Advanced Chinese Medicine最新文献

{"title":"Multiomics integration of 16S rRNA, metagenomic, and metabolomic analyses unveils gut microbiota–metabolite interactions in Guizhi Fuling capsule‐treated chronic pelvic inflammatory disease rats","authors":"Hongli Chen, Mengyu Qian, Zhelong Feng, Xia Gao, Ruotong Huang, Yan Xie, Liang Cao, Xialin Chen, Wei Xiao","doi":"10.1002/acm4.70006","DOIUrl":"https://doi.org/10.1002/acm4.70006","url":null,"abstract":"Abstract Background Chronic pelvic inflammatory disease (CPID) is a persistent upper reproductive tract disorder characterized by microbial dysbiosis, pelvic adhesions, and infertility. Guizhi Fuling capsule (GZFLC), a multiherb traditional formula, has demonstrated therapeutic potential for CPID. Methods A CPID rat model was established via mixed‐pathogen infection. Evaluations included uterine histopathology, inflammatory cytokine levels (interleukin‐6, tumor necrosis factor‐α, interleukin‐18, interleukin‐1β), coagulation parameters (prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen), uterine metabolomics, 16S rRNA sequencing, and metagenomic sequencing to assess microbial composition and functional pathway alterations. Results CPID rats exhibited weight loss, uterine structural damage, elevated inflammation, and a hypercoagulable state. Uterine metabolomics showed significant reductions in key TCA cycle intermediates (α‐ketoglutarate, isocitrate). 16S rRNA sequencing revealed enrichment of the pathogenic bacterium Clostridia_UCG‐014 . Metagenomic analysis indicated upregulation of quorum sensing (QS) pathway genes (thoil‐activated cytolysin, TrbB, Gmr) and downregulation of CAZymes, specifically glycoside hydrolase 2 and carbohydrate esterase 1. Correlation analysis suggested that GZFLC modulates specific microbial taxa, influencing host metabolites and inflammatory responses. Conclusion GZFLC likely alleviates CPID by exerting anti‐inflammatory effects, restoring TCA cycle energy metabolism, reshaping gut microbiota structure, inhibiting QS signaling, and improving polysaccharide metabolic functions.","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 4","pages":"163-177"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acm4.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress of research on delaying bone destruction of rheumatoid arthritis by combining traditional Chinese and Western medicine","authors":"Dier Jin,&nbsp;Yuanyuan Xu,&nbsp;Wenwen Qi,&nbsp;Tianyi Lan,&nbsp;Ting Liu,&nbsp;Rihong Liu,&nbsp;Zihan Wang,&nbsp;Yuan Xu","doi":"10.1002/acm4.70003","DOIUrl":"https://doi.org/10.1002/acm4.70003","url":null,"abstract":"<p>Rheumatoid arthritis (RA) is a common autoimmune disease with bone destruction as the core pathology, which belongs to the category of “impediment disease” in traditional Chinese medicine (TCM), and its etiology and pathogenesis are still not completely clear. It is characterized by high prevalence, high disability rate, and high recurrence rate, which seriously affects human health and has become a worldwide research hot spot. At present, although modern medicine has made significant progress in the treatment of RA bone destruction, such as biologics and small-molecule targeted drugs, it still faces problems such as poor efficacy, drug resistance, drug side effects, and long-term treatment costs. It has been found that the use of TCM decoction and acupuncture in combination with Western medicine for the treatment of RA bone destruction can enhance the efficacy of the treatment while reducing the adverse effects of Western medicine. However, no one has systematically reviewed the current research status on the combination of Chinese and Western medicine in the treatment of RA bone destruction. Therefore, this paper reviews the research progress of combined Chinese and Western medicine in the treatment of RA bone destruction, aiming to promote the application of combined Chinese and Western medicine in clinical practice and provide new treatment ideas for the clinical treatment of RA bone destruction.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 3","pages":"120-133"},"PeriodicalIF":0.0,"publicationDate":"2025-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on research paradigms and technological layout for clinical priority diseases in traditional Chinese medicine: Rheumatoid arthritis","authors":"Dier Jin,&nbsp;Jinping Wang,&nbsp;Zihan Wang,&nbsp;Mei Mo,&nbsp;Xiaojing Liu,&nbsp;Nan Zhang,&nbsp;Xiaoxiao Zhang,&nbsp;Qingwen Tao,&nbsp;Yuan Xu","doi":"10.1002/acm4.70002","DOIUrl":"https://doi.org/10.1002/acm4.70002","url":null,"abstract":"<p>Rheumatoid arthritis (RA) is a chronic, highly disabling autoimmune disease. Although modern medical treatments have made progress, challenges such as suboptimal efficacy, relapse, difficulties in comorbidity management, and side effects persist. Traditional Chinese medicine (TCM) demonstrates unique advantages in the treatment of RA throughout the entire course of the disease, particularly in early intervention, consolidation during remission, reducing the side effects of Western medicines, and preventing relapse. Based on this, the article explores the research paradigm and scientific and technological strategic approaches for RA, which is recognized as a disease with clinical advantages in TCM. It proposes a three-pronged approach: optimizing the integrated traditional Chinese and Western medicine diagnostic and treatment system, strengthening comprehensive prevention and control of RA-related complications and comorbidities, and establishing a chronic disease management system for RA based on TCM theories. Through the synergy of clinical and basic research, the aim is to clarify the advantageous aspects of TCM in RA diagnosis and treatment, develop effective treatment protocols, enhance RA prevention and management, and underscore the value of TCM.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 3","pages":"134-142"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145537976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota","authors":"Jinlan Di,&nbsp;Xiaochun Zhang","doi":"10.1002/acm4.70001","DOIUrl":"https://doi.org/10.1002/acm4.70001","url":null,"abstract":"<p>The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time-honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders. Emerging evidence indicates that the metabolic fate, pharmacokinetics, and bioavailability of SLBZS's complex herbal constituents are profoundly influenced by interactions with specific intestinal microorganisms and their enzymatic repertoire. This review systematically summarizes advances in five key areas: (1) the major bioactive components of SLBZS and their modern therapeutic applications; (2) characterization of gut microbial communities and their relevant degradative enzymes; (3) in vitro and in vivo studies elucidating microbe-mediated biotransformation of SLBZS constituents; (4) modulation of host signaling pathways—such as NF-κB, peroxisome proliferator-activated receptor, and AMPK—by SLBZS metabolites; and (5) the pharmacological implications of these microbial conversions for enhancing compound bioactivity and therapeutic outcomes. By integrating phytochemical analyses, microbial genomics, and metabolomics data, researchers have begun to identify the specific microbial taxa responsible for key hydrolysis, reduction, and deglycosylation reactions. Understanding these host–microbe–herb interactions not only sheds light on the mechanistic basis of SLBZS's efficacy, but also informs strategies to optimize its formulation and dosing. Such insights will facilitate the modernization and precision application of traditional Chinese medicine, ultimately improving patient prognosis in gastrointestinal and systemic diseases.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 3","pages":"103-119"},"PeriodicalIF":0.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145537934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology-based screening and pharmacokinetic evaluation of key active compounds in Jinhong tablets against chronic superficial gastritis","authors":"Tingyu Zhang,&nbsp;Jian Feng,&nbsp;Mengyu Qian,&nbsp;Xia Gao,&nbsp;Xialin Chen,&nbsp;Ran Xiao,&nbsp;Hongyu Peng,&nbsp;Xiaoxue Fan,&nbsp;Xin Meng,&nbsp;Mingke Yin,&nbsp;Zhenzhong Wang,&nbsp;Bo Zhang,&nbsp;Liang Cao","doi":"10.1002/acm4.35","DOIUrl":"https://doi.org/10.1002/acm4.35","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Ethnopharmacological relevance&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Jinhong tablet (JHT), a traditional Chinese patent medicine prepared from four Chinese medicinal materials, is highly effective in soothing the liver and relieving depression, regulating qi and promoting blood circulation, and regulating the stomach and relieving pain. It is clinically used to treat chronic superficial gastritis (CSG) with liver-stomach disharmony. However, research on its pharmacokinetics remains limited.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim of the study&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aims to investigate the pharmacokinetic characteristics of JHT in normal rats and examine its pharmacokinetic differences across normal, CSG, and intestinal microbial disorder rats.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Materials and methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The chemical composition of JHT was identified using Orbitrap, and the main components were quantitatively analyzed. A network pharmacology screening framework was established to screen the key active ingredients of JHT in treating CSG. A quantitative method was developed to measure these ingredients in rat plasma. After oral administration of JHT at different doses, the pharmacokinetics of seven ingredients was evaluated in normal rats. Pharmacokinetic differences of four major compounds were further compared among normal, CSG, and fecal microbiota transplantation (FMT) rats. Gut microbiota changes in the three groups were analyzed using high-throughput sequencing, and Spearman correlation analysis was conducted to explore the relationship between the in vivo exposure and microbial alterations.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Leveraging network pharmacology analysis, we screened seven key active compounds of JHT in the treatment of CSG and conducted pharmacokinetic studies on them. In normal rats, all seven ingredients were rapidly absorbed. Tetrahydropalmatine, corydaline, costunolide, and rhamnosylvitexin showed good exposure, whereas dehydrocorydaline, allocryptopine, and palmatine hydrochloride had low exposure. Additionally, tetrahydropalmatine, corydaline, and costunolide exhibited linear pharmacokinetics between 0.7–5.6 g/kg, whereas rhamnosylvitexin and dehydrocorydaline were linear within 0.7 and 2.8 g/kg. In CSG and FMT rats, pharmacokinetic profiles changed. CSG increased the exposure and &lt;i&gt;C&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt; of costunolide and rhamnosylvitexin, whereas FMT enhanced the exposure of corydaline and &lt;i&gt;C&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt; of rhamnosylvitexin, which correlated with 20 altered gut bacterial genera.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 ","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 2","pages":"62-84"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.35","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and functional characterization of EFNA3 as a dual diagnostic biomarker and immune therapeutic target in rectal cancer","authors":"Tianqi Liu,&nbsp;Jiuyuan Fang,&nbsp;Bohan Liu,&nbsp;Hangqi Liu,&nbsp;Yidan Wang,&nbsp;Yipei Jing,&nbsp;Hui Zhang,&nbsp;Huanwen Wu","doi":"10.1002/acm4.36","DOIUrl":"https://doi.org/10.1002/acm4.36","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The Eph/ephrin signaling system has emerged as an important regulator of oncogenic processes, yet its specific involvement in rectal adenocarcinoma (READ) pathogenesis requires further elucidation. This study employed an integrative analytical approach combining computational biology with experimental validation to characterize Eph/ephrin family members in READ, with emphasis on <i>EFNA3</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We employed an integrative multi-omics approach combining bioinformatics analysis with experimental validation. Transcriptomic data from the Cancer Genome Atlas and Genotype-Tissue Expression were analyzed to evaluate Eph/ephrin family expression, clinical correlations, and immune infiltration patterns. Functional validation was performed using CCK-8, wound healing, transwell migration assays, and Western blotting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our integrated multi-omics analysis identified <i>EFNA3</i> as a dual-function biomarker with both prognostic and immunological relevance in READ. Specifically, <i>EFNA3</i> expression was elevated in READ tissues and correlated with poor patient prognosis. Functional characterization revealed that <i>EFNA3</i> contributes to an immunosuppressive tumor microenvironment, marked by reduced cytotoxic lymphocyte infiltration and downregulation of key immune checkpoints. Mechanistically, <i>EFNA3</i> overexpression promoted rectal cancer cell proliferation and migration, with pathway analysis and Western blot validation implicating Phosphoinositide 3-Kinase (PI3K)/Ak strain Transforming (AKT)/Mechanistic Target of Rapamycin (mTOR) signaling activation. Furthermore, <i>EFNA3</i> expression exhibited significant correlations with drug sensitivity and potential associations with traditional Chinese herbs, suggesting its broader implications in therapeutic response and alternative medicine approaches.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings establish <i>EFNA3</i> as a key regulator of READ progression, driving both tumor aggressiveness and immune evasion. These results provide a translational framework for targeting <i>EFNA3</i>-mediated pathways, suggesting combined PI3K/AKT/mTOR inhibition and immune modulation as a potential therapeutic strategy for aggressive READ.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 2","pages":"85-97"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.36","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cross talk between cancer-associated fibroblasts and neutrophil extracellular traps in the tumor microenvironment","authors":"Jiangbo Chen,&nbsp;Tongkun Song,&nbsp;Kai Weng,&nbsp;Hao Hao,&nbsp;Yifan Hou,&nbsp;Xiangqian Su","doi":"10.1002/acm4.37","DOIUrl":"https://doi.org/10.1002/acm4.37","url":null,"abstract":"<p>The tumor microenvironment (TME) plays a pivotal role in tumorigenesis and metastasis, with cancer-associated fibroblasts (CAFs) and neutrophil extracellular traps (NETs) identified as key contributors to its dynamic regulation. This review elucidates the multifaceted roles of CAFs and NETs in tumor progression and clarifies their intricate cross talk. The underlying mechanisms by which these components promote tumor growth, metastasis, and immune evasion are also discussed. Promising therapeutic strategies include both direct targeting of CAFs and inhibition of their downstream effectors. Likewise, the disruption of NET formation using DNase or peptidylarginine deiminase 4 inhibitors represents a potential avenue for anticancer therapy. In addition, the review highlights the regulatory effects of natural products and traditional Chinese medicines on CAF–tumor interactions. Despite these advances, further investigation is necessary to facilitate clinical translation. Overall, this review provides a comprehensive understanding of the TME and promote the development of innovative therapies targeting CAF–NET cross talk to improve cancer prognosis.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 2","pages":"56-61"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.37","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond p-values: Assessing clinical significance in acupuncture research","authors":"Changzhen Gong","doi":"10.1002/acm4.34","DOIUrl":"https://doi.org/10.1002/acm4.34","url":null,"abstract":"<p>In acupuncture randomized controlled trials (RCTs), the proper interpretation of results requires a thorough understanding of key statistical concepts such as <i>p</i>-value, effect size, and the minimal clinically important difference (MCID). This paper explores the relationships among these metrics and their implications for assessing the clinical significance of acupuncture interventions. Through case studies, the paper highlights the limitations of relying solely on <i>p</i>-values for determining the clinical relevance of outcomes. Although statistically significant results may be reported, these studies often fail to meet the prespecified MCID, raising concerns about their real-world applicability. This paper argues that <i>p</i>-values must be interpreted alongside effect size and MCID to ensure that reported benefits reflect meaningful improvements for patients. By examining both short- and long-term outcomes, this analysis emphasizes the need for a holistic approach when evaluating acupuncture RCTs, ensuring that statistical findings are translated into clinically significant improvements.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 2","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.34","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An updated review on the phytochemistry and pharmacological activity of black cumin (Nigella sativa L.)","authors":"Raghvendra Pandey,&nbsp;Brijesh Pandey,&nbsp;Atul Bhargava","doi":"10.1002/acm4.33","DOIUrl":"https://doi.org/10.1002/acm4.33","url":null,"abstract":"<p>In this review, a comprehensive and systematic evaluation of the phytochemical constituents, traditional medicinal applications, current pharmacological research, toxicity, and nanobiotechnology of black cumin has been undertaken. An exhaustive database retrieval was conducted to collect scientific information about <i>Nigella sativa</i> L. from 1956 to 2025 using PubMed, Scopus, ISI Web of Science, SciFinder, and CABI. Search was carried out using the keywords “<i>Nigella sativa</i>,” “<i>Nigella</i> oil,” “Ethnobotany,” “Phytochemistry,” “Pharmacological activity,” “Toxicity,” and “Nanotechnology.” Several important phytochemicals are found in the seeds of <i>N</i>. <i>sativa</i> L., and many of which seem to have a good impact on human health and are put to important use in the Ayurvedic, Unani, and Siddha systems of medicine. Among the active compounds, thymoquinone is the most important, forming about 30%–48% of the oil fraction. Besides thymoquinone, a wide range of phytochemicals such as thymohydroquinone, dithymoquinone, <i>p</i>-cymene, sabinene, carvacrol, 4-terpineol, kaempferol (glucoside) <i>t</i>-anethol, longifolene (sesquiterpene), <i>α</i>-pinene, <i>α</i>-hederin (pentacyclic triterpene), and thymol have also been reported. Current research has provided scientific evidence for the traditional uses of black cumin, especially antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, anticancer, antidiabetic, neuroprotective, gastroprotective, and antiarthritic effects. The review provides an in-depth analysis of the phytochemistry, traditional uses as well as potential pharmacological properties of <i>N</i>. <i>sativa</i> L. Since the plant is being extensively investigated for its medicinal properties, this review provides valuable up-to-date information on the current research status and will act as a reference for future research and applications of this important medicinal plant.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 1","pages":"13-29"},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.33","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing data mining and network pharmacology to analyze the formulation rule and function of enhancing immunity of Acanthopanax Radix et Rhizoma-containing health products","authors":"Meiyue Li,&nbsp;Pei Ma,&nbsp;Xue Li,&nbsp;Lijia Xu,&nbsp;Lifeng Yue","doi":"10.1002/acm4.31","DOIUrl":"https://doi.org/10.1002/acm4.31","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to analyze the formulation rules of Ciwujia (<i>Acanthopanax Radix et Rhizoma</i>)-containing health products and investigate the potential mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>By searching the Ciwujia-containing health products from the special food information inquiry platform of the State Administration for Market Regulation and MedSciNet, the basic information, including efficacy, tropism of taste, dosage form, health function etc., was analyzed using R language software packages and Excel. The formulation rules and core drug combinations were analyzed using the Apriori algorithm of IBM SPSS Modeler 18.0. By searching TCMID and other databases and reviewing relevant literature, the chemical components and potential targets database of Ciwujia was constructed. The protein–protein interaction network was analyzed using R package, String database, and Cytoscape software to screen for key components and targets related to health functions. Gene ontology functional annotation and Kyoto encyclopedia of genes and genomes pathway enrichment analysis were performed. Finally, molecular docking was used to verify the binding affinity of core targets and key components.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 315 cases of Ciwujia-containing health products were collected. The major health functions were to relieve physical fatigue and immune enhancement. A total of 205 effective components and 775 targets related to Ciwujia were obtained. By intersecting the genes related to Ciwujia and immune enhancement, 212 key target genes were identified. Ciwujia has an effect on immune enhancement through signaling pathways such as C-type lectin receptor, toll-like receptor, and NOD-like receptor. Molecular docking results also indicated a spontaneous and stable binding between the key components of Ciwujia and the core targets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Through data mining, network pharmacology, and molecular docking research, this study analyzed the relevant information of Ciwujia-containing health products, preliminarily revealing its potential targets and mechanism pathways of immune enhancement and providing a theoretical basis for the development of future health products.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 1","pages":"30-44"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.31","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}