干细胞外泌体与医疗器械结合的研究进展——结合产品的新方向。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2024-12-01 DOI:10.1016/S1875-5364(24)60637-0

Yuewen ZHAI, Fang HE, Ji FANG, Siwen LI

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引用次数: 0

摘要

外泌体（exos）是纳米级细胞外囊泡，在组织发育和功能中起着关键作用。干细胞衍生的外显子含有多种组织修复成分，有望成为疾病治疗和再生医学的天然治疗剂。然而，它们的应用仍然存在挑战，特别是在靶向给药和控释方面，这对提高它们的生物功效至关重要。医疗器械的集成可以为提高药物的生物利用度提供一个优越的平台。因此，干细胞衍生的外泌体和医疗器械的组合产品为扩大外泌体的治疗潜力提供了新的机会。本文综述了目前干细胞衍生外显子与医疗器械结合的研究前沿，并讨论了该领域的潜在挑战和未来前景。

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Advances in the combination of stem cell exosomes with medical devices-the new direction for combination products

Exosomes (exos), nanoscale extracellular vesicles, play a critical role in tissue development and function. Stem cell-derived exos, containing various tissue repair components, show promise as natural therapeutic agents in disease treatment and regenerative medicine. However, challenges persist in their application, particularly in targeted delivery and controlled release, which are crucial for enhancing their biological efficacy. The integration of medical devices may provide a superior platform for improving drug bioavailability. Consequently, the combination products of stem cell-derived exos and medical devices present novel opportunities for expanding the therapeutic potential of exosomes. This review offers a comprehensive overview of the current research frontier in stem cell-derived exos combined with medical devices and discusses the prospective challenges and future prospects in this field.

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.