Archives of Gerontology and Geriatrics Plus最新文献

{"title":"Intergenerational relationship quality links generativity to positive life attitudes in community-dwelling older adults: a cross-sectional mediation study","authors":"Wafaa Samy Abd El-Sattar ,&nbsp;Rasha Ahmed Fouad ,&nbsp;Mohamed H.R. Atta ,&nbsp;Ahmed Abdellah Othman ,&nbsp;Abeer Ramadan Awade Gamaa","doi":"10.1016/j.aggp.2026.100252","DOIUrl":"10.1016/j.aggp.2026.100252","url":null,"abstract":"<div><h3>Background</h3><div>Generativity is a central psychosocial resource in later life, yet the mechanisms through which it shapes older adults’ attitudes toward life remain insufficiently understood. Intergenerational relationship quality (IRQ) may represent a key relational pathway linking generativity to psychological well-being.</div></div><div><h3>Objectives</h3><div>This study examined the associations among generativity, intergenerational relationship quality, and attitudes toward life in community-dwelling older adults and tested whether IRQ mediates the relationship between generativity and life attitudes.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional correlational design was employed. A convenience sample of 200 community-dwelling older adults was recruited from elderly clubs in Egypt. Data were collected using the Intergenerational Relationship Quality Scale for Aging Parents, the Loyola Generativity Scale, and the Life Attitude Scale–Brief. Pearson correlation analysis and path analysis were conducted.</div></div><div><h3>Results</h3><div>Generativity was positively associated with intergenerational relationship quality (<em>r</em> = 0.309, <em>p</em> &lt; 0.001) and attitudes toward life (<em>r</em> = 0.424, <em>p</em> &lt; 0.001). Intergenerational relationship quality was strongly associated with attitudes toward life (<em>r</em> = 0.518, <em>p</em> &lt; 0.001). Path analysis demonstrated a significant direct effect of generativity on life attitudes and a significant indirect effect via intergenerational relationship quality, indicating partial mediation.</div></div><div><h3>Conclusions</h3><div>High-quality intergenerational relationships serve as a critical psychosocial mechanism through which generativity translates into more positive attitudes toward life in later adulthood. Interventions that strengthen intergenerational bonds may promote adaptive aging and psychological well-being among community-dwelling older adults.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"3 1","pages":"Article 100252"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The respiratory geriatric severity index (RGSI): A multidimensional prognostic tool integrating geriatric syndromes to predict in-hospital mortality in older adults with respiratory diseases","authors":"Daniela Josefina Cataneo-Piña ,&nbsp;Natalia Sánchez-Garrido ,&nbsp;Blanca Patricia Sánchez-Hernández ,&nbsp;Lidia Aurora Mondragón-Posadas ,&nbsp;Brenda Paola Castillo-Marmolejo ,&nbsp;Adriana Bautista-Ruiz ,&nbsp;Miguel Ángel Mendoza-Escamilla ,&nbsp;Eduardo Ortiz-Reyes ,&nbsp;Elizabeth Pacheco-Marín ,&nbsp;María Fernanda Santana-Balderas ,&nbsp;Stephanie Michelle Ruiz-Ortiz ,&nbsp;Ana Karen Herrera-Hernández ,&nbsp;Yolanda Nancy Pérez-García ,&nbsp;Rocío de los Ángeles Pardo-Mendoza","doi":"10.1016/j.aggp.2026.100251","DOIUrl":"10.1016/j.aggp.2026.100251","url":null,"abstract":"<div><h3>Background and aims</h3><div>Older adults hospitalized with respiratory diseases face high mortality risk, but existing prognostic models neglect geriatric vulnerability. We aimed to develop and internally validate the Respiratory Geriatric Severity Index (RGSI), integrating geriatric syndromes with clinical factors to predict in-hospital mortality.</div></div><div><h3>Methods</h3><div>We retrospectively studied 728 patients aged ≥75 years admitted to a national respiratory referral center (2022–2024). Comprehensive geriatric assessment within 24 h included frailty, sarcopenia, disability, cognition, delirium, dysphagia, and nutritional measures. Independent mortality predictors were identified using multivariable logistic regression and weighted to construct the RGSI. Model discrimination and calibration were evaluated with bootstrap validation.</div></div><div><h3>Results</h3><div>In-hospital mortality was 18.3% (133/728). Predictors included acute clinical factors (dyspnea, oxygen requirement) and geriatric syndromes (delirium, pressure ulcers, disability, frailty, sarcopenia, cognitive impairment, dysphagia, urinary incontinence, low handgrip strength, low BMI). The RGSI showed good discrimination (AUC 0.716, 95% CI 0.669–0.763) and calibration, stratifying mortality from 9.2% (low risk) to 38.1% (high risk).</div></div><div><h3>Conclusions</h3><div>The RGSI incorporates multidimensional geriatric assessment into respiratory prognostication, demonstrating robust predictive performance. It offers a practical tool to support individualized care, timely palliative integration, and resource allocation for vulnerable older adults.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"3 1","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinematic analysis of one-leg standing for locomotive syndrome screening using marker-less motion capture and machine learning: A cross-sectional study","authors":"Kazuaki Hamada B.S. ,&nbsp;Yu Inoue Ph.D. ,&nbsp;Shigeharu Tanaka Ph.D. ,&nbsp;Hungu Jung Ph.D. ,&nbsp;Kenta Hirohama M.S. ,&nbsp;Ryo Yamasaki B.S. ,&nbsp;Koji Ono Ph.D. ,&nbsp;Ryo Tanaka Ph.D.","doi":"10.1016/j.aggp.2026.100244","DOIUrl":"10.1016/j.aggp.2026.100244","url":null,"abstract":"<div><h3>Objectives</h3><div>Locomotive syndrome (LS), caused by musculoskeletal dysfunction, is a major concern for older adults, contributing to physical decline, increased caregiving needs, and loss of autonomy. This study aimed to develop a novel LS screening method by analyzing kinematic data from the one-leg standing (OLS) test using a marker-less motion capture system combined with machine learning.</div></div><div><h3>Methods</h3><div>A total of 294 community-dwelling older adults participated, and LS severity was evaluated using the LS risk test. Kinematic data were collected during the OLS test by marker-less motion capture system and analyzed with neural network models to classify LS severity into stage 1 or higher and stage 2 or higher.</div></div><div><h3>Results</h3><div>The proposed model demonstrated superior classification accuracy compared to conventional OLS time-based assessments, with area under the curve (AUC) values of 0.901 for stage 1 or higher and 0.904 for stage 2 or higher, exceeding the performance reported in previous studies.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the feasibility of integrating kinematic analysis with machine learning to screen LS. The developed model offers a noninvasive and efficient tool for LS detection, suitable for both telemedicine and community-based applications. By facilitating early detection of LS, this approach has the potential to improve enhance clinical outcomes and reduce caregiving burdens.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"3 1","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between social capital, health status, and physical and social frailty among older adults: A cross-sectional analysis of the Gunma aging cohort","authors":"Tomoyuki Shinohara ,&nbsp;Yuta Takahashi ,&nbsp;Mari Takeuchi ,&nbsp;Sayaka Nagao-Sato ,&nbsp;Daisuke Higuchi","doi":"10.1016/j.aggp.2026.100255","DOIUrl":"10.1016/j.aggp.2026.100255","url":null,"abstract":"<div><div>Social capital refers to the resources that individuals can access through their membership in networks or groups. As the relationship of social capital with older adults’ health is gaining increasing attention, this cross-sectional study investigated the associations between cognitive social capital, one dimension of social capital, and physical and social frailty, and explored the indirect associations with health status in older adults. The participants were community-dwelling older adults in Japan, and data were collected at community centers and public halls. The analyses examined the associations between social capital and frailty, accounting for health status and adjusting for age, sex, and other covariates. Supplementary models included physical activity and nutritional status. For physical frailty, the indirect association through health status was significant (β = -0.035, <em>p</em> = 0.009), while neither the direct (β = -0.028, <em>p</em> = 0.443) nor the total association (β = -0.063, <em>p</em> = 0.105) were statistically significant. For social frailty, both the indirect association (β = -0.026, <em>p</em> = 0.011) and total association (β = -0.088, <em>p</em> = 0.020) were statistically significant, while the direct association was not (β = -0.062, <em>p</em> = 0.097). In supplementary analyses, the total association with social frailty was no longer statistically significant, whereas the indirect association through health status remained significant. These findings indicate that social capital is associated with physical and social frailty, with health status statistically accounting for part of these associations.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"3 1","pages":"Article 100255"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-domain intervention for prevention of cognitive decline among older adults with mild cognitive impairment: A cluster randomized trial protocol (TINAGE trial)","authors":"Saritha Susan Vargese ,&nbsp;Neha Elizabath Eldho ,&nbsp;Pramod Thomas ,&nbsp;Deepak Thomas Varughese ,&nbsp;Thomas Mathew","doi":"10.1016/j.aggp.2025.100239","DOIUrl":"10.1016/j.aggp.2025.100239","url":null,"abstract":"<div><h3>Background</h3><div>With global demographic shifts leading to an increasingly aging population, the prevalence of cognitive decline, including mild cognitive impairment (MCI), is on the rise. Despite significant research efforts, effective interventions for preventing cognitive decline and dementia remain limited. This study aims to investigate the effects of a 2-year multidomain intervention on cognition in community-dwelling older adults above 60 years with mild cognitive impairment.</div></div><div><h3>Methods</h3><div>A two-arm cluster randomized trial will be conducted among older adults aged 60–75 years with MCI. The eligible participants will be identified through house-to-house visits in the selected wards (20 wards) of Tiruvalla taluk. Identified, consented adults will be screened using a validated tool. The 20 wards will be randomly divided into two arms: intervention and control. Among those diagnosed with MCI, 21 individuals from each ward will be randomly enrolled in the study. The multidomain intervention includes nutrition, physical activity, social support and engagement, cognitive stimulation training, and management of metabolic and vascular risk factors. Approval from the Institutional Review Board (IRB) has been obtained (IEC Study Number: IEC/2022/08/279. Trial has been registered in CTRI, CTRI registration number: CTRI/2023/11/060181.</div></div><div><h3>Conclusion</h3><div>The cluster randomized trial will investigate the effectiveness of a culturally adapted multidomain intervention in the prevention of cognitive decline among older adults with mild cognitive impairment. If found effective can be scaled to similar settings.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"3 1","pages":"Article 100239"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who falls and why? Navigating the physiological and psychological contributors in fall outcomes among self-perceived unhealthy middle-aged and older adults in India","authors":"Madhurima Sharma ,&nbsp;Sandip Das ,&nbsp;Indrajit Goswami","doi":"10.1016/j.aggp.2025.100240","DOIUrl":"10.1016/j.aggp.2025.100240","url":null,"abstract":"<div><h3>Background</h3><div>Incidental falls are a leading cause of mortality and serious injury among elderly persons, particularly those who perceive themselves as unhealthy. This study aimed to examine the impact of physiological and psychological factors on fall outcomes among Indian adults with negative self-rated health (SRH).</div></div><div><h3>Methods</h3><div>Secondary data from the first wave (2017–18) of the Longitudinal Ageing Study in India were analyzed, including 10,326 respondents aged 45 years and above with poor or very poor self-rated health. Multivariate logistic regression models were used to examine associations between physiological and psychological factors and three fall outcomes (fall, multiple falls, and fall-related injuries). Analyses accounted for age-group differences (45–59 vs. ≥60 years) and state-level variation in fall prevalence.</div></div><div><h3>Results</h3><div>Among adults with poor SRH, 14.5% reported at least one fall, 7.1% multiple falls, and 6.8% fall-related injuries. Fall prevalence was higher among women, adults aged ≥60 years, rural residents, those with no schooling, and physically inactive individuals. Chronic pain showed the strongest association with falls (aOR=1.61), multiple falls (aOR=1.54), and injuries (aOR=1.47). Sensory impairments (visual: aOR=1.15; hearing: aOR=1.28), functional limitations (ADL limitations: aOR=1.21 for falls; mobility impairment: aOR=1.30 for multiple falls), and psychological factors (depressive symptoms: aOR=1.05 for falls; cognitive impairment: aOR=1.33 for injuries) were also significant predictors.</div></div><div><h3>Conclusion</h3><div>Physiological and psychological factors, particularly chronic pain and sensory impairments substantially increase fall risk among Indian adults with poor SRH. The higher risk among older adults and notable state-level variation underscore the need for age- and region-specific fall prevention strategies.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"3 1","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional social support subtypes as mediators of the association between depression and executive function: A moderated mediation analysis of the Canadian Longitudinal Study on Aging Comprehensive cohort","authors":"Emily C Rutter ,&nbsp;Anita Iacono ,&nbsp;Carrie L. Shorey ,&nbsp;Mark Oremus ,&nbsp;Colleen J Maxwell ,&nbsp;Suzanne L Tyas","doi":"10.1016/j.aggp.2026.100248","DOIUrl":"10.1016/j.aggp.2026.100248","url":null,"abstract":"<div><h3>Background</h3><div>For adults living with depression, social support interventions may offer a potential strategy to protect key cognitive domains, such as executive function. However, the extent to which the association between depression and executive function is mediated by social support, and how this varies by specific subtypes of support, is unknown. The objective of this study was to investigate whether functional social support subtypes mediated the association between depressive symptoms and executive function, and whether this mediation was moderated by age and sex.</div></div><div><h3>Methods</h3><div>Using the Canadian Longitudinal Study on Aging (CLSA) Comprehensive cohort (<em>n</em> = 14,133) of community-dwelling adults 45 to 85 years at baseline and conditional process analysis of baseline and 3-year follow-up data, this study investigated whether functional (perceived) social support subtypes mediated the association between depressive symptoms and executive function, and whether this mediation was moderated by age and sex.</div></div><div><h3>Results</h3><div>Functional social support significantly mediated the association between depression and executive function, with this mediation varying by subtype of support, age, and sex. Overall, low levels of emotional/informational support, affectionate support, and positive social interactions (but not tangible support) showed more pronounced and consistent mediation for females 75 and older, compared to males or younger age groups.</div></div><div><h3>Conclusions</h3><div>Clinical and health policy interventions targeting specific subtypes of functional social support may be useful in mitigating the negative impacts of depression on cognitive function; these interventions to support cognitive health may be particularly relevant for older females.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"3 1","pages":"Article 100248"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for older people utilizing care services in the long-term care insurance system","authors":"Takahiro Nishida ,&nbsp;Ayumi Honda ,&nbsp;Kenichiro Fukuda ,&nbsp;Yoshihiko Ide ,&nbsp;Sumihisa Honda","doi":"10.1016/j.aggp.2025.100235","DOIUrl":"10.1016/j.aggp.2025.100235","url":null,"abstract":"<div><h3>Background</h3><div>Preventing the deterioration of health of older adults who need preventive care services from the “support level” to the “care level” in the long-term care insurance (LTCI) system in Japan is an important issue. This study aimed to explore the risk factors related to the deterioration of health among service users at the support level of LTCI.</div></div><div><h3>Methods</h3><div>The participants were 200 Japanese community-dwelling older adults aged ≥ 65 years who were newly certificated as “support level” and used preventive care services. The users’ physical and cognitive conditions were assessed based on the primary doctor’s opinion and the Kihon checklist. The outcome event was defined as certification at care level 1 or higher. Cox models were used to assess the risk of health deterioration, with adjustments for age, sex, family composition, body mass index, frailty, stroke, dementia status, baseline support level, and social participation in community support projects in the LTCI system.</div></div><div><h3>Results</h3><div>The 5-year support level maintenance rate was 49.1 %. Male gender (hazard ratio [HR] = 1.7), support level 2 (HR = 2.1), and dementia (HR = 2.1) were identified as factors associated with an adverse outcome, whereas social participation was identified as a preventive outcome (HR = 0.4).</div></div><div><h3>Conclusions</h3><div>Male gender, support level 2, and dementia were associated with health deterioration among users from the support level to the care level in the LTCI system in Japan. On the other hand, social participation in community support projects may delay deterioration of health.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"3 1","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145685278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The moderating effect of health status and physical problems on the relationship between life satisfaction and psychological resilience in older adults: An examination by age groups","authors":"Zeynep Seray AKYOL,&nbsp;Dilek ŞİRVANLI ÖZEN,&nbsp;Burak Emre GÜRSOY","doi":"10.1016/j.aggp.2025.100220","DOIUrl":"10.1016/j.aggp.2025.100220","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to examine the moderating effect of health status and physical problems on the relationship between life satisfaction and psychological resilience in older adults, considering different age groups. In this context, it investigates how health status and physical problems shape this relationship across various age groups.</div></div><div><h3>Method</h3><div>The research was conducted between 2023 and 2024 with 337 individuals aged 60 to 97 living in Turkey. During the data collection process, the Demographic Information Form, the Life Satisfaction Scale and the Brief Resilience Scale were used. Regression and moderation analyses were performed to assess the relationship between life satisfaction and psychological resilience, and the varying effects of health status and physical problems across different age groups were tested.</div></div><div><h3>Results</h3><div>Life satisfaction showed a significant association with psychological resilience. Moderation analyses showed that the effects of health status and physical problems on this relationship varied across age groups. It was found that the relationship between life satisfaction and psychological resilience was stronger in individuals with moderate and poor health status, while there was no significant relationship in individuals with very good health status. While this relationship was determined to be the strongest in the 71-80 age group, it varied at different levels in other age groups.</div></div><div><h3>Conclusion</h3><div>The findings indicate that health status and physical problems shape the relationship between life satisfaction and psychological resilience, and this effect varies across age groups. Life satisfaction was observed to have a stronger association with psychological resilience among individuals experiencing health problems. Accordingly, it is emphasized that interventions aimed at enhancing life satisfaction should be designed with sensitivity to age and health status.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"3 1","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145685383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain health and inflammation in older adults: Preventive care insights from the association between high-sensitivity CRP and hippocampal volume","authors":"Ryuzo Orihashi ,&nbsp;Narumi Fujino ,&nbsp;Yoshito Mizoguchi","doi":"10.1016/j.aggp.2025.100233","DOIUrl":"10.1016/j.aggp.2025.100233","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the association between serum high-sensitivity C-reactive protein (hs-CRP) levels, cognitive function, and brain structure in community-dwelling older adults aged 65 years and older. Given the role of inflammation in neurodegeneration, we hypothesized that higher hs-CRP levels would be associated with hippocampal volume and cognitive performance.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 93 participants (25 men, 68 women) from Kurokawa-cho, Japan. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Clinical Dementia Rating (CDR). Serum hs-CRP levels were measured using an enzyme-linked immunosorbent assay. Brain structural analysis was conducted using voxel-based morphometry (VBM) on MRI scans. Multiple regression analyses were performed, adjusting for age, sex, years of education, and total intracranial volume.</div></div><div><h3>Results</h3><div>Serum hs-CRP levels were not significantly associated with cognitive function scores. However, VBM analysis revealed a significant negative association between hs-CRP levels and brain volume in the region including the right hippocampus (<em>P</em> &lt; 0.05, corrected for multiple comparisons using family-wise error and false discovery rate corrections). A similar negative association was observed in the region including the left hippocampus, though it did not reach statistical significance.</div></div><div><h3>Conclusions</h3><div>These findings suggest that systemic inflammation, as indicated by hs-CRP levels, may be linked to smaller hippocampal volume in older adults, independent of cognitive function. This potential association highlights the role of inflammation in brain aging and underscores the importance of preventive healthcare strategies aimed at mitigating inflammation-related neurodegeneration.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"3 1","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145685384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}