Chinese Journal of Natural Medicines最新文献

{"title":"Glasesterterpenoids A−C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca","authors":"Shiting HE ,&nbsp;Qinghui ZOU ,&nbsp;Qi ZHANG ,&nbsp;Yingming LUO ,&nbsp;Die YAN ,&nbsp;Jingxin HE ,&nbsp;Yena LIU ,&nbsp;Hui CUI","doi":"10.1016/S1875-5364(24)60657-6","DOIUrl":"10.1016/S1875-5364(24)60657-6","url":null,"abstract":"<div><div>Three novel sesterterpenoids glasesterterpenoids A−C (<strong>1</strong>−<strong>3</strong>), featuring an unprecedented 7-cyclohexyldecahydronaphthalene carbon skeleton, were isolated from the root of <em>Lindera glauca</em> (<em>L. glauca</em>). Their structures were elucidated by quantum chemical calculations and spectroscopic methods. The biogenetic pathway for <strong>1</strong>−<strong>3</strong> is proposed. In the bioassay, glasesterterpenoid C exhibited DNA topoisomerase 1 (Top1) inhibitory activity compared with the positive control, camptothecin. These findings represent the first examples of sesterterpenoids with a 7-cyclohexyldecahydronaphthalene carbon skeleton from the root of <em>L. glauca</em>.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 9","pages":"Pages 864-868"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis","authors":"Yinhao ZHANG ,&nbsp;Kexin JIA ,&nbsp;Yufei LI ,&nbsp;Zhi MA ,&nbsp;Guifang FAN ,&nbsp;Ranyi LUO ,&nbsp;Yajing LI ,&nbsp;Yang YANG ,&nbsp;Fanghong LI ,&nbsp;Runping LIU ,&nbsp;Jia LIU ,&nbsp;Xiaojiaoyang LI","doi":"10.1016/S1875-5364(24)60719-3","DOIUrl":"10.1016/S1875-5364(24)60719-3","url":null,"abstract":"<div><div>Hepatic ischemia/reperfusion injury (HIRI) is a common pathophysiological condition occurring during or after liver resection and transplantation, leading to hepatic viability impairment and functional deterioration. Recently, ferroptosis, a newly recognized form of programmed cell death, has been implicated in IRI. Rehmanniae Radix Praeparata (RRP), extensively used in Chinese herbal medicine for its hepatoprotective, anti-inflammatory, and antioxidant properties, presents a potential therapeutic approach. However, the mechanisms by which RRP mitigates HIRI, particularly through the regulation of ferroptosis, remain unclear. In this study, we developed a HIRI mouse model and monocrotaline (MCT)- and erastin-induced <em>in vitro</em> hepatocyte injury models. We conducted whole-genome transcriptome analysis to elucidate the protective effects and mechanisms of RRP on HIRI. The RRP aqueous extract was characterized by the presence of acteoside, rehmannioside D, and 5-hydroxymethylfurfural. Our results demonstrate that the RRP aqueous extract ameliorated oxidative stress, reduced intracellular iron accumulation, and attenuated HIRI-induced liver damage. Additionally, RRP significantly inhibited hepatocyte death by restoring intracellular iron homeostasis both <em>in vivo</em> and <em>in vitro</em>. Mechanistically, the RRP aqueous extract reduced intrahepatocellular iron accumulation by inhibiting ZIP14-mediated iron uptake, promoting hepcidin- and ferroportin-mediated iron efflux, and ameliorating mitochondrial iron aggregation through upregulation of Cisd1 expression. Moreover, siRNA-mediated inhibition of hamp synergistically enhanced the RRP aqueous extract’s inhibitory effect on ferroptosis. In conclusion, our study elucidates the mechanisms by which RRP aqueous extracts alleviate HIRI, highlighting the restoration of iron metabolic balance. These findings position RRP as a promising candidate for clinical intervention in HIRI treatment.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 9","pages":"Pages 769-784"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis","authors":"Xinyue XU ,&nbsp;Wenping ZHU ,&nbsp;Mengqiu MIAO ,&nbsp;Mi BAI ,&nbsp;Jiaojiao FAN ,&nbsp;Yujia NIU ,&nbsp;Yuting LI ,&nbsp;Aihua ZHANG ,&nbsp;Zhanjun JIA ,&nbsp;Mengqiu WU","doi":"10.1016/S1875-5364(24)60608-4","DOIUrl":"10.1016/S1875-5364(24)60608-4","url":null,"abstract":"<div><div>Pharmaceutical formulations derived from Aristolochiaceae herbs, which contain aristolochic acids (AAs), are widely used for medicinal purposes. However, exposure to these plants and isolated AAs is linked to renal toxicity, known as AA nephropathy (AAN). Currently, the mechanisms underlying AAN are not fully understood, leading to unsatisfactory treatment strategies. In this study, we explored the protective role of 84-B10 (5-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl) phenyl] amino]-5-oxo-3-phenylpentanoic acid) against AAN. RNA-seq analysis revealed that the mitochondrion and peroxisome were the most affected cellular components following 84-B10 treatment in AAN mice. Consistently, 84-B10 treatment preserved mitochondrial ultrastructure, restored mitochondrial respiration, enhanced the expression of key transporters (carnitine palmitoyltransferase 2) and enzymes (acyl-Coenzyme A dehydrogenase, medium chain) involved in mitochondrial fatty acid <em>β</em>-oxidation, and reduced mitochondrial ROS generation in both aristolochic acid I (AAI)-challenged mice kidneys and cultured proximal tubular epithelial cells. Additionally, 84-B10 treatment increased the expression of key transporters (ATP binding cassette subfamily D) and rate-limiting enzymes (acyl-CoA oxidase 1) involved in peroxisomal fatty acid <em>β</em>-oxidation and restored peroxisomal redox balance. Knocking down LONP1 expression diminished the protective effects of 84-B10 against AAN, suggesting LONP1-dependent protection. In conclusion, our study provides evidence that AAN is associated with significant disturbances in both mitochondrial and peroxisomal functions. The LONP1 activator 84-B10 demonstrates therapeutic potential against AAN, likely by maintaining homeostasis in both mitochondria and peroxisomes.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 9","pages":"Pages 808-821"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and cytotoxic metabolites produced by Streptomyces tanashiensis BYF-112 isolated from Odontotermes formosanus","authors":"Jun WU ,&nbsp;Tao SONG ,&nbsp;Le ZHANG ,&nbsp;Zhongdi HUANG ,&nbsp;Fang HUANG ,&nbsp;Caiping YIN ,&nbsp;Shuxiang ZHANG ,&nbsp;Xinhua LIU ,&nbsp;Yinglao ZHANG","doi":"10.1016/S1875-5364(24)60720-X","DOIUrl":"10.1016/S1875-5364(24)60720-X","url":null,"abstract":"<div><div>Chemical investigations of the termite-associated <em>Streptomyces tanashiensis</em> BYF-112 resulted in the discovery of four novel alkaloid derivatives: vegfrecines A and B (<strong>1</strong> and <strong>2</strong>), exfoliazone A (<strong>3</strong>), and venezueline H (<strong>7</strong>), in addition to nine known metabolites (<strong>4</strong>−<strong>6</strong>, <strong>8</strong>−<strong>13</strong>). The structures of these compounds were elucidated through comprehensive spectroscopic analysis and comparison with existing literature data. Antibacterial assays revealed that viridomycin A (<strong>11</strong>) exhibited potent antibacterial activity against <em>Staphylococcus aureus</em>, with a zone of inhibition (ZOI) of 12.67 mm, in comparison to a ZOI of 17.67 mm for the positive control gentamicin sulfate. Viridomycin A (<strong>11</strong>) showed moderate activity against <em>Micrococcus tetragenus</em> and <em>Pseudomonas syringae</em> pv. <em>actinidae</em>, with ZOI values of 15.50 and 14.33 mm, respectively, which were inferior to those of gentamicin sulfate (34.67 and 24.00 mm). Viridomycin F (<strong>12</strong>) also exhibited moderate antibacterial effects against <em>S. aureus</em>, <em>M. tetragenus</em>, and <em>P. syringae</em> pv. <em>actinidae</em>, with ZOI values of 8.33, 16.50, and 10.83 mm, respectively. Cytotoxicity assays demonstrated that viridobruunine A (<strong>5</strong>), exfoliazone (<strong>6</strong>), viridomycin A (<strong>11</strong>), and X-14881E (<strong>13</strong>) exhibited significant cytotoxicity against human malignant melanoma (A375), ovarian cancer (SKOV-3), and gastric cancer (MGC-803) cell lines, with IC₅₀ values ranging from 4.61 to 19.28 μmol·L⁻¹. Furthermore, bioinformatic analysis of the complete genome of <em>S. tanashiensis</em> suggested a putative biosynthetic gene cluster (BGC) responsible for the production of compounds <strong>1−12</strong>. These findings indicate that the secondary metabolites of insect-associated <em>S. tanashiensis</em> BYF-112 hold promise as potential sources of novel antibacterial and anticancer agents.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 9","pages":"Pages 822-830"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrocyclic trichothecenes from Myrothecium verrucaria PA 57 and their cytotoxic activity","authors":"Jisong MO ,&nbsp;Yufen TAN ,&nbsp;Wenjing AI ,&nbsp;Yunyun LI ,&nbsp;Yiyun YUAN ,&nbsp;Yueping JIANG ,&nbsp;Kangping XU ,&nbsp;Guishan TAN ,&nbsp;Wenxuan WANG ,&nbsp;Jing LI ,&nbsp;Shao LIU","doi":"10.1016/S1875-5364(24)60573-X","DOIUrl":"10.1016/S1875-5364(24)60573-X","url":null,"abstract":"<div><div>Four novel macrocyclic trichothecenes, termed mytoxins D−G (<strong>1</strong>−<strong>4</strong>), along with four known analogs (<strong>5</strong>−<strong>8</strong>), were isolated from the ethyl acetate extract of fermented rice inoculated with the fungus <em>Myrothecium verrucaria</em> PA57. Each compound features a tricyclic 12,13-epoxytrichothec-9-ene (EPT) core. Notably, mytoxin G (<strong>4</strong>) represents the first instance of a macrocyclic trichothecene incorporating a glucosyl unit within the trichothecene structure. The structures of the newly identified compounds were elucidated through comprehensive spectroscopic analysis combined with quantum chemical calculations. All isolated compounds demonstrated cytotoxic activity against the CAL27 and HCT116 cell lines, which are models for human oral squamous cell carcinoma and colorectal cancer, respectively. Specifically, mytoxin D (<strong>1</strong>) and mytoxin F (<strong>3</strong>) exhibited pronounced cytotoxic effects against both cancer cell lines, with IC₅₀ values ranging from 3 to 6 nmol·L⁻¹. Moreover, compounds <strong>1</strong> and <strong>3</strong> were found to induce apoptosis in HCT116 cells by activating caspase-3.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 9","pages":"Pages 854-863"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural medicine can substitute antibiotics in animal husbandry: protective effects and mechanisms of rosewood essential oil against Salmonella infection","authors":"Lanqiao WANG ,&nbsp;Juan FANG ,&nbsp;Heng WANG ,&nbsp;Baoyu ZHANG ,&nbsp;Nan WANG ,&nbsp;Xinyu YAO ,&nbsp;He LI ,&nbsp;Jiazhang QIU ,&nbsp;Xuming DENG ,&nbsp;Bingfeng LENG ,&nbsp;Jianfeng WANG ,&nbsp;Wenxi TAN ,&nbsp;Qiaoling ZHANG","doi":"10.1016/S1875-5364(24)60576-5","DOIUrl":"10.1016/S1875-5364(24)60576-5","url":null,"abstract":"<div><div><em>Aniba rosaeodora</em> essential oil (RO) has been traditionally used in natural medicine as a substitute for antibiotics due to its notable antidepressant and antibacterial properties. <em>Salmonella</em>, a prevalent pathogen in foodborne illnesses, presents a major challenge to current antibiotic treatments. However, the antibacterial efficacy and mechanisms of action of RO against <em>Salmonella</em> spp. remain underexplored. This study aims to elucidate the chemical composition of RO, evaluate its antibacterial activity and mechanisms against <em>Salmonella in vitro</em>, and further delineate its anti-inflammatory mechanisms <em>in vivo</em> during <em>Salmonella</em> infection. Gas chromatography-mass spectrometry (GC-MS) was utilized to characterize the chemical constituents of RO. The antibacterial activity of RO was assessed using minimal inhibitory concentration (MIC) and time-kill assays<em>.</em> Various biochemical assays were employed to uncover the potential bactericidal mechanisms. Additionally, mouse and chick models of <em>Salmonella</em> infection were established to investigate the prophylactic effects of RO treatment. RO exhibited significant antibacterial activity against both Gram-positive and Gram-negative bacteria, with an MIC of 4 mg·mL⁻¹ for <em>Salmonella</em> spp. RO treatment resulted in bacterial damage through the disruption of lipid and purine metabolism. Moreover, RO reduced injury and microbial colonization in infected mice and chicks. RO treatment also modulated the host inflammatory response by inhibiting proinflammatory pathways. In conclusion, our findings demonstrate that RO is effective against <em>Salmonella</em> infection, highlighting its potential as an alternative to antibiotics for antibacterial therapy.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 9","pages":"Pages 785-796"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of antitumor diterpenoids from Casearia graveolens targeting VEGFR-2 to inhibit angiogenesis","authors":"Sibei WANG ,&nbsp;Yuhui LIU ,&nbsp;Yue LIANG ,&nbsp;Yaru XI ,&nbsp;Yupeng ZHAI ,&nbsp;Dongho LEE ,&nbsp;Jing XU ,&nbsp;Yuanqiang GUO","doi":"10.1016/S1875-5364(24)60566-2","DOIUrl":"10.1016/S1875-5364(24)60566-2","url":null,"abstract":"<div><div>Eight novel clerodane diterpenoids (<strong>1</strong>−<strong>8</strong>) were isolated from the twigs of <em>Casearia graveolens</em>. Their structures were elucidated through comprehensive nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and electronic circular dichroism (ECD) analyses. In addition to structural determination, surface plasmon resonance (SPR) assays were conducted to investigate molecular interactions, revealing that compound <strong>8</strong> exhibited high affinity for vascular endothelial growth factor receptor 2 (VEGFR2), a key regulator of tumor angiogenesis. Subsequent <em>in vivo</em> experiments demonstrated that compound <strong>8</strong> effectively inhibited angiogenesis and displayed significant antitumor activity by suppressing tumor proliferation and metastasis in zebrafish xenograft models. These findings suggest that compound <strong>8</strong> holds promise as an anticancer lead compound targeting VEGFR-2 to obstruct tumor angiogenesis.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 9","pages":"Pages 842-853"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery and characterization of naturally occurring covalent inhibitors of SARS-CoV-2 Mpro from the antiviral herb Ephedra","authors":"Qing HU ,&nbsp;Yiwen ZHANG ,&nbsp;Pengcheng CHEN ,&nbsp;Yani ZHANG ,&nbsp;Guanghao ZHU ,&nbsp;Wei LIU ,&nbsp;Chaoran WANG ,&nbsp;Shuilian ZHENG ,&nbsp;Nonger SHEN ,&nbsp;Haonan WANG ,&nbsp;Ping HUANG ,&nbsp;Guangbo GE","doi":"10.1016/S1875-5364(24)60577-7","DOIUrl":"10.1016/S1875-5364(24)60577-7","url":null,"abstract":"<div><div>The Chinese herb Ephedra (also known as Mahuang) has been extensively utilized for the prevention and treatment of coronavirus-induced diseases, including coronavirus disease 2019 (COVID-19). However, the specific anti-SARS-CoV-2 compounds and mechanisms have not been fully elucidated. The main protease (M^pro) of SARS-CoV-2 is a highly conserved enzyme responsible for proteolytic processing during the viral life cycle, making it a critical target for the development of antiviral therapies. This study aimed to identify naturally occurring covalent inhibitors of SARS-CoV-2 M^pro from Ephedra and to investigate their covalent binding sites. The results demonstrated that the non-alkaloid fraction of Ephedra (ENA) exhibited a potent inhibitory effect against the SARS-CoV-2 M^pro effect, whereas the alkaloid fraction did not. Subsequently, the chemical constituents in ENA were identified, and the major constituents’ anti-SARS-CoV-2 M^pro effects were evaluated. Among the tested constituents, herbacetin (HE) and gallic acid (GA) were found to inhibit SARS-CoV-2 M^pro in a time- and dose-dependent manner. Their combination displayed a significant synergistic effect on this key enzyme. Additionally, various techniques, including inhibition kinetic assays, chemoproteomic methods, and molecular dynamics simulations, were employed to further elucidate the synergistic anti-M^pro mechanisms of the combination of HE and GA. Overall, this study deciphers the naturally occurring covalent inhibitors of SARS-CoV-2 M^pro from Ephedra and characterizes their synergistic anti-M^pro synergistic effect, providing robust evidence to support the anti-coronavirus efficacy of Ephedra.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 9","pages":"Pages 797-807"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China’s endemic plant species","authors":"Yanjun SUN ,&nbsp;Chen ZHAO ,&nbsp;Hongyun BAI ,&nbsp;Meng LI ,&nbsp;Junmin WANG ,&nbsp;Zhiyou HAO ,&nbsp;Weisheng FENG","doi":"10.1016/S1875-5364(24)60721-1","DOIUrl":"10.1016/S1875-5364(24)60721-1","url":null,"abstract":"<div><div>Eight novel arylnaphthalide lactone lignans, designated as diphylignan A−H (<strong>1</strong>−<strong>8</strong>), and a new dibenzyltyrolactone lignan, designated as diphylignan I (<strong>9</strong>), were isolated from the roots and rhizomes of <em>Diphylleia sinensis</em>, along with two additional novel natural products (<strong>11</strong> and <strong>14</strong>) and four known metabolites (<strong>10</strong>, <strong>12</strong>, <strong>13</strong>, <strong>15</strong>). The structural and stereochemical characterization of these compounds was accomplished using NMR spectroscopy and electronic circular dichroism (ECD) analysis. The cytotoxic activities of all isolated compounds were assessed against A-549 and SMMC-7721 cell lines. Notably, compound <strong>2</strong> demonstrated the most significant cytotoxicity, with IC₅₀ values of 10.27 and 11.58 µmol·L⁻¹ against A-549 and SMMC-7721 cell lines, respectively, exhibiting greater potency than the positive control, cisplatin.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 9","pages":"Pages 831-841"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approved drugs and natural products at clinical stages for treating Alzheimer’s disease","authors":"Yajing MA ,&nbsp;Sufang LIU ,&nbsp;Qingfeng ZHOU ,&nbsp;Zhonghua LI ,&nbsp;Zhijian ZHANG ,&nbsp;Bin YU","doi":"10.1016/S1875-5364(24)60606-0","DOIUrl":"10.1016/S1875-5364(24)60606-0","url":null,"abstract":"<div><p>Alzheimer’s disease (AD) remains the foremost cause of dementia and represents a significant unmet healthcare need globally. The complex pathogenesis of AD, characterized by various pathological and physiological events, has historically challenged the development of anti-AD drugs. However, recent breakthroughs in AD drug development, including the approvals of aducanumab, lecanemab, and sodium oligomannate (GV-971), have ended a nearly two-decade hiatus in the introduction of new AD drugs. These developments have addressed long-standing challenges in AD drug development, marking a substantial shift in the therapeutic landscape of AD. Moreover, natural products (NPs) have shown promise in AD drug research, with several currently under clinical investigation. Their distinct properties and mechanisms of action offer new avenues to complement and enhance existing AD treatment approaches. This review article aims to provide an overview of the recent advancements and prospects in AD therapeutics, focusing on both NPs and approved drugs.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 8","pages":"Pages 699-710"},"PeriodicalIF":4.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}