Advanced Chinese Medicine最新文献

{"title":"Network pharmacology-based screening and pharmacokinetic evaluation of key active compounds in Jinhong tablets against chronic superficial gastritis","authors":"Tingyu Zhang, Jian Feng, Mengyu Qian, Xia Gao, Xialin Chen, Ran Xiao, Hongyu Peng, Xiaoxue Fan, Xin Meng, Mingke Yin, Zhenzhong Wang, Bo Zhang, Liang Cao","doi":"10.1002/acm4.35","DOIUrl":"https://doi.org/10.1002/acm4.35","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Ethnopharmacological relevance</h3>\u0000 \u0000 <p>Jinhong tablet (JHT), a traditional Chinese patent medicine prepared from four Chinese medicinal materials, is highly effective in soothing the liver and relieving depression, regulating qi and promoting blood circulation, and regulating the stomach and relieving pain. It is clinically used to treat chronic superficial gastritis (CSG) with liver-stomach disharmony. However, research on its pharmacokinetics remains limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim of the study</h3>\u0000 \u0000 <p>This study aims to investigate the pharmacokinetic characteristics of JHT in normal rats and examine its pharmacokinetic differences across normal, CSG, and intestinal microbial disorder rats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and methods</h3>\u0000 \u0000 <p>The chemical composition of JHT was identified using Orbitrap, and the main components were quantitatively analyzed. A network pharmacology screening framework was established to screen the key active ingredients of JHT in treating CSG. A quantitative method was developed to measure these ingredients in rat plasma. After oral administration of JHT at different doses, the pharmacokinetics of seven ingredients was evaluated in normal rats. Pharmacokinetic differences of four major compounds were further compared among normal, CSG, and fecal microbiota transplantation (FMT) rats. Gut microbiota changes in the three groups were analyzed using high-throughput sequencing, and Spearman correlation analysis was conducted to explore the relationship between the in vivo exposure and microbial alterations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Leveraging network pharmacology analysis, we screened seven key active compounds of JHT in the treatment of CSG and conducted pharmacokinetic studies on them. In normal rats, all seven ingredients were rapidly absorbed. Tetrahydropalmatine, corydaline, costunolide, and rhamnosylvitexin showed good exposure, whereas dehydrocorydaline, allocryptopine, and palmatine hydrochloride had low exposure. Additionally, tetrahydropalmatine, corydaline, and costunolide exhibited linear pharmacokinetics between 0.7–5.6 g/kg, whereas rhamnosylvitexin and dehydrocorydaline were linear within 0.7 and 2.8 g/kg. In CSG and FMT rats, pharmacokinetic profiles changed. CSG increased the exposure and <i>C</i><sub>max</sub> of costunolide and rhamnosylvitexin, whereas FMT enhanced the exposure of corydaline and <i>C</i><sub>max</sub> of rhamnosylvitexin, which correlated with 20 altered gut bacterial genera.</p>\u0000 </section>\u0000 \u0000 ","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 2","pages":"62-84"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.35","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and functional characterization of EFNA3 as a dual diagnostic biomarker and immune therapeutic target in rectal cancer","authors":"Tianqi Liu,&nbsp;Jiuyuan Fang,&nbsp;Bohan Liu,&nbsp;Hangqi Liu,&nbsp;Yidan Wang,&nbsp;Yipei Jing,&nbsp;Hui Zhang,&nbsp;Huanwen Wu","doi":"10.1002/acm4.36","DOIUrl":"https://doi.org/10.1002/acm4.36","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The Eph/ephrin signaling system has emerged as an important regulator of oncogenic processes, yet its specific involvement in rectal adenocarcinoma (READ) pathogenesis requires further elucidation. This study employed an integrative analytical approach combining computational biology with experimental validation to characterize Eph/ephrin family members in READ, with emphasis on <i>EFNA3</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We employed an integrative multi-omics approach combining bioinformatics analysis with experimental validation. Transcriptomic data from the Cancer Genome Atlas and Genotype-Tissue Expression were analyzed to evaluate Eph/ephrin family expression, clinical correlations, and immune infiltration patterns. Functional validation was performed using CCK-8, wound healing, transwell migration assays, and Western blotting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our integrated multi-omics analysis identified <i>EFNA3</i> as a dual-function biomarker with both prognostic and immunological relevance in READ. Specifically, <i>EFNA3</i> expression was elevated in READ tissues and correlated with poor patient prognosis. Functional characterization revealed that <i>EFNA3</i> contributes to an immunosuppressive tumor microenvironment, marked by reduced cytotoxic lymphocyte infiltration and downregulation of key immune checkpoints. Mechanistically, <i>EFNA3</i> overexpression promoted rectal cancer cell proliferation and migration, with pathway analysis and Western blot validation implicating Phosphoinositide 3-Kinase (PI3K)/Ak strain Transforming (AKT)/Mechanistic Target of Rapamycin (mTOR) signaling activation. Furthermore, <i>EFNA3</i> expression exhibited significant correlations with drug sensitivity and potential associations with traditional Chinese herbs, suggesting its broader implications in therapeutic response and alternative medicine approaches.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings establish <i>EFNA3</i> as a key regulator of READ progression, driving both tumor aggressiveness and immune evasion. These results provide a translational framework for targeting <i>EFNA3</i>-mediated pathways, suggesting combined PI3K/AKT/mTOR inhibition and immune modulation as a potential therapeutic strategy for aggressive READ.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 2","pages":"85-97"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.36","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cross talk between cancer-associated fibroblasts and neutrophil extracellular traps in the tumor microenvironment","authors":"Jiangbo Chen,&nbsp;Tongkun Song,&nbsp;Kai Weng,&nbsp;Hao Hao,&nbsp;Yifan Hou,&nbsp;Xiangqian Su","doi":"10.1002/acm4.37","DOIUrl":"https://doi.org/10.1002/acm4.37","url":null,"abstract":"<p>The tumor microenvironment (TME) plays a pivotal role in tumorigenesis and metastasis, with cancer-associated fibroblasts (CAFs) and neutrophil extracellular traps (NETs) identified as key contributors to its dynamic regulation. This review elucidates the multifaceted roles of CAFs and NETs in tumor progression and clarifies their intricate cross talk. The underlying mechanisms by which these components promote tumor growth, metastasis, and immune evasion are also discussed. Promising therapeutic strategies include both direct targeting of CAFs and inhibition of their downstream effectors. Likewise, the disruption of NET formation using DNase or peptidylarginine deiminase 4 inhibitors represents a potential avenue for anticancer therapy. In addition, the review highlights the regulatory effects of natural products and traditional Chinese medicines on CAF–tumor interactions. Despite these advances, further investigation is necessary to facilitate clinical translation. Overall, this review provides a comprehensive understanding of the TME and promote the development of innovative therapies targeting CAF–NET cross talk to improve cancer prognosis.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 2","pages":"56-61"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.37","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond p-values: Assessing clinical significance in acupuncture research","authors":"Changzhen Gong","doi":"10.1002/acm4.34","DOIUrl":"https://doi.org/10.1002/acm4.34","url":null,"abstract":"<p>In acupuncture randomized controlled trials (RCTs), the proper interpretation of results requires a thorough understanding of key statistical concepts such as <i>p</i>-value, effect size, and the minimal clinically important difference (MCID). This paper explores the relationships among these metrics and their implications for assessing the clinical significance of acupuncture interventions. Through case studies, the paper highlights the limitations of relying solely on <i>p</i>-values for determining the clinical relevance of outcomes. Although statistically significant results may be reported, these studies often fail to meet the prespecified MCID, raising concerns about their real-world applicability. This paper argues that <i>p</i>-values must be interpreted alongside effect size and MCID to ensure that reported benefits reflect meaningful improvements for patients. By examining both short- and long-term outcomes, this analysis emphasizes the need for a holistic approach when evaluating acupuncture RCTs, ensuring that statistical findings are translated into clinically significant improvements.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 2","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.34","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An updated review on the phytochemistry and pharmacological activity of black cumin (Nigella sativa L.)","authors":"Raghvendra Pandey,&nbsp;Brijesh Pandey,&nbsp;Atul Bhargava","doi":"10.1002/acm4.33","DOIUrl":"https://doi.org/10.1002/acm4.33","url":null,"abstract":"<p>In this review, a comprehensive and systematic evaluation of the phytochemical constituents, traditional medicinal applications, current pharmacological research, toxicity, and nanobiotechnology of black cumin has been undertaken. An exhaustive database retrieval was conducted to collect scientific information about <i>Nigella sativa</i> L. from 1956 to 2025 using PubMed, Scopus, ISI Web of Science, SciFinder, and CABI. Search was carried out using the keywords “<i>Nigella sativa</i>,” “<i>Nigella</i> oil,” “Ethnobotany,” “Phytochemistry,” “Pharmacological activity,” “Toxicity,” and “Nanotechnology.” Several important phytochemicals are found in the seeds of <i>N</i>. <i>sativa</i> L., and many of which seem to have a good impact on human health and are put to important use in the Ayurvedic, Unani, and Siddha systems of medicine. Among the active compounds, thymoquinone is the most important, forming about 30%–48% of the oil fraction. Besides thymoquinone, a wide range of phytochemicals such as thymohydroquinone, dithymoquinone, <i>p</i>-cymene, sabinene, carvacrol, 4-terpineol, kaempferol (glucoside) <i>t</i>-anethol, longifolene (sesquiterpene), <i>α</i>-pinene, <i>α</i>-hederin (pentacyclic triterpene), and thymol have also been reported. Current research has provided scientific evidence for the traditional uses of black cumin, especially antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, anticancer, antidiabetic, neuroprotective, gastroprotective, and antiarthritic effects. The review provides an in-depth analysis of the phytochemistry, traditional uses as well as potential pharmacological properties of <i>N</i>. <i>sativa</i> L. Since the plant is being extensively investigated for its medicinal properties, this review provides valuable up-to-date information on the current research status and will act as a reference for future research and applications of this important medicinal plant.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 1","pages":"13-29"},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.33","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing data mining and network pharmacology to analyze the formulation rule and function of enhancing immunity of Acanthopanax Radix et Rhizoma-containing health products","authors":"Meiyue Li,&nbsp;Pei Ma,&nbsp;Xue Li,&nbsp;Lijia Xu,&nbsp;Lifeng Yue","doi":"10.1002/acm4.31","DOIUrl":"https://doi.org/10.1002/acm4.31","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to analyze the formulation rules of Ciwujia (<i>Acanthopanax Radix et Rhizoma</i>)-containing health products and investigate the potential mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>By searching the Ciwujia-containing health products from the special food information inquiry platform of the State Administration for Market Regulation and MedSciNet, the basic information, including efficacy, tropism of taste, dosage form, health function etc., was analyzed using R language software packages and Excel. The formulation rules and core drug combinations were analyzed using the Apriori algorithm of IBM SPSS Modeler 18.0. By searching TCMID and other databases and reviewing relevant literature, the chemical components and potential targets database of Ciwujia was constructed. The protein–protein interaction network was analyzed using R package, String database, and Cytoscape software to screen for key components and targets related to health functions. Gene ontology functional annotation and Kyoto encyclopedia of genes and genomes pathway enrichment analysis were performed. Finally, molecular docking was used to verify the binding affinity of core targets and key components.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 315 cases of Ciwujia-containing health products were collected. The major health functions were to relieve physical fatigue and immune enhancement. A total of 205 effective components and 775 targets related to Ciwujia were obtained. By intersecting the genes related to Ciwujia and immune enhancement, 212 key target genes were identified. Ciwujia has an effect on immune enhancement through signaling pathways such as C-type lectin receptor, toll-like receptor, and NOD-like receptor. Molecular docking results also indicated a spontaneous and stable binding between the key components of Ciwujia and the core targets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Through data mining, network pharmacology, and molecular docking research, this study analyzed the relevant information of Ciwujia-containing health products, preliminarily revealing its potential targets and mechanism pathways of immune enhancement and providing a theoretical basis for the development of future health products.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 1","pages":"30-44"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.31","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine for the treatment of chronic inflammatory diseases: A review of inhibitors for NLRP3 inflammasome","authors":"Yucen Zou,&nbsp;Pei Ma,&nbsp;Bin Li,&nbsp;Jiushi Liu,&nbsp;Lifeng Yue,&nbsp;Bengang Zhang,&nbsp;Haitao Liu","doi":"10.1002/acm4.32","DOIUrl":"https://doi.org/10.1002/acm4.32","url":null,"abstract":"<p>The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a vital part of the innate immune response, whilst its aberrant activation drives the progression of several noncommunicable diseases. It induces caspase-1 activation and the downstream substrates involved with the processing and secretion of the pro-inflammatory cytokines IL-1β and IL-18 and TNF-α. Activation of this complex often involves the adapter ASC and upstream sensors including NLRP1, NLRP3, NLRC4, AIM2, and pyrin, which are activated by different stimuli including infectious agents and changes in cell homeostasis, and play key roles in inflammation, development, and related cell death. However, the molecular mechanisms that integrate multiple inflammasome sensors to facilitate optimal host defense remain unknown; therefore, treatment is challenging. Natural medicine and small molecule-based therapies have been well-documented for their effectiveness in modulating inflammatory pathways and reestablishing the lost proteostasis inside the cells to combat several chronic diseases related to inflammation. Traditional Chinese medicines (TCMs) have potent clinical effects against NLRP3 inflammasome activation and could be used as complementary therapy. Therefore, this review summarizes various similar reports and highlights the important effects of nutraceuticals and bioactive compounds derived from medicinal plants on NLRP3 inflammasome activation and their possible mechanisms of action. Thus, TCM prescriptions, herbs, and bioactive compounds can be considered novel, practical, and accessible agents in chronic inflammatory diseases by inhibiting NLRP3 inflammasome activation.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"2 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.32","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of primary cutaneous CD30-positive anaplastic large cell lymphoma with Wenyang Shengji decoction and Huanglian ointment: A case report","authors":"Kai Li,&nbsp;Tingting Bao,&nbsp;Ruonan Wei,&nbsp;Yingying Yang,&nbsp;Mengjiao Kang,&nbsp;Wei Zhang,&nbsp;Xianyu Zeng,&nbsp;Yiqun Duan,&nbsp;Liuqing Chen,&nbsp;Linhua Zhao","doi":"10.1002/acm4.27","DOIUrl":"https://doi.org/10.1002/acm4.27","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Primary cutaneous CD30 positive anaplastic large cell lymphoma (PC-ALCL) is a rare non-Hodgkin's lymphoma. Combined chemotherapy regimens such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin), or F-MACHOP (5-fluorouracil, methotrexate, cytosine-arabinoside, cyclophosphamide, doxorubicin, vincristine, and prednisone) are often used for its clinical treatment. In this study, we reported a new treatment method using a traditional Chinese therapy involving oral <i>Wenyang Shengji decoction</i> (WSD) combined with <i>Huanglian ointment</i> applied externally in a 32-year-old female patient with PC-ALCL. Introduction: A 32-year-old woman who complained of an ulcer on the forehead accompanied by significant pain. PC-ALCL was diagnosed by histopathological examination and immunohistochemical analysis. Treatment plan: WSD was prepared in 300 mL water and administered orally as a 150 mL decoction twice daily, and <i>Huanglian ointment</i> was applied to the ulcer three times daily. After 8 weeks of treatment with WSD combined with <i>Huanglian ointment</i>, the lesion healed completely. Immunohistochemical analysis revealed the presence of scattered CD3+++, CD4++, CD8++, CD20++, and CD30-positive cells. After 12 weeks of treatment, the ulcer healed completely, leaving only a marked pale red-pitted scar. The patient was followed up for 3 years without recurrence and no adverse events. Conclusion: oral WSD combined with <i>Huanglian ointment</i> applied to the ulcer for PC-ALCL can promote the healing of ulcers, reduce or alleviate the formation of scar, and eliminate CD30-positive cells. This case report provides a reference for the clinical treatment of PC-ALCL using traditional Chinese medicine.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 3","pages":"172-178"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.27","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in the application of cardiopulmonary exercise testing for overweight and obese populations","authors":"Tingshuai Fu,&nbsp;Mingzhong Xiao,&nbsp;Jiajia Ding,&nbsp;Chenxia Lu,&nbsp;Peiran Wang,&nbsp;Jingjing Yang,&nbsp;Qing Zhang","doi":"10.1002/acm4.26","DOIUrl":"https://doi.org/10.1002/acm4.26","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the advancements in cardiopulmonary exercise testing (CPET) among overweight or obese patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Reviewed the recent studies on clinical trials of CPET in overweight and obese patients, thought about the CPET advantage in obesity, while CPET equipment use for elucidating the principles underlying obesity and using CPET kinematic scheme to explore fat metabolism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The exercise program developed by CPET is scientific, sustainable and advantageous. With this trial, we can develop a relatively effective, fast and measurable amount of exercise, on the basis of the exercise test in obese people, CPET can provide scientific and digital motion reducing weight for overweight patients. At the same time, the trial has become widely applied in research into drug and surgical treatments for overweight patients. It is possible to quantify the efficacy of a trial and ultimately assess the merits of CPET.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CPET is considered as a fundamental criterion for designing motion schemes. Despite limitations of equipment errors and patient endurance, the benefits of CPET in program formulation have been gradually recognized, which made it a promising tool in the field of obesity management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 3","pages":"162-171"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.26","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates of surgical treatment in hemorrhoidal disease","authors":"Jianan Li,&nbsp;Huangfu Ma,&nbsp;Yue Wang,&nbsp;Lixia Lai,&nbsp;Xuecheng Zhang,&nbsp;Yanmei Wang","doi":"10.1002/acm4.25","DOIUrl":"https://doi.org/10.1002/acm4.25","url":null,"abstract":"<p>Hemorrhoidal disease is one of the most prevalent and frequently occurring conditions worldwide. Treatment modalities for hemorrhoids are multifaceted and tailored according to the severity of the condition. Various surgical procedures and modified approaches had been invented since 1937. Here we review the workflow, advantages, and disadvantages of different types of hemorrhoid surgery (conventional excisional hemorrhoidectomy, modified excisional surgery, stapled/partial stapled hemorrhoidopexy, and Doppler-guided hemorrhoidal artery ligation). There is no single treatment that fits all hemorrhoid patients. Surgeons should make the operation plan based on patients' conditions and wills.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 3","pages":"156-161"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.25","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}