Archives of Gerontology and Geriatrics Plus最新文献

{"title":"Association between IL-17 and sarcopenia in older adults","authors":"Everson de Cássio Robello ,&nbsp;Gabriela Cabett Cipolli ,&nbsp;Natália Almeida Lima ,&nbsp;Isabela Fernandes Nonato ,&nbsp;Mônica Sanches Yassuda ,&nbsp;Danillo Magalhães Xavier Assunção ,&nbsp;Ronei Luciano Mamoni ,&nbsp;Andréia de Oliveira Pain ,&nbsp;Ana Maria Kemp ,&nbsp;Richard C. Oude Voshaar ,&nbsp;Gustavo Duque ,&nbsp;Ivan Aprahamian","doi":"10.1016/j.aggp.2025.100200","DOIUrl":"10.1016/j.aggp.2025.100200","url":null,"abstract":"<div><h3>Background</h3><div>Chronic low-grade inflammation has been implicated as a potential contributor to sarcopenia, but the specific inflammatory mediators involved remain under investigation. This study explores the association between serum interleukin-17 levels and sarcopenia in older outpatients without pre-existing inflammatory or autoimmune diseases.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted using data from the MiMiCS-FRAIL cohort. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People 2 criteria. IL-17 plasma levels were measured using enzyme-linked immunosorbent assay (ELISA). A multivariate binary logistic regression model was used to assess the association between sarcopenia and IL-17 levels.</div></div><div><h3>Results</h3><div>A total of 255 older adults aged ≥60 years (67.6 % women) were included, with a mean age of 70.8 ± 7.3 years. The prevalence of sarcopenia was 16.9 %. Advanced age (OR = 4.26; 95 % CI: 1.75–10.41; <em>p</em> = 0.001) was significantly associated with sarcopenia. In the fully adjusted model, IL-17 (log-transformed) remained significantly associated with sarcopenia (OR = 1.74; 95 % CI: 1.11–2.74; <em>p</em> = 0.017). Age (OR = 1.10; 95 % CI: 1.03–1.17; <em>p</em> = 0.003) and BMI (OR = 0.69; 95 % CI: 0.60–0.79; <em>p</em> &lt; 0.001) were also associated. IL-6, TNF-α, number of medications, sex, and cognitive score were not statistically significant.</div></div><div><h3>Conclusions</h3><div>Elevated IL-17 levels were associated with higher odds of sarcopenia among older adults. These findings suggest that IL-17 may serve as a potential biomarker for sarcopenia, although further longitudinal studies are needed to elucidate its causal role.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100200"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Archives and Health program for dementia: A pilot study of a non-pharmacological creative arts-based intervention protocol","authors":"Sara Uboldi ,&nbsp;Lorenza Iannacci ,&nbsp;Vanda Menon ,&nbsp;Alessandro Bortolotti ,&nbsp;Giulia Candeloro ,&nbsp;Alessandro Crociata ,&nbsp;Valeria Pica ,&nbsp;Angelo Romagnoli ,&nbsp;Maria Tartari ,&nbsp;Andrea Fabbo ,&nbsp;Alessandra Marasco ,&nbsp;Pier Luigi Sacco","doi":"10.1016/j.aggp.2025.100199","DOIUrl":"10.1016/j.aggp.2025.100199","url":null,"abstract":"<div><h3>Introduction</h3><div>The global rise in dementia prevalence necessitates innovative non-pharmacological interventions to enhance cognitive function and the quality of life of affected individuals. This pilot study evaluates the \"Archives and Health\" program, a creative arts-based initiative that uses archival materials to facilitate reminiscence therapy for individuals with dementia.</div></div><div><h3>Methods</h3><div>This mixed-methods study involved a total of 50 participants (aged 65-94), divided into three different activities, with varying levels of cognitive impairment, recruited from different care settings. The program featured three interventions: \"Memory Box,\" \"My Memory Box,\" and the \"Pre-Texts Protocol,\" incorporating music to enhance personal engagement. Quantitative emotional well-being was assessed using the RADAR toolkit, while qualitative insights were derived from focus groups, interviews, and ethnographic observations</div></div><div><h3>Results</h3><div>The \"My Memory Box\" intervention led to a significant decrease in negative affect (Mean pre = 8.73, Mean post = 7.00, p = 0.007) without altering positive affect. Conversely, the \"Pre-Texts Protocol\" exhibited consistent increases in positive affect across sessions (p-values ranging from 0.0001 to 0.0023). Qualitative analyses indicated that the program effectively activated autobiographical memories, improved social interactions, and fostered emotional resonance through multisensory engagement, particularly via music. Participants expressed enhanced social connectivity and personal relevance during activities.</div><div>The results should be considered preliminary also in light of the mixed qualitative design evaluation, specifically chosen and studied by the researchers as a methodological reflection on the development of mixed qualitative methodologies.</div></div><div><h3>Discussion</h3><div>The \"Archives and Health\" program demonstrated potential in improving emotional and social well-being among individuals with dementia. Its ability to evoke positive emotional responses and decrease negative states indicates the utility of archival materials and creative engagement in therapeutic contexts. Future studies with larger samples are necessary to confirm these findings and explore their clinical implications more robustly.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 4","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of depression, anxiety, burden, burnout, and stress in informal caregivers: An umbrella review of meta-analyses","authors":"Xun Ci Soh ,&nbsp;Andree Hartanto ,&nbsp;Naoki Ling ,&nbsp;Mary Reyes ,&nbsp;Lester Sim ,&nbsp;Nadyanna M. Majeed","doi":"10.1016/j.aggp.2025.100197","DOIUrl":"10.1016/j.aggp.2025.100197","url":null,"abstract":"<div><div>Informal caregiving is a physically and emotionally taxing role that has a profound impact on caregivers’ emotional and mental well-being. Previous research has examined the mental health of caregivers and found elevated levels of depression, anxiety, burden, burnout, or stress. However, the global rates of the five mental health factors and/or outcomes (i.e., depression, anxiety, burden, burnout, and stress) among caregivers remain largely unclear. Therefore, this umbrella review examines the prevalence of these factors and/or outcomes, including various subgroup factors, such as gender, medical and/or psychological condition of the care recipient, region, and assessment tools. A systematic search was conducted in five databases and two sources, and a total of 18 meta-analyses were included for final analysis. The overall median prevalence was 33.35% for depression, 35.25% for anxiety, and 49.26% for burden. However, we could not examine the rates of stress and burnout due to insufficient meta-analysis. Subgroup analyses were comparable across gender, medical and/or psychological condition of the care recipient, and region, suggesting that caregivers face comparable mental health risks across these diverse groups. These findings highlight the need for greater mental health awareness and for governmental and healthcare institutions to introduce effective interventions and stronger support systems.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty assessment as a predictor of postoperative complications and life space in Indian older adults undergoing elective major orthopaedic surgery: A prospective study from a tertiary care centre","authors":"Abhijith Rajaram Rao ,&nbsp;Sumitab Singh ,&nbsp;Baburao Gudeti ,&nbsp;Pramod Kumar Mehta ,&nbsp;Rajesh Malhotra ,&nbsp;Avinash Chakrawarty ,&nbsp;Aparajit Ballav Dey ,&nbsp;Prasun Chatterjee","doi":"10.1016/j.aggp.2025.100198","DOIUrl":"10.1016/j.aggp.2025.100198","url":null,"abstract":"<div><h3>Introduction</h3><div>Preoperative risk assessment is important, and the traditional evaluation is ineffective in identifying frail older patients. We intend to report the association between frailty, as diagnosed using the National Surgical Quality Improvement Program (NSQIP) modified frailty index, and immediate and one-month postoperative outcome in older adults undergoing elective orthopaedic surgery.</div></div><div><h3>Methods</h3><div>This prospective study was conducted in the inpatient department of a tertiary care centre. The preoperative data along with comorbidity, frailty and other geriatric syndromes were collected from 100 older adults, undergoing elective orthopaedic surgery. The outcomes were day 3 postoperative complications such as delirium, electrolyte imbalance, acute kidney injury, pulmonary embolism, intensive care unit admission and infection. Mobility, and mortality were assessed on 30^th post-operative day.</div></div><div><h3>Results</h3><div>The mean age of the study population was 67.8±6.75 years, 80 % were between the age of 60-74 years, 55 (55 %) were females, 28 patients were frail. Hypertension (<em>n =</em> 48) was the most prevalent comorbidity, followed by diabetes (<em>n =</em> 29). Among the immediate post-operative complications, frail patients had higher risk of hyponatremia (OR: 39.44; CI: 4.84-1734.41), acute kidney injury (OR: 6.8; CI: 1.58-33.37), delirium (OR: 23; CI: 5.23-134.84), and infection (OR: 9.44; CI: 2.32-44.87). At 30-day post-operative day frail patients had poor mobility (18.05±8.4 vs 24.45±5.6).</div></div><div><h3>Conclusion</h3><div>Frailty is an important predictor of immediate and short-term post-operative complications in older adults undergoing major elective orthopaedic surgery. Pre-operative screening for frailty could help focus care towards vulnerable patients and prevent adverse events during post-operative period.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health on the move: cardiovascular disease risk among ageing male migrants in India","authors":"Vasim Ahamad ,&nbsp;Ujjwal Das","doi":"10.1016/j.aggp.2025.100196","DOIUrl":"10.1016/j.aggp.2025.100196","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality globally, with a growing burden in low- and middle-income countries such as India. Rapid urbanization, lifestyle changes, and demographic shifts have made internal migration a critical determinant of health. The present study aims to investigate the association between migration and CVD among older males in India.</div></div><div><h3>Methods</h3><div>Data were drawn from the Longitudinal Aging Study in India (LASI Wave-1), including 29,944 male respondents aged 45 years and above. Descriptive statistics, multivariate logistic regression, and Fairlie decomposition analysis were employed to analyze the association between migration and self-reported CVD. Migration streams were categorized as rural–rural, rural–urban, urban–rural, and urban–urban.</div></div><div><h3>Results</h3><div>Migrants had significantly higher odds of CVD compared to non-migrants (Adjusted OR: 1.12, 95% CI: 1.05–1.19). Migration streams involving urban exposure (rural–urban and urban–urban) were associated with a higher CVD risk. Longer duration of stay at the destination, inter-state and early-life migration were also associated with increased CVD risk. Urban residence, higher education, better economic status, and being unemployed were independently associated with elevated CVD risk. Fairlie decomposition showed that 81% of the CVD disparity between migrants and non-migrants could be explained by observed factors, with place of residence (50.25%), education (18.85%), and MPCE quintile (9.23%) being the major contributors.</div></div><div><h3>Conclusion</h3><div>Migration, particularly to or within urban areas, is significantly associated with increased CVD risk among older Indian males. The findings underscore the need for public health policies that address urban lifestyle risks and improve health monitoring and preventive care for migrant populations.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid-stimulating hormone and cognitive impairment in non-depressed non-demented multiethnic middle-aged and older US adults: Assessing sex-specific risk prediction","authors":"Asma Hallab ,&nbsp;Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.aggp.2025.100195","DOIUrl":"10.1016/j.aggp.2025.100195","url":null,"abstract":"<div><h3>Background</h3><div>Understanding the particularities of thyroid-cognition interactions in older adults is crucial in assessing the risks and evaluating therapeutic options.</div></div><div><h3>Methods</h3><div>Cross-sectional analyses where participants from Alzheimer’s Disease Neuroimaging Initiative (ADNI) with mild cognitive impairment (MCI) and healthy controls (HC), with complete neurocognitive tests, thyroid stimulating hormone (TSH) &lt;10 µIU/mL, and geriatric depression scale (GDS) &lt;5, were eligible. Linear and logistic regression models, including testing for non-linearity, were performed. Sex strata were explored.</div></div><div><h3>Results</h3><div>Of the total 1845 multiethnic US-participants, with a median age of 73 (IQR: 68, 78); 887 (48 %) were females, and 1056 (57 %) had MCI. The median TSH level was 1.70 µIU/mL (IQR: 1.15, 2.40); significantly lower in MCI than HC (1.66 vs. 1.74 µIU/mL, <em>p</em>-value=0.02). There was a significant association between TSH and overall cognition only in males (adj. <em>ß</em>_Males=-0.40[-0.74, -0.07], <em>p</em>-value=0.019). The odds of being diagnosed with MCI at baseline decreased with higher TSH levels in the total study population (adj. OR_Total=0.87[0.79, 0.95], <em>p</em>-value=0.002) and in males (adj. OR_Males=0.80[0.70, 0.92], <em>p</em>-value=0.001).</div></div><div><h3>Conclusions</h3><div>There was a sex-specific, statistically significant association between TSH levels and cognition in multiethnic middle-aged and older ADNI adults. Lower TSH levels and worse global cognition were statistically associated only in males. To precisely delineate the chronological onset of these disorders, longitudinal clinical studies are needed.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary heart disease racial disparities among older adults in the U.S.: Systematic review, 2000-2024","authors":"Sanggon Nam","doi":"10.1016/j.aggp.2025.100194","DOIUrl":"10.1016/j.aggp.2025.100194","url":null,"abstract":"<div><h3>Background</h3><div>Coronary heart disease (CHD) remains a leading cause of morbidity and mortality among older U.S. adults, with significant racial and ethnic disparities in prevalence, treatment, and outcomes. This systematic review synthesizes evidence from 44 studies published between 2000 and 2024 to examine these disparities among adults aged ≥65, focusing on prevalence, access to care, treatment quality, outcomes, contributing factors, and effective interventions.</div></div><div><h3>Methods</h3><div>The review adhered to PRISMA 2020 guidelines. A comprehensive search was conducted across six databases: PubMed, Embase, Scopus, Web of Science, CINAHL, and the Cochrane Library. Studies were included if they examined racial/ethnic differences in CHD among U.S. adults aged ≥65. Two independent reviewers screened titles and abstracts, followed by full-text review, with disagreements resolved by a third reviewer. Inter-rater reliability was assessed using Cohen’s kappa (0.85 for title/abstract, 0.90 for full-text). Quality assessment used the Newcastle-Ottawa Scale (NOS; high quality ≥7 points, moderate 4–6 points, low ≤3 points) for observational studies and the Cochrane Risk of Bias tool for randomized trials. Due to heterogeneity, a narrative synthesis was conducted, with subgroup analyses for key outcomes.</div></div><div><h3>Results</h3><div>The 44 included studies revealed persistent disparities in CHD prevalence, access, treatment, and outcomes, particularly affecting Black, Hispanic, and American Indian/Alaska Native (AI/AN) older adults. Minority groups exhibited higher CHD prevalence and risk factors (e.g., hypertension, diabetes), lower access to guideline-directed therapies, and worse outcomes, including higher readmission and mortality rates. Structural racism, socioeconomic factors, and systemic biases were key drivers. Interventions like policy reforms, community-based programs, and telehealth showed promise in reducing disparities.</div></div><div><h3>Conclusions</h3><div>Despite progress in acute care, significant disparities persist in long-term CHD management among minority older adults. Addressing social determinants, improving access to equitable care, and implementing culturally competent interventions are essential for health equity.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can targeted cognitive intervention improve rehabilitation outcome in hip fracture patients: a randomized controlled trial","authors":"Yedida Borow,&nbsp;Renata Efrati,&nbsp;Noa Doron,&nbsp;Michal Tzin,&nbsp;Yaara Ginsburg,&nbsp;Daniela Gesner,&nbsp;Avital Hershkovitz","doi":"10.1016/j.aggp.2025.100193","DOIUrl":"10.1016/j.aggp.2025.100193","url":null,"abstract":"<div><h3>Background</h3><div>Hip fractures lead to disability, loss of independence, and a decline in quality of life. Rehabilitation success depends on various factors, such as, age, pre-fracture function, level of cognitive function, nutritional status, comorbidity, and family support. Most studies exploring the question of whether cognitive-based interventions can lead to functional improvement were conducted on community-dwelling elderly individuals with acquired brain injury, dementia, and cognitive impairments. Our aim was to compare targeted cognitive intervention with conventional occupational therapy in improving rehabilitation outcomes amongst post-acute hip fracture patients.</div></div><div><h3>Methods</h3><div>A randomized controlled single blinded study. Eighty patients were randomly assigned to two groups: group A (intervention) received targeted cognitive intervention, based on concepts from \"The multi-context approach to cognitive rehabilitation of executive dysfunction\" and group B (controls) received conventional occupational therapy. T-test and chi-square tests assessed significant differences between demographic, clinical, functional variables. ANOVA with repeated measures assessed significant improvement in cognitive/functional test scores in the two groups.</div></div><div><h3>Results</h3><div>43 patients were assigned to the intervention group; 37 to the controls. All patients significantly improved in their cognitive tests. No significant differences were found between the groups regarding discharge scores of the cognitive test, degree of cognitive improvement, functional outcomes and patient reported outcome measures questions.</div></div><div><h3>Conclusions</h3><div>Targeted cognitive intervention did not lead to a better outcome in hip fracture patients. As most were cognitively impaired, further research is warranted in order to explore whether different cognitive interventions might improve their rehabilitation outcomes.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100193"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A UK study: Menopausal and perimenopausal women’s biopsychosocial experiences, understanding of treatment options, and thoughts towards their future lives","authors":"Mandy Simpson,&nbsp;Cynthia Tuuli,&nbsp;Elizabeth Eate","doi":"10.1016/j.aggp.2025.100191","DOIUrl":"10.1016/j.aggp.2025.100191","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to draw attention and give voice to women’s experiences, knowledge, future thoughts and general understanding of perimenopause and menopause, exploring this natural event holistically through a biopsychosocial lens.</div></div><div><h3>Methods</h3><div>One focus group of four self-identified perimenopausal or menopausal women was conducted to gather data. Purposive sampling was used to recruit the participants through a social media campaign. Interpretative Phenomenological Analysis provided a framework to study this important topic through exploring and examining lived experiences in a small group sample size, using the framework’s seven-step data analysis to identify key themes within the data.</div></div><div><h3>Results</h3><div>Four main group experiential themes were highlighted through analysis of the participants' responses: (1) onset and impact of symptoms, (2) menopause and relationships, (3) the knowledge gap, and (4) future thoughts: a desire for change. A prominent overarching theme involved the participants showing less concern for how they were being personally affected by their climacteric experience but demonstrating greater concern for the impact of their perimenopause or menopause experience upon others. This overarching theme was evident within all four group experiential themes.</div></div><div><h3>Conclusions</h3><div>The participants were deeply concerned about how their symptoms affected others. They had limited knowledge when their own symptoms started, but after seeking support, particularly from people with lived experiences rather than academic literature, they became inspired to be a part of bringing about change for the next generation, so that in the future menopause experiences would not occur so unexpectedly for others.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translating inflammaging: The bidirectional relationship between oral and systemic health in geriatric prosthodontics","authors":"Olga Naka,&nbsp;Panagiota Chatzidou,&nbsp;Katia Sarafidou,&nbsp;Vassiliki Anastassiadou","doi":"10.1016/j.aggp.2025.100192","DOIUrl":"10.1016/j.aggp.2025.100192","url":null,"abstract":"<div><div>The aging population presents complex challenges to oral health, particularly due to inflammaging, a chronic, low-grade systemic inflammation linked to tissue degeneration and frailty syndrome. Despite its relevance, inflammaging remains underexplored in geriatric prosthodontics. This scoping review aimed to systematically examine and classify existing literature on oral-systemic inflammaging, with emphasis on diagnostic biomarkers, therapeutic strategies, and interdisciplinary integration. Bloom’s cognitive taxonomy was used to structure the evidence according to levels of complexity and clinical application. Following the PRISMA-ScR guidelines, 1686 records were screened across four databases (PubMed, Scopus, Web of Science, and Embase), and 49 studies met the inclusion criteria. The review employed a dual framework: the PICO model for clinical relevance and Bloom’s instructional taxonomy to categorize evidence from recall-level biological markers to higher-order insights, such as senotherapeutics, multi-omics diagnostics, and digital integration. Findings highlighted strong correlations between systemic inflammatory markers and oral aging conditions. Novel interventions, including senolytics, mTOR inhibitors, and microbiome-targeted therapies, showed translational promise. However, gaps persist in standardized biomarker panels, long-term clinical trials, and integration of frailty metrics into prosthodontic care. In conclusion, inflammaging offers a compelling biological perspective for transitioning prosthodontic strategies from mechanical approaches to precision-based methodologies. Integrating concepts including geroscience, salivary diagnostics, and personalized biomaterials can enhance outcomes and resilience in older adults. Future research should prioritize biologically informed protocols, interdisciplinary collaboration, and AI-supported predictive tools to align prosthodontics with the broader goals of healthy aging.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}