Archives of Gerontology and Geriatrics Plus最新文献

{"title":"New advances in the study of postmenopausal osteoporosis and arteriosclerosis: Exploration of metabolite changes and their mechanisms","authors":"Yang Lei ,&nbsp;Li Misi ,&nbsp;Chen Xiaoyun ,&nbsp;An Yangxin ,&nbsp;Hu Xueqin ,&nbsp;Li Weijuan","doi":"10.1016/j.aggp.2025.100222","DOIUrl":"10.1016/j.aggp.2025.100222","url":null,"abstract":"<div><div>Postmenopausal women face a significantly increased risk of osteoporosis and arteriosclerosis due to a marked decline in estrogen levels, making it an important issue in public health. In recent years, metabolomic studies have revealed dynamic changes in various charged metabolites in the bodies of postmenopausal women, which are closely related to abnormal bone metabolism and vascular lesions. Although some research has explored the correlation between osteoporosis and arteriosclerosis in postmenopausal women, systematic studies on metabolite changes and their mechanisms remain relatively scarce. This article reviews the latest research progress on postmenopausal osteoporosis and arteriosclerosis, focusing on the changes in metabolite profiles and their roles in the tricarboxylic acid cycle, urea cycle, and homocysteine metabolism, discussing their mechanisms affecting bone and vascular health. By integrating the latest metabolomic data and clinical studies, this article aims to provide theoretical basis and research directions for the early diagnosis and treatment of osteoporosis and arteriosclerosis in postmenopausal women.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100222"},"PeriodicalIF":0.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between gait performance at discharge and total anticholinergic burden in elderly patients after hip fracture surgery: A single-center retrospective cohort study","authors":"Daisuke Komiya ,&nbsp;Hirofumi Takeya ,&nbsp;Kenta Minakami ,&nbsp;Katsuki Egoh ,&nbsp;Kohji Iwai ,&nbsp;Keisuke Hatase","doi":"10.1016/j.aggp.2025.100223","DOIUrl":"10.1016/j.aggp.2025.100223","url":null,"abstract":"<div><h3>Background</h3><div>Although the association between total anticholinergic burden (Total ACB) and rehabilitation outcomes following hip fracture (HF) surgery has been suggested, the specific impact of Total ACB on gait performance remains uncertain. This study aimed to investigate the relationship between Total ACB and gait performance at hospital discharge.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included 273 patients with HFs (median age: 87 [interquartile range (IQR): 80–91], 78.8 % female) admitted to a 320-bed acute care hospital between April 2017 and August 2023. The primary outcome was gait performance at discharge, evaluated using the Functional Ambulation Categories (FAC), with FAC ≤2 defined as requiring physical assistance. Total ACB was assessed using the Japanese Anticholinergic Risk Scale. Multivariable logistic regression and receiver operating characteristic (ROC) analyses were conducted to estimate associations and quantify discrimination.</div></div><div><h3>Results</h3><div>Total ACB was significantly associated with limited gait performance at discharge (FAC ≤2) after adjustment for predefined covariates, and the association remained in sensitivity analyses. ROC analysis showed modest discrimination, with the highest discrimination in the 75–84 age group.</div></div><div><h3>Conclusions</h3><div>Higher Total ACB was associated with a greater likelihood of requiring physical assistance for walking at discharge after HF surgery. Given the modest overall discrimination, these findings are hypothesis-generating. An age-stratified analysis suggested higher discrimination in those aged 75–84 years, but this subgroup result is exploratory and not part of the primary conclusion. We did not evaluate whether deprescribing or modifying anticholinergic therapy improves gait outcomes; external validation and interventional studies are needed before clinical implementation.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in stroke mortality among older adults (≥65 years) with chronic kidney disease in the U.S. from 1999 to 2020","authors":"Muhammad Hasnain Azeem,&nbsp;Danish Hassan,&nbsp;Sahar Imtiaz,&nbsp;Abdullah Shahbaz,&nbsp;Inamullah Soomro,&nbsp;Syed Rayyan Ahmed,&nbsp;Sukoon Mehdi Raza,&nbsp;Safiullah Soomro,&nbsp;Sheikh Abdul Qadir Jillani","doi":"10.1016/j.aggp.2025.100215","DOIUrl":"10.1016/j.aggp.2025.100215","url":null,"abstract":"<div><h3>Background</h3><div>The U.S. population is aging alongside rising rates of chronic kidney disease (CKD). However, trends in stroke-related mortality among adults with CKD, particularly those aged &gt;65 years, remain under-explored nationally.</div></div><div><h3>Objectives</h3><div>To assess temporal and regional trends in stroke-related mortality among older U.S. adults with CKD.</div></div><div><h3>Methods</h3><div>Mortality data from the CDC WONDER database were analyzed from 1999 to 2020 for stroke-related deaths in adults with CKD aged &gt;65 years. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change (APC) were calculated and stratified by year, sex, race/ethnicity, and geographic region.</div></div><div><h3>Results</h3><div>Between 1999 and 2020, 115935 stroke-related deaths occurred among adults with CKD aged &gt;65 years. The AAMR declined from 14.4 in 1999 to 14.3 in 2020, with fluctuating trends throughout the period. Similar patterns were observed across sexes. Black individuals had the highest AAMRs, followed by American Indians and Hispanics. Regional variation was substantial, with the highest AAMRs in the West (13.5), and the lowest in the Northeast (9.6). Rural areas had higher AAMRs (13.5) than urban areas (12.4). States in the top 90th percentile of stroke-related mortality had approximately double the AAMRs compared to those in the lowest 10th percentile.</div></div><div><h3>Conclusions</h3><div>Stroke-related mortality among older adults with CKD has fluctuated over time, with a recent upward trend since 2014. Disparities by race, region, and rurality persist. Targeted interventions are needed to reduce stroke mortality in this high-risk population.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring mobile device proficiency: a cross-sectional validation of the shortened japanese version of the mobile device proficiency questionnaire","authors":"Suguru Shimokihara ,&nbsp;Hiroyuki Tanaka ,&nbsp;Walter R. Boot ,&nbsp;Yoshikazu Iwakura ,&nbsp;Arisa Nishitani ,&nbsp;Yuta Tanaka ,&nbsp;Takayuki Tabira","doi":"10.1016/j.aggp.2025.100221","DOIUrl":"10.1016/j.aggp.2025.100221","url":null,"abstract":"<div><h3>Background</h3><div>Mobile devices enhance the independence and quality of life of older adults by supporting communication, information access, and daily functioning. However, many older individuals struggle to effectively use such technologies. Accurate assessment of mobile device proficiency is essential for tailoring support and promoting digital inclusion in the aging population. Although the Japanese version of the Mobile Device Proficiency Questionnaire (MDPQ-J) has demonstrated strong validity, its 46-item format imposes a burden on respondents and limits its utility in field settings.</div></div><div><h3>Objective</h3><div>This study aimed to develop and validate shortened versions of the MDPQ-J using item response theory to provide efficient and psychometrically sound tools for assessing mobile device proficiency in older Japanese adults.</div></div><div><h3>Methods</h3><div>A total of 229 Japanese participants, including 108 older adults (aged &gt;65years), completed the full 46-item MDPQ-J. Rasch analysis and item response theory were applied to evaluate dimensionality, item fit, and local independence.</div></div><div><h3>Results</h3><div>A reduction in the number of items in the MDPQ-J was appropriate, and two shortened versions were developed: MDPQ-J14 for the general population and MDPQ-J20OA for older adults. Items were selected based on model fit, local independence, and discrimination parameters. In MDPQ-J14, “Use video-messaging apps” showed the highest discrimination, whereas in MDPQ-J20OA, “Copy and paste text using the touchscreen” demonstrated the strongest item discrimination.</div></div><div><h3>Conclusions</h3><div>The MDPQ-J14 and MDPQ-J20OA are efficient, valid, and culturally appropriate tools for assessing mobile device proficiency. Their brevity and flexibility make them suitable for wide application in research, education, and gerontechnology interventions in aging societies.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human rights of persons with dementia and their care partners: An exploratory study","authors":"Alexandra Lemay-Compagnat ,&nbsp;Yves Couturier ,&nbsp;Laura Rojas-Rozo ,&nbsp;Pamela Roach ,&nbsp;Megan E. O’Connell ,&nbsp;Carrie McAiney ,&nbsp;Deniz Cetin-Sahin ,&nbsp;Geneviève Arsenault-Lapierre ,&nbsp;Evgeny Neiterman ,&nbsp;Debra Morgan ,&nbsp;Marie-Claude Lafleur ,&nbsp;Diane Dumaresq ,&nbsp;Thérèse Trépanier ,&nbsp;Paul Lea ,&nbsp;Heather Eagleson ,&nbsp;Denis O’Connor ,&nbsp;Jody Peters ,&nbsp;Rosette Fernandez Loughlin ,&nbsp;Mary Beth Wighton ,&nbsp;Isabelle Vedel","doi":"10.1016/j.aggp.2025.100217","DOIUrl":"10.1016/j.aggp.2025.100217","url":null,"abstract":"<div><div>Background: Human rights concerns are well documented in the care for persons living with dementia (PLWDs), who often face isolation, exclusion, abuse, injustice, and marginalization. Aim: This study explored the experiences of PLWDs and their care partners (CPs) with health and social services in Canada during the COVID-19 pandemic, through a human rights lens. Methodology: A qualitative multiple case study using a participatory approach was conducted between April 2022 and April 2023. Semi-structured interviews were held with 11 PLWDs and 55 CPs across Quebec, Ontario, Saskatchewan, and Alberta. Guided by the World Health Organization Framework on human-rights for PLWDs, a hybrid thematic analysis was conducted within each province, followed by cross-provincial synthesis. Results: Four major themes were identified: (1) Health and social care professionals’ practices and behaviors; (2) Care partners’ role and burden; (3) Unpreparedness of the healthcare system; (4) Public health measures. Conclusion: PLWDs experienced widespread rights violations, largely due to the cognitive nature of the illness. Despite regional differences, a shared experience of rights infringement was evident. Findings underscore the need for meaningful involvement of PLWDs and CPs in care decisions, accessible rights education, and sustained access to services. Tailored policies must address the needs of PLWDs and CPs, and decision-makers should carefully weigh the risks and benefits of allowing CPs into care facilities.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and chronic diseases among older adults: The moderating role of smoking","authors":"Yong Kang Cheah ,&nbsp;Sharifah Nazeera Syed Anera ,&nbsp;Mohd Azahadi Omar ,&nbsp;Noor Hazilah Abd Manaf ,&nbsp;Zera Zuryana Idris","doi":"10.1016/j.aggp.2025.100219","DOIUrl":"10.1016/j.aggp.2025.100219","url":null,"abstract":"<div><div>Depression and chronic diseases often coexist. They possess negative impacts on health outcomes among older adults. The present study explores the associations between depression and chronic diseases, as well as the moderating role of smoking within a large sample of older adults. Cross-sectional data from the Malaysian National Health and Morbidity Survey 2018 were utilised. Probit models were used to assess parameters influencing the probability of experiencing depression. The moderating effect of smoking was examined by adding diabetes-smoking and hypertension-smoking interaction terms to the regression models. Results showed that older adults with diabetes and hypertension were more likely to experience depression compared to their non-diabetic and non-hypertensive counterparts. While smoking was not independently associated with depression, it moderated the relationship between diabetes and depression. However, the hypertension-depression relationship was not moderated by smoking. Other factors that were correlated with depression included gender, ethnicity, marital status, education, income, physical activity and body mass index (BMI). In conclusion, smoking played an important role in strengthening the relationship between depression and diabetes. Anti-depression policies should give particular consideration to diabetic older adults who smoked tobacco. Interventions to reduce the prevalence of depression should also take account of older adults’ demographic traits and lifestyles.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare service utilization and treatment costs among elderly citizens in Bangladesh","authors":"Abdur Razzaque Sarker","doi":"10.1016/j.aggp.2025.100218","DOIUrl":"10.1016/j.aggp.2025.100218","url":null,"abstract":"<div><div>Bangladesh’s population is aging rapidly, with 8 % of the population currently aged 60 or older, projected to reach 21.5 million by 2030. Elderly citizens face significant health challenges and healthcare costs, increasing demands on the healthcare system. This study assessed self-reported illnesses, treatment costs, and factors influencing healthcare utilization among the elderly in Bangladesh. A cross-sectional survey of 585 elderly citizens (aged 60+ as per Bangladesh’s National Policy on Elderly People) was conducted in Tangail district from December 2019 to February 2020. Descriptive statistics and logistic regression analysis were used to analyze factors associated with healthcare utilization. We found about 92 % of elderly respondents reported illness, with hypertension, ulcers, pain, and diabetes being most common. Average treatment cost per case was BDT 7714 (SD ± 32,472; Median: 1809; IQR: 4926), with medicine as the largest cost driver. Factors such as education, marital status, residence, and wealth were significantly associated with healthcare utilization. These findings provide valuable baseline health data for elderly citizens and can guide policymakers in designing appropriate disease control strategies to improve their health outcomes. Financial risk protection mechanisms, such as the introduction of social health insurance, should be considered to ensure healthcare is both affordable and accessible for all elderly citizens.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National trends in cardiovascular mortality with hip fracture as a contributing cause among older adults in the United States, 1999–2019","authors":"Muhammad Faisal Iqbal ,&nbsp;Rayyan Nabi ,&nbsp;Shahreena Athar Siddiqui ,&nbsp;Marhaba Fatima ,&nbsp;Muzamil Akhtar ,&nbsp;Muhammad Ahmed ,&nbsp;Saqib Jan Shah ,&nbsp;Saadullah Khalid ,&nbsp;Tabeer Zahid ,&nbsp;Ali Hasan ,&nbsp;Raheel Ahmed","doi":"10.1016/j.aggp.2025.100216","DOIUrl":"10.1016/j.aggp.2025.100216","url":null,"abstract":"<div><h3>Background</h3><div>Hip fractures and cardiovascular disease (CVD) represent major, interrelated health burdens among older adults in the United States. This study characterizes national trends in CVD‐related mortality among individuals aged ≥ 65 years with hip fractures from 1999 through 2019.</div></div><div><h3>Methods</h3><div>We conducted a cross‐sectional analysis of CDC WONDER mortality data, identifying deaths with CVD (ICD-10: I00–I99) recorded as the underlying cause and hip-fracture codes (S72.0–S72.9) listed as contributing causes. Crude and age‐adjusted mortality rates (AAMRs) per 100,000 population were calculated annually and standardized to the 2000 U.S. population. Joinpoint regression estimated annual percent changes (APCs) with 95 % confidence intervals (CIs). Trends were stratified by sex, race/ethnicity, metropolitan status, geographic region, and 10-year age groups.</div></div><div><h3>Results</h3><div>From 1999 to 2019, 214,992 CVD‐related deaths occurred in older adults with hip fractures. The overall AAMR declined from 29.99 in 1999 to 21.50 in 2013 (APC –2.72; 95 % CI, –3.97 to –2.43), followed by a nonsignificant decrease to 21.16 by 2019 (APC –0.52; 95 % CI, –1.27 to 0.81). Disparities in AAMR were seen among all variables with highest mortality rates observed among females, non-metropolitan areas and White individuals. Mortality increased markedly with age, up to 124.30 in those ≥ 85 years.</div></div><div><h3>Conclusion</h3><div>Although CVD-related mortality with hip fracture as a contributing cause has generally declined over two decades, substantial disparities persist by sex, race, geography, and age. Integrated, equity‐centered public health and clinical interventions targeting both cardiovascular and bone health are needed to further reduce preventable mortality in this vulnerable population.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urban–rural disparities in dementia-related mortality among older adults in the U.S. from 1999 to 2020","authors":"Suleman Shah ,&nbsp;Rahman Syed ,&nbsp;Ameer Afzal Khan ,&nbsp;Anfal Khan ,&nbsp;Mohsin Ali ,&nbsp;Fazal Syed","doi":"10.1016/j.aggp.2025.100214","DOIUrl":"10.1016/j.aggp.2025.100214","url":null,"abstract":"<div><h3>Background and Aim</h3><div>Dementia, including Alzheimer’s disease and related dementias (ADRD), is a major cause of death among older adults in the United States. However, limited data exist on how dementia-related mortality patterns vary across urban and rural settings. This study aimed to examine national trends in dementia-related mortality from 1999 to 2020, with a focus on geographic disparities and differences in place of death.</div></div><div><h3>Methods</h3><div>We analyzed mortality data from the CDC WONDER Multiple Cause of Death database for U.S. adults aged ≥65 years. Dementia-related deaths were identified using ICD-10 codes F01, F03, and G30. Age-adjusted mortality rates (AAMRs) per 100,000 were calculated using the 2000 U.S. standard population. Trends were assessed using joinpoint regression to estimate annual percent change (APC). Urbanization was classified using the 2013 NCHS Urban–Rural scheme. The place of death was examined by urban and rural residence.</div></div><div><h3>Results</h3><div>From 1999 to 2020, 6516,402 dementia-related deaths were recorded. The AAMR nearly doubled, increasing from 434.9 to 855.1 per 100,000. Females had higher AAMRs (from 444.5 to 905.9) than males (from 405.7 to 767.4). The steepest rise occurred in noncore rural counties (APC: 2.02 %; <em>p</em> &lt; 0.001), while large central metropolitan areas showed slower growth (APC: 0.57 %). In rural areas, 61.8 % of dementia deaths occurred in nursing homes compared to 53.9 % in urban areas. Hospice facility deaths were less common in rural regions (2.1 % vs. 4.6 %), and home deaths were slightly lower (15.0 % vs. 18.6 %). Disparities persisted across age and racial/ethnic groups, with the oldest-old (≥85) and rural Black and White adults bearing the greatest burden.</div></div><div><h3>Conclusion</h3><div>Dementia-related mortality has increased significantly over two decades, with disproportionately higher rates and institutional deaths in rural communities. These findings call for targeted interventions to reduce geographic disparities in dementia care and end-of-life services.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classificating middle-aged and older adults through physiological and functional measures","authors":"Veysel Alcan Ph.D","doi":"10.1016/j.aggp.2025.100212","DOIUrl":"10.1016/j.aggp.2025.100212","url":null,"abstract":"<div><div>Aging affects the functional capacity of individuals by causing gradual changes in metabolic, gait, balance and muscle functions. Identifying these changes between middle-aged (45–64) and older (≥65) adults is critical to understanding the biological and functional effects of aging. This study aims to evaluate the differences between middle-aged and older adults in an objective and scalable manner by analyzing metabolic indicators, gait parameters, balance measurements and muscle functions using machine learning (ML) methods. In this study, 57 high-dimensional variables from the MIDUS dataset including gait parameters (e.g. gait speed, cadence, cycle time), muscle function, balance measurements (e.g. path length, swing area), bone mineral density and bioelectrical impedance spectroscopy markers were used. Supervised ML models were applied to classify the age groups: Partial Least Squares Discriminant Analysis (PLS-DA), Principal Component Analysis-Linear Discriminant Analysis (PCA-LDA), Support Vector Machine (SVM), and k-Nearest Neighbors (k-NN). Venetian blind cross-validation approach was applied to evaluate the model performance. Among the models, SVM showed the highest classification accuracy (87 %) on the training data and 77 % accuracy on the testing data. PLS-DA model achieved 82 % accuracy in training and 86 % in testing. While k-NN model showed 87 % accuracy in training, it dropped to 68 % in testing. In terms of sensitivity and specificity values, SVM showed the best performance (96 % sensitivity, 67 % specificity - training; 86 % sensitivity, 55 % specificity - test), while PLS-DA and PCA-LDA models exhibited similar trends. The results show that walking speed, cadence, and balance measurements provide significant contributions to age group discrimination. These findings highlight the role of neuromuscular and physiological factors in functional decline due to aging, demonstrating the potential of machine learning-based classification in aging research.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}