hazard ratios (AHR).</div></div><div><h3>Results</h3><div>Of 16,357 participants, 1505 (9.2 %) had serious falls over the median (IQR) follow-up of 4.4 (3.3–5.5) years. Slow gait, weak grip, and depressive symptoms at baseline were associated with serious falls (AHR = 1.38, 95 %CI: 1.22–1.56; AHR = 1.22, 95 %CI: 1.07–1.38, and AHR=1.28, 95 %CI:1.10–1.50, respectively). Combined slow gait, weak grip, and depressive symptoms were associated with a more than two-fold increase in the risk of serious falls (AHR=2.15, 95 %CI: 1.56–2.97). The presence of slow gait and weak grip were associated with a 66 % increase in the risk of serious falls (AHR=1.66, 95 %CI:1.40–1.97). Depressive symptoms worsened the risk of falls among individuals with chronic conditions such as diabetes.</div></div><div><h3>Conclusion</h3><div>Combined gait speed, grip strength, and depressive symptoms have a strong association with serious falls in an aging population. Therefore, incorporating strength and mobility training interventions to improve physical functions and addressing depression through timely diagnosis and effective treatment may help to prevent the risk of falls among older adults.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of CBC and CBC-derived inflammatory markers with depression and post-diabetes mellitus depression: A large cohort NHANES study spanning 2011–2020","authors":"Wen Chen ,&nbsp;Fasheng Deng","doi":"10.1016/j.aggp.2025.100131","DOIUrl":"10.1016/j.aggp.2025.100131","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation promotes the risk of depression-related diseases but remains controversial. Therefore, this study investigated the association between complete blood count (CBC)/CBC-derived inflammatory markers and depression/post-diabetes mellitus (DM) depression.</div></div><div><h3>Method</h3><div>Initially, based on NHANES database during 2011-2020, 17,628 participants were included to construct generalized linear models (GLMs) and restricted cubic spline (RCS) curves to explore associations and dose-response relationship between CBC/CBC-derived inflammatory markers and depression, respectively. Furthermore, 2,197 DM participants were selected to build GLMs and RCS curves to investigate associations and dose-response between CBC/CBC-derived inflammatory markers and post-DM depression, respectively.</div></div><div><h3>Result</h3><div>After GLMs and RCS curves analyses, we found that high CBC inflmmatory markers including white blood cells (WBC), lymphocytes, neutrophils and red blood cell distribution width (RDW) were positively association and linear dose-response relationships with depression. CBC-derived inflammatory marker like systemic immune inflammation index (SII) was association with the risk of developing depression, exhibiting a nonlinear dose-response relationship. Additionally, high WBC increased the risk of having post-1 type DM (T1DM) with nonlinear dose-response relationship, while high monocytes resulted in a susceptibility to post-2 type DM (T2DM) depression with linear relationship.</div></div><div><h3>Conclusion</h3><div>The association of CBC/CBC-derived inflammatory markers with depression/post-depression suggested that inflammtion contributed to depression-related diseases.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100131"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}