Janet Ramírez Torres , Ana Luisa Sanchez Arizmendi , César J. Serrano Andrade , Carlos D. Coronado-Alvarado
{"title":"Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study","authors":"Janet Ramírez Torres , Ana Luisa Sanchez Arizmendi , César J. Serrano Andrade , Carlos D. Coronado-Alvarado","doi":"10.1016/j.aggp.2024.100105","DOIUrl":"10.1016/j.aggp.2024.100105","url":null,"abstract":"<div><div><em>Background:</em> Older adults remain vulnerable to COVID-19 waves, particularly in low-income countries with health disparities, so the discovery and validation of accessible clinical tools are required. Despite the expected changes associated with aging, little has been studied on ferritinemia as a prognostic marker, specifically in this population. <em>Objective:</em> Evaluate the use of serum ferritin levels at hospital admission as a prognostic marker in older adults hospitalized for COVID-19. <em>Material and methods:</em> This monocentric study included people over 60 hospitalized for COVID-19 between 2021 and 2022. Disease presence was assessed with polymerase chain reaction and ferritin with spectrophotometry. Multiple logistic regression models, as well as ROC and Kaplan-Meier curves, were used. <em>Results:</em> In 239 older adults, the association between serum ferritin and mortality was modified by the presence of clinical severity data at admission, being a poor prognosis factor only for those with severe COVID-19 (OR=2.82, <em>p</em> = 0.028, controlling for age and immunization doses). The best cut-off point was 355 ng/dl (Sensitivity: 88.3 %; Specificity: 27.4 %). However, there were no differences in survival curves. <em>Conclusions:</em> Serum ferritin levels could help guide therapeutic decisions in older adults with severe COVID-19 but do not predict mortality independently.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tianma Xu, Vivian Soo, Hui Yi Clara Chang, Maegan Leong, Nur Haidi Hakim Bin Mahmod, Jing Shi
{"title":"Dance programme for older adults with pre-frailty: A mixed-methods feasibility study","authors":"Tianma Xu, Vivian Soo, Hui Yi Clara Chang, Maegan Leong, Nur Haidi Hakim Bin Mahmod, Jing Shi","doi":"10.1016/j.aggp.2024.100104","DOIUrl":"10.1016/j.aggp.2024.100104","url":null,"abstract":"<div><div>The prevalence of older adults with frailty and pre-frailty is increasing with the rapidly ageing population in Singapore. This study aimed to evaluate the feasibility of a 12-week Dance-Up program and test its effects on the physical and psychosocial well-being of older adults with pre-frailty in the community setting in Singapore. A mixed-method approach was used. Pre-post assessments in physical and mobility functions, fear of falling, pain and goal achievements were statistically analysed to detect any changes. Participants’ attendance, drop-out rate, and perception of the program via semi-structured interviews were gathered post-intervention to determine its feasibility. Thirteen eligible participants (mean age: 78.7 years) with mild frailty (Clinical Frailty Scale scored 3 and 4) enrolled in the program and nine completed the 12-week intervention. The majority (<em>n</em> = 8) were female. The average attendance rate was 83 %. Only some assessment tools (e.g. Dynamic Gait Index, Goal Attainment Scale) were sensitive to detect changes pre-/post-intervention. Thematic analysis of the interviews revealed: 1) the acceptance of the program among participants; 2) both positive factors (e.g. self-belief of the importance of regular dance practice) and negative factors (e.g. functional limitations and other commitments) may have influenced the program's outcomes. Participants provided recommendations for future implementation. The <em>Dance-up</em> programme was well received by participants but requires fine-tuning and other assessment tools should be explored in future studies.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of dual caregiving on well-being and loneliness among ever-married women in Japan: A pre- and post-COVID-19 pandemic comparison","authors":"Makiko Kawabe , Yoko Moriyama , Takehiro Sugiyama , Nanako Tamiya","doi":"10.1016/j.aggp.2024.100101","DOIUrl":"10.1016/j.aggp.2024.100101","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic has significantly impacted people involved in a combination of childcare and elderly care (dual caregivers). As their number is expected to rise in some countries, there remains limited research on the impact of the pandemic on their well-being and loneliness.</div></div><div><h3>Methods</h3><div>We utilized repeated cross-sectional data from a large internet survey conducted between 2019 and 2021 to examine the association between informal caregiving status (no care, childcare only, elderly care only, and dual care) and the deterioration of well-being and loneliness among married women aged 20–59.</div></div><div><h3>Results</h3><div>In 2019, the total sample size was 7,357 (60 dual care, 3,630 elderly care only, 3,470 childcare only, and 3,197 no care). In 2021, the sample comprised 6,645 (77 dual care, 3,164 elderly care only, 148 childcare only, and 3,256 no care). In 2019, the adjusted odds ratio (95 % confidence interval [CI]) for lower well-being and higher loneliness in informal caregiving statuses (childcare only, elderly care only, and dual care) compared to no care was 1.38 (1.03–1.86), significant only for elderly care only. In 2021, elderly care only remained significant, with an odds ratio of 1.84 (1.15–2.97), while dual care was associated with lower well-being (1.55 (1.11–2.20) and higher loneliness (2.08 (1.24–3.49).</div></div><div><h3>Conclusions</h3><div>Our study found that dual caregivers experienced greater declines in well-being and increased loneliness following the pandemic than non-caregivers. This highlights the importance of enhancing support for dual caregivers during current and future crises to prevent worsening well-being and loneliness.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Negative attitudes toward the majority and perceived hostile and modern prejudices: Focus on older adults and people with disabilities","authors":"Yuho Shimizu","doi":"10.1016/j.aggp.2024.100102","DOIUrl":"10.1016/j.aggp.2024.100102","url":null,"abstract":"<div><div>With the growing emphasis on diversity in recent years, we need to form a society wherein older adults and people with disabilities can play active roles together with younger and able-bodied people. However, hostile and modern prejudices against older adults and people with disabilities have inhibited their participation in society. This study examined the association between perceived prejudices against older adults and people with disabilities and their attitudes toward younger and able-bodied people. We administered an online survey to 503 older adults (aged 65–97, <em>M</em> = 74.08 years; 267 women) and 518 people with disabilities (aged 18–64, <em>M</em> = 40.25 years; 180 women). The results showed that older adults (people with disabilities) with more perceived hostile and modern prejudices had more negative attitudes toward younger (able-bodied) people.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cognitive decline gap between male and female in Indian context: Examining the contribution of underlying factors using non-linear decomposition analysis","authors":"Subhadeep Saha, Priya Das, Tanu Das, Partha Das, Tamal Basu Roy","doi":"10.1016/j.aggp.2024.100103","DOIUrl":"10.1016/j.aggp.2024.100103","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive decline denotes the condition of having memory loss, reduced or slower thinking skills. It is an alarming issue with the increasing age of individuals and sometimes it hinders the smooth functioning of daily activities in life. Affirmations from both developed and developing countries manifest that older people are at risk of cognitive decline; however, the study about male-female differential remained scanty. So, the study examines gender-specific differences in cognitive decline among middle-aged and older adults by identifying the significant covariates responsible for the change in cognitive decline through the FDA.</div></div><div><h3>Methods</h3><div>The study used information collected from 52,569 participants (females 26,665 and males 25,904) aged 45 years and above from the latest cross-sectional dataset of LASI. Descriptive statistics, multivariable logistic regression, and FDA techniques were utilized.</div></div><div><h3>Results</h3><div>Multivariable logistic regression revealed that female individuals had 1.90 times [95% CI: (1.77-2.05)] higher odds of cognitive decline than male individuals. In addition, the FDA revealed that school attainment alone was found enough to narrate the difference in the pervasiveness of cognitive decline among individuals between males and females by 54.75%. Marital status, working status, and reading habits were found to express a profound impact on the male-female gap in the prevalence of cognitive decline by 9.41%, 6.47%, and 12.25% respectively.</div></div><div><h3>Conclusions</h3><div>Findings suggest that there is a need for comprehensive public service intervention like community healthcare and formulation of various health programs to address the cognitive decline, more so for female individuals without neglecting the male ones.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kanon Tsukada , Tomoya Takahashi , Yuho Shimizu , Yan Li , Toshihito Tsuchiya , Kiyo Kawakubo , Tomoya Sagara , Koki Ito , Tomoki Furuya , Hiroyuki Suzuki
{"title":"Do healthy older adults use SNS? Focus on LINE, Facebook, Twitter (now X), and Instagram","authors":"Kanon Tsukada , Tomoya Takahashi , Yuho Shimizu , Yan Li , Toshihito Tsuchiya , Kiyo Kawakubo , Tomoya Sagara , Koki Ito , Tomoki Furuya , Hiroyuki Suzuki","doi":"10.1016/j.aggp.2024.100096","DOIUrl":"10.1016/j.aggp.2024.100096","url":null,"abstract":"<div><h3>Background</h3><div>The use of social networking services (SNS) by older adults within the context of the digital divide has become a hot topic. Several studies have shown that SNS use among older adults is related to their health status; however, few studies have examined the association between health and specific SNS platforms.</div></div><div><h3>Objective</h3><div>This study investigates the relationship between older adults’ use of four major SNS platforms in Japan (LINE, Facebook, Twitter [now X], and Instagram) and the health of older adults. Subjective health and frequency of going out were used as health indicators. Method: A survey was conducted among participants in a health promotion program for older adults in Tokyo between 2020 and 2022. A total of 391 older adults participated in the study (<em>M</em> = 72.11 years, 65–86 years, 363 women).</div></div><div><h3>Results</h3><div>Logistic regression analysis revealed that subjective health was higher in users of Facebook, Twitter [now X], and Instagram (but not LINE) compared to non-users. Frequency of going out was not associated with SNS use.</div></div><div><h3>Conclusions</h3><div>Older adults with higher subjective health may be more likely to use SNS platforms due to their willingness to learn new skills and actively participate in social activities. Additionally, SNS may help improve the health of older adults by enabling communication with distant family and friends, even for those who are unable to go out frequently due to health problems.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bryce Van Vleet M.S. , Heather R. Fuller Ph.D. , Andrea Huseth-Zosel Ph.D.
{"title":"“There's a lot of factors”: Researcher reflections on using I-poetry to empathetically understand vaccine hesitant individuals","authors":"Bryce Van Vleet M.S. , Heather R. Fuller Ph.D. , Andrea Huseth-Zosel Ph.D.","doi":"10.1016/j.aggp.2024.100100","DOIUrl":"10.1016/j.aggp.2024.100100","url":null,"abstract":"<div><h3>Background</h3><div>Despite higher vaccination rates compared to other age groups, many US older adults remain under-vaccinated against preventable diseases leading to increased risk of serious illness, hospitalization, or death posed from disease. This study investigates the underlying reasons for older adults not getting vaccinated.</div></div><div><h3>Methods</h3><div>From a larger interview study conducted in North Dakota, eight older adults (Mean Age = 73) were identified as being vaccine hesitant. Participants were asked, “How do you decide about whether or not to get a specific vaccine?” Then, participants' responses were analyzed using the I-poetry qualitative methodology, which involves creating a poem from interview transcripts to capture the essence of participants' experiences.</div></div><div><h3>Results</h3><div>Poetic findings clarify interacting sources of immunization unease and highlight potential intervention avenues for medical professionals. Specifically, the poetic analysis revealed themes of mistrust in the healthcare system, preference for natural immunity, and concerns about vaccine side effects. The study suggests that healthcare professionals should consider using empathetic communication strategies to address vaccine hesitancy in older adults.</div></div><div><h3>Conclusions</h3><div>Understanding vaccine hesitancy as a tapestry instead of individual factors may be more useful for older adults who culminate their hesitant beliefs from prior life experiences. Additionally, to improve trust in healthcare providers, it is suggested that more first-person narratives of older adult experiences are used and solicited by healthcare providers. Possible interventions are discussed.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Nabihah Mohamad Fadzli , Jagjit Singh Dhaliwal , Faiza Alam , Jacqueline Kamaluddin , Hanif Abdul Rahman
{"title":"The link between periodontitis and Alzheimer's disease – Brunei context","authors":"Sarah Nabihah Mohamad Fadzli , Jagjit Singh Dhaliwal , Faiza Alam , Jacqueline Kamaluddin , Hanif Abdul Rahman","doi":"10.1016/j.aggp.2024.100097","DOIUrl":"10.1016/j.aggp.2024.100097","url":null,"abstract":"<div><h3>Aim</h3><div>The study aims to explore the relationship between periodontitis and Alzheimer's disease, focusing on the association and their potential impact on cognitive health.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted utilizing data obtained from the Brunei Health Information Management System (Bru-HIMS). The research study examined the correlation between periodontitis and Alzheimer's disease in individuals admitted to government healthcare settings between January 2014 and December 2023. Logistic regression and survival analysis were applied.</div></div><div><h3>Results</h3><div>After diagnosis of periodontitis, 81.6 %, 59.2 % and 40.8 % developed Alzheimer's disease after 1–3- and 5-years, respectively. Women (34.3 %) had significantly lower proportion of developing Alzheimer's disease after 5 years compared to men (46.3 %). Furthermore, those with history of tooth extraction has a high risk of developing Alzheimer's disease (Adjusted Hazard Ratio = 5.00; 95 % CI: 2.04, 12.28; <em>p</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>The study highlights the importance of understanding periodontal health in Alzheimer's patients and suggests further research and targeted interventions to mitigate its impact on cognitive function.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agli Océane , Bailly Nathalie , Cuervo-Lombard Christine-Vanessa
{"title":"Spirituality, forgiveness and self-esteem throughout adulthood in France","authors":"Agli Océane , Bailly Nathalie , Cuervo-Lombard Christine-Vanessa","doi":"10.1016/j.aggp.2024.100098","DOIUrl":"10.1016/j.aggp.2024.100098","url":null,"abstract":"<div><h3>Purpose</h3><div>It appears that spirituality, forgiveness, and self-esteem are important values which transcend human actions. This transversal study aims to observe spirituality, forgiveness, and self-esteem during aging.</div></div><div><h3>Methods</h3><div>A quantitative protocol was conducted with 206 participants divided into two groups: younger adults (M = 23.05 years old) and older people (M = 73.09 years old). Three tests measured spirituality, forgiveness and self-esteem.</div></div><div><h3>Principal results</h3><div>Results showed that older people have higher scores than younger adults in spirituality (peace dimension), forgiveness (transcendence and emotional factors) and self-esteem. Moreover, all dimensions of spirituality (peace, mean, faith) were correlated with the transcendence and emotional factors of forgiveness and with self-esteem during aging.</div></div><div><h3>Major conclusion</h3><div>It seems that with age, individuals have a better self-esteem linked to more pronounced spiritual needs (sense of peace, meaning of life, faith) and manage to forgive more unconditionally with less resentment than younger people.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wei-Min Chu , Mio Goto , Keiko Kabetani , Yukiko Nishita , Shu Zhang , Hiroshi Shimokata , Meng-Chih Lee , Akiko Satoh , Rei Otsuka
{"title":"Circulating miR-323–3p as a novel potential plasma biomarker for multimorbidity burden and cognitive decline in middle-aged and older adults: Results from the national institute for longevity sciences–longitudinal study of aging in Japan","authors":"Wei-Min Chu , Mio Goto , Keiko Kabetani , Yukiko Nishita , Shu Zhang , Hiroshi Shimokata , Meng-Chih Lee , Akiko Satoh , Rei Otsuka","doi":"10.1016/j.aggp.2024.100099","DOIUrl":"10.1016/j.aggp.2024.100099","url":null,"abstract":"<div><h3>Background</h3><div>Several circulating microRNAs (miRNAs) in the blood are indicators of chronic diseases, but their association with multimorbidity burden is unknown. The aim of this study was to assess the association of plasma levels of circulating miR-323–3p and miR-135–3p with age, cognitive performance, and number of comorbidities in middle-aged and older individuals.</div></div><div><h3>Methods</h3><div>Data from 295 community dwellers (≥40 years) who participated in the second wave (2000‒2002) of the National Institute for Longevity Sciences-Longitudinal Study of Aging in Japan were analyzed. miRNAs were isolated from the plasma, and miR-323–3p and miR-135–3p levels were measured using quantitative reverse-transcription polymerase chain reaction and normalized, with miR-16 as an endogenous reference gene. Cognitive performance was assessed using the Information and Similarities subtests and the Digit Symbol Substitution Test of the Wechsler Adult Intelligence Scale-Revised Short Form (WAIS-R-SF). Correlation tests and multivariate general linear regression analyses were performed to examine the relationship among circulating miRNA levels, burden of multimorbidity, and cognitive performance.</div></div><div><h3>Results</h3><div>The mean age of the participants was 59.15 ± 10.26 years. Pearson's correlation analysis revealed that the miR-323–3p level positively correlated with age and number of comorbidities but negatively correlated with WAIS-R-SF subtest performance. In men, miR-323–3p level negatively correlated with the performance of all three WAIS-R-SF subtests. The general linear regression analysis showed that the miR-323–3p level increased in participants with four comorbidities compared with those with one comorbidity.</div></div><div><h3>Conclusion</h3><div>Circulating miR-323–3p level is associated with the burden of multimorbidity and decreased cognitive performance in middle-aged and older adults.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}